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Volumn 53, Issue 5-6, 2010, Pages 193-199

Lacidipine has antiatherosclerotic effects independent of its actions on lipid metabolism and blood pressure

Author keywords

5 HT sensitivity; Collar induced atherosclerosis; Intimal thickening; Lacidipine; MMP 9; Nitric oxide; Rabbit carotid artery; Vascular reactivity

Indexed keywords

3 NITROTYROSINE; ACETYLCHOLINE; CHOLESTEROL; GELATINASE B; LACIDIPINE; NITRIC OXIDE; SEROTONIN;

EID: 78349308923     PISSN: 15371891     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vph.2010.08.003     Document Type: Article
Times cited : (11)

References (45)
  • 1
    • 77749254756 scopus 로고    scopus 로고
    • Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kgamma-dependent manner. Am J Physiol Cell Physiol, 298, C679-92.
    • Awad A.E., Kandalam V., Chakrabarti S., Wang X., Penninger J.M., Davidge S.T., Oudit G.Y. & Kassiri Z., 2010. Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kgamma-dependent manner. Am J Physiol Cell Physiol, 298, C679-92.
    • (2010)
    • Awad, A.E.1    Kandalam, V.2    Chakrabarti, S.3    Wang, X.4    Penninger, J.M.5    Davidge, S.T.6    Oudit, G.Y.7    and Kassiri, Z.8
  • 2
    • 77749233907 scopus 로고    scopus 로고
    • Matrix metalloproteinases in atherothrombosis. Prog Cardiovasc Dis, 52, 410-28.
    • Back M., Ketelhuth D.F. & Agewall S., 2010. Matrix metalloproteinases in atherothrombosis. Prog Cardiovasc Dis, 52, 410-28.
    • (2010)
    • Back, M.1    etelhuth, D.F.2    andAgewall, S.3
  • 3
    • 0006322375 scopus 로고
    • Ultrastructural assessment of lesion development in the collared rabbit carotid artery model
    • Beesley J.H.A., Martin J. Ultrastructural assessment of lesion development in the collared rabbit carotid artery model. Cell Mater. 1992, 2:201-203.
    • (1992) Cell Mater. , vol.2 , pp. 201-203
    • Beesley, J.H.A.1    Martin, J.2
  • 5
    • 0026271734 scopus 로고
    • Calcium antagonists and cholesteryl ester metabolism in macrophages
    • Bernini F., Bellosta S., Didoni G., Fumagalli R. Calcium antagonists and cholesteryl ester metabolism in macrophages. J. Cardiovasc. Pharmacol. 1991, 18(Suppl 10):S42-S45.
    • (1991) J. Cardiovasc. Pharmacol. , vol.18 , Issue.SUPPL 10
    • Bernini, F.1    Bellosta, S.2    Didoni, G.3    Fumagalli, R.4
  • 8
    • 0028626346 scopus 로고
    • The E.L.S.A. trial: protocol of a randomized trial to explore the differential effect of antihypertensive drugs on atherosclerosis in hypertension
    • Bond G., Dal Palu C., Hansson L., Magnani B., Mancia G., Neiss A., Rahn K.H., Reid J.L., Rodicio J.L., Safar M., et al. The E.L.S.A. trial: protocol of a randomized trial to explore the differential effect of antihypertensive drugs on atherosclerosis in hypertension. J. Cardiovasc. Pharmacol. 1994, 23(Suppl 5):S85-S87.
    • (1994) J. Cardiovasc. Pharmacol. , vol.23 , Issue.SUPPL 5
    • Bond, G.1    Dal Palu, C.2    Hansson, L.3    Magnani, B.4    Mancia, G.5    Neiss, A.6    Rahn, K.H.7    Reid, J.L.8    Rodicio, J.L.9    Safar, M.10
  • 9
    • 0024594861 scopus 로고
    • Rapid development of atherosclerotic lesions in the rabbit carotid artery induced by perivascular manipulation
    • Booth R.F., Martin J.F., Honey A.C., Hassall D.G., Beesley J.E., Moncada S. Rapid development of atherosclerotic lesions in the rabbit carotid artery induced by perivascular manipulation. Atherosclerosis 1989, 76:257-268.
    • (1989) Atherosclerosis , vol.76 , pp. 257-268
    • Booth, R.F.1    Martin, J.F.2    Honey, A.C.3    Hassall, D.G.4    Beesley, J.E.5    Moncada, S.6
  • 10
    • 0028906790 scopus 로고
    • Identification of 92-kD gelatinase in human coronary atherosclerotic lesions. Association of active enzyme synthesis with unstable angina
    • Brown D.L., Hibbs M.S., Kearney M., Loushin C., Isner J.M. Identification of 92-kD gelatinase in human coronary atherosclerotic lesions. Association of active enzyme synthesis with unstable angina. Circulation 1995, 91:2125-2131.
    • (1995) Circulation , vol.91 , pp. 2125-2131
    • Brown, D.L.1    Hibbs, M.S.2    Kearney, M.3    Loushin, C.4    Isner, J.M.5
  • 11
    • 34547750848 scopus 로고    scopus 로고
    • Adventitial application of the NADPH oxidase inhibitor apocynin in vivo reduces neointima formation and endothelial dysfunction in rabbits
    • Chan E.C., Datla S.R., Dilley R., Hickey H., Drummond G.R., Dusting G.J. Adventitial application of the NADPH oxidase inhibitor apocynin in vivo reduces neointima formation and endothelial dysfunction in rabbits. Cardiovasc. Res. 2007, 75:710-718.
    • (2007) Cardiovasc. Res. , vol.75 , pp. 710-718
    • Chan, E.C.1    Datla, S.R.2    Dilley, R.3    Hickey, H.4    Drummond, G.R.5    Dusting, G.J.6
  • 13
    • 2542558107 scopus 로고    scopus 로고
    • Reduced progression of atherosclerosis in apolipoprotein E-deficient mice treated with lacidipine is associated with a decreased susceptibility of low-density lipoprotein to oxidation
    • Cristofori P., Crivellente F., Campagnola M., Pasini A.F., Garbin U., Rigoni A., Tosetti M., Turton J., Faustinelli I., Cominacini L. Reduced progression of atherosclerosis in apolipoprotein E-deficient mice treated with lacidipine is associated with a decreased susceptibility of low-density lipoprotein to oxidation. Int. J. Exp. Pathol. 2004, 85:105-114.
    • (2004) Int. J. Exp. Pathol. , vol.85 , pp. 105-114
    • Cristofori, P.1    Crivellente, F.2    Campagnola, M.3    Pasini, A.F.4    Garbin, U.5    Rigoni, A.6    Tosetti, M.7    Turton, J.8    Faustinelli, I.9    Cominacini, L.10
  • 16
    • 0034731404 scopus 로고    scopus 로고
    • Phorbol ester-induced generation of reactive oxygen species is protein kinase cbeta-dependent and required for SAPK activation
    • Datta R., Yoshinaga K., Kaneki M., Pandey P., Kufe D. Phorbol ester-induced generation of reactive oxygen species is protein kinase cbeta-dependent and required for SAPK activation. J. Biol. Chem. 2000, 275:41000-41003.
    • (2000) J. Biol. Chem. , vol.275 , pp. 41000-41003
    • Datta, R.1    Yoshinaga, K.2    Kaneki, M.3    Pandey, P.4    Kufe, D.5
  • 17
    • 0027081013 scopus 로고
    • Selective muscarinic alterations of nitric oxide-mediated relaxations by neointima
    • De Meyer G.R., Bult H., Herman A.G. Selective muscarinic alterations of nitric oxide-mediated relaxations by neointima. J. Cardiovasc. Pharmacol. 1992, 20(Suppl 12):S205-S207.
    • (1992) J. Cardiovasc. Pharmacol. , vol.20 , Issue.SUPPL 12
    • De Meyer, G.R.1    Bult, H.2    Herman, A.G.3
  • 19
    • 0030954150 scopus 로고    scopus 로고
    • A new role for an old molecule: serotonin as a mitogen
    • Fanburg Bl L.S. A new role for an old molecule: serotonin as a mitogen. Am. J. Physiol. 1997, 16:L795-L806.
    • (1997) Am. J. Physiol. , vol.16
    • Fanburg Bl, L.S.1
  • 20
    • 4444237726 scopus 로고    scopus 로고
    • Perivascular injury leads to a reduction in vascular reactivity of the collared and to an enhancement on contralateral carotid artery of rats
    • Fukada S.Y., Correa F.M., Ramalho L.N., Mizusaki C.I., De Oliveira A.M. Perivascular injury leads to a reduction in vascular reactivity of the collared and to an enhancement on contralateral carotid artery of rats. Cardiovasc. Pathol. 2004, 13:251-259.
    • (2004) Cardiovasc. Pathol. , vol.13 , pp. 251-259
    • Fukada, S.Y.1    Correa, F.M.2    Ramalho, L.N.3    Mizusaki, C.I.4    De Oliveira, A.M.5
  • 21
    • 0028063408 scopus 로고
    • Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques
    • Galis Z.S., Sukhova G.K., Lark M.W., Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J. Clin. Invest. 1994, 94:2493-2503.
    • (1994) J. Clin. Invest. , vol.94 , pp. 2493-2503
    • Galis, Z.S.1    Sukhova, G.K.2    Lark, M.W.3    Libby, P.4
  • 22
    • 0032589248 scopus 로고    scopus 로고
    • Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery
    • Geerts I.S., Matthys K.E., Herman A.G., Bult H. Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery. Br. J. Pharmacol. 1999, 127:1327-1336.
    • (1999) Br. J. Pharmacol. , vol.127 , pp. 1327-1336
    • Geerts, I.S.1    Matthys, K.E.2    Herman, A.G.3    Bult, H.4
  • 23
    • 0034528379 scopus 로고    scopus 로고
    • Collar-induced elevation of mRNA and functional activity of 5-HT(1B) receptor in the rabbit carotid artery
    • Geerts I.S., De Meyer G.R., Bult H. Collar-induced elevation of mRNA and functional activity of 5-HT(1B) receptor in the rabbit carotid artery. Br. J. Pharmacol. 2000, 131:1723-1731.
    • (2000) Br. J. Pharmacol. , vol.131 , pp. 1723-1731
    • Geerts, I.S.1    De Meyer, G.R.2    Bult, H.3
  • 24
    • 0028610108 scopus 로고
    • The molecular basis for lacidipine's unique pharmacokinetics: optimal hydrophobicity results in membrane interactions that may facilitate the treatment of atherosclerosis
    • Herbette L.G., Mason P.E., Gaviraghi G., Tulenko T.N., Mason R.P. The molecular basis for lacidipine's unique pharmacokinetics: optimal hydrophobicity results in membrane interactions that may facilitate the treatment of atherosclerosis. J. Cardiovasc. Pharmacol. 1994, 23(Suppl 5):S16-S25.
    • (1994) J. Cardiovasc. Pharmacol. , vol.23 , Issue.SUPPL 5
    • Herbette, L.G.1    Mason, P.E.2    Gaviraghi, G.3    Tulenko, T.N.4    Mason, R.P.5
  • 25
    • 0034130140 scopus 로고    scopus 로고
    • The involvement of intracellular Ca(2+) in 5-HT(1B/1D) receptor-mediated contraction of the rabbit isolated renal artery
    • Hill P.B., Dora K.A., Hughes A.D., Garland C.J. The involvement of intracellular Ca(2+) in 5-HT(1B/1D) receptor-mediated contraction of the rabbit isolated renal artery. Br. J. Pharmacol. 2000, 130:835-842.
    • (2000) Br. J. Pharmacol. , vol.130 , pp. 835-842
    • Hill, P.B.1    Dora, K.A.2    Hughes, A.D.3    Garland, C.J.4
  • 26
    • 33746335649 scopus 로고    scopus 로고
    • 5-hydroxytryptamine receptors in the human cardiovascular system
    • Kaumann A.J., Levy F.O. 5-hydroxytryptamine receptors in the human cardiovascular system. Pharmacol. Ther. 2006, 111:674-706.
    • (2006) Pharmacol. Ther. , vol.111 , pp. 674-706
    • Kaumann, A.J.1    Levy, F.O.2
  • 29
    • 0033566888 scopus 로고    scopus 로고
    • Interactions between NO and reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure
    • Kojda G., Harrison D. Interactions between NO and reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure. Cardiovasc. Res. 1999, 43:562-571.
    • (1999) Cardiovasc. Res. , vol.43 , pp. 562-571
    • Kojda, G.1    Harrison, D.2
  • 30
    • 0035045885 scopus 로고    scopus 로고
    • Lacidipine prevents endothelial dysfunction in salt-loaded stroke-prone hypertensive rats
    • Krenek P., Salomone S., Kyselovic J., Wibo M., Morel N., Godfraind T. Lacidipine prevents endothelial dysfunction in salt-loaded stroke-prone hypertensive rats. Hypertension 2001, 37:1124-1128.
    • (2001) Hypertension , vol.37 , pp. 1124-1128
    • Krenek, P.1    Salomone, S.2    Kyselovic, J.3    Wibo, M.4    Morel, N.5    Godfraind, T.6
  • 31
    • 4043161974 scopus 로고    scopus 로고
    • Mitochondrial redox control of matrix metalloproteinases
    • Nelson K.K., Melendez J.A. Mitochondrial redox control of matrix metalloproteinases. Free Radic. Biol. Med. 2004, 37:768-784.
    • (2004) Free Radic. Biol. Med. , vol.37 , pp. 768-784
    • Nelson, K.K.1    Melendez, J.A.2
  • 33
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis-an inflammatory disease
    • Ross R. Atherosclerosis-an inflammatory disease. N Engl J. Med. 1999, 340:115-126.
    • (1999) N Engl J. Med. , vol.340 , pp. 115-126
    • Ross, R.1
  • 35
    • 0025736670 scopus 로고
    • Enhanced vasoconstriction by serotonin in rabbit carotid arteries with atheroma-like lesions in vivo
    • Sobey C.G., Dusting G.J., Woodman O.L. Enhanced vasoconstriction by serotonin in rabbit carotid arteries with atheroma-like lesions in vivo. Clin. Exp. Pharmacol. Physiol. 1991, 18:367-370.
    • (1991) Clin. Exp. Pharmacol. Physiol. , vol.18 , pp. 367-370
    • Sobey, C.G.1    Dusting, G.J.2    Woodman, O.L.3
  • 38
    • 0034121425 scopus 로고    scopus 로고
    • Antioxidant enzyme activities and total nitrite/nitrate levels in the collar model. Effect of nicardipine
    • Sozmen E.Y., Kerry Z., Uysal F., Yetik G., Yasa M., Ustunes L., Onat T. Antioxidant enzyme activities and total nitrite/nitrate levels in the collar model. Effect of nicardipine. Clin. Chem. Lab. Med. 2000, 38:21-25.
    • (2000) Clin. Chem. Lab. Med. , vol.38 , pp. 21-25
    • Sozmen, E.Y.1    Kerry, Z.2    Uysal, F.3    Yetik, G.4    Yasa, M.5    Ustunes, L.6    Onat, T.7
  • 39
    • 0029610460 scopus 로고
    • The impact of lacidipine, a novel dihydropyridine calcium antagonist, on carbohydrate and lipid metabolism
    • Spieker C., Zidek W. The impact of lacidipine, a novel dihydropyridine calcium antagonist, on carbohydrate and lipid metabolism. J. Cardiovasc. Pharmacol. 1995, 25(Suppl 3):S23-S26.
    • (1995) J. Cardiovasc. Pharmacol. , vol.25 , Issue.SUPPL 3
    • Spieker, C.1    Zidek, W.2
  • 40
    • 0029900394 scopus 로고    scopus 로고
    • Effect of verapamil on intimal thickening and vascular reactivity in the collared carotid artery of the rabbit
    • Ustunes L., Yasa M., Kerry Z., Ozdemir N., Berkan T., Erhan Y., Ozer A. Effect of verapamil on intimal thickening and vascular reactivity in the collared carotid artery of the rabbit. Br. J. Pharmacol. 1996, 118:1681-1688.
    • (1996) Br. J. Pharmacol. , vol.118 , pp. 1681-1688
    • Ustunes, L.1    Yasa, M.2    Kerry, Z.3    Ozdemir, N.4    Berkan, T.5    Erhan, Y.6    Ozer, A.7
  • 41
    • 0029558290 scopus 로고
    • Dexamethasone influences intimal thickening and vascular reactivity in the rabbit collared carotid artery
    • Van Put D.J., Van Hove C.E., De Meyer G.R., Wuyts F., Herman A.G., Bult H. Dexamethasone influences intimal thickening and vascular reactivity in the rabbit collared carotid artery. Eur. J. Pharmacol. 1995, 294:753-761.
    • (1995) Eur. J. Pharmacol. , vol.294 , pp. 753-761
    • Van Put, D.J.1    Van Hove, C.E.2    De Meyer, G.R.3    Wuyts, F.4    Herman, A.G.5    Bult, H.6
  • 42
    • 0022599509 scopus 로고
    • Effect of hypercholesterolemia on vascular reactivity in the rabbit. I. Endothelium-dependent and endothelium-independent contractions and relaxations in isolated arteries of control and hypercholesterolemic rabbits
    • Verbeuren T.J., Jordaens F.H., Zonnekeyn L.L., Van Hove C.E., Coene M.C., Herman A.G. Effect of hypercholesterolemia on vascular reactivity in the rabbit. I. Endothelium-dependent and endothelium-independent contractions and relaxations in isolated arteries of control and hypercholesterolemic rabbits. Circ. Res. 1986, 58:552-564.
    • (1986) Circ. Res. , vol.58 , pp. 552-564
    • Verbeuren, T.J.1    Jordaens, F.H.2    Zonnekeyn, L.L.3    Van Hove, C.E.4    Coene, M.C.5    Herman, A.G.6
  • 44
    • 0037027501 scopus 로고    scopus 로고
    • Calcium antagonist lacidipine slows down progression of asymptomatic carotid atherosclerosis: principal results of the European Lacidipine Study on Atherosclerosis (ELSA), a randomized, double-blind, long-term trial
    • Zanchetti A., Bond M.G., Hennig M., Neiss A., Mancia G., Dal Palu C., Hansson L., Magnani B., Rahn K.H., Reid J.L., Rodicio J., Safar M., Eckes L., Rizzini P. Calcium antagonist lacidipine slows down progression of asymptomatic carotid atherosclerosis: principal results of the European Lacidipine Study on Atherosclerosis (ELSA), a randomized, double-blind, long-term trial. Circulation 2002, 106:2422-2427.
    • (2002) Circulation , vol.106 , pp. 2422-2427
    • Zanchetti, A.1    Bond, M.G.2    Hennig, M.3    Neiss, A.4    Mancia, G.5    Dal Palu, C.6    Hansson, L.7    Magnani, B.8    Rahn, K.H.9    Reid, J.L.10    Rodicio, J.11    Safar, M.12    Eckes, L.13    Rizzini, P.14
  • 45
    • 2642554650 scopus 로고    scopus 로고
    • Absolute and relative changes in carotid intima-media thickness and atherosclerotic plaques during long-term antihypertensive treatment: further results of the European Lacidipine Study on Atherosclerosis (ELSA)
    • Zanchetti A., Bond M.G., Hennig M., Tang R., Hollweck R., Mancia G., Eckes L., Micheli D. Absolute and relative changes in carotid intima-media thickness and atherosclerotic plaques during long-term antihypertensive treatment: further results of the European Lacidipine Study on Atherosclerosis (ELSA). J. Hypertens. 2004, 22:1201-1212.
    • (2004) J. Hypertens. , vol.22 , pp. 1201-1212
    • Zanchetti, A.1    Bond, M.G.2    Hennig, M.3    Tang, R.4    Hollweck, R.5    Mancia, G.6    Eckes, L.7    Micheli, D.8


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