Reversed-phase high-performance liquid chromatographic separation of diastereomers of (R,S)-mexiletine prepared by microwave irradiation with four new chiral derivatizing reagents based on trichloro-s-triazine having amino acids as chiral auxiliaries and 10 others having amino acid amides

Journal of Chromatography A

Volumn 1217, Issue 49, 2010, Pages 7669-7676

  Bhushan, Ravi ^a   Dixit, Shuchi ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY ROORKEE   (India)

Author keywords

(R,S) mexiletine; Chiral derivatizing reagents; Diastereomers; Dichloro s triazine; Monochloro s triazine; Reversed phase high performance liquid chromatographic separation

Indexed keywords

CHIRAL DERIVATIZING REAGENTS; DIASTEREOMERS; MEXILETINE; REVERSED PHASE; S-TRIAZINES;

AMIDES; CHLORINE; COLUMN CHROMATOGRAPHY; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IRRADIATION; LIQUIDS; METHANOL; MICROWAVE IRRADIATION;

AMINO ACIDS;

DICHLOROTRIAZINE; METHANOL; MEXILETINE; MONOCHLOROTRIAZINE; TRIAZINE DERIVATIVE; TRICHLOROTRIAZINE; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

AMINO ACID COMPOSITION; ARTICLE; CHEMICAL COMPOSITION; CHEMICAL MODIFICATION; CONTROLLED STUDY; DIASTEREOISOMER; DRUG DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROPHOBICITY; MICROWAVE RADIATION; NUCLEOPHILICITY; PRIORITY JOURNAL; REACTION TIME; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAVIOLET RADIATION;

AMIDES; AMINO ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; HYDROGEN-ION CONCENTRATION; LINEAR MODELS; MEXILETINE; MICROWAVES; REPRODUCIBILITY OF RESULTS; STEREOISOMERISM; TRIAZINES;

EID: 78349312472     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.09.072     Document Type: Article

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