Oxidative stress status, clinical outcome, and β-globin gene cluster haplotypes in pediatric patients with sickle cell disease

European Journal of Haematology

Volumn 85, Issue 6, 2010, Pages 529-537

  Rusanova, Iryna ^a,b   Escames, Germaine ^b,c   Cossio, Gladys ^d   De Borace, Rosaura G ^e   Moreno, Belgica ^d   Chahboune, Mariam ^b,c   López, Luís C ^b,c   Díez, Tomas ^f   Acuña Castroviejo, Dario ^b,c,g  

^a Facultad de Ciencias Médicas y Clínicas   (Panama)

^b Centro de Investigacion Biomedica   (Spain)

^c UNIVERSITY OF GRANADA   (Spain)

^d Hospital del Niño   (Panama)

^e Instituto Conmemorativo Gorgas de Estudios de la Salud   (Panama)

^f UNIVERSIDAD DE PANAMÁ   (Panama)

^g HOSPITAL UNIVERSITARIO SAN CECILIO   (Spain)

Author keywords

Children; Oxidative stress; Redox markers; Sickle cell disease

Indexed keywords

BETA GLOBIN; GLUTATHIONE; GLUTATHIONE DISULFIDE; HEMOGLOBIN F; NITRATE; NITRITE;

ARTICLE; CHILD; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE SEVERITY; ERYTHROCYTE; FEMALE; GENE CLUSTER; HAPLOTYPE; HUMAN; INFANT; LIPID PEROXIDATION; MAJOR CLINICAL STUDY; MALE; OXIDATIVE STRESS; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SICKLE CELL ANEMIA;

EID: 78349290741     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2010.01528.x     Document Type: Article

References (55)

1. Schroeder WA, Munger ES, Powars DR. Sickle cell anemia, genetic variations and the trade to the United States. J Afr Hist 1990;31:163-80.
2. World Health Organization, 59th World Health Assembly, A59/9. Sickle Cell Anemia: Report of the Secretariat 2006.
3. Ballas SK. Sickle cell anemia with few painful crises is characterized by decreased red cell deformability and increased number of dense cells. Am J Hematol 1991;36:122-30.
4. Alexander N, Higgs D, Dover G, Serjeant GR. Are there clinical phenotypes of homozygous sickle cell disease? Br J Haematol 2004;126:606-11.
5. Kato GJ, Gladwin MT, Steinberg MH. Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes. Blood Rev 2007;21:37-47.
6. Eaton WA, Hofrichter J. Sickle cell hemoglobin polymerization. Adv Protein Chem 1990;40:63-279.
7. Hebbel RP, Schwartz RS, Mohandas N. The adhesive sickle erythrocyte: cause and consequence of abnormal interactions with endothelium, monocytes/macrophages and model membranes. Clin Haematol 1985;14:141-61.
8. Steinberg MH, Hsu H, Nagel RL, et al. Gender and haplotype effects upon hematological manifestations of adult sickle cell anemia. Am J Hematol 1995;48:175-81.
9. Lu ZH, Steinberg MH. Fetal hemoglobin in sickle cell anemia: relation to regulatory sequences cis to the beta-globin gene. Multicenter study of hydroxyurea. Blood 1996;87:1604-11.
10. Pagnier J, Mears JG, Dunda-Belkhodja OD, Schaefer-Rego KE, Beldjord C, Nagel RL, Labie D. Evidence for the multicentric origin of the sickle cell hemoglobin gene in Africa. Proc Natl Acad Sci USA 1984;81:1771-3.
11. Gladwin MT, Sachdev V, Jison ML, et al. Pulmonary hypertension as a risk factor for death in patients with sickle cell disease. N Engl J Med 2004;350:886-95.
12. Reiter CD, Wang X, Tanus-Santos JE, et al. Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nat Med 2002;8:1383-9.
13. Hebbel RP, Morgan WT, Eaton JW, Hedlund BE. Accelerated autoxidation and heme loss due to instability of sickle hemoglobin. Proc Natl Acad Sci USA 1988;85:237-41.
14. Mack KA, Kato GJ. Sickle cell disease and nitric oxide: a paradigm shift? Int J Biochem Cell Biol 2006;38:1237-43.
15. Aslan M. Redox-dependent impairment of vascular function in sickle cell disease. Free Radic Biol Med 2007;43:1469-83.
16. Aslan M, Ryan TM, Townes TM, et al. Nitric oxide-dependent generation of reactive species in sickle cell disease. Actin tyrosine induces defective cytoskeletal polymerization. J Biol Chem 2003;278:4194-204.
17. Schulz E, Anter E, Keaney JF Jr. Oxidative stress, antioxidants, and endothelial function. Curr Med Chem 2004;11:1093-104.
18. Aslan M, Ryan TM, Adler B, et al. Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease. Proc Natl Acad Sci USA 2001;98:15-215.
19. Wood KC, Hebbel RP, Granger DN. Endothelial cell NADPH oxidase mediates the cerebral microvascular dysfunction in sickle cell transgenic mice. FASEB J 2005;19:989-91.
20. Haynes J Jr, Obiako B, King JA, Hester RB, Ofori-Acquah S. Activated neutrophil-mediated sickle red blood cell adhesion to lung vascular endothelium: role of phosphatidylserine-exposed sickle red blood cells. Am J Physiol Heart Circ Physiol 2006;291:1679-85.
21. Hebbel RP, Osarogiagbon R, Kaul D. The endothelial biology of sickle cell disease: inflammation and a chronic vasculopathy. Microcirculation 2004;11:129-51.
22. Steinberg MH, Barton F, Castro O, et al. Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment. J Am Med Assoc 2003;289:1645-51.
23. Cokic VP, Andric SA, Stojilkovic SS, Noguchi CT, Schechter AN. Hydroxyurea nitrosylates and activates soluble guanylyl cyclase in human erythroid cells. Blood 2008;111:1117-23.
24. Kohn J. Separation of haemoglobins on cellulose acetate. J Clin Pathol 1969;22:109-11.
25. Varawalla NY, Fitches AC, Old JM. Analysis of β-globin gene haplotypes in Asian Indians: origin and spread of β-thalassaemia on the Indian subcontinent. Hum Genet 1992;90:443-9.
26. Hissin PJ, Russell H. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 1976;74:214-26.
27. Esterbauer H, Cheeseman KH. Determination of aldehydic LPO products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol 1990;186:407-21.
28. Green LC, Ruiz de Luzuriaga K, Wagner DA. Nitrate biosynthesis in man. Proc Natl Acad Sci USA 1982;78:7764-8.
29. Verdon CP, Burton CA, Prior RL. Sample pretreatment with nitrate reductase and glucose-6-phosphate dehydrogenase quantitatively reduces nitrate while avoiding interference by NADP+ when the Griess reaction is used to assay for nitrite. Anal Biochem 1995;224:502-8.
30. Jaskot RH, Charlet EG, Grose EC, Grady MA, Roycroft JH. An automatic analysis of glutathione peroxidase, glutathione-S-transferase, and reductase activity in animal tissue. J Anal Toxicol 1983;7:86-8.
31. Misra HP, Fridovich I. The role of super oxide anion in the auto oxidation of epinephrine and a simple assay for super oxide dismutase. J Biol Chem 1972;247:3170-5.
32. Betke K, Martin H, Schilicht I. Estimation small percentages of fetal haemoglobin. Nature 1959;184:1877-8.
33. Antonarakis SE, Boehm CD, Giardina PJ, Kazazian HH. Nonrandom association of polymorphic restriction sites in the beta-globin gene cluster. Proc Natl Acad Sci USA 1982;79:137-41.
34. Kulozik AE, Wainscoat JS, Serjeant GR, et al. Geographical survey of beta S-globin gene haplotypes: evidence for an independent Asian origin of the sickle-cell mutation. Am J Hum Genet 1986;39:239-44.
35. Inati A, Taher A, Bou Alawi W, Koussa S, Kaspa H, Shbaklo H, Zalloua PA. Globin gene cluster haplotypes and HbF levels are not the only modulators of sickle cell disease in Lebanon. Eur J Haematol 2003;70:79-83.
36. Nagel RL, Fabry ME, Pagnier J, et al. Hematologically and genetically distinct forms of sickle cell anemia in Africa. N Engl J Med 1985;312:880-4.
37. Steinberg MH. Predicting clinical severity in sickle cell anemia. Br J Haematol 2005;129:465-81.
38. Khan BV, Harrison DG, Olbrych MT, et al. Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox sensitive transcriptional events in human vascular endothelial cells. Proc Natl Acad Sci USA 1996;93:9114-9.
39. Lachant NA, Davidson WD, Tanaka KR. Impaired pentose phosphate shunt function in sickle cell disease: a potential mechanism for increased Heinz body formation and membrane lipid peroxidation. Am J Hematol 1983;15:1-13.
40. Hebbel RP, Leung A, Mohandas N. Oxidation-induced changes in microrheologic properties of the red blood cell membrane. Blood 1990;76:1015-20.
41. Wood KC, Granger K. Sickle cell disease: role of reactive oxygen and nitrogen metabolites. Clin Exp Pharmacol Physiol 2007;34:926-32.
42. Escames G, Khaldy H, León J, Gonzalez L, Acuña-Castroviejo D. Changes in iNOS activity, oxidative stress and melatonin levels in hypertensive patients treated with lacidipine. J Hypertens 2004;22:626-35.
43. Aslan M, Canatan D. Modulation of redox pathways in neutrophils from sickle cell disease patients. Exp Hematol 2008;36:1535-44.
44. Wood KC, Hsu LL, Gladwin MT. Sickle cell disease vasculopathy: a state of nitric oxide resistance. Free Radic Biol Med 2008;44:1506-28.
45. Lopez BL, Barnett J, Ballas SK, Christopher TA, Davis-Moon L, Ma X. Nitric oxide metabolite levels in acute vaso-occlusive sickle-cell crisis. Acad Emerg Med 1996;3:1098-103.
46. Lopez BL, Davis-Moon L, Ballas SK, Ma XL. Sequential nitric oxide measurements during the emergency department treatment of acute vasoocclusive sickle cell crisis. Am J Hematol 2000;64:151-9.
47. Ren H, Chebreneskel K, Okpala I, Lee A, Ibegbulam O, Crawford M. Patients with sickle cell disease have reduced blood antioxidant protection. Int J Vitam Nutr Res 2008;78:139-148.
48. Kiessling K, Roberts N, Gibson JS, Ellory JC. A comparison in normal individuals and sickle cell patients of reduced glutathione precursors and their transport between plasma and red cells. Hematol J 2000;1:243-9.
49. Fujii S, Kaneko T. Selenium, glutathione peroxidase and oxidative hemolysis in sickle cell disease. Acta Haematol 1992;87:105-6.
50. Reid M, Badaloo A, Forrester T, Jahoor F. In vivo rates of erythrocyte glutathione synthesis in adults with sickle cell disease. Am J Physiol Endocrinol Metab 2006;291:73-9.
51. Dasgupta T, Fabry ME, Kaul DK. Antisickling property of fetal hemoglobin enhances nitric oxide bioavailability and ameliorates organ oxidative stress in transgenic-knockout sickle mice. Am J Physiol Regul Integr Comp Physiol 2010;298:394-402.
52. Morris CR, Suh JH, Hagar W, et al. Erythrocyte hypertension in sickle cell disease. Blood 2008;111:402-10.
53. Cho CS, Kato GJ, Yang SH, Bae SW, Lee JS, Gladwin MT, Rhee SG. Hydroxyurea-induced expression of glutathione peroxidase 1 in red blood cells of individuals with sickle cell anemia. Antioxid Redox Signal 2010;13:1-11.
54. Kutlar A. Sickle cell disease: a multigenic perspective of a single gene disorder. Hemoglobin 2007;31:209-24.
55. Morris CR, Kato GJ, Poljakovic M, Wang X, Blackwelder WC, Sachdev V, Hazen SL, Vichinsky EP, Morris SM Jr, Gladwin MT. Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease. J Am Med Assoc 2005;294:81-90.