The Uncertainty of Nanotoxicology: Report of a Society for Risk Analysis Workshop

Risk Analysis

Volumn 30, Issue 11, 2010, Pages 1663-1670

  Canady, Richard A ^a  

^a International Life Sciences Institute   (United States)

Author keywords

Nanomaterial; Nanotechnology; Nanotoxicology; Regulation; Science policy

Indexed keywords

DATA SETS; DYNAMIC NATURE; ENVIRONMENTAL PROTECTION AGENCY'S; NANO SCALE; NANO-MATERIALS; NANO-SCALE MATERIALS; NANOMATERIAL; NANOTOXICOLOGY; REFERENCE DOSE; REGULATION; RISK ASSESSMENT METHODS; SCIENCE POLICIES; TOXICOKINETICS; UNCERTAINTY FACTORS;

ENVIRONMENTAL PROTECTION AGENCY; HEALTH RISKS; IMPURITIES; NANOSTRUCTURED MATERIALS; PHARMACODYNAMICS; RISK ANALYSIS; TOXICITY; UNCERTAINTY ANALYSIS;

RISK ASSESSMENT;

DATA SET; ENVIRONMENTAL IMPACT ASSESSMENT; NANOTECHNOLOGY; REGULATORY APPROACH; RESEARCH WORK; RISK ASSESSMENT; TECHNOLOGY POLICY; TOXICOLOGY;

ARTICLE; NANOTECHNOLOGY; PARTICLE SIZE; RISK ASSESSMENT; TOXICOLOGY; UNCERTAINTY;

NANOTECHNOLOGY; PARTICLE SIZE; RISK ASSESSMENT; TOXICOLOGY; UNCERTAINTY;

EID: 78349262300     PISSN: 02724332     EISSN: 15396924     Source Type: Journal    
DOI: 10.1111/j.1539-6924.2010.01512.x     Document Type: Article

References (19)

1. Nano Risk Analysis: Advancing the Science for Nanomaterial Risk Management. September 10-11, 2008. Washington, DC Organized by the Society for Risk Analysis, Emerging Nanoscale Materials Specialty Group. Available at:, Accessed on September 20, 2010.
2. Morgan K. Development of a preliminary framework for informing the risk analysis and risk management of nanoparticles. Risk Analysis, 2005; 25(6):1621-1635.
3. U.S. National Cancer Institute, Nanotechnology Characterization Laboratory. Available at:, Accessed on September 20, 2010.
4. Brown DM, Wilson MR, MacNee W, Stone V, Donaldson K. Size-dependent proinflammatory effects of ultrafine polystyrene particles: A role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicology and Applied Pharmacology, 2001; 175:191-199.
5. Workshops and proposals from the NIEHS Nanohealth Enterprise. Available at
6. Sanhai WR, Sakamoto JH, Canady RA, Ferrari M. Seven challenges for nanomedicine. Nature Nanotechnology, 2008; 3:242-244.
7. Taylor MR. Assuring the safety of nanomaterials in food packaging: The regulatory process and key issues. Project on Emerging Nanotechnologies, July 12, 2008. Available at:, Accessed on September 20, 2010.
8. European Food Safety Authority. The Potential Risks Arising from Nanoscience and Nanotechnologies on Food and Feed Safety. Opinion of the European Food Safety Authority, 2009. Available at:, Accessed on September 20, 2010.
9. Risk Assessment of Products of Nanotechnologies. Opinion of the Scientific Committee on Emerging and Newly Identified Health Risks, 2009. Available at:, Accessed on September 20, 2010.
10. Warheit DB, Webb TR, Colvin VL, Reed KL, Sayes CM. Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: Toxicity is not dependent upon particle size but on surface characteristics. Toxicological Sciences, 2007; 95(1):270-280.
11. Warheit DB, Brock WJ, Lee KP, Webb TR, Reed KL. Comparative pulmonary toxicity inhalation and instillation studies with different TiO2 particle formulations: Impact of surface treatments on particle toxicity. Toxicological Sciences, 2005; 88(2):514-524.
12. Lockman PR, Koziara JM, Mumper RL, Allen DD. Nanoparticle surface charges alter blood-brain barrier integrity and permeability. Journal of Drug Targeting, 2004; 12(9-10):635-641.
13. Derfus AM, et al. Probing the cytotoxicity of semiconductor quantum dots. 2004 Nano Letters, 4(1):11-18.
14. Ballou B, Lagerholm BC, Ernst LA, Bruchez MP, Waggoner AS. Noninvasive imaging of quantum dots in mice. Bioconjugate Chemistry, 2004; 15(1):79-86.
15. Hoshino A, Fujioka K, Oku T, Suga M, Sasaki YF, Oh'ta T, et al. Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification. Nano Letters, 2004 Nov; 4(11):2163-2169
16. Cedervall T, Lynch I, Lindman S, Berggård T, Thulin E, Nilsson H, Dawson KA, Linse S. Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles. Proceedings of the National Academy of Sciences USA, 2007 Feb 13; 4(7):2050-2055.
17. Lynch I, Cedervall T, Lundqvist M, Cabaleiro-Lago C, Linse S, Dawson KA. The nanoparticle-protein complex as a biological entity; a complex fluids and surface science challenge for the 21st century. Advances in Colloid Interface Science, 2007; 134-136:167-174.
18. Teeguarden JG, Hinderliter PM, Orr G, Thrall BD, Pounds JG. Particokinetics in vitro: Dosimetry considerations for in vitro nanoparticle toxicity assessments. Toxicological Sciences, 2007; 95:300-312.
19. Nanotechnologies-Part 2: Guide to Safe Handling and Disposal of Manufactured Nanomaterials, ICS 13.100; 71.100.99 PD 6699-2:2007. Available at:, Accessed on September 20, 2010.