Serine proteases-directed small molecule probe libraries

Medicinal Chemistry Research

Volumn 8, Issue 4-5, 1998, Pages 187-205

  Dhanoa, Dale S ^a   Soll, Richard M ^a   Subasinghe, Nalin ^a   Wu, Zhengdong ^a   Rinker, James ^a   Hoffman, James ^a   Eisennagel, Stephen ^a   Graybill, Todd ^a   Bone, Roger ^a   Radzicka, Anna ^a   Murphy, Larry ^a   Salemme, F Raymond ^a  

^a JOHNSON AND JOHNSON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; AROMATIC HYDROCARBON; BLOOD CLOTTING FACTOR 10A; GUANIDINE DERIVATIVE; SERINE PROTEINASE INHIBITOR; SULFONAMIDE; SULFONIC ACID DERIVATIVE; THROMBIN; UREA DERIVATIVE;

ARTICLE; AUTOMATION; CHEMICAL STRUCTURE; DRUG DESIGN; MASS SPECTROMETRY; METHODOLOGY; MOLECULAR PROBE; SYNTHESIS;

EID: 7844251893     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. (a) Gallop, M. A.; Barrett, R.W.; Dower, W.J.; Fodor, S. P. A.; Gordon, E. M. J. Med. Chem. 1994, 37, 1233.
2. (b) Gordon, E. M.; Barrett, R. W.; Dower, W. J.; Fodor, S. P. A.; Gallop, M. A. J. Med. Chem. 1994, 37, 1385.
3. Terrett, N. K.; Gardner, M.; Gordon, D. W.; Kobylecki, R. J.; Steele, J. Tetrahedron 1995, 51, 8135.
4. Ellman, J. A. Acc. Chem. Res. 1996, 29, 132.
5. Balkenhohl, F.; von dem Bussche-Hunnefeld, Lansky, A.; Zechel, C. Angew. Chem. Int. Ed. Engl. 1996, 35, 2288.
6. Cheng, S.; Comer, D. D.; Williams, J. P.; Myers, P. L.; Boger, D. L. J. Am. Chem. Soc. 1996, 118, 2567.
7. Molecular Diversity and Combinatorial Chemistry, Eds. Chaiken, I. M.; Janda, K. D. ACS, Washington, DC.
8. Bone, R.; Salemme, F. R. In Structure-Based Drug Design.; Ed. Veerapandian, P.; pp 525-539, Marcel Dekker, Inc. New York, 1997.
9. Illig, C.; , Stephen Eisennagel.; Bone, R.; Radzicka, A.; Murphy, L.; Randle, T.; Spurlino, J.; Jaeger, E.; Salemme, F. R. ; Soll, R. M. Following Paper in this issue.
10. Dolle, R. E. Molecular Diversity 1996, 2, 223.
11. Ripca, W. C.; Vlasuk, G. P.; Ann. Rep. Med. Chem. 1997, 32, 71.
12. Bone, R.; Lu, T.; Illig, C. R.; Soll, R. M.; Spurlino, J. C. J. Med. Chem. 1998, in press.
13. Engh, R. A.; Brandsetter, H.; Sucher, G.; Eichinger, A.; Baumann, U.; Bode, W.; Huber, R.; Poll, T.; Rudolph, R.; von der Saal, W. Structure 1996, 4, 1353.
14. Hartman, G. D.; Egbertson, M. S.; Halczenko, W.; Laswell, W. L.; Duggan, M. E.; Smith, R. S.; Naylor, A. M.; Manno, P. D.; Lynch, R. L.; Zhang, G.; Chang, C. T.-C.; Gould, R. J. J. Med. Chem. 1992, 35, 4640.
15. Qian, Y.; Vogt, A.; Sebti, S. M.; Hamilton, A. D. J. Med. Chem. 1996, 39, 217.
16. 1H NMR was performed on a Bruker AMX-300 MHz Spectrometer using internal standard; Mass Spectral data was obtained using Kratos Kompact Maldi III Time of Flight mass spectron using α-cyano-4-hydroxycinnamicacid (CHCA) or gentisic acid as matrix.