Redundancy and variation in the ubiquitin-mediated proteolytic targeting of a transcription factor

Cell Cycle

Volumn 9, Issue 21, 2010, Pages 4282-4285

  Rubenstein, Eric M ^a   Hochstrasser, Mark ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

Functional redundancy; Mating type; Proteasome; SUMO; Ubiquitin; Yeast

Indexed keywords

PROTEASOME; SUMO PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MAT ALPHA 2; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

GENE CONTROL; HUMAN; MOLECULAR RECOGNITION; PHENOTYPE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN MODIFICATION; REVIEW; YEAST;

EUKARYOTA; SACCHAROMYCETALES;

EID: 78349232724     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.21.13741     Document Type: Review

References (29)

1. Westermarck J. Regulation of transcription factor function by targeted protein degradation: an overview focusing on p53, c-Myc and c-Jun. Methods Mol Biol 2010; 647:31-6.
2. Chen P, et al. Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MATalpha2 repressor. Cell 1993; 74:357-69. (Pubitemid 23221711)
3. Hochstrasser M, et al. The short-lived MATalpha2 transcriptional regulator is ubiquitinated in vivo. Proc Natl Acad Sci USA 1991; 88:4606-10. (Pubitemid 21914590)
4. Nasmyth K, Shore D. Transcriptional regulation in the yeast life cycle. Science 1987; 237:1162-70.
5. Herskowitz I. Life cycle of the budding yeast Saccharomyces cerevisiae. Microbiol Rev 1988; 52:536-53.
6. Laney JD, Hochstrasser M. Ubiquitin-dependent degradation of the yeast Mat(alpha)2 repressor enables a switch in developmental state. Genes Dev 2003; 17:2259-70.
7. Swanson R, Locher M, Hochstrasser M. A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation. Genes Dev 2001; 15:2660-74. (Pubitemid 32988877)
8. Sommer T, S. Jentsch. A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum. Nature 1993; 365:176-9.
9. Biederer T, Volkwein C, Sommer T. Role of Cue1p in ubiquitination and degradation at the ER surface. Science 1997; 278:1806-9.
10. Bays NW, et al. Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Nat Cell Biol 2001; 3:24-9.
11. Deak PM, Wolf DH. Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation. J Biol Chem 2001; 276:10663-9.
12. Vashist S, Ng DT. Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control. J Cell Biol 2004; 165:41-52.
13. Huyer G, et al. Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein. J Biol Chem 2004; 279:38369-78.
14. Yamasaki S, et al. Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. EMBO J 2007; 26:113-22.
15. Arteaga MF, et al. An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery. Proc Natl Acad Sci USA 2006; 103:11178-83.
16. Worman HJ, Courvalin JC. The inner nuclear membrane. J Membr Biol 2000; 177:1-11.
17. Deng M, Hochstrasser M. Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase. Nature 2006; 443:827-31. (Pubitemid 44622689)
18. Ravid T, Kreft SG, Hochstrasser M. Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways. EMBO J 2006; 25:533-43.
19. McBratney S, Winey M. Mutant membrane protein of the budding yeast spindle pole body is targeted to the endoplasmic reticulum degradation pathway. Genetics 2002; 162:567-78.
20. Xie Y, et al. SUMO-independent in vivo activity of a SUMO-targeted ubiquitin ligase toward a short-lived transcription factor. Genes Dev 2010.
21. Perry JJ, Tainer JA, Boddy MN. A SIM-ultaneous role for SUMO and ubiquitin. Trends Biochem Sci 2008; 33:201-8.
22. Uzunova K, et al. Ubiquitin-dependent proteolytic control of SUMO conjugates. J Biol Chem 2007; 282:34167-75. (Pubitemid 350159437)
23. Xie Y, et al. The yeast Hex3.Slx8 heterodimer is a ubiquitin ligase stimulated by substrate sumoylation. J Biol Chem 2007; 282:34176-84.
24. Zhang C, et al. Suppression of genomic instability by SLX5 and SLX8 in Saccharomyces cerevisiae. DNA Repair (Amst) 2006; 5:336-46.
25. Yang L, Mullen JR, Brill SJ. Purification of the yeast Slx5-Slx8 protein complex and characterization of its DNA-binding activity. Nucleic Acids Res 2006; 34:5541-51. (Pubitemid 44742442)
26. Wilcox AJ, Laney JD. A ubiquitin-selective AAAA-TPase mediates transcriptional switching by remodelling a repressor-promoter DNA complex. Nat Cell Biol 2009; 11:1481-6.
27. Johnson PR, et al. Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitinproteasome pathway. Cell 1998; 94:217-27.
28. Jain AK, Barton MC. Regulation of p53: TRIM24 enters the RING. Cell Cycle 2009; 8:3668-74.
29. Dai MS, et al. Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-Myc. Neoplasia 2006; 8:630-44.