Urate uptake and lowered ATP levels in human muscle after high-intensity intermittent exercise

American Journal of Physiology - Endocrinology and Metabolism

Volumn 274, Issue 4 37-4, 1998, Pages

  Hellsten, Y ^a   Sjodin B ^b   Richter, E A ^a   Bangsbo, J ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Adenine nucleotides; Adenosine 5' triphosphate; Antioxidant; Hypoxanthine

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADRENALIN; HYPOXANTHINE; NORADRENALIN; PURINE; URATE;

ADULT; ARM EXERCISE; ARTICLE; CONTROLLED STUDY; EXERCISE; HUMAN; HUMAN EXPERIMENT; KNEE; LEG BLOOD FLOW; LEG EXERCISE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; QUADRICEPS FEMORIS MUSCLE;

EID: 0031977278     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1998.274.4.e600     Document Type: Article

References (23)

1. Andersen, P., R. P. Adams, G. Sjøgaard, A. Thorboe, and B. Saltin. Dynamic knee extension as a model for the study of an isolated exercising muscle in man. J. Appl. Physiol. 59: 1647-1653, 1985.
2. Andersen, P., and B. Saltin. Maximal perfusion of skeletal muscle in man. J. Physiol. (Lond.) 366: 233-249, 1985.
3. Bangsbo, J., B. Sjödin, and Y. Hellsten-Westing. Exchange of hypoxanthine in muscle during intense exercise in man. Acta Physiol. Scand. 146: 549-550, 1992.
4. Becker, B. F., N. Reinholz, T. Özcelic, B. Leipert, and E. Gerlach. Uric acid as a radical scavenger and antioxidant in the heart. Pflügers Arch. 415: 127-135, 1989.
5. Christensen, N. J., P. Vestergaard, T. Sørensen, and O. T. Rafaelsen. Cerebrospinal fluid adrenaline and noradrenaline in depressed patients. Acta Psychiatr. Scand. 61: 178-182, 1980.
6. Hellsten, Y. Xanthine dehydrogenase and purine metabolism in man. With special reference to exercise. Acta Physiol. Scand. 621, Suppl. 151: 1-73, 1994.
7. Hellsten, Y., P. C. Tullson, E. A. Richter, and J. Bangsbo. Oxidation of urate in human skeletal muscle during exercise. Free Radic. Biol. Med. 22: 169-174, 1996.
8. Hellsten-Westing, Y., P. D. Balsom, B. Norman, and B. Sjödin. The effect of high intensity training on purine metabolism in human skeletal muscle. Acta Physiol. Scand. 149: 405-412, 1993.
9. Hellsten-Westing, Y., B. Ekblom, L. Kaijser, and B. Sjödin. Exchange of purines in human liver and skeletal muscle with short-term exhaustive exercise. Am. J. Physiol. 266 (Regulatory Integrative Camp. Physiol. 35): R81-R86, 1994.
10. Hellsten-Westing, Y., B. Ekblom, and B. Sjödin. The metabolic relation between hypoxanthine and uric acid in man following maximal short-distance running. Acta Physiol. Scand. 137: 341-345, 1989.
11. Hellsten-Westing, Y., B. Norman, P. D. Balsom, and B. Sjödin. Decreased resting levels of adenine nucleotides in skeletal muscle following high intensity intermittent exercise in man. J. Appl. Physiol. 74: 2523-2528, 1993.
12. Hellsten-Westing, Y., A. Sollevi, and B. Sjödin. Plasma accumulation of hypoxanthine, uric acid and creatine kinase following exhaustive runs of differing duration in man. Eur. J. Appl. Physiol. 62: 380-384, 1991.
13. Jones, P. R. M., and J. Pearson. Anthropometric determination of leg fat and muscle plus bone volumes in young male and female adults. J. Physiol. (Lond.) 204: 36P, 1969.
14. Leal-Pinto, E., W. Tao, J. Rappaport, M. Richardson, and B. A. Knorr. Molecular cloning and functional reconstitution of a urate transporter/channel. J. Biol. Chem. 272: 617-625, 1997.
15. Moyer, J. D., and J. F. Henderson. Salvage of circulating hypoxanthine by tissues of the mouse. Can. J. Biochem. Cell Biol. 61: 1153-1157, 1983.
16. Richter, E. A., K. J. Mikines, H. Galbo, and B. Kiens. Effect of exercise on insulin action in human skeletal muscle. J. Appl. Physiol. 66: 876-885, 1989.
17. Sahlin, K., K. Ekberg, and S. Cizinsky. Changes in plasma hypoxanthine and free radical markers during exercise in man. Acta Physiol. Scand. 142: 275-281, 1991.
18. Sahlin, K., G. Palmskog, and E. Hultman. Adenine nucleotide and IMP contents of the quadriceps in man after exercise. Pflügers Arch. 374: 193-198, 1978.
19. Schweinsberger, P. D., and T. L. Loo. Simultaneous analysis of ATP, ADP, AMP and other purines in human erythrocytes by HPLC. J. Chromatogr. A 181: 103-107, 1980.
20. Stathis, C. G., M. A. Febbraio, M. F. Carey, and R. J. Snow. Influence of sprint training on human skeletal muscle purine nucleotide metabolism. J. Appl. Physiol. 76: 1802-1809, 1994.
21. Tullson, P. C., J. Bangsbo, Y. Hellsten, and E. A. Richter. IMP metabolism in human skeletal muscle after exhaustive exercise. J. Appl. Physiol. 78: 146-152, 1995.
22. Vincent, M.-F., G. van den Berghe, and H. G. Hers. Metabolism of hypoxanthine in isolated rat hepatocytes. Biochem. J. 222: 145-155, 1984.
23. Wung, W. E., and S. B. Howell. Simultaneous liquid of 5-fluorouracil, uridine, hypoxanthine, xanthine, uric acid and oxypurinol in plasma. Clin. Chem. 26: 1704-1708, 1980.