Protective effect of PACAP against doxorubicin-induced cell death in cardiomyocyte culture

Journal of Molecular Neuroscience

Volumn 42, Issue 3, 2010, Pages 419-427

  Racz, Boglarka ^a   Reglodi, Dora ^b   Horvath, Gabriella ^b   Szigeti, Andras ^a   Balatonyi, Borbala ^b   Roth, Erzsebet ^b   Weber, Gyorgy ^b   Alotti, Nasri ^c   Toth, Gabor ^d   Gasz, Balazs ^c  

^a UNIVERSITY OF PÉCS   (Hungary)

^b UNIVERSITY OF PÉCS   (Hungary)

^c Zala County Hospital   (Hungary)

^d UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Cardiomyocyte; Cleaved caspase 3; Doxorubicin; Flow cytometry; Phospho Bad

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CASPASE 3; DOXORUBICIN; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; LIPOCORTIN 5; PROPIDIUM IODIDE; PROTEIN BAD;

ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; CARDIOTOXICITY; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME INACTIVATION; FLOW CYTOMETRY; HEART MUSCLE CELL; HEART PROTECTION; IN VITRO STUDY; NITROBLUE TETRAZOLIUM TEST; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL DEATH; CELLS, CULTURED; DOXORUBICIN; HUMANS; MYOCYTES, CARDIAC; OXIDATIVE STRESS; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; PROTEIN ISOFORMS; RANDOM ALLOCATION; RATS; RATS, WISTAR;

EID: 78349305677     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-010-9349-6     Document Type: Article

References (52)

1. A Baron D Monnier A Roatti AJ Baertschi 2001 Pituitary adenylate cyclase activating polypeptide activates K(ATP) current in rat atrial myocytes Am J Physiol Heart Circ Physiol 280 H1058 H1065 1:CAS:528:DC%2BD3MXjtV2gt7g%3D 11179047
2. A Berdichevski G Meiry F Milman, et al. 2010 TVP1022 protects neonatal rat ventricular myocytes against doxorubicin-induced functional derangements J Pharmacol Exp Ther 332 413 420 1:CAS:528:DC%2BC3cXltVCksbg%3D 10.1124/jpet.109.161158 19915070
3. KM Braas TM Rossignol BM Girard V May RL Parsons 2004 Pituitary adenylate cyclase activating polypeptide (PACAP) decreases neuronal somatostatin immunoreactivity in cultured guinea-pig parasympathetic cardiac ganglia Neuroscience 126 335 346 1:CAS:528:DC%2BD2cXltVCjtrs%3D 10.1016/j.neuroscience. 2004.04.007 15207351
4. L Bruch R Bychkov A Kastner, et al. 1997 Pituitary adenylate cyclase activating peptides relax human coronary arteries by activating K(ATP) and K(Ca) channels in smooth muscle J Vasc Res 34 11 18 1:CAS:528:DyaK2sXhvV2lsrc%3D 9075821
5. Y Chang LJ Lawson JC Hancock DB Hoover 2005 Pituitary adenylate cyclase activating polypeptide: localization and differential influence on isolated hearts from rats and gunea pigs Regul Pept 129 139 146 1:CAS:528: DC%2BD2MXltFWhsL4%3D 10.1016/j.regpep.2005.02.012 15927709
6. QM Chen VC Tu 2002 Apoptosis and heart failure: mechanisms and therapeutic implications Am J Cardiovasc Drugs 2 43 57 1:CAS:528: DC%2BD38XmsFWmt7w%3D 10.2165/00129784-200202010-00006 14727998
7. T Dalsgaard J Hannibal J Fahrenkrug CR Larsen B Ottesen 2003 VIP and PACAP display different vasodilatory effects in rabbit coronary and cerebral arteries Regul Pept 110 179 188 1:CAS:528:DC%2BD3sXovFCrtg%3D%3D 10.1016/S0167-0115(02)00205-7 12573798
8. A Dejda V Jolivel S Bourgault, et al. 2008 Inhibitory effect of PACAP on caspase activity in neuronal apoptosis: a better understanding towards therapeutic applications in neurodegenerative diseases J Mol Neurosci 36 26 37 1:CAS:528:DC%2BD1cXhsVagtLjM 10.1007/s12031-008-9087-1 18506634
9. M Delgado D Ganea 2000 VIP and PACAP inhibit activation induced apoptosis in T lymphocytes Ann N Y Acad Sci 921 55 67 1:CAS:528:DC%2BD3MXntVahsA%3D%3D 10.1111/j.1749-6632.2000.tb06951.x 11193880
10. MC Dvorakova 2005 Cardioprotective role of the VIP signaling system Drugs News Perspect 18 387 391 1:CAS:528:DC%2BD2MXht1Cls7rP 10.1358/dnp.2005.18.6. 927930
11. A Falluel-Morel N Aubert D Vaudry, et al. 2008 Interactions of PACAP and ceramides in the control of granule cell apoptosis during cerebellar development J Mol Neurosci 36 8 15 1:CAS:528:DC%2BD1cXhsVagtLrN 10.1007/s12031-008-9111-5 18574733
12. B Gasz B Racz E Roth, et al. 2006 PACAP inhibits oxidative stress-induced activation of MAP kinase dependent apoptotic pathway in cultured cardiomyocytes Ann N Y Acad Sci 1070 293 297 1:CAS:528:DC%2BD28XpvVehtL4%3D 10.1196/annals.1317.029 16891268
13. B Gasz B Racz E Roth, et al. 2006 Pituitary adenylate cyclase activating polypeptide protects cardiomyocytes against oxidative stress-induced apoptosis Peptides 27 87 94 1:CAS:528:DC%2BD28Xktl2nug%3D%3D 10.1016/j.peptides.2005.06. 022 16095757
14. M Gilleron X Marechal D Montaigne J Franczak R Neviere S Lancel 2009 NADPH oxidases participate to doxorubicin-induced cardiac myocyte apoptosis Biochem Biophys Res Commun 388 727 731 1:CAS:528:DC%2BD1MXhtFajsbzN 10.1016/j.bbrc.2009.08.085 19699179
15. I Gutierrez-Canas N Rodriguez-Henche O Bolanos MJ Carmena JC Prieto MG Juarranz 2003 VIP and PACAP are autocrine factors that protect the androgen-independent prostate cancer cell line PC-3 from apoptosis induced by serum withdrawal Br J Pharmacol 139 1050 1058 1:CAS:528:DC%2BD3sXlvVCisrg%3D 10.1038/sj.bjp.0705317 12839880
16. P Han MT Lucero 2005 Pituitary adenylate cyclase activating polypeptide reduces A-type K+ currents and caspase activity in cultured adult mouse olfactory neurons Neuroscience 134 745 756 1:CAS:528:DC%2BD2MXosVait7s%3D 10.1016/j.neuroscience.2005.05.007 16019148
17. X Han D Ren P Fan T Shen H Lou 2008 Protective effects of naringenin-7-O-glucoside on doxorubicin-induced apoptosis in H9C2 cells Eur J Pharmacol 581 47 53 1:CAS:528:DC%2BD1cXhsVCmsb4%3D 10.1016/j.ejphar.2007.11.048 18154951
18. M Hirose S Chiba 2003 Cellular mechanism of pituitary adenylate cyclase activating polypeptide-induced atrial tachyarrhythmia in canince isolated arterially perfused right atria Clin Exp Pharmacol Physiol 30 937 942 1:CAS:528:DC%2BD2cXpvVyl 10.1111/j.1440-1681.2003.03940.x 14678233
19. D Jantas W Lason 2009 Protective effect of memantine against doxorubicin toxicity in primary neuronal cell cultures: influence a developmental stage Neurotox Res 15 24 37 1:CAS:528:DC%2BD1MXnsVahtbg%3D 10.1007/s12640-009-9002-8 19384585
20. EA Konorev S Vanamala B Kalyanaraman 2008 Differences in doxorubicin-induced apoptotic signaling in adult and immature cardiomyocytes Free Radic Biol Med 45 1723 1728 1:CAS:528:DC%2BD1cXhsVGhurjO 10.1016/j.freeradbiomed.2008.09.006 18926904
21. J Lee HJ Park HS Choi, et al. 1999 Gonadotropin stimulation of pituitary adenylate cyclase activating polypeptide (PACAP) messenger ribonucleic acid in the rat ovary and the role of PACAP as a follicle survival factor Endocrinology 140 818 826 1:CAS:528:DyaK1MXntl2ntg%3D%3D 10.1210/en.140.2.818 9927311
22. L Lenti F Domoki D Kis, et al. 2007 Pituitary adenylate cyclase activating polypeptide induces pial arteriolar vasodilation through cyclooxigenase-dependent and independent mechanisms in newborn pigs Brain Res 1165 18 88 10.1016/j.brainres.2007.06.032
23. L Lenti A Zimmermann D Kis, et al. 2009 PACAP and VIP differentially preserve neurovascular reactivity after global cerebral ischemia in newborn pigs Brain Res 1283 50 57 1:CAS:528:DC%2BD1MXptVCjs7o%3D 10.1016/j.brainres.2009.06. 021 19538945
24. M Li C David T Kikuta A Somogyvari-Vigh A Arimura 2005 Signaling cascades involved in neuroprotection by subpicomolar pituitary adenylate cyclase activating polypeptide 38 J Mol Neurosci 27 91 105 10.1385/JMN:27:1:091 16055949
25. DM Liu J Cuevas DJ Adams 2000 VIP and PACAP potentiation of nicotinic Ach-evoked currents in rat parasympathetic neurons is mediated by G-protein activation Eur J NeuroSci 12 2243 2251 1:STN:280:DC%2BD3cvjtlenug%3D%3D 10.1046/j.1460-9568.2000.00116.x 10947803
26. M Luodonpa O Vuolteenaho S Eskelinen H Ruskoaho 2001 Effects of adrenomedullin on hypertrophic responses induced by angiotensin II, endothelin-1 and phenylephrine Peptides 22 1859 1866 10.1016/S0196-9781(01)00505-8
27. Mori H, Nakamachi T, Ohtaki H et al (2009) Endogenous PACAP as a cardioprotectant in Doxorubicin-induced cardiomyopathy model in rats. Abstract NoP15, Presented at Phylogenetic Aspects of Neuropeptides/from Invertebrates to Humans, Satellite Symposium of the 9th International Symposium on VIP, PACAP and Related Peptides, Yakushima, Japan, 2009
28. H Oka L Jin E Kulig BW Scheithauer RV Lloyd 1999 Pituitary adenylate cyclase activating polypeptide inhibits transforming growth factor-beta 1-induced apoptosis in a human pituitary adenoma cell line Am J Pathol 155 1893 1900 1:CAS:528:DC%2BD3cXit1Khuw%3D%3D 10595920
29. C Otto L Hein M Brede, et al. 2004 Pulmonary hypertension and right heart failure in pituitary adenylate cyclase activating polypeptide type I receptor-deficient mice Circulation 110 3245 3251 1:CAS:528:DC%2BD2cXpsFahs7w%3D 10.1161/01.CIR.0000147235.53360.59 15520307
30. Z Pirger J Nemeth L Hiripi, et al. 2008 PACAP has antiapoptotic effect in the salivary gland of an invertebrate species, Helix pomatia J Mol Neurosci 36 105 114 1:CAS:528:DC%2BD1cXhsVagtLvL 10.1007/s12031-008-9070-x 18473188
31. PC Pugh JF Margiotta 2006 PACAP support of neuronal survival requires MAPK- and activity-generated signals Mol Cell Neurosci 31 586 595 1:CAS:528:DC%2BD28Xit1Cmu70%3D 10.1016/j.mcn.2005.11.012 16431129
32. B Racz B Gasz B Borsiczky, et al. 2007 Protective effects of pituitary adenylate cyclase activating polypeptide in endothelial cells against oxidative stress-induced apoptosis Gen Comp Endocrinol 153 115 123 1:CAS:528: DC%2BD2sXotlSit7g%3D 10.1016/j.ygcen.2006.12.006 17270184
33. B Racz F Gallyas Jr P Kiss, et al. 2007 Effects of pituitary adenylate cyclase activating polypeptide (PACAP) on the PKA-Bad-14-3-3 signaling pathway in glutamate-induced retinal injury in neonatal rats Neurotox Res 12 95 104 1:CAS:528:DC%2BD2sXhtlKiu7bE 10.1007/BF03033918 17967733
34. B Racz B Gasz F Gallyas Jr, et al. 2008 PKA-Bad-14-3-3 and Akt-Bad-14-3-3 signaling pathways are involved in the protective effects of PACAP against ischemia/reperfusion-induced cardiomyocyte apoptosis Regul Pept 145 105 115 1:CAS:528:DC%2BD2sXhsVOltrrJ 10.1016/j.regpep.2007.09.015 17981349
35. B Racz G Horvath D Reglodi, et al. 2010 PACAP ameliorates oxidative stress in the chicken inner ear: an in vitro study Regul Pept 160 91 98 1:CAS:528:DC%2BC3cXhtlWktbk%3D 10.1016/j.regpep.2009.12.003 19969027
36. NT Ross-Ascuitto RJ Ascuitto D Ramage DW Kydon DH Coy PJ Kadowitz 1993 Pituitary adenylate cyclase activating polypeptide: a neuropeptide with potent inotropic and coronary vasodilatory effects in neonatal pig heart Pediatr Res 34 323 328 1:CAS:528:DyaK3sXmsVWlsbs%3D 10.1203/00006450-199309000-00017 7510869
37. E Roth G Weber P Kiss, et al. 2009 Effects of PACAP and preconditioning against ischemia/reperfusion-induced cardiomyocyte apoptosis in vitro Ann N Y Acad Sci 1163 512 516 1:CAS:528:DC%2BD1MXmvVWjt7c%3D 10.1111/j.1749-6632.2008. 03635.x 19456402
38. A Sanchez HV Rao P Grammas 2009 PACAP38 protects rat cortical neurons against neurotoxicity evoked by sodium nitroprusside and thrombin Regul Pept 152 33 40 1:CAS:528:DC%2BD1cXhsV2lur7F 10.1016/j.regpep.2008.07.004 18682263
39. H Sano A Miyata T Horio T Nishikimi H Matsuo K Kangawa 2002 The effect of pituitary adenylate cyclase activating polypeptide on cultured rat cardiocytes as a cardioprotective factor Regul Pept 109 107 113 1:CAS:528: DC%2BD38Xot1Wrt7Y%3D 10.1016/S0167-0115(02)00193-3 12409222
40. LK Schoenfeld JA Souder JC Hardwick 2000 Pituitary adenylate cyclase activating polypeptide innervation of the mudpuppy cardiac ganglion Brain Res 882 180 190 1:CAS:528:DC%2BD3cXns12ns70%3D 10.1016/S0006-8993(00)02885-7 11056197
41. A Somogyvari-Vigh D Reglodi 2004 Pituitary adenylate cyclase activating polypeptide: a potential neuroprotective peptide-review Curr Pharm Des 10 2861 2889 1:CAS:528:DC%2BD2cXmslKkuro%3D 10.2174/1381612043383548 15379674
42. Y Suzuki K Kasai K Takekoshi, et al. 1993 Effects of pituitary adenylate cyclase activating polypeptide (PACAP) on the cardiovascular system Regul Pept 47 213 220 1:CAS:528:DyaK3sXmsVWltrk%3D 10.1016/0167-0115(93)90426-9 7901874
43. H Tokola K Salo O Vuolteenaho H Ruskoaho 1994 Basal and acidic fibroblast growth factor-induced atrial natriuretic peptide gene expression and secretion is inhibited by staurosporine Eur J Pharmacol 267 195 206 1:CAS:528: DyaK2cXivFSgur8%3D 10.1016/0922-4106(94)90171-6 7519562
44. JD Tompkins RL Parsons 2008 Identification of intracellular signaling cascades mediating the PACAP-induced increase in guinea pig cardiac neuron excitability J Mol Neurosci 36 292 298 1:CAS:528:DC%2BD1cXhsVagtL3J 10.1007/s12031-008-9086-2 18509761
45. D Vaudry BJ Gonzalez M Basille, et al. 2000 The neuroprotective effect of pituitary adenylate cyclase activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32 Proc Natl Acad Sci USA 97 13390 13395 1:CAS:528: DC%2BD3cXosVOjsL4%3D 10.1073/pnas.97.24.13390 11087878
46. D Vaudry A Falluel-Morel A Bourgault, et al. 2009 Pituitary adenylate cyclase activating polypeptide and its receptors: 20 years after the discovery Pharmacol Rev 61 283 357 10.1124/pr.109.001370 19805477
47. I Vermes C Haanen H Steffens-Nakken C Reutelingsperger 1995 A novel assay for apoptosis. Flow cytometric detection of phospatidylserine expression on early apoptotic cells using fluorescein labelled annexin V J Immunol Methods 184 39 51 1:CAS:528:DyaK2MXnt1Ojsbo%3D 10.1016/0022-1759(95)00072-I 7622868
48. G Wang C Qi GH Fan HY Zhou SD Chen 2005 PACAP protects neuronal differentiated PC12 cells against the neurotoxicity induced by a mitochondrial complex I inhibitor, rotenone FEBS Lett 579 4005 4011 1:CAS:528: DC%2BD2MXmt1eisrw%3D 10.1016/j.febslet.2005.06.013 16004991
49. RB Weiss 1992 The anthracyclines: will we ever find a better doxorubicin? Semin Oncol 19 670 686 1:CAS:528:DyaK3sXhtl2jsbo%3D 1462166
50. G Zaccone A Mauceri M Maisano A Giannetto V Parrino S Fasulo 2009 Distribution and neurotransmitter localization in the heart of the ray-finned fish, bichir (Polypterus bichir bichir Geoffroy St. Hilare, 1802) Acta Histochem 111 93 103 1:CAS:528:DC%2BD1MXlsFOhu7g%3D 10.1016/j.acthis.2008.05.003 18805572
51. Y Zhang LP Liu ZL Liang XL Li YZ Jin X Cui 2008 cAMP produced by pituitary adenylate cyclase activating polypeptide 27 inhibits atrial natriuretic peptide secretion in rabbit beating atria Clin Exp Pharmacol Physiol 35 1233 1237 1:CAS:528:DC%2BD1cXhtFCqtr%2FF 10.1111/j.1440-1681.2008.04996.x 18637020
52. SH Zhang WQ Wang JL Wang 2009 Protective effects of tetrahydroxystilbene glucoside on cardiotoxicity induced by doxorubicin in vitro and in vivo Acta Pharmacologica Sinica 30 1479 1487 1:CAS:528:DC%2BD1MXhtlKrtbjE 10.1038/aps.2009.144 19890356