VR-1 receptor blockade attenuates the pressor response to capsaicin but has no effect on the pressor response to contraction in cats

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 288, Issue 4 57-4, 2005, Pages

  Kindig, Angela E ^a,b   Heller, Todd B ^a   Kaufman, Marc P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Exercise pressor reflex; Group III and IV muscle afferents; Reflex control of circulation; Sympathetic nervous system

Indexed keywords

CAPSAICIN; IODORESINAFERATOXIN; TOXIN; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ARTERY BLOOD FLOW; ARTICLE; CAT; CIRCULATION; CONTROLLED STUDY; EXERCISE; HYPOTHESIS; MUSCLE CONTRACTION; MUSCLE SPINDLE AFFERENT NERVE; NONHUMAN; POPLITEAL ARTERY; PRESSOR RESPONSE; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR BLOCKING; TRICEPS SURAE MUSCLE;

ANIMALS; BLOOD PRESSURE; CAPSAICIN; CATS; DECEREBRATE STATE; DITERPENES; MUSCLE CONTRACTION; MUSCLE, SKELETAL; RECEPTORS, DRUG; REFLEX; SYMPATHETIC NERVOUS SYSTEM;

EID: 15744396827     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00735.2004     Document Type: Article

References (42)

1. Alam M and Smirk FH. Observation in man upon a blood pressure raising reflex arising from the voluntary muscles. J Physiol 89: 372-383, 1937.
2. Averill S, McMahon SB, Clary DO, Reichardt LF, and Priestley JV. Immunocytochemical localization of trkA receptors in chemically identified subgroups of adult rat sensory neurons. Eur J Neurosci 7: 1484-1494, 1995.
3. Bennett DL, Averill S, Clary DO, Priestley JV, and McMahon SB. Postnatal changes in the expression of the trkA high-affinity NGF receptor in primary sensory neurons. Eur J Neurosci 8: 2204-2208, 1996.
4. Bennett DL, Michael DJ, Ramachandran N, Muson JB, Averill S, Yan Q, McMahon SB, and Priestley JV. A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons after nerve injury. J Neurosci 18: 3059-3072, 1998.
5. Caterina MJ and Julius D. The vanilloid receptor: a molecular gateway to the pain pathway. Annu Rev Neurosci 24: 487-517, 2001.
6. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, and Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389: 816-824, 1997.
7. Coote JH, Hilton SM, and Perez-Gonzalez JF. The reflex nature of the pressor response to muscular exercise. J Physiol 215: 789-804, 1971.
8. Crayton SC, Mitchell JH, and Payne FC III. Reflex cardiovascular response during the injection of capsaicin into skeletal muscle. Am J Physiol Heart Circ Physiol 240: H315-H319, 1981.
9. 4-positive and -negative unmyelinated sensory neurons to protons and capsaicin. J Neurophysiol 89: 513-524, 2003.
10. Drew L, Wood JN, and Cesare P. Distinct mechanosensitive properties of capsaicin-sensitive and -insensitive sensory neurons. J Neurosci 22: RC228-RC232, 2002.
11. Eldridge FL. Relationship between phrenic nerve activity and ventilation. Am J Physiol 221: 535-543, 1971.
12. Ettinger S, Gray K, Whisler S, and Sinoway L. Dichloroacetate reduces sympathetic nerve responses to static exercise. Am J Physiol Heart Circ Physiol 261: H1653-H1658, 1991.
13. Kaufman MP and Forster HV. Reflexes controlling circulatory, ventilatory and airway responses to exercise, In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. Bethesda. MD: Am. Physiol. Soc., 1996, sect. 12, chapt. 10, p. 381-447.
14. Kaufman MP, Iwamoto GA, Longhurst JC, and Mitchell JH. Effects of capsaicin and bradykinin on afferent fibers with endings in skeletal muscle. Circ Res 50: 133-139, 1982.
15. Kaufman MP, Longhurst JC, Rybicki KJ, Wallach JH, and Mitchell JH. Effects of static muscular contraction on impulse activity of groups III and IV afferents in cats. J Appl Physiol 55: 105-112, 1983.
16. Kaufman MP and Rybicki KJ. Discharge properties of group III and IV muscle afferents: their responses to mechanical and metabolic stimuli. Circ Res 61: 160-165, 1987.
17. Kaufman MP, Rybicki KJ, Waldrop TG, and Ordway GA. Effect of ischemia on responses of group III and IV afferents to contraction. J Appl Physiol 57: 644-650, 1984.
18. Lawson SN and Waddell PJ. Soma neurofilament immunoreactivity is related to cell size and conduction velocity in rat primary sensory neurons. J Physiol 435: 41-63, 1991.
19. Li J, Maile MD, Sinoway A, and Sinoway LI. Muscle pressor reflex: potential role of vanilloid type 1 receptor and acid-sensing ion channel. J Appl Physiol 97: 1709-1714, 2004.
20. MacLean DA, La Noue KF, Gray KS, and Sinoway LI. Effects of hindlimb contraction on pressor and muscle interstitial metabolite responses in the cat. J Appl Physiol 85: 1583-1592, 1998.
21. McCloskey DI and Mitchell JH. Reflex cardiovascular and respiratory responses originating in exercising muscle. J Physiol 224: 173-186, 1972.
22. Mitchell JH, Kaufman MP, and Iwamoto GA. The exercise pressor reflex: its cardiovascular effects, afferent mechanisms, and central pathways. Annu Rev Physiol 45: 229-242, 1983.
23. 4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life. Neuron 19: 849-861, 1997.
24. Pan HL, Stebbins CL, and Longhurst JC. Bradykinin contributes to the exercise pressor reflex: mechanism of action. J Appl Physiol 75: 2061-2068, 1993.
25. Rigoni R, Trevisani M, Gazzieri D, Nadaletto R, Tognetto M, Creminom C, Davis JB, Campi B, Amadesi S, Geppetti P, and Harrison S. Neurogenic responses mediated by vanilloid receptor-1 (TRPV1) are blocked by the high affinity antagonist, iodo-resiniferatoxin. Br J Pharmacol 138: 977-985, 2003.
26. Rotto DM and Kaufman MP. Effects of metabolic products of muscular contraction on the discharge of group III and IV afferents. J Appl Physiol 64: 2306-2313, 1988.
27. + activity in cat hindlimb muscle. J Appl Physiol 67: 256-263, 1989.
28. Rowell L and O'Leary D. Reflex control of the circulation during exercise: chemoreflexes and mechanoreflexes. J Appl Physiol 69: 407-418, 1990.
29. Rybicki KJ, Waldrop TG, and Kaufman MP. Increasing gracilis interstitial potassium concentrations stimulates group III and IV afferents. J Appl Physiol 58: 936-941, 1985.
30. Schmitt PM and Kaufman MP. Estrogen attenuates the exercise pressor reflex in female cats. J Appl Physiol 95: 1418-1424, 2003.
31. Sinoway L, Prophet S, Gorman I, Mosher TJ, Shenberger J, Dolecki M, Briggs R, and Zelis R. Muscle acidosis during static exercise is associated with calf vasoconstriction. J Appl Physiol 66: 429-436, 1989.
32. Sinoway LI, Hill JM, Pickar JG, and Kaufman MP. Effects of contraction and lactic acid on the discharge of group III muscle afferents in cats. J Neurophysiol 69: 1053-1059, 1993.
33. Sinoway LI, Wroblewski KJ, Prophet SA, Ettinger SM, Gray KS, Whisler SK, Miller G, and Moore RL. Glycogen depletion-induced lactate reductions attenuate reflex responses in exercising humans. Am J Physiol Heart Circ Physiol 263: H1499-H1505, 1992.
34. Stebbins CL, Brown B, Levin D, and Longhurst JC. Reflex effect of skeletal muscle mechanoreceptor stimulation on the cardiovascular system. J Appl Physiol 65: 1539-1547, 1988.
35. Stebbins CL and Longhurst JC. Potentiation of the exercise pressor reflex by muscle ischemia. J Appl Physiol 66: 1046-1053, 1989.
36. Stebbins CL, Maruoka Y, and Longhurst JC. Prostaglandins contribute to cardiovascular reflexes evoked by static muscular contraction. Circ Res 59: 645-654, 1988.
37. Ugawa S, Ueda T, Ishida Y, Nishigaki M, Shibata Y, and Shimada S. Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors. J Clin Invest 110: 1185-1190, 2002.
38. Victor RG, Bertocci LA, Pryor SL, and Nunnally RL. Sympathetic nerve discharge is coupled to muscle cell pH during exercise in humans. J Clin Invest 82: 1301-1305, 1988.
39. Wahl P, Foged C, Tullin S, and Thomsen C. Iodo-resiniferatoxin, a new potent vanilloid receptor antagonist. Mol Pharmacol 59: 9-15, 2001.
40. Waldrop TG, Eldridge FL, Iwamoto GA, and Mitchell JH. Central neural control of respiration and circulation during exercise. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 12, chapt. 9, p. 333-380.
41. Webb-Peploe MM, Brender D, and Shepherd JT. Vascular responses to stimulation of receptors in muscle by capsaicin. Am J Physiol 222: 189-195, 1972.
42. Wilson LB, Wall PT, Pawelczyk JA, and Matsukawa K. Divergence of ventilatory responses to isometric contraction in anesthetized cats. Respir Physiol 104: 137-146, 1996.