BAY 11-7082, a nuclear factor-κB inhibitor, reduces inflammation and apoptosis in a rat cardiac ischemia-reperfusion injury model

International Heart Journal

Volumn 51, Issue 5, 2010, Pages 348-353

  Kim, Yong Sook ^a   Kim, Ji Su ^b   Kwon, Jin Sook ^a   Jeong, Myung Ho ^a,b   Cho, Jeong Gwan ^a,b   Park, Jong Chun ^a,b   Kang, Jung Chaee ^a,b   Ahn, Youngkeun ^a,b  

^a Chonnam National University Medical School   (South Korea)

^b Bundang CHA Hospital   (South Korea)

Author keywords

Apoptosis; BAY 11 7082; Inflammation; Myocardial ischemia reperfusion; Nf B

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; VASCULAR ADHESION PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG MECHANISM; DRUG TOLERABILITY; GENE EXPRESSION REGULATION; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART MUSCLE ISCHEMIA; HEART PROTECTION; IMMUNOCYTOCHEMISTRY; MALE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK REDUCTION; TRANSCRIPTION TERMINATION; TWO DIMENSIONAL ECHOCARDIOGRAPHY; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELLS, CULTURED; CHEMOKINE CCL2; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MYOCYTES, CARDIAC; NF-KAPPA B; NITRILES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SULFONES;

EID: 78249275855     PISSN: 13492365     EISSN: 13493299     Source Type: Journal    
DOI: 10.1536/ihj.51.348     Document Type: Article

References (17)

1. Albelda SM, Smith CW, Ward PA. Adhesion molecules and inflammatory injury. FASEB J 1994; 8: 504-512. (Review)
2. Ahn Y, Kim YS, Park HW, et al. In vivo cardiac gene transfer of dominant negative IKK-β reduces myocardial inflammation, apoptosis, and infarction after ischemia-reperfusion injury. Korean Circ J 2005; 35: 206-214.
3. Baldwin AS Jr. Series introduction: the transcription factor NF-kappaB and human disease. J Clin Invest 2001; 107: 3-6. (Review)
4. Barnes PJ, Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997; 336: 1066-1071. (Review)
5. Brown JM, Anderson BO, Repine JE, et al. Neutrophils contribute to TNF induced myocardial tolerance to ischaemia. J Mol Cell Cardiol 1992; 24: 485-495.
6. Carlos TM, Harlan JM. Leukocyte-endothelial adhesion molecules. Blood 1994; 84: 2068-2101. (Review)
7. Cook-Mills JM. VCAM-1 signals during lymphocyte migration: role of reactive oxygen species. Mol Immunol 2002; 39: 499-508. (Review)
8. Karin M, Lin A. NF-kappaB at the crossroads of life and death. Nat Immunol 2002; 3: 221-227. (Review)
9. Morishita R, Sugimoto T, Aoki M, et al. In vivo transfection of cis element "decoy" against nuclear factor-kappaB binding site prevents myocardial infarction. Nat Med 1997; 3: 894-899.
10. Nakamura M, Wang NP, Zhao ZQ, et al. Preconditioning decreases Bax expression, PMN accumulation and apoptosis in reperfused rat heart. Cardiovasc Res 2000; 45: 661-670.
11. Nichols TC. NF-kappaB and reperfusion injury. Drug News Perspect 2004; 17: 99-104. (Review)
12. Nitobe J, Yamaguchi S, Okuyama M, et al. Reactive oxygen species regulate FLICE inhibitory protein (FLIP) and susceptibility to Fas-mediated apoptosis in cardiac myocytes. Cardiovasc Res 2003; 57: 119-128.
13. Pasternak R, Braunwald E, Sobel B. Acute myocardial infarction. In: Braunwald E, editor. Heart Disease. 4th ed. pp. 1200-1291, Philadelphia: WB Saunders & Company, 1992.
14. Planavila A, Laguna JC, Vázquez-Carrera M. Atorvastatin improves peroxisome proliferator-activated receptor signaling in cardiac hypertrophy by preventing nuclear factor-kappa B activation. Biochim Biophys Acta 2005; 1687: 76-83.
15. Shames BD, Barton HH, Reznikov LL, et al. Ischemia alone is sufficient to induce TNF-alpha mRNA and peptide in the myocardium. Shock 2002; 17: 114-119.
16. Valen G, Yan ZQ, Hansson GK. Nuclear factor kappa-B and the heart. J Am Coll Cardiol 2001; 38: 307-314. (Review)
17. Yin MJ, Yamamoto Y, Gaynor RB. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I (kappa) B kinase-beta. Nature 1998; 396: 77-80.