Immunohistochemical detection of proliferating cell nuclear antigen in middle ear cholesteatoma

European Archives of Oto-Rhino-Laryngology

Volumn 253, Issue 1-2, 1996, Pages 21-24

  Bujia J ^a   Sudhoff, H ^b   Holly, A ^a   Hildmann, H ^b   Kastenbauer, E ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Cholesteatoma proliferation; DNA synthesis; Immunohistochemistry; Proliferating cell nuclear antigen

Indexed keywords

CYCLINE; FORMALDEHYDE; MARKER; PARAFFIN;

ARTICLE; AUDITORY OSSICLE; BASAL CELL; BONE DESTRUCTION; CELL PROLIFERATION; CHOLESTEATOMA; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; EPIDERMIS CELL; EPITHELIUM; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; MIDDLE EAR; PRIORITY JOURNAL; SPATIAL ORIENTATION; STAINING; TEMPORAL BONE; TISSUE SECTION; TUMOR BIOPSY;

CELL DIVISION; CELL NUCLEUS; CHOLESTEATOMA, MIDDLE EAR; DNA REPLICATION; EAR, MIDDLE; EPITHELIUM; HUMANS; IMMUNOENZYME TECHNIQUES; KERATINOCYTES; PROLIFERATING CELL NUCLEAR ANTIGEN; SKIN;

EID: 0030040349     PISSN: 09374477     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Ahn JM, Huang CC,Abramson M (1990) Localization of interleukin-1 in human cholesteatoma. Am J Otolaryngol 11:71-77
2. Almendral JM, Huebsch D, Blundell PA, Macdonald-Bravo H, Bravo R (1987) Cloning and sequence of the human nuclear protein cyclin: homology with DNA binding proteins. Proc Natl Acad Sc USA 84:1575-1579
3. Bravo R, Fey SJ, Bellatin J (1981) Identification of a nuclear and of a cytoplasmic polypeptide whose relative proportions are sensitive to changes in the rate of cell proliferation. Exp Cell Res 136:311-319
4. Bujia J, Holly A, Schilling V, Negri B, Pitzke P, Schulz P (1993) Aberrant expression of epidermal growth factor receptor in aural cholesteatoma. Laryngoscope 103:326-329
5. Bujia J, Schilling V, Holly A, Stammberger M, Kastenbauer E (1993) Hyperproliferation-associated keratin expression in human middle ear cholesteatoma. Acta Otolaryngol (Stockh) 113: 364-368
6. Bujia J, Holly A, Sudhoff H, Kim C, Kastenbauer E (1995) Identification of proliferating keratinocytes in middle ear cholesteatoma using the monoclonal antibody Ki-67. ORL (in press)
7. Cells JE, Celis A (1985) Cell cycle dependent variations in the distribution of the nuclear protein cyclin proliferating cell nuclear antigen in cultured cells: subdivision of S phase. Proc Natl Acad Sci USA 82:3262-3266
8. Celis JE, Bravo R, Larsen PM (1984) Cyclin: a nuclear protein whose level correlates directly with the proliferative state of normal as well as transformed cells. Leuk Res 8:143-157
9. Garcia RL, Coltreta MD, Gown AM (1989) Analysis of proliferative grade using anti-PCNA/cyclin monoclonal antibodies in fixed, embedded tissues: comparison with flow cytometric analysis. Am J Pathol 134:733-739
10. Reference deleted
11. Gerdes J, Lemke J, Baisch H, Wacher HH, Schwab U, Stein H (1984) Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133:1710-1715
12. Hall PA, Levison DA, Woods AL, Yu CW, Kellock DB, Watkins JA, Barnes DM, Gillett CE, Camplejohn R, Dover R, Waseem NH, Lane DB (1990) Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol 162:285-294
13. Jaskulksi D, Deriel JK, Mercer WE, Calabretta B, Beserga R (1988) Inhibition of cellular proliferation by antisense digodesoxynucleotides to PCNA/cyclin. Science 240:1544-1546
14. Landberg G, Goran R (1991) Antibodies to proliferating cell nuclear antigen as S-phase probes in flow cytometric analysis. Cancer Res 51:4570-5474
15. Mathews MB, Bernstein RM, Franza BR (1984) Identity of the proliferating nuclear antigen and cyclin. Nature 309:374-376
16. Miyachi K, Fritzler MJ, Tan EM (1978) Autoantibody to a nuclear antigen in proliferating cells. J Immunol 121:2228-2234
17. Penneys NS, Bogaert M, Serfling U, Sisto M (1992) PCNA expression in cutaneous keratinous neoplasms and verruca vulgaris. Am J Pathol 141:139-142
18. Persson H, Hennighausen L, Taub R (1984) Antibodies of an evolutionarily conserved protein induced during cell proliferation. Cell 225:687-694
19. Robbins BA, De La Vega D, Ogata K, Tan EM, Nakamura RM (1987) Immunohistochemical detection of proliferating cell nuclear antigen in solid human malignancies. Arch Pathol Lab Med 111:841-845
20. Schilling V, Negri B, Bujia J, Schulz P, Kastenbauer E (1991) Possible role of interleukin-1 alpha and interleukin-1 beta in the pathogenesis of cholesteatoma of the middle ear. Am J Otol 11:249-253
21. Schilling V, Bujia J, Negri B, Schulz P, Kastenbauer E (1992) Immunologically activated cells in aural cholesteatoma. Am J Otolaryngol 12:249-253
22. Schulz P, Bujia J, Holly A (1993) Possible autocrine growth Stimulation of cholesteatoma epithelium by transforming growth factor-alpha. Am J Otolaryngol 4:82-87
23. Shurbaji MS, Brooks SK, Thurmond TS (1993) Proliferating cell nuclear antigen immunoreactivity in cervical intraepithelial neoplasia and benign cervical epithelium. Am J Clin Pathol 100:22-26
24. Sittinger S, Bujia J, Burmester G (1994) Inexpensive computer analysis of cell and tissue stainings. In Vitro Cell Dev Biol 30A:559-561
25. Smetana K, Gyorkey E, Chan PK (1983) Proliferating cell nuclear antigen (PCNA) and human malignant tumor nucleolar antigens (HMTNA) in nucleoli of human hematological malignancies. Blut 46:133-141
26. Takasaki Y, Deng JS, Tan EM (1981) A nuclear antigen associated with cell proliferation and blast transformation: its distribution in synchronized cells. J Exp Med 154:1899-1909
27. Takasaki Y, Robinson WA, Tan EM (1984) Proliferating cell nuclear antigen in blast crisis cells of patients with chronic myeloid leukemia. J Natl Cancer Inst 73:655-661