Effect of verapamil on intimal thickening and vascular reactivity in the collared carotid artery of the rabbit

British Journal of Pharmacology

Volumn 118, Issue 7, 1996, Pages 1681-1688

  Üstünes, Levent ^a   Yasa, Mukadder ^a   Kerry, Zeliha ^a   Özdemir, Necmettin ^a   Berkan, Tayfun ^a   Erhan, Yildiz ^a   Özer, Asli ^a  

^a EGE UNIVERSITY   (Turkey)

Author keywords

5 hydroxytryptamine; Acetylcholine; Atherosclerosis; Calcium antagonist; Collar; Endothelium; Intima; Phenylephrine; Vascular reactivity; Verapamil

Indexed keywords

ACETYLCHOLINE; CALCIUM CHANNEL BLOCKING AGENT; PHENYLEPHRINE; POTASSIUM CHLORIDE; SEROTONIN; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL REACTIVITY; CAROTID ARTERY; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; MALE; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PRIORITY JOURNAL; RABBIT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0029900394     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15592.x     Document Type: Article

References (52)

1. ADAMS, D.J., BARAKEH, J., LASKEY, R. & VAN BREEMEN, C. (1989). Ion channels and regulation of intracellular calcium in vascular endothelial cells. FASEB J., 3, 2389-2400.
2. ARTHUR, J.F. & DUSTING, G.J. (1992), Selective endothelial dysfunction in early atheroma-like lesions in the rabbit. Coronary Artery Dis., 3, 623-629.
3. BEESLEY, J.E. HONEY, A.C. & MARTIN, J.F. (1992). Ultrastructural assessment of lesion development in the collared rabbit carotid artery model. Cell Materials, 2, 201-203.
4. BLUMLEIN, S.L., SIEVERS, R., KIDD, P. & PARMLEY, W.W. (1984). Mechanism of protection from atherosclerosis by verapamil in the cholesterol-fed rabbit. Am. J. Cardiol., 54, 884-889.
5. BOOTH, R.F.G., MARTIN, J.F., HONEY, A.C., HASSAL, J.H., BEESLEY, J.E. & MONCADA, S. (1989). Rapid development of atherosclerotic lesions in the rabbit carotid artery induced by perivascular manipulation. Atherosclerosis, 76, 257-268.
6. CATAPANO, A.L. (1992). The antiatherogenic potential of calcium antagonists: experimental evidence. J Cardiovasc. Pharmacol., 20, (Suppl.A) S44-S50.
7. DE MEYER, G.R.Y., BULT, H., MARTIN, J.F., HOYDONCK, A.V. & HERMAN, A.G. (1990). The effect of a developing neointima on serotonergic and adrenergic contractions. Eur. J. Pharmacol., 187, 519-524.
8. DE MEYER, G.R.Y., BULT, H., VAN HOYDONCK, A.-E., JORDAENS, F.H., BUYSSENS, N. & HERMAN, A. (1991). Neointima formation impairs endothelial muscarinic receptors while enhancing prostacyclin-mediated responses in the rabbit carotid artery. Circ. Res., 68, 1669-1680.
9. DE MEYER, G.R.Y., BULT, H. & HERMAN, A. (1992). Selective muscarinic alterations of nitric oxide-mediated relaxations by neointima. J. Cardivasc. Pharmacol., 20 (Suppl.12), S205-S207.
10. DE MEYER, G.R., BULT, H., ÜSTÜNES, L., KOCKX, M., JORDAENS, F.H., ZONNEKEYN, L.L. & HERMAN, A.G. (1994). Vasoconstrictor responses after neointima formation and endothelial removal in the rabbit carotid artery. Br. J. Pharmacol., 112, 471-476.
11. DE MEYER, G.R.Y., BULT, H., ÜSTÜNES, L., KOCKX, M.M., FEELISCH, M. & HERMAN, A.G. (1995). Effect of nitric oxide donors on neointima formation and vascular reactivity in the collared carotid artery of rabbits. J. Cardiovasc. Pharmacol., 26, 272-279.
12. DUSTING, G.J., CURCIO, A., HARRIS, P.J., LIMA, B., ZAMBETIS, M & MARTIN, J.F. (1990). Supersensitivity to vasoconstrictor action of serotonin precedes the development of atheroma-like lesions in the rabbit. J. Cardiovasc. Pharmacol., 16, 667-670.
13. ELLENBOGEN, K.A., GERMAN, L.D. & O'CALLAGHAN, W.G. (1985). Frequency dependent effects of verapamil on atrioventricular nodal conduction in man. Circulation, 72, 344-352.
14. FLECKENSTEIN-GRÜN, G., THIMM, F., CZIRFUZS, A., MATYAS, S. & FREY, M. (1994). Experimental vasoprotection by calcium antagonists against calcium-mediated arteriosclerotic alterations. J. Cardiovasc. Pharmacol., 24 (Suppl.2) S75-S84.
15. GODFRAIND, T., DESSY, C. & SALOMONE, S. (1992). A comparison of the potency of selective L-calcium channel blockers in human coronary and internal mammary arteries exposed to serotonin. Pharmacol. Exp. Ther., 263, 112-122.
16. GODFRAIND, T., MILLER, R. & WIBO, M. (1986). Calcium antagonism and calcium entry blockade. Pharmacol. Rev., 38, 321-416.
17. HADEISHI, H., MAYBERG, M.R., SETO, M., DACEY, R.G. & SOLOMON, R.A. (1994). Local application of calcium antagonists inhibits intimal hyperplasia after arterial injury. Neurosurgery, 34, 114-121.
18. HEASLIP, R.J. & RAHWAN, R.G. (1982). Evidence for the existence of two distinct pools of intracellular calcium in the rat aorta accessible to mobilization by norepinephrine. Pharmacol. Exp. Ther., 221, 7-13.
19. HEISTAD, D.D., ARMSTRONG, M.L., PIEGORS, D.J. & MARK, A. (1984). Augmented responses to vasoconstrictor stimuli in hypercholesterolemic and atherosclerotic monkeys. Circ. Res., 54711, 711-718.
20. HENRY, P.D. (1990). Atherogenesis, calcium and calcium antagonists. Am. J. Cardiol., 66, 31-61.
21. HENRY, P.D. & YOKOYAMA, M. (1980). Supersensitivity of atherosclerotic rabbit aorta to ergonovine. J. Clin. Invest., 66, 306-313.
22. HOF, R.P. & HOF, A. (1988). Vasoconstrictor and vasodilator effects in normal and atherosclerotic conscious rabbits. Br. J. Pharmacol., 95, 1075-1080.
23. HOF, R.P. & RÜEGG, T.U. (1989). Antivasoconstrictor effects of isradipine. A quantitative approach in anaesthetised rats and conscious rabbits. Am. J. Med., 86 (Suppl 4A), 50-56.
24. HOF, R.P. & RÜEGG, T.U. (1991). Calcium antagonists in experimental atherosclerosis use-dependence of isradipine: a potential explanation for enhanced action in atherosclerotic animals and tissue selectivity. Am. J. Hypertens, 4, 107-113.
25. JACKSON, C.L., BUSH, R.C. & BOWYER, D.E. (1988). Inhibitory effect of calcium antagonists on balloon catheter-induced arterial smooth muscle cell proliferation and lesion size. Atherosclerosis, 69, 115-122.
26. KALSNER, S. & RICHARDS, R. (1984). Coronary arteries of cardiac patients are hyperreactive and contain stores of amines. A mechanism for coronary spasm. Science, 223, 1435-1437.
27. KANAYA, S., ARLOCK, P., KATZUNG, B.C. & HONDEGHEM, L.M. (1983). Diltiazem and verapamil preferentially block inactivated cardiac calcium channels. J. Mol. Cell. Cardiol., 15, 145-148.
28. 1-adrenergic and muscarinic but not beta-adrenergic receptors in rat myocardium. J. Cardiovasc. Pharmacol., 4, 515-520.
29. KOBER, G., SCHNEIDER, W. & KALTENBACH, M. (1989). Can the progression of coronary sclerosis be influenced by calcium antagonists? J. Cardiovasc. Pharmacol., 4, S2-S6.
30. KOCKX, M.M., DE MEYER, G.R.Y., JACOB, W.A., BULT, H. & HERMAN, A.G. (1992). Triphasic sequence of neointimal formation in the cuffed carotid artery of the rabbit. Arteriosceler. Thromb., 12, 1447-1457.
31. KOCKX, M.M., DE MEYER, G.R.Y., ANDRIES, L.J., BULT, H., JACOB, W.A. & HERMAN, A.G. (1993). The endothelium during cuff-induced neo-intima formation in the rabbit carotid artery. Arterioscler. Thromb., 13, 1874-1884.
32. 1-adrenoceptors in thoracic aorta, renal artery and portal vein from rabbit. Gen. Pharmacol., 19, 541-545.
33. MARRIOT, J.F. (1988). A comparison of the effects of the calcium entry blockers, verapamil, diltiazem and flunarizine against contractions of the rat isolated aorta and portal vein. Br. J. Pharmacol., 95, 145-154.
34. MCDONALD, T.F., PELZER, D. & TRAUTWEIN, W. (1980). On the mechanism of slow calcium channel block in heart. Pflugers Arch., 385, 175-179.
35. 2+ dynamics in endothelial cells. Am. J. Physiol., 253, C588-C598.
36. MÜGGE, A., PETERSON, T. & HARRISON, D.G. (1991). Release of nitrogen oxides from cultured bovine aortic endothelial cells is not impaired by calcium channel antagonists. Circulation, 83, 1404-1409.
37. NOMOTO, A., HIROSUMI, J., SEKIGUCHI, C., MUTOH, S., YAMAGUCHI, I. & AOKI, H. (1987). Antiatherogenic activity of FR34235 (Nilvadipine). a new potent calcium antagonist. Atherosclerosis, 64, 255-261.
38. OHASHI, M., KANAI, R. & TAKAYANAGI, I. (1985). Do D 600 and diltiazem interact with serotonin receptors in rabbit vascular tissues? J. Pharmacol. Exp. Ther., 233, 830-835.
39. PEACH, M.J., SINGER, H.A., IZZO, N.J. & LOEB, A.L. (1987). Role of calcium in endothelium-dependent relaxation of arterial smooth muscle. Am. J. Cardiol., 59, 35A-43A.
40. ROULEAU, J.L., PARMLEY, W.W., STEVENS, J., WIKMAN-COFFELT, J., SIEVERS, R., MAHLEY, R.W. & HAVEL, R.J. (1983). Verapamil suppresses atherosclerosis in cholesterol-fed rabbits. J. Am. Coll. Cardiol., 1, 1453-1460.
41. SCHINI, V.B., BUSSE. R. & VANHOUTTE, P.M. (1994). Inducible nitric oxide synthase in vascular smooth muscle. Arzneim. Forsch./Drug Res., 44, 432-435.
42. SIEVERS, R.E., RASHID, T. GARRETT, J., BLUMLEIN, S. & PARMLEY, W.W. (1987). Verapamil and diet halt progression of atherosclerosis in cholesterol fed rabbits. Card. Drugs Ther., 1, 65-69.
43. SINGER, H.A. & PEACH, M.J. (1982). Calcium- and endothelial-mediated vascular smooth muscle relaxation in rabbit aorta. Hypertension, 4 (Suppl II), II-19-II-25.
44. STARY, H.C., BLANKENHORN, D.H., CHANDLER, A.B., GLAGOV, S., INSULL, W., JR., RICHARDSON, M., ROSENFELD, M.E., SCHAFFER, S.A., SCHWARTZ, C.J., WAGNER, W.D. & WISSLER, R.W. (1992). A definition of the intima of human arteries and of its atherosclerosis-prone regions. Arterioscler. Thromb., 12, 120-134.
45. STENDER, S., RAVN, H., HAUGEGAARD, M. & KJELDSEN, K. (1986). Effect of verapamil on accumulation of free and esterified cholesterol in the thoracic aorta of cholesterol fed rabbits. Atherosclerosis, 61, 15-23.
46. TESFAMARIAM, B., WEISBROD, R.M. & COHEN, R.A. (1989). Augmented adrenergic contractions of carotid arteries from cholesterol-fed rabbits due to endothelial cell dysfunction. J. Cardiovasc. Pharmacol., 13, 820-825.
47. VAN PUT, D.J.M., VAN HOVE, C.E., DE MEYER, G.R.Y., WUYTS. F., HERMAN, A.G. & BULT, H. (1996). Dexamethasone influences intimai thickening and vascular reactivity in the rabbit collared carotid artery. Eur. J. Pharmacol., (in press).
48. VERBEUREN, T.J., JORDAENS, F.H., ZONNEKEYN, L., VAN HOVE, C., COENE, M.-C. & HERMAN. A. (1986). Effect of hypercholesterolemia on vascular reactivity in the rabbit I. Endothelium-dependent and endothelium-independent contractions and relaxations in isolated arteries of control and hypercholesterolemic rabbits. Circ. Res., 58, 552-564.
49. VERBEUREN, T.J., JORDAENS, F.H., BULT, H. & HERMAN, A. (1988). The endothelium inhibits the penetration of serotonin and norephinephrine in the isolated canine saphaneous vein. J. Pharmacol. Exp. Ther., 244, 276-282.
50. WEINSTEIN, D.B. & HEIDER, J.G. (1989). Antiatherogenic properties of calcium antagonists, State of the art. Am. J. Med., 86, 27-32.
51. YAMASHITA, K., TAKAGI, T. & HOTTA, K. (1977). Mobilization of cellular calcium and contraction-relaxation of vascular smooth muscle. Jpn. J. Physiol., 27, 551-564.
52. YOKOYAMA, M., AKITA, H., MIZUTANI, T., FUKUZAKI, H. & WATANABE, Y. (1983). Hyperreactivity of coronary arterial smooth muscle in response to ergonovine from rabbits with hereditary hyperlipidemia. Circ. Res., 53, 63-71.