The effect of epitope variation on the profile of cytotoxic T lymphocyte responses to the HIV envelope glycoprotein

International Immunology

Volumn 10, Issue 12, 1998, Pages 1789-1799

  Kmieciak, Dariusz ^a,f   Bednarek, Ilona ^a   Takiguchi, Masafumi ^b   Wasik, Thomas J ^a   Bratosiewicz, Jolanta ^a   Wierzbicki, Andrzej ^a   Teppler, Hedy ^c,g   Pientka, Janet ^c,g   Hsu, Susan H ^d   Kaneko, Yutaro ^e   Kozbor, Danuta ^a,c  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b KUMAMOTO UNIVERSITY   (Japan)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d AMERICAN RED CROSS   (United States)

^e AJINOMOTO CO INC   (Japan)

^f POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^g MERCK RESEARCH LABORATORIES   (United States)

Author keywords

HLA A*0201 restriction; MHC complex; Peptide motifs; TCR

Indexed keywords

CD8 ANTIGEN; HLA A2 ANTIGEN; T LYMPHOCYTE RECEPTOR; VIRUS ENVELOPE PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; VIRUS MUTATION;

EID: 7844241553     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/10.12.1789     Document Type: Article

References (30)

1. Falk, K., Rotzschke, O., Stevanovic, S., Jung, G. and Rammensee, H.-G. 1991. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 351:290.
2. Rammensee, H.-G., Friede, T. and Stevanovic, M. 1995. MHC ligands and peptide motifs: first listing. Immunogenetics 41:178.
3. Phillips, R. E., Rowland-Jones, S., Nixon, D. F., Gotch, F. M., Edwards, J. P., Ogunlesi. A. O., Elvin, J. G., Rothbard, J. A., Bangham, C. R. and Rizza, C. R. 1991. Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature 354:453.
4. Klenerman, P., Rowland-Jones, S., McAdam, S., Edwards, J., Daenke, S., Lalloo, D., Koppe, B., Rosenberg, W., Boyd, D., Edwards, A., Giangrande, P., Phillips, R. E. and McMichael, A. J. 1994. Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants. Nature 369:403.
5. Klenerman, P., Meier, U. C., Phillips, R. E. and McMichael, A. J. 1995. The effects of natural altered peptide ligands on the whole blood cytotoxic T lymphocyte response to human immunodeficiency virus. Eur. J. Immunol. 25:1927.
6. Nowak, M. A., May, R. M., Phillips, R. E., Rowland-Jones, S., Lalloo, D. G., McAdam, S., Klenerman, P., Koppe, B., Sigmund, K., Bangham, C. R. M. and McMichael, A. J. 1995. Antigenic oscillations and shifting immunodominance in HIV-1 infections. Nature 375:606.
7. Goulder, P. J. R., Phillips, R. E., Colbert, R. A., McAdam, S., Ogg, G., Nowak, M. A., Giangrande, P., Luzzi, G., Morgan, B., Edwards, A., McMichael, A. J. and Rowland-Jones, S. 1997. Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS Nature Med. 3:212.
8. Borrow, P., Lewicki, H., Wei X., Horwitz, M. S., Peffer, N., Meyers, H., Nelson, J. A., Gairin, J. E., Hahn, B. H., Oldstone, M. B. A. and Shaw, G. M. 1997. Antiviral pressure excerpted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nature Med. 3:205.
9. Zagury, D. 1997. A naturally unbalanced combat. Nature Med. 3:156.
10. Johson, R. P. and Walker, B. D. 1994. CTL in HIV-1 infection: responses to structural proteins. Curr Top. Microbiol. Immunol. 189:35M.
11. Kalams, S. A., Johnson, R. P., Trocha, A. K., Dynan, M. J., Ngo H. S., D'Aquila, R. T., Kurnick, J. T. and Walker, B. D. 1994. Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire. J. Exp. Med. 179:1261.
12. + cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS 10:F17.
13. + T cell turnover. Science 274:1543.
14. + T cells from HIV-discordant monozygotic twins. J. Exp. Med. 185:1381.
15. Carmichael, A., Jin, X., Sissons, P. and Borysiewicz, L. 1993 Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) responses at different stages of HIV-1 infection: differential CTL responses to HIV and Epstein-Barr virus in late disease. J. Exp. Med. 177:249.
16. Otvos, L. Jr., Urge, L., Xiang, Z. Q., Krivulka, G. R., Nagy, L., Szenderei, G. I. and Ertl, H. C. 1994. Glycosylation of synthetic T-helper cell epitopic peptides influences their antigenic potency and conformation in a sugar location-specific manner. Biochim. Biophys. Acta. 1224:68.
17. Takamiya, Y., Schonbach, C., Nokihara, K., Yamaguchi, M. Ferrone, S., Kano, K., Egawa, K and Takiguchi, M. 1993. HLA-B*3501-peptide interactions: role of anchor residues of peptides in their binding to HLA-B*3501 molecules. Int. Immunol. 6:255.
18. Nietfeld W., Bauer, M., Fevrier, M., Maier, R., Holzwarth, B., Frank Maier B. R., Riviere, Y. and Meyerhans, A. 1994. Sequence constrains and recognition by CTL of an HLA-B27-restricted HIV-1 gag epitope. J. Immunol 154:2188.
19. Kozbor, D. and Roder, J. C. 1981. Requirements for the establishment of high-titered human monoclonal antibodies against tetanus toxoid using the Epstein-Barr virus technique J. Immunol. 127: 1275.
20. Hyjek, E., Lischner, H. W., Hyslop, T., Bartkowiak, J., Kubin, M. Trinchieri, G. and Kozbor D. 1995. Cytokine patterns during progression to AIDS in children with perinatal HIV infection. J. Immunol. 155:4060.
21. Dupuis, M., Kundu, S. M. and Merigan, T. 1995. Characterization of HLA-A*0201-restricted cytotoxic T cell epitopes in conserved regions of the HIV type 1 gp160 protein. J. Immunol. 155:2232.
22. Koup, R. A., Pikora, C. A., Luzuriaga, K., Brettler, D. B., Day, E. S., Mazzara, G. P. and Sullivan, J. L. 1991. Limiting dilution analysis of cytotoxic T lymphocytes to human immunodeficiency virus gag antigens in infected persons: in vitro quantitation of effector cell populations with p17 and p24 specificities. J. Exp. Med. 174:1593.
23. Safrit, J. T., Andrews, C. A., Zhu, T., Ho, D. D. and Koup, R. A. 1994. Characterization of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte clones isolated during acute seroconversion: recognition of autologous virus sequences within a conserved immunodominant epitope. J. Exp. Med. 179:463.
24. Myers, G., Korber, S., Wain-Hobson, S., Smith, R. F. and Pavlakis, G. N. 1993 Human Retroviruses and AIDS. Los Alamos National Laboratory, Los Alamos, NM.
25. β subsets are not preferentially deleted in AIDS. AIDS 7:625.
26. Damle, N. K., Mohagheghpour, N., Hansen, J. A. and Engelman, E. G,. 1983. Alloantigen-specific cytotoxic and suppressor T lymphocytes are derived from phenotypically distinct precursors. J. Immunol. 131:2296.
27. Selin, L. K., Nahill, S. R. and Welsh, R. M. 1994 Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses. J. Exp. Med. 179:1933.
28. Wasik, T. J., Jagodzinski P, P., Hyjek, E. M., Lischner, H. W. and Kozbor, D. 1996. Dimin shed HIV-specific CTL activity associated with enhanced type 2 responses to HIV-specific peptides during perinatal HIV infection. J. Immunol. 158:6029.
29. + T cell responses associated with control of viremia. Science 278:1447.
30. Giovarelli, M., Santoni, A., Jemma, C., Musso, T., Giuffrida, A. M., Cavallo, G, Landolfo, S. and Forni, G. 1988. Obligatory role of IFN-γ in induction of lymphokine-activated and T lymphocyte killer activity, but not in boosting of natural cytotoxicity. J. Immunol. 141:2831.