Human immunoglobulin G autoantibodies to the thyrotropin receptor from Epstein-Barr virus-transformed B lymphocytes: Characterization by immunoprecipitation with recombinant antigen and biological activity

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 9, 1996, Pages 3155-3161

  Morgenthaler, Nils G ^a,c   Kim, Mi Rim ^b   Tremble, Jennifer ^a   Huang, Guo Cai ^a   Richter, Wiltrud ^a   Gupta, Manjula ^b   Scherbaum, Werner A ^c   McGregor, Alan M ^d   Banga, J Paul ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b LERNER RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF LEIPZIG   (Germany)

^d UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN G; RECOMBINANT PROTEIN; THYROTROPIN RECEPTOR; THYROTROPIN RECEPTOR ANTIBODY;

ADULT; ANTIGEN ANTIBODY COMPLEX; ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; EPSTEIN BARR VIRUS; FEMALE; GRAVES DISEASE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LYMPHOCYTE TRANSFORMATION; MALE; MYXEDEMA; PRIORITY JOURNAL; RECEPTOR BINDING;

ANTIGENS; AUTOANTIBODIES; B-LYMPHOCYTES; CELL LINE; CELL LINE, TRANSFORMED; CYCLIC AMP; FEMALE; GRAVES DISEASE; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOGLOBULIN G; IMMUNOMAGNETIC SEPARATION; IMMUNOSORBENT TECHNIQUES; MALE; RECEPTORS, THYROTROPIN; RECOMBINANT PROTEINS; THYROID GLAND; THYROTROPIN;

EID: 0029792876     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.9.3155     Document Type: Article

References (7)

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2. McKenzie JM, Zakarija M. 1989 The clinical use of thyrotropin receptor antibody measurements. J Clin Endocrinol Metab. 69:1093-1096.
3. McGregor AM. 1990 Autoantibodies to the TSH receptor in patients with autoimmune thyroid disease. Clin Endocrinol (Oxf). 33:683-685.
4. Gupta M. 1992 Thyrotropin receptor antibodies: advances and importance of detection techniques in thyroid disease. Clin Biochem. 25:193-199.
5. Nagayama Y, Wadsworth HL, Russo D, Chazenbalk GD, Rapoport B. 1991 Binding domain of stimulatory and inhibitory thyrotropin (TSH) receptor autoantibodies determined with chimeric TSH-lutropin/choriogonadotropin receptors. J Clin Invest. 88:336-340.
6. Kosugi S, Ban T, Akamizu T, Kohn LD. 1992 Identification of separate determinants on the thyrotropin receptor reactive with Graves' thyroid stimulating antibodies and with thyroid-stimulating blocking antibodies in idiopathic myxoedema: these determinants have no homologous sequences on gonadotropin receptors. Mol Endocrinol. 6:168-180.
7. Nagayama Y, Rapoport B. 1992 The thyrotropin receptor twenty five years after its discovery: new insights following its molecular cloning. Mol Endocrinol. 6:145-156.