Expression and regulation of the chemokine CXCL16 in Crohns disease and models of intestinal inflammation

Inflammatory Bowel Diseases

Volumn 16, Issue 11, 2010, Pages 1871-1881

  Diegelmann, Julia ^a   Seiderer, Julia ^a   Niess, Jan Hendrik ^b   Haller, Dirk ^c   Göke, Burkhard ^a   Reinecker, Hans Christian ^d   Brand, Stephan ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF ULM   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

chemokine; Crohns disease; CXCL16; CXCR6; cytokine; inflammatory bowel disease; intestinal epithelial cells; intestinal inflammation; mouse model; signaling; ulcerative colitis

Indexed keywords

AZATHIOPRINE; CHEMOKINE RECEPTOR CXCR6; CORTICOSTEROID; CXCL16 CHEMOKINE; INFLIXIMAB; INTERLEUKIN 8; MESALAZINE; MESSENGER RNA; METHOTREXATE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CANCER CELL CULTURE; CLINICAL ARTICLE; COLON BIOPSY; COLORECTAL CANCER; CONTROLLED STUDY; CORRELATION ANALYSIS; CROHN DISEASE; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DESCENDING COLON; ENTERITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN TISSUE; ILEITIS; IN VITRO STUDY; INTESTINE CELL; INTESTINE EPITHELIUM CELL; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; SERUM; SIGNAL TRANSDUCTION; SMALL INTESTINE; UPREGULATION;

ANIMALS; CELL LINE; CHEMOKINE CXCL6; CHEMOKINES, CXC; COLITIS; COLON; CROHN DISEASE; HERPESVIRIDAE INFECTIONS; HUMANS; ILEITIS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MUROMEGALOVIRUS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CHEMOKINE; RECEPTORS, CXCR; RECEPTORS, SCAVENGER; RECEPTORS, VIRUS; T-LYMPHOCYTES; UP-REGULATION;

EID: 78249281655     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.21306     Document Type: Article

References (45)

1. Westendorf AM, Fleissner D, Hansen W, Buer J,. T cells, dendritic cells and epithelial cells in intestinal homeostasis. Int J Med Microbiol. 2010; 300: 11-18.
2. Dwinell MB, Eckmann L, Leopard JD, et al. Chemokine receptor expression by human intestinal epithelial cells. Gastroenterology. 1999; 117: 359-367.
3. Jordan NJ, Kolios G, Abbot SE, et al. Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells. J Clin Invest 1999; 104: 1061-1069.
4. Brand S, Sakaguchi T, Gu X, et al. Fractalkine-mediated signals regulate cell-survival and immune-modulatory responses in intestinal epithelial cells. Gastroenterology. 2002; 122: 166-177.
5. Brand S, Hofbauer K, Dambacher J, et al. Increased expression of the chemokine fractalkine in Crohns disease and association of the fractalkine receptor T280M polymorphism with a fibrostenosing disease phenotype. Am J Gastroenterol. 2006; 101: 99-106.
6. Brand S, Dambacher J, Beigel F, et al. CXCR4 and CXCL12 are inversely expressed in colorectal cancer cells and modulate cancer cell migration, invasion and MMP-9 activation. Exp Cell Res. 2005; 310: 117-130.
7. Brand S, Olszak T, Beigel F, et al. Cell differentiation dependent expressed CCR6 mediates ERK-1/2, SAPK/JNK, and Akt signaling resulting in proliferation and migration of colorectal cancer cells. J Cell Biochem. 2006; 97: 709-723.
8. Silva MA,. Intestinal dendritic cells and epithelial barrier dysfunction in Crohns disease. Inflamm Bowel Dis. 2009; 15: 436-453.
9. Iliev ID, Mileti E, Matteoli G, et al. Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning. Mucosal Immunol. 2009; 2: 340-350.
10. Smith JM, Johanesen PA, Wendt MK, et al. CXCL12 activation of CXCR4 regulates mucosal host defense through stimulation of epithelial cell migration and promotion of intestinal barrier integrity. Am J Physiol Gastrointest Liver Physiol. 2005; 288: G316-G326.
11. Heidemann J, Ogawa H, Rafiee P, et al. Mucosal angiogenesis regulation by CXCR4 and its ligand CXCL12 expressed by human intestinal microvascular endothelial cells. Am J Physiol Gastrointest Liver Physiol. 2004; 286: G1059-G1068.
12. Wilbanks A, Zondlo SC, Murphy K, et al. Expression cloning of the STRL33/BONZO/TYMSTRligand reveals elements of CC, CXC, and CX3C chemokines. J Immunol. 2001; 166: 5145-5154.
13. Shimaoka T, Nakayama T, Kume N, et al. Cutting EDGE: SR-PSOX/CXC chemokine ligand 16 mediates bacterial phagocytosis by APCs through its chemokine domain. J Immunol. 2003; 171: 1647-1651.
14. Nanki T, Shimaoka T, Hayashida K, et al. Pathogenic role of the CXCL16-CXCR6 pathway in rheumatoid arthritis. Arthritis Rheum. 2005; 52: 3004-3014.
15. Matsumura S, Wang B, Kawashima N, et al. Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol. 2008; 181: 3099-3107.
16. Matloubian M, David A, Engel S, et al. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nat Immunol. 2000; 1: 298-304.
17. Deng HK, Unutmaz D, KewalRamani VN, Littman DR,. Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature. 1997; 388: 296-300.
18. Liao F, Alkhatib G, Peden KW, et al. STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. J Exp Med. 1997; 185: 2015-2023.
19. Loetscher M, Amara A, Oberlin E, et al. TYMSTR, a putative chemokine receptor selectively expressed in activated T cells, exhibits HIV-1 coreceptor function. Curr Biol. 1997; 7: 652-660.
20. Kim CH, Kunkel EJ, Boisvert J, et al. Bonzo/CXCR6 expression defines type 1-polarized T-cell subsets with extralymphoid tissue homing potential. J Clin Invest. 2001; 107: 595-601.
21. Hase K, Murakami T, Takatsu H, et al. The membrane-bound chemokine CXCL16 expressed on follicle-associated epithelium and M cells mediates lympho-epithelial interaction in GALT. J Immunol. 2006; 176: 43-51.
22. Wagsater D, Dimberg J,. Expression of chemokine receptor CXCR6 in human colorectal adenocarcinomas. Anticancer Res. 2004; 24: 3711-3714.
23. Nishiyama R, Sakaguchi T, Kinugasa T, et al. Interleukin-2 receptor beta subunit-dependent and -independent regulation of intestinal epithelial tight junctions. J Biol Chem. 2001; 276: 35571-35580.
24. Muehlhoefer A, Saubermann LJ, Gu X, et al. Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa. J Immunol. 2000; 164: 3368-3376.
25. Elewaut D, DiDonato JA, Kim JM, et al. NF-kappa B is a central regulator of the intestinal epithelial cell innate immune response induced by infection with enteroinvasive bacteria. J Immunol. 1999; 163: 1457-1466.
26. Kontoyiannis D, Pasparakis M, Pizarro TT, et al. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity. 1999; 10: 387-398.
27. Ruiz PA, Shkoda A, Kim SC, et al. IL-10 gene-deficient mice lack TGF-beta/Smad signaling and fail to inhibit proinflammatory gene expression in intestinal epithelial cells after the colonization with colitogenic Enterococcus faecalis. J Immunol. 2005; 174: 2990-2999.
28. Dambacher J, Beigel F, Seiderer J, et al. Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease. Gut. 2007; 56: 1257-1265.
29. Rawlinson WD, Farrell HE, Barrell BG,. Analysis of the complete DNA sequence of murine cytomegalovirus. J Virol. 1996; 70: 8833-8849.
30. Brand S, Beigel F, Olszak T, et al. IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression. Am J Physiol Gastrointest Liver Physiol. 2005; 289: G960-G968.
31. Niess JH, Brand S, Gu X, et al. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science. 2005; 307: 254-258.
32. Eckmann L, Jung HC, Schurer-Maly C, et al. Differential cytokine expression by human intestinal epithelial cell lines: regulated expression of interleukin 8. Gastroenterology. 1993; 105: 1689-1697.
33. Tilton B, Ho L, Oberlin E, et al. Signal transduction by CXC chemokine receptor 4. Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes. J Exp Med. 2000; 192: 313-324.
34. Waetzig GH, Seegert D, Rosenstiel P, et al. p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease. J Immunol. 2002; 168: 5342-5351.
35. Hommes D, van den Blink B, Plasse T, et al. Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohns disease. Gastroenterology. 2002; 122: 7-14.
36. Wang J, Lu Y, Koch AE, et al. CXCR6 induces prostate cancer progression by the AKT/mammalian target of rapamycin signaling pathway. Cancer Res. 2008; 68: 10367-10376.
37. Hu W, Zhen X, Xiong B, et al. CXCR6 is expressed in human prostate cancer in vivo and is involved in the in vitro invasion of PC3 and LNCap cells. Cancer Sci. 2008; 99: 1362-1369.
38. Seidl H, Richtig E, Tilz H, Stefan, et al. Profiles of chemokine receptors in melanocytic lesions: de novo expression of CXCR6 in melanoma. Hum Pathol. 2007; 38: 768-780.
39. Meijer J, Ogink J, Kreike B, et al. The chemokine receptor CXCR6 and its ligand CXCL16 are expressed in carcinomas and inhibit proliferation. Cancer Res. 2008; 68: 4701-4708.
40. Darash-Yahana M, Gillespie JW, Hewitt SM, et al. The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers. PLoS One. 2009; 4: e6695.
41. Abel S, Hundhausen C, Mentlein R, et al. The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10. J Immunol. 2004; 172: 6362-6372.
42. Araki-Sasaki K, Tanaka T, Ebisuno Y, et al. Dynamic expression of chemokines and the infiltration of inflammatory cells in the HSV-infected cornea and its associated tissues. Ocul Immunol Inflamm. 2006; 14: 257-266.
43. Gursel M, Gursel I, Mostowski HS, Klinman DM,. CXCL16 influences the nature and specificity of CpG-induced immune activation. J Immunol. 2006; 177: 1575-1580.
44. Lehrke M, Konrad A, Schachinger V, Tillack C, Seibold F, Stark R, Parhofer IG, Broedl UC,. CXCL16 is a surrogate marker of inflammatory bowel disease. Scand J Gastroenterol. 2008; 43: 283-298.
45. Seiderer J, Dambacher J, Leistner D, et al. Genotype-phenotype analysis of the CXCL16 p.Ala181Val polymorphism in inflammatory bowel disease. Clin Immunol. 2008; 127: 49-55.