Bone marrow mononuclear cell therapy led to alveolar-capillary membrane repair, improving lung mechanics in endotoxin-induced acute lung injury

Cell Transplantation

Volumn 19, Issue 8, 2010, Pages 965-971

  Prota, Luiz Felipe M ^a   Lassance, Roberta M ^a   Maron Gutierrez, Tatiana ^a   Castiglione, Raquel C ^a   Baez Garcia, Cristiane Souza ^a   Ebole Santana, Maria Cristina ^a   Souza Menezes, Jackson ^a   Abreu, Soraia C ^a   Samoto, Vivian ^a   Santiago, Marcelo Felipe ^a   Capelozzi, Vera Luiza ^b   Takiya, Christina Maeda ^a   Rocco, Patricia R M ^a   Morales, Marcelo M ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Bone marrow derived mononuclear cells (BMDMC); Electron microscopy; Inflammation; Lung mechanics

Indexed keywords

ENDOTOXIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW MONONUCLEAR CELL THERAPY; CAPILLARY WALL; CELL THERAPY; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; HISTOPATHOLOGY; IMMUNOGOLD ELECTRON MICROSCOPY; LUNG ALVEOLUS; LUNG COLLAPSE; LUNG EDEMA; LUNG MECHANICS; MALE; MOUSE; MULTINUCLEAR CELL; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL;

ACUTE LUNG INJURY; ANIMALS; BONE MARROW TRANSPLANTATION; DISEASE MODELS, ANIMAL; ENDOTOXINS; EPITHELIAL CELLS; FEMALE; GOLD; IMMUNOHISTOCHEMISTRY; LUNG; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON, TRANSMISSION;

ANIMALIA; ESCHERICHIA COLI; MUS;

EID: 78349266081     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368910X506845     Document Type: Article

References (16)

1. Bates, J. H.; Ludwig, M. S.; Sly, P. D.; Brown, K.; Martin, J. G.; Fredberg, J. J. Interrupter resistance elucidated by alveolar pressure measurement in open-chest normal dogs. J. Appl. Physiol. 65(1):408-414; 1988.
2. Cargnoni, A.; Gibelli, L.; Tosini, A.; Signoroni, P. B.; Nassuato, C.; Arienti, D.; Lombardi, G.; Albertini, A.; Wengler, G. S.; Parolini, O. Transplantation of allogeneic and xenogeneic placenta-derived cells reduces bleomycin-induced lung fibrosis. Cell Transplant. 18(4):405-422; 2009.
3. Chang, Y. S.; Oh, W.; Choi, S. J.; Sung, D. K.; Kim, S. Y.; Choi, E. Y.; Kang, S.; Jin, H. J.; Yang, Y. S.; Park, W. S. Human umbilical cord blood-derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats. Cell Transplant. 18(8):869-886; 2009.
4. Gupta, N.; Su, X.; Popov, B.; Lee, J. W.; Serikov, V.; Matthay, M. A. Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice. J. Immunol. 179(3):1855-1863; 2007.
5. Herzog, E. L.; Van Arnam, J.; Hu, B.; Zhang, J.; Chen, Q.; Haberman, A. M.; Krause, D. S. Lung-specific nuclear reprogramming is accompanied by heterokaryon formation and Y chromosome loss following bone marrow transplantation and secondary inflammation. FASEB J. 21(10):2592-2601; 2007.
6. Leite-Junior, J. H.; Garcia, C. S.; Souza-Fernandes, A. B.; Silva, P. L.; Ornellas, D. S.; Larangeira, A. P.; Castro-Faria-Neto, H. C.; Morales, M. M.; Negri, E. M.; Capelozzi, V. L.; Zin, W. A.; Pelosi, P.; Bozza, P. T.; Rocco, P. R. Methylprednisolone improves lung mechanics and reduces the inflammatory response in pulmonary but not in extrapulmonary mild acute lung injury in mice. Crit. Care Med. 36(9):2621-2628; 2008.
7. Mei, S. H.; McCarter, S. D.; Deng, Y.; Parker, C. H.; Liles, W. C.; Stewart, D. J. Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1. PLoS Med. 4(9):1525-1537; 2007.
8. Menezes, S. L.; Bozza, P. T.; Neto, H. C.; Laranjeira, A. P.; Negri, E. M.; Capelozzi, V. L.; Zin, W. A.; Rocco, P. R. Pulmonary and extrapulmonary acute lung injury: Inflammatory and ultrastructural analyses. J. Appl. Physiol. 98(5):1777-1783; 2005.
9. Nagase, T.; Lei, M.; Robatto, F. M.; Eidelman, D. H.; Ludwig, M. S. Tissue viscance during induced constriction in rabbit lungs: Morphological-physiological correlations. J. Appl. Physiol. 73(5):1900-1907; 1992.
10. Ohnishi, S.; Yasuda, T.; Kitamura, S.; Nagaya, N. Effect of hypoxia on gene expression of bone marrow-derived mesenchymal stem cells and mononuclear cells. Stem Cells 25(5):1166-1177; 2007. (Pubitemid 46684876)
11. Santos, F. B.; Nagato, L. K.; Boechem, N. M.; Negri, E. M.; Guimaraes, A.; Capelozzi, V. L.; Faffe, D. S.; Zin, W. A.; Rocco, P. R. Time course of lung parenchyma remodeling in pulmonary and extrapulmonary acute lung injury. J. Appl. Physiol. 100(1):98-106; 2006.
12. Weibel, E. R. Morphometry: Stereological theory and practical methods. In: Gil, J., ed. Models of lung disease - microscopy and structural methods. New York: Marcel Dekker Inc.; 1990:199-247.
13. Xu, J.; Qu, J.; Cao, L.; Sai, Y.; Chen, C.; He, L.; Yu, L. Mesenchymal stem cell-based angiopoietin-1 gene therapy for acute lung injury induced by lipopolysaccharide in mice. J. Pathol. 214(4):472-481; 2008. (Pubitemid 351340567)
14. Xu, J.; Woods, C. R.; Mora, A. L.; Joodi, R.; Brigham, K. L.; Iyer, S.; Rojas, M. Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice. Am. J. Physiol. Lung Cell Mol. Physiol. 293(1):131-141; 2007.
15. Yamada, M.; Kubo, H.; Kobayashi, S.; Ishizawa, K.; Numasaki, M.; Ueda, S.; Suzuki, T.; Sasaki, H. Bone marrow-derived progenitor cells are important for lung repair after lipopolysaccharide-induced lung injury. J. Immunol. 172(2):1266-1272; 2004. (Pubitemid 38113790)
16. Yukawa, H.; Noguchi, H.; Oishi, K.; Takagi, S.; Hamaguchi, M.; Hamajima, N.; Hayashi, S. Cell transplantation of adipose tissue-derived stem cells in combination with heparin attenuated acute liver failure in mice. Cell Transplant. 18(5):611-618; 2009.