Mechanistic and structural analysis of a family 31 α-glycosidase and its glycosyl-enzyme intermediate

Journal of Biological Chemistry

Volumn 280, Issue 3, 2005, Pages 2105-2115

  Lovering, Andrew L ^a   Seung, Seo Lee ^a   Kim, Young Wan ^a   Withers, Stephen G ^a   Strynadka, Natalie C J ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Howard Hughes Med Inst Intl S   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; ESCHERICHIA COLI; MASS SPECTROMETRY; MONOMERS; REACTION KINETICS; STRUCTURAL ANALYSIS; SUGARS;

GLYCOSYL-ENZYME INTERMEDIATE; MUTATIONS; STRUCTURAL ELEMENTS; SUGAR RINGS;

ENZYMES;

1 DEOXYNOJIRIMYCIN; 1 DEOXYXYLONOJIRIMYCIN; ACARBOSE; ALPHA GLUCOSIDASE; ENZYME INHIBITOR; GLYCOSIDASE YICI; GLYCOSIDASE YIHQ; OLIGO 1,6 GLUCOSIDASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; COVALENT BOND; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; ESCHERICHIA COLI; HYDROLYSIS; MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; SEQUENCE ALIGNMENT; SPECIES COMPARISON; STRUCTURE ANALYSIS; SULFOLOBUS SOLFATARICUS; TEMPERATURE DEPENDENCE;

ALPHA-GLUCOSIDASES; AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING SITES; BIOPOLYMERS; CLONING, MOLECULAR; DNA PRIMERS; ESCHERICHIA COLI; KINETICS; LYSOSOMES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID;

ESCHERICHIA COLI; MAMMALIA; NEGIBACTERIA; SULFOLOBUS; SULFOLOBUS SOLFATARICUS;

EID: 12544256784     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M410468200     Document Type: Article

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