Blood uridine concentration may be an indicator of the degradation of pyrimidine nucleotides during physical exercise with increasing intensity

Journal of Physiology and Biochemistry

Volumn 66, Issue 3, 2010, Pages 189-196

  Dudzinska, Wioleta ^a   Lubkowska, Anna ^a,b   Dolegowska, Barbara ^b   Safranow, Krzysztof ^b  

^a UNIVERSITY OF SZCZECIN   (Poland)

^b POMERANIAN MEDICAL UNIVERSITY   (Poland)

Author keywords

Exercis; Hypoxanthine; Inosine; Metabolism; Purine and pyrimidine nucleotides; Uridine

Indexed keywords

HYPOXANTHINE; INOSINE; PYRIMIDINE NUCLEOSIDE; URIC ACID; URIDINE; HYPOXANTHINE DERIVATIVE; LACTIC ACID; PURINE DERIVATIVE; PYRIMIDINE NUCLEOTIDE;

ADULT; ARTICLE; BLOOD LEVEL; BODY HEIGHT; BODY MASS; CORRELATIONAL STUDY; DEGRADATION; HEART RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; MUSCLE EXERCISE; NORMAL HUMAN; OXYGEN CONSUMPTION; REST; URIDINE BLOOD LEVEL; VENOUS BLOOD; BLOOD; EXERCISE; EXERCISE TEST; METABOLISM; PHYSIOLOGY; SKELETAL MUSCLE;

EXERCISE; EXERCISE TEST; HUMANS; HYPOXANTHINES; INOSINE; LACTIC ACID; MALE; MUSCLE, SKELETAL; PURINES; PYRIMIDINE NUCLEOTIDES; REST; URIC ACID; URIDINE; YOUNG ADULT;

EID: 78349272430     PISSN: 11387548     EISSN: 18778755     Source Type: Journal    
DOI: 10.1007/s13105-010-0023-9     Document Type: Article

References (29)

1. Astrand PO, Rodhal K (1986) Textbook of work physiology: physiological bases of exercise. McGraw-Hill, New York
2. Bangsbo J, Sjödin B, Hellsten-Westing Y (1992) Exchange of hypoxanthine in muscle during intense exercise in man. Acta Physiol Scand 146:528-533
3. Cansev M (2006) Uridine and cytidine in the brain: their transport and utilization. Brain Res Rev 52:389-397
4. Hamada T, Mizuta E, Yanagihara K, Kaestu Y, Sugihara S, Sonoyama K, Yamamoto Y, Kato M, Igawa O, Shigemasa Ch, Inokuchi T, Yamamoto T, Shimada T, Ohtahara A, Ninomiya H, Hisatome I (2007) Plasma levels of uridine correlate with blood pressure and indicators of myogenic purine degradation and insulin resistance in hypertensive patients. Circ J 71:354-356
5. Hellsten Y, Sjödin B, Richter A, Bangsbo J (1998) Urate uptake and lowered ATP levels in human muscle after highintensity intermittent exercise. Am J Physiol Endocrinol Metab 274:600-606
6. Hellsten Y, Richter EA, Kiens B, Bangsbo J (1999) AMP deamination and purine exchange in human skeletal muscle during and after intense exercise. J Physiol 520:909-920
7. Hellsten-Westing Y, Ekblom B, Sjödin B (1989) The metabolic relation between hypoxanthine and uric acid in man following maximal short-distance running. Acta Physiol Scand 137:341-345
8. Hellsten-Westing Y, Balsom PD, Norman B, Sjödin B (1993) Changes in plasma hypoxanthine and free radical markers during exercise in man. Acta Physiol Scand 149:405-412
9. Hellsten-Westing Y, Norman B, Balsom PD, Sjödin B (1993) Decreased resting levels of adenine nucleotides in human skeletal muscle after high intensity training. J Appl Physiol 74:2523-2528
10. Hellsten-Westing Y, Ekblom B, Kajser I, Sjödin B (1994) Exchange of purines in human liver and skeletal muscle with short-term exhaustive exercise. Am J Physiol 266:81-86
11. Nyhan WL (2005) Disorders of purine and pyrimidine metabolism. Mol Genet Metab 86:25-33
12. Ohno M, Ka T, Inokuchi T, Moriwaki Y, Yamamoto A, Takahashi S, Tsutsumi Z, Tsuzita J, Yamamoto T, Nishiguchi S (2008) Effects of exercise and grape juice ingestion in combination on plasma concentrations of purine bases and uridine. Clin Chim Acta 388:167-172 (Pubitemid 350266591)
13. Page T, Yu A, Fontanesi J, NyhanWL (1997) Developmental disorder associated with increased cellular nucleotidase activity. Proc Natl Acad Sci USA 94(21):11601-11606
14. Sahlin K, Ekberg K, Cizinsky S (1991) Changes in plasma hypoxanthine and free radical markers during exercise in man. Acta Physiol Scand 142:275-281
15. Sahlin K, Tonkonogi M, Söderlund K (1999) Plasma hypoxanthine and ammonia in humans during prolonged exercise. Eur J Appl Physiol 80:417-422
16. Smolenski RT, Lachno DR, Ledingham SJM, Yacoub MH (1990) Determination of sixteen nucleotides, nucleosides and bases using high-performance liquid chromatography and its application to the study of purine metabolism in heart for transplantation. J Chromatogr 527:414-420
17. Smolenski RT, Lachno DR, Yacoub MH (1992) Adenine nucleotide catabolism in human myocardium during heart and heart-lung transplantation. Eur J Cardiothorac Surg 6:25-30
18. Smoleński RT, de Jong JW, Janssen M, Lachno DR, Zydowo MM, Tavenier M, Huizer T, Yacoub MH (1993) Formation and breakdown of uridine in ischemic hearts of rats and humans. J Mol Cell Cardiol 25:67-74
19. Stathis CG, Febbraio MA, Carey MF, Snow RJ (1994) Influence of sprint training on human skeletal muscle purine nucleotide metabolism. J Appl Physiol 76:1802-1809
20. Stathis CG, Zhao S, Carey MF, Snow RJ (1999) Purine loss after repeated sprint bouts in humans. J Appl Physiol 87:2037-2042
21. Sutton JR, Toews CJ, Ward R (1980) Purine metabolism during strenuous exercise in man. Metabolism 29:254-260
22. Traut TW, Jones ME (1996) Uracil metabolism-UMP synthesis from orotic acid or uridine and conversion of uracil to β-alanine: enzymes and cDNAs. Prog Nucleic Acid Res Mol Biol 53:1-78
23. Wice BM, Kennell D (1982) Ribose-1-P is the essential precursor for nucleic acid synthesisin animal cells growing on uridine in the absence of sugar. J Biol Chem 257 (5):2578-2583
24. Yamamoto T, Moriwaki Y, Takahashi S, Tsutsumi Z, Yamakita J, Higashino K (1997) Effect of muscular exercise on the concentration of uridine and purine bases in plasma-adenosine triphosphate consumption-induced pyrimidine degradation. Metabolism 46:1339-1342
25. Yamamoto T, Moriwaki Y, Takahashi S, Tsutsumi Z, Yamakita J, Higashino K (1997) Is the plasma uridine level a marker of the overproduction of uric acid. Metabolism 46:801-804
26. Yamamoto T, Moriwaki Y, Takahashi S, Yamakita J, Tsutsumi Z, Ohata H, Hiroishi K, Nakano T, Higashino K (1997) Effect of ethanol and fructose on plasma uridine and purine bases. Metabolism 46:544-547
27. Yamamoto T, Moriwaki Y, Takahashi S, Yamakita J, Nakano T, Hiroishi K, Higashino K (1998) Xylitolinduced increase in the plasma concentration and urinary excretion of uridine and purine bases. Metabolism 47:739-743 (Pubitemid 28265180)
28. Yilmaz MS, Coskun C, Suzer O, Yalcin M, Mutlu D, Savci V (2008) Hypotensive effects of intravenously administered uridine and cytidine in conscious rats: involvement of adenosine receptors. Eur J Pharmacol 584:125-136
29. Zhao S, Snow RJ, Stathis G, Febbraio MA, Carey MF (2000) Muscle adenine nucleotide metabolism during and recovery from maximal exercise in humans. J Appl Physiol 88:1513-1519