Importance of membrane- or matrix-associated forms of M-CSF and RANKL/ODF in osteoclastogenesis supported by SaOS-4/3 cells expressing recombinant PTH/PTHrP receptors

Journal of Bone and Mineral Research

Volumn 15, Issue 9, 2000, Pages 1766-1775

  Itoh, Kanami ^a   Udagawa, Nobuyuki ^a   Matsuzaki, Kenichiro ^a   Takami, Masamichi ^a   Amano, Hitoshi ^a   Shinki, Toshimasa ^a   Ueno, Yutaka ^a   Takahashi, Naoyuki ^a   Suda, Tatsuo ^a  

^a SHOWA UNIVERSITY   (Japan)

Author keywords

Macrophage colony stimulating factor; Osteoclastogenesis; Parathyroid hormone; Receptor activator nuclear factor B ligand

Indexed keywords

BETA TUBULIN; CALCITRIOL; COLONY STIMULATING FACTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUKOPROL; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PARATHYROID HORMONE RECEPTOR; RECOMBINANT COLONY STIMULATING FACTOR;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CONTROLLED STUDY; HORMONAL REGULATION; HUMAN; HUMAN CELL; MALE; MOLECULAR CLONING; MOUSE; NEWBORN; NONHUMAN; OSTEOCLAST; OSTEOSARCOMA; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ANIMALS; BONE MARROW CELLS; CARRIER PROTEINS; CELL MEMBRANE; CELLS, CULTURED; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; GLYCOPROTEINS; HISTOCYTOCHEMISTRY; HUMANS; MACROPHAGE COLONY-STIMULATING FACTOR; MALE; MEMBRANE GLYCOPROTEINS; MICE; OSTEOCLASTS; OSTEOGENESIS; OSTEOPROTEGERIN; PARATHYROID HORMONE; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; RECEPTOR, PARATHYROID HORMONE, TYPE 1; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, PARATHYROID HORMONE; RECEPTORS, TUMOR NECROSIS FACTOR; RNA, MESSENGER; STEM CELLS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0033848680     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2000.15.9.1766     Document Type: Article

References (39)

1. Osteoblastic cells are involved in osteoclast formation
2. The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells
3. Modulation of osteoclast differentiation
4. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
5. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
6. TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells
7. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
8. Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function
9. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene
10. Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
11. Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis
12. Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival
13. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
14. Macrophage colony stimulating factor restores in vivo bone resorption in the op/op osteopetrotic mouse
15. Congenital osteoclast deficiency in osteopetrotic (op/op) mice is cured by injections of macrophage colony-stimulating factor
16. Deficiency of osteoclasts in osteopetrotic mice is due to a defect in the local microenvironment provided by osteoblastic cells
17. Human macrophage colony stimulating factor (M-CSF): Alternate RNA splicing generates three different proteins that are expressed on the cell surface and secreted
18. Differential processing of colony-stimulating factor 1 precursors encoded by two human cDNAs
19. Synthesis of membrane- and matrix-bound colony-stimulating factor-1 by cultured osteoblasts
20. 3
21. Colony stimulating factor-1 (macrophage colony-stimulating factor)
22. The cell-surface form of colony-stimulating factor-1 is regulated by osteotropic agents and supports formation of multinucleated osteoclast-like cells
23. The predominant form of secreted colony stimulating factor-1 is a proteoglycan
24. Identification of a high molecular weight macrophage colony-stimulating factor as a glycosaminoglycan-containing species
25. Biological activity of a proteoglycan form of macrophage colony-stimulating factor and its binding to type V collagen
26. A proteoglycan form of macrophage colony-stimulating factor that binds to bone-derived collagens and can be extracted from bone matrix
27. Parathyroid hormone-related protein
28. Human osteoclast-like cells are formed from peripheral blood mononuclear cells in a co-culture with SaOS-2 cells transfected with the PTH/PTHrP receptor gene
29. 3 in osteoclast differentiation and function
30. Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor
31. Role of colony stimulating factors in osteoclast development
32. Macrophage colony-stimulating factor release and receptor expression in bone cells
33. Inhibition of bone resorption by 17beta-estradiol in human bone marrow cultures
34. Biology and action of colony-stimulating factor-1
35. Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin
36. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
37. Detection of transcripts and binding sites for colony-stimulating factor-1 during bone development
38. Immunohistochemical identification of proteoglycan form of macrophage colony-stimulating factor on bone surface
39. Commitment and differentiation of osteoclast precursor cells by sequential expression of c-Fms and receptor activator of nuclear factor kB (RANK) reseptors