Increased proliferation and migration of epithelium in advancing experimental cholesteatomas

Otology and Neurotology

Volumn 23, Issue 6, 2002, Pages 840-844

  Kim, Hyung Jong ^a   Tinling, Steven P ^b   Chole, Richard A ^c  

^a Hallym University   (South Korea)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Canal ligation; Cholesteatoma; Cytokeratin; Propylene glycol; Retraction pocket

Indexed keywords

CYTOKERATIN; PROPYLENE GLYCOL; KERATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CHOLESTEATOMA; CONTROLLED STUDY; DENSITOMETRY; EARDRUM; GERBIL; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; ANIMAL; CELL DIVISION; CELL MOTION; COMPARATIVE STUDY; DISEASE MODEL; EPITHELIUM; MIDDLE EAR; PATHOLOGY; PHYSIOLOGY;

ANIMALS; CELL DIVISION; CELL MOVEMENT; CHOLESTEATOMA, MIDDLE EAR; DISEASE MODELS, ANIMAL; EAR, MIDDLE; EPITHELIUM; GERBILLINAE; KERATINOCYTES; KERATINS;

EID: 0036835985     PISSN: 15317129     EISSN: None     Source Type: Journal    
DOI: 10.1097/00129492-200211000-00005     Document Type: Article

References (25)

1. Goycoolea MV, Hueb MM, Muchow D, et al. The theory of the trigger, the bridge and the transmigration in the pathogenesis of acquired cholesteatoma. Acta Otolaryngol 1999;119:244-8.
2. Young R, Rowles P. The spatial organization of keratinocytes in acquired middle ear cholesteatoma resembles that of external auditory canal skin and pars flaccida. Acta Otolaryngol 1990;110: 115-9.
3. Sudhoff H, Bujia J, Borkowshi G, et al. Basement membrane in middle ear cholesteatoma: immunohistochemical and ultrastrucrural observations. Ann Otol Rhinol Laryngol 1996;105:804-10.
4. O'Donoghue GM. The migration theory of cholesteatoma formation: some experimental observations. J Laryngol Otol 1986;100: 395-8.
5. Van Blitterswijk CA, Grote JJ, Lutgert RW, et al. Cytokeratin patterns of tissues related to cholesteatoma pathogenesis. Ann Otol Rhinol Laryngol 1989;98:635-40.
6. Vennix PP, Kuijpers W, Peters TA, et al. Keratinocyte differentiation in acquired cholesteatoma and perforated tympanic membranes. Arch Otolaryngol Head Neck Surg 1996;122:825-32.
7. Chao WY, Huang CC. An immunocytochemical study of cytokeratin expression in human middle ear cholesteatoma. Arch Otorhinolaryngol 1989;246:37-42.
8. Kim CS, Chung JW. Morphologic and biologic changes of experimentally induced cholesteatoma in Mongolian gerbils with anticytokeratin and lectin study. Am J Otol 1999;20:13-8.
9. Huang CC, Shi GS, Yi ZX. Experimental induction of middle ear cholesteatoma in rats. Am J Otolaryngol 1988;9:165-72.
10. Masaki M, Wright CG, Meyerhoff WL. Experimental cholesteatoma: Epidermal ingrowth through tympanic membrane following middle ear application of propylene glycol. Acta Otolaryngol 1989;108:113-21.
11. Weiss RA, Eichner R, Sun T. Monoclonal antibody analysis of keratin expression in epidermal disease: a 48- and 56-k Dalton keratin as molecular markers for hyperproliferative keratinocytes. J Cell Biol 1984;98:1397-406.
12. Mare SD, Jong ED, Van Erp PEJ, et al. Markers for proliferation and keratinization in the margin of the active psoriatic lesion. Br J Dermatol 1990;122:469-75.
13. Vennix PPCA, Kuijpers W, Tonnaer ELGM, et al. Cytokeratins in induced epidermoid formation and cholesteatoma lesions. Arch Otolaryngol Head Neck Surg 1990;116:560-5.
14. Vennix PPCA, Kuijpers W, Peters TA, et al. Growth and differentiation of meatal skin grafts in the middle ear of the rat. Arch Otolaryngol Head Neck Surg 1994;120:1102-11.
15. Broekaert D, Cornille A, Eto E, et al. A comparative Immunohistochemical analysis of the cytokeratin and vimentin expression in middle ear mucosa and cholesteatoma, and in epidermis. Virchows Arch A Pathol Anat 1988;413:39-51.
16. Broekaert D, Coucke P, Leperque S, et al. Immunohistochemical analysis of the cytokeratin expression in middle ear cholesteatoma and related epithelial tissues. Ann Otol Rhinol Laryngol 1992;101:931-8.
17. Bujia J, Schilling V, Holly A, et al. Hyperproliferation-associated keratin expression in human middle ear cholesteatoma. Acta Otolaryngol 1993;113:364-8.
18. Sasaki H, Huang CC. Expression of cytokeratins 13 and 16 in middle ear cholesteatoma. Otolaryngol Head Neck Surg 1994;110: 310-7.
19. Kim HJ, Chole RA. Experimental models of aural cholesteatoma in Mongolian gerbils. Ann Otol Rhinol Laryngol 1998;107:129-34.
20. Anniko M, Mendel L. Cholesteatoma: a clinical and morphological Analysis. Acta Otolaryngol 1981;91:275-83.
21. Kim HJ, Tinling SP, Chole RA. Expression patterns of cytokeratins in cholesteatomas: evidence of increased migration and proliferation. J Korean Med Sci 2002;17:381-8.
22. Kim HJ, Tinling SP, Chole RA. Expression patterns of cytokeratins in retraction pocket cholesteatoma. Laryngoscope 2001;111: 1032-6.
23. Sano S, Schachern PA, Haruna S, et al. Cytokeratin patterns of normal middle ear epithelia in human, cats, and chinchillas. Ann Otol Rhinol Laryngol 1994;103:227-34.
24. Stammberger M, Bujia J, Kastenbauer E. Alteration of epidermal differentiation in middle ear cholesteatoma. Am J Otol 1995;16: 527-31.
25. Chole RA, Tinling SP. Basal lamina breaks in the histogenesis of cholesteatoma. Laryngoscope 1985;95:270-5.