Variants of the adenosine A2A receptor gene are protective against proliferative diabetic retinopathy in patients with type 1 diabetes

Ophthalmic Research

Volumn 46, Issue 1, 2011, Pages 1-8

  Charles, Bashira A ^a,b,c   Conley, Yvette P ^c   Chen, Guanjie ^a   Miller, Rachel G ^c   Dorman, Janice S ^c   Gorin, Michael B ^d,e   Ferrell, Robert E ^c   Sereika, Susan M ^c   Rotimi, Charles N ^a   Orchard, Trevor J ^c  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF NURSING RESEARCH   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d JULES STEIN EYE INSTITUTE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adenosine receptor; Diabetes; Diabetic retinopathy; Single nucleotide polymorphism

Indexed keywords

ADENOSINE A2A RECEPTOR;

ADULT; ALLELE; ARTICLE; DIABETIC RETINOPATHY; EYE PROTECTION; FEMALE; GENETIC ASSOCIATION; GENETIC RISK; HAPLOTYPE MAP; HOMOZYGOSITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN VARIANT; RECEPTOR GENE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; DIABETES MELLITUS, TYPE 1; DIABETIC RETINOPATHY; FEMALE; GENOTYPE; HUMANS; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; RECEPTOR, ADENOSINE A2A; RETINAL NEOVASCULARIZATION; YOUNG ADULT;

EID: 78349269197     PISSN: 00303747     EISSN: 14230259     Source Type: Journal    
DOI: 10.1159/000317057     Document Type: Article

References (52)

1. American Diabetes Association: All about diabetes; in American Diabetes Association (ed): All About Diabetes. American Diabetes Association, 2008.
2. Frank R: Diabetic retinopathy. N Engl J Med 2004;350:48-58.
3. Klein R, Klein BEK, Moss SE, Davis MD, DeMets DL: The Wisconsin epidemiologic study of diabetic retinopathy. 3. Prevalence and risk of diabetic retinopathy when age at diagnosis is 30 or more years. Arch Ophthalmol 1984;102:527-532.
4. Hallman M, Huber C, Gonzalez V, Klein BE, Klein R, Hanis C: Familial aggregation of severity of diabetic retinopathy in Mexican Americans from Starr County, Texas. Diabetes Care 2005;28:1163-1168. (Pubitemid 40616629)
5. Rema M, Saravanan R, Deepa R, Mohan V: Familial clustering of diabetic retinopathy in South Indian type 2 diabetic patients. Diabet Med 2002;19:910-916. (Pubitemid 35356916)
6. Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group: Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. N Engl J Med 2000;342:381-389.
7. Arar NH, Freedman BI, Adler SG, Iyengar SK, Chew EY, Davis MD, Satko SG, Bowden DW: Heritability of severity of diabetic retinopathy: the FIND-Eye study. Invest Ophthalmol Vis Sci 2008;49:3839-3845.
8. Diabetes Control and Complications Trial Research Group: Clustering of long-term complications in families with diabetes in the Diabetes Control and Complications Trial. Diabetes 1997;46:1829-1839.
9. Harris M, Klein R, Cowie C, Rowland M, Byrd-Holt D: Is the risk of diabetic retinopathy greater in non-Hispanic blacks and Mexican Americans than in non-Hispanic whites with type 2 diabetes? A US population study. Diabetes Care 1998;21:1230-1235. (Pubitemid 28365675)
10. Tudor S, Hamman R, Baron A, Johnson D, Shetterly S: Incidence and progression of diabetic retinopathy in Hispanics and non-Hispanic whites with type 2 diabetes. San Luis Valley Diabetes Study, Colorado. Diabetes Care 1998;21:53-61.
11. 2+ entry and endothelial hyperpermeability. Circ Res 2008;102:347-355.
12. 1-receptors. J Immunol 1993;151:2775-2785.
13. McKusick VA: Mendelian Inheritance in Man. A Catalog of Human Genes and Genetic Disorders. Baltimore, Johns Hopkins University Press, 2006.
14. 2A adenosine receptor expression and functioning following permanent focal ischemia in rat brain. J Neurochem 2008;104:479-490.
15. Xu Z, Park S-S, Mueller RA, Bagnell RC, Patterson C, Boysen PG: Adenosine produces nitric oxide and prevents mitochondrial oxidant damage in rat cardiomyocytes. Cardiovasc Res 2005;65:803-812. (Pubitemid 40253575)
16. 2 receptor activation at reperfusion. J Cardiovasc Pharmacol 2005;46:794-802.
17. 1, a porcine kidney cell line. Jpn J Pharmacol 1999;80:163-167.
18. Kostolanska J, Jakus V, Barak L: HbA1c and serum levels of advanced glycation and oxidation protein products in poorly and well-controlled children and adolescents with type 1 diabetes mellitus. J Pediatr Endocrinol Metab 2009;22:433-442.
19. Kostolanska J, Jakus V, Barak L: Monitoring of early and advanced glycation in relation to the occurrence of microvascular complications in children and adolescents with type 1 diabetes mellitus. Physiol Res 2009;58:553-561.
20. Negre-Salvayre A, Salvayre R, Augé N, Pamplona R, Portero-Otín M: Hyperglycemia and glycation in diabetic complications. Antioxid Redox Signal 2009;11:3071-3109.
21. Takagi H, Kinh GL, Aiello LP: Hypoxia upregulates glucose transport activity through and adenosine-mediated increase of GLUT1 expression in retinal capillary endothelial cells. Diabetes 1998;47:1480-1488. (Pubitemid 28396953)
22. Macaluso C, Frishman LJ, Frueh B, Kaelin-Lang A, Onoe S, Niemeyer G: Multiple effects of adenosine in the arterially perfused mammalian eye: possible mechanisms for the neuroprotective function of adenosine in the retina. Doc Ophthalmol 2003;106:51-59. (Pubitemid 36355972)
23. Sugiyama T, Oku H, Komori A, Ikeda T: Effect of P2X7 receptor activation on the retinal blood velocity of diabetic rabbits. Arch Ophthalmol 2006;124:1143-1149. (Pubitemid 44232344)
24. Sugiyama T, Kobayashi M, Kawamura H, Li Q, Puro DG: Enhancement of P2X7-induced pore formation and apoptosis: an early effect of diabetes on the retinal microvasculature. Invest Ophthalmol Vis Sci 2004;45:1026-1032. (Pubitemid 38868407)
25. Liao SD, Puro DG: NAD+-induced vasotoxicity in the pericyte-containing microvasculature of the rat retina: effect of diabetes. Invest Ophthalmol Vis Sci 2006;47:5032-5038. (Pubitemid 46586410)
26. Pan H-Z, Zhang H, Chang D, Li H, Sui H: The change of oxidative stress products in diabetes mellitus and diabetic retinopathy. Br J Ophthalmol 2008;92:548-551. (Pubitemid 351497989)
27. 2 receptor-cAMP system in human aortic endothelial cells. Biochem Biophys Res Commun 1994;199:905-910.
28. Adair TH, Montani JP, Strick DM, Guyton AC: Vascular development in chick embryos: a possible role for adenosine. Am J Physiol 1989;256:H240-H246.
29. 2B receptors in angiogenic factor regulation. Circ Res 2002;90:531-538.
30. Sapieha P, Hamel D, Shao Z, Rivera JC, Zaniolo K, Joyal JS, Chemtob S: Proliferative retinopathies: angiogenesis that blinds. Int J Biochem Cell Biol 2010;42:5-12.
31. Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Joyal J-S, Cho J-H, Honoré J-C, Kermorvant-Duchemin E, Varma DR, Tremblay S, Leduc M, Rihakova L, Hardy P, Klein WH, Mu X, Mamer O, Lachapelle P, di Polo A, Beauséjour C, Andelfinger G, Mitchell G, Sennlaub F, Chemtob S: The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis. Nat Med 2008;14:1067-1076.
32. Grant MB, Tarnuzzer RW, Caballero S, Ozeck MJ, Davis MI, Spoerri PE, Feoktistov I, Biaggioni I, Shryock JC, Belardinelli L: Adenosine receptor activation induces vascular endothelial growth factor in human retinal endothelial cells. Circ Res 1999;85:699-706. (Pubitemid 29480810)
33. Kostraba JN, Klein R, Dorman JS, Becker DJ, Drash AL, Maser RE, Orchard TJ: The epidemiology of diabetes complications study. Am J Epidemiol 1991;133:381-391.
34. Costacou T, Chang Y, Ferrell RE, Orchard TJ: Identifying genetic susceptibilities to diabetes-related complications among individuals at low risk of complications: an application of tree-structured survival analysis. Am J Epidemiol 2006;164:862-872. (Pubitemid 44627271)
35. Lloyd CE, Klein R, Maser RE, Kuller LH, Becker DJ, Orchard TJ: The progression of retinopathy over 2 years: the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study. J Diabetes Complications 1995;9:140-148.
36. Orchard TJ, Dorman JS, Maser RE, Becker DJ, Drash AL, Ellis D, LaPorte RE, Kuller LH: Prevalence of complications in IDDM by sex and duration. Pittsburgh Epidemiology of Diabetes Complications Study II. Diabetes 1990;39:1116-1124.
37. Diabetic Retinopathy Study Research Group: A modification of the Arlie House classification of diabetic retinopathy: Diabetic Retinopathy Study report No. 7. Invest Ophthalmol Vis Sci 1981;21:210-226.
38. Moss SE, Meuer S, Klein R, et al: Are seven standard photographic fields necessary for classification of diabetic retinopathy? Invest Ophthalmol Vis Sci 1989;30:823-828.
39. International HapMap Consortium: The International HapMap Project. Nature 2003;426:789-796.
40. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira M, Bender D, Maller J, Sklar P, de Bakker P, Daly M, Sham PC: PLINK: a tool-set for whole-genome association and population-based linkage analysis. Am J Hum Genet 2007;81:559-575. (Pubitemid 47330214)
41. Maglott D, Ostell J, Pruitt KD, Tatusova T: Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res 2007;35:D26-D31. (Pubitemid 46056164)
42. Hubbard TJP, Aken BL, Beal K, Ballester B, Caccamo M, Chen Y, Clarke L, Coates G, Cunningham F, Cutts T, Down T, Dyer SC, et al: Ensembl 2007. Nucleic Acids Res 2007;35:D610-D617.
43. 2A. Biochem Biophys Res Commun 1996;223:461-467.
44. 2A receptor gene by molecular and bioinformatics analysis. Brain Res 2004;1000:156-173.
45. Sherry S, Ward M, Kholodov M, Baker J, Phan L, Smigielski E, Sirotkin K: dbSNP: the NCBI database of genetic variation. Nucleic Acids Res 2001;29:308-311. (Pubitemid 32054478)
46. 2A adenosine receptor activation in PC12 pheochromocytoma cells. J Pharmacol Exp Ther 2000;293:779-787.
47. Lutty G, Matthews M, Merges C, McLeod D: Adenosine stimulates canine retinal microvascular endothelial cell migration and tube formation. Curr Eye Res 1998;17:594-607. (Pubitemid 28288658)
48. Leibovich S, Chen J, Pinhal-Enfield G, Belem P, Elson G, Rosania A, et al: Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A2 receptor agonists and endotoxin. Am J Pathol 2002;160:2231-2244. (Pubitemid 34663413)
49. Valls MD, Cronstein BN, Montesinos MC: Adenosine receptor agonists for promotion of dermal wound healing. Biochem Pharmacol 2009;77:1117-1124.
50. 2A receptor involvement in hypoxia-induced vasodilation. J Physiol 2006;570:375-384.
51. 2A adenosine receptor activation. Am J Kidney Dis 2001;38:610-618.
52. Rotimi C, Danile H, Zhou J, Obisesan A, Chen G, Chen Y, Amoah A, Opoku V, Acheampong J, Agyenim-Boateng K, Eghan BA Jr, Oli J, Okafor G, Ofoegbu E, Osotimehin B, Abbiyesuku F, Johnson T, Fasanmade O, Doumatey A, Aje T, Collins F, Dunston G: Prevalence and determinants of diabetic retinopathy and cataract in West African type 2 diabetes patients. Ethn Dis 2003;13:S100-S107.