A novel synthetic route for the anti-HIV drug MC-1220 and its analogues

ChemMedChem

Volumn 5, Issue 11, 2010, Pages 1847-1849

  Loksha, Yasser M ^a   Globisch, Daniel ^a   Loddo, Roberta ^b   Collu, Gabriella ^b   La Colla, Paolo ^b   Pedersen, Erik B ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

antiviral agents; Grignard reaction; HIV; MC 1220; NNRTIs; pyrimidines

Indexed keywords

4,6 DICHLORO N,N,5 TRIMETHYLPYRIMIDIN 2 AMINE; ACETONITRILE DERIVATIVE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DIHYDROALKOXYBENZYLOXOPYRIMIDINE DERIVATIVE; MC 1220; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; NONHUMAN; PRIORITY JOURNAL; SUBSTITUTION REACTION;

ANTI-HIV AGENTS; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; PYRIMIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78349279613     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000244     Document Type: Article

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