Clinical pathology and cardiovascular parameters are not influenced by housing rats under increased environmental complexity

Animal Welfare

Volumn 19, Issue 4, 2010, Pages 449-460

  Mikkelsen, L F ^a,b   Sorensen D B ^b,c   Krohn, T ^b,c   Lauritzen, B ^a,b   Dragsted, N ^a,b   Hansen, A K ^b,c   Ottesen, J L ^a,b  

^a NOVO NORDISK A S   (Denmark)

^b Centre for Applied Laboratory Animal Research (CALAR)   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Animal welfare; Clinical pathology; Environmental enrichment; Housing conditions; Rats; Telemetry

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL HOUSING; ANIMAL WELFARE; ARTICLE; BLOOD CLOTTING TEST; BLOOD PRESSURE; CARDIOVASCULAR PARAMETERS; ENVIRONMENTAL FACTOR; HEART RATE; MALE; NONHUMAN; RAT;

ANIMALIA; RATTUS;

EID: 78349291120     PISSN: 09627286     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Augustsson H, van de Weerd HA, Kruitwagen CLJJ and Baumans V 2003 Effects of enrichment on variation and results in the light/dark test. Laboratory Animals 37: 328-340
2. Baumans V 2005 Environmental enrichment for laboratory rodents and rabbits: requirements of rodents, rabbits, and research. ILAR Journal 46: 162-170
3. Bayne K 2005 Potential for unintended consequences of environmental enrichment for laboratory animals and research results. ILAR Journal 46: 129-139
4. Benefiel AC, Dong WK and Greenough WT 2005 Mandatory 'enriched' housing of laboratory animals: the need for evidence-based evaluation. ILAR Journal 46: 95-105
5. Blanchard RJ and Blanchard DC 2003 Bringing natural behaviors into the laboratory: a tribute to Paul MacLean. Physiology & Behavior 79: 515-524
6. Council of Europe 2006 European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes (ETS 123), revised Appendix A. Council of Europe: Strasbourg, France
7. Eskola S, Lauhikari M, Voipio HM and Nevalainen T 1999 The use of aspen blocks and tubes to enrich the cage environment of laboratory rats. Scandinavian Journal of Laboratory Animal Science 26: 1-10
8. Garner JP 2005 Stereotypies and other abnormal repetitive behaviors: potential impact on validity, reliability, and replicability of scientific outcomes. ILAR Journal 46: 106-117
9. Hansen AK, Baumans V, Elliott H, Francis R, Holgate B, Hubrecht RC, Jennings M, Peters A and Stauffacher M 2002 Future principles for housing and care of laboratory rodents and rabbits. Report for the revision of the Council of Europe Convention ETS 123 appendix A for rodents and rabbits. PART A. 2002. Council of Europe: Strasbourg, France. http://www.coe.int/T/E/Legal-affairs/ Legal-cooperation/ Biological-safety,-use-of-animals/Laboratory-animals/ GT123(2000)57rodents-rabbits.pdf
10. Hutchinson E, Avery A and Van de Woude S 2005 Environmental enrichment for laboratory rodents. ILAR Journal 46: 148-161
11. Institute of Laboratory Animal Resources 1996 Guide for the Care and Use of Laboratory Animals. Commission on Life Sciences. National Academy Press: Washington DC, USA
12. Jones TA and Greenough WT 1996 Ultrastructural evidence for increased contact between astrocytes and synapses in rats reared in a complex environment. Neurobiology of Learning and Memory 65: 48-56
13. Krohn TC, Mikkelsen LF, Sørensen DB, Haagensen AMJ, Hansen AK and Ottesen JL 2010 The ability of SD-rats to distinguish between three different housing environments. Scandinavian Journal Laboratory Animal Science, submitted
14. Lewejohann L, Reinhard C, Schrewe A, Brandewiede J, Haemisch A, Görtz N, Schachner M and Sachser N 2006 Environmental bias? Effects of housing conditions, laboratory environment and experimenter on behavioral tests. Genes, Brain and Behavior 5: 64-72
15. Mering S, Kaliste-Korhonen E and Nevalainen T 2001 Estimates of appropriate number of rats: interaction with housing environment. Laboratory Animals 35: 80-90
16. Newberry RC 1995 Environmental enrichment: Increasing the biological relevance of captive environments. Applied Animal Behaviour Science 44: 229-243
17. Ottesen JL, Weber A, Gurtler H and Mikkelsen LF 2004 New housing conditions: improving the welfare of experimental animals. Atla-Alternatives To Laboratory Animals 32: 397-404
18. Richter SH, Garner JP and Würbel H 2009 Environmental standardization: cure or cause of poor reproducibility in animal experiments? Nature Methods 6: 257-261
19. Russell WMS and Burch RL 1959 The Principles of Humane Experimental Technique. Methuen & Co Ltd: London, UK
20. Schrijver NCA, Bahr NI, Weiss IC and Würbel H 2002 Dissociable effects of isolation rearing and environmental enrichment on exploration, spatial learning and HPA activity in adult rats. Pharmacology Biochemistry and Behavior 73: 209-224
21. Schrijver NCA, Pallier PN, Brown VJ and Würbel H 2004 Double dissociation of social and environmental stimulation on spatial learning and reversal learning in rats. Behavioural Brain Research 152: 307-314
22. Smith AL and Corrow DJ 2005 Modifications to husbandry and housing conditions of laboratory rodents for improved wellbeing. ILAR Journal 46: 140-147
23. Sørensen DB, Mikkelsen LF, Nielsen SG, Ersbøll AK and Krohn TC 2010 The influence of three standardised enriched environments on learning and memory in group-housed SD rats. Scandinavian Journal of Laboratory Animal Science, in press
24. Sørensen DB, Ottesen JL and Hansen AK 2004 Consequences of enhancing environmental complexity for laboratory rodents : a review with emphasis on the rat. Animal Welfare 13: 193-204
25. Stauffacher M, Peters A, Jennings M, Hubrecht RC, Holgate B, Francis R, Elliott H, Baumans V and Hansen AK 2002 Future principles for housing and care of laboratory rodents and rabbits. Report for the revision of the Council of Europe Convention ETS 123 Appendix A for rodents and rabbits. PART B. Council of Europe: Strasbourg, France
26. Tsai PP, Stelzer HD, Hedrich HJ and Hackbarth H 2003 Are the effects of different enrichment designs on the physiology and behaviour of DBA/2 mice consistent? Laboratory Animals 37: 314-327
27. van de Weerd HA, Aarsen EL, Mulder A, Kruitwagen CLJJ, Hendriksen CFM and Baumans V 2002 Effects of environmental enrichment for mice: variation in experimental results. Journal of Applied Animal Welfare Science 5: 109
28. van de Weerd HA, van Loo PLP and Baumans V 2004 Environmental enrichment: room for reduction? Atla-Alternatives To Laboratory Animals 32: 69-71
29. Weed JL and Raber JM 2005 Balancing animal research with animal well-being: establishment of goals and harmonization of approaches. ILAR Journal 46: 118-128
30. Wolfer DP, Litvin O, Morf S, Nitsch RM, Lipp HP and Würbel H 2004 Cage enrichment and mouse behaviour test responses by laboratory mice are unperturbed by more entertaining housing. Nature 432: 821-822
31. Würbel H and Garner JP 2007 Refinement of Rodent Research Through Environmental Enrichment and Systematic Randomization. National Centre for the Replacement, Refinement, and Reduction of Animals in Research: London, UK. www.nc3rs.org.uk