Preventing HIV transmission in married and cohabiting HIV-discordant couples in sub-Saharan Africa through combination prevention

Current HIV Research

Volumn 8, Issue 6, 2010, Pages 430-440

  Matovu, Joseph K B ^a  

^a MAKERERE UNIVERSITY SCHOOL OF PUBLIC HEALTH   (Uganda)

Author keywords

Africa; Combination; Couples; HIV discordant; Prevention

Indexed keywords

ACICLOVIR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AFRICA SOUTH OF THE SAHARA; ALCOHOL CONSUMPTION; ANTIVIRAL THERAPY; ARTICLE; AWARENESS; BEHAVIOR CHANGE; CIRCUMCISION; CONDOM; DYSURIA; HEALTH PROMOTION; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION CONTROL; INFECTION PREVENTION; INFECTION SENSITIVITY; MARITAL THERAPY; NONHUMAN; RISK REDUCTION; SEXUAL BEHAVIOR; SEXUAL INTERCOURSE; VIRUS LOAD; VIRUS TRANSMISSION;

EID: 78249259665     PISSN: 1570162X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157016210793499303     Document Type: Article

References (94)

1. UNAIDS & WHO. 2009 AIDS Epidemic Update: December 2009. UNAIDS/09.36E
2. Dunkle KL, Stephenson R, Karita E, et al. New heterosexually transmitted HIV infections in married or cohabiting couples in urban Zambia and Rwanda: an analysis of survey and clinical data. Lancet 2008; 371: 2183-91
3. Hladik W, Musinguzi J, Opio A, et al. Determinants for HIV acquisition among adults in Uganda: a population-based, nationally representative study. Presented at the 15th Conference on Retroviruses and Opportunistic Infections, Boston, MA, USA. February 3-6, 2008. Abstract #123.
4. Wabwire-Mangen F, Odiit M, Kirungi W, Kisitu KD. Uganda: HIV modes of transmission & prevention response analysis. Final Report, March 2009. Kampala: Uganda AIDS Commission.
5. Trask SA, Derdeyn CA, Fideli U, et al. Molecular epidemiology of Human Immunodeficiency Virus Type 1 transmission in a heterosexual cohort of discordant couples in Zambia. J Virol 2002; 76: 397-405.
6. Wawer MJ, Gray RH, Sewankambo NK, et al. Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda. J Infect Dis 2005; 191: 1403-9.
7. Baeten JM, Donnell D, Kapiga SH, et al. Male circumcision and risk of male-to-female HIV-1 transmission: a multinational prospective study in African HIV-1-serodiscordant couples. AIDS 2010; 24: 737-44.
8. De Walque D. Sero-discordant couples in five African countries: implications for prevention strategies. Popul Dev Rev 2007; 33(3): 501-23.
9. th Conference on Retroviruses and Opportunistic Infections, Boston, MA, USA. Feb 3-6, 2008. Abstract #33LB.
10. Lingappa JR, Lambdin B, Bukusi AE, et al. Regional differences in prevalence of HIV-1 discordance in Africa and enrollment of HIV-1 discordant couples into an HIV-1 prevention trial. PLoS One 2008; 3(1): e1411.
11. Wawer MJ, Kigozi G, Serwadda D, et al. Circumcision in HIV-infected men and its effect on HIV transmission to female partners in Rakai, Uganda: a randomized controlled trial. Lancet 2009; 374: 229-37.
12. Carpenter LM, Kamali A, Ruberantwari A, Malamba SS, Whitworth JAG. Rates of HIV-1 transmission within marriage in rural Uganda in relation to the HIV status of the partners. AIDS 1999; 13: 1083-9.
13. Hugonnet S, Mosha F, Todd J, et al. Incidence of HIV infection in stable sexual partnerships: a prospective cohort study of 1802 couples in Mwanza Region, Tanzania. J Acquir Immune Defic Syndr 2002; 30 (1): 73-80.
14. Quinn TC, Wawer MJ, Sewankambo N, et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. N Engl J Med 2000; 342: 921-9.
15. Malamba SS, Mermin JH, Bunnell RE, et al. Couples at risk: HIV-1 concordance & discordance among spouses receiving voluntary counseling and testing in Uganda. J Acquir Immune Defic Syndr 2005; 39: 576-80.
16. th Conference on Retroviruses and Opportunistic Infections, Boston, MA, USA. Feb 3-6, 2008. Abstract #29.
17. Nicolosi A, Correa Leite ML, Musicco M, et al. The efficiency of male-to-female and female-to-male sexual transmission of the human immunodeficiency virus: a study of 730 stable couples. Epidemiology 1994; 5: 570-5.
18. Sewankambo N, Gray RH, Wawer MJ, et al. HIV-1 infection associated with abnormal vaginal flora and morphology and bacterial vaginosis. Lancet 1997; 350(9077): 546-50.
19. Kapiga SH, Sam NE, Bang H, et al. The role of herpes simplex virus type 2 and other genital infections in the acquisition of HIV-1 among high-risk women in northern Tanzania. J Infect Dis 2007; 195(9): 1260-9.
20. Bunnell RE, Opio A, Musinguzi J, et al. HIV transmission risk behavior among HIV-infected adults in Uganda: results of a nationally representative survey. AIDS 2008; 22: 617-24.
21. Kalichman SC, Rompa D, Luke W, Austin J. HIV transmission risk behaviors among HIV-positive persons in serodiscordant relationships. Int J STD AIDS 2002; 13: 677-82.
22. Morah EU. Are people aware of their HIV-positive status responsible for driving the epidemic in sub-Saharan Africa? The case of Malawi. Dev Policy Rev 2007; 25(2): 215-42.
23. Marks G, Crepaz N, Janssen RS. Estimating sexual transmission of HIV from persons aware and unaware that they are infected with the virus in the United States of America. AIDS 2006; 20: 1447-50.
24. Allen S, Tice J, van de Perre P, et al. Effect of serotesting with counseling on condom use and seroconversion among HIV-discordant couples in Africa. Br Med J 1992; 304: 1605-9.
25. Allen S, Serufilira A, Bogaerts J, et al. Confidential HIV testing and condom promotion in Africa: impact on HIV and gonnorhea rates. JAMA 1992; 268(23): 3338-43.
26. Allen S, Meinzen-Derr J, Kautzman M, et al. Sexual behavior of HIV-discordant couples after HIV counseling & testing. AIDS 2003; 17: 733-40.
27. Allen S, Karita E, Chomba E, et al. Promotion of couples' voluntary counseling and testing for HIV through influential networks in two African capital cities. BMC Public Health 2007; 7: 349.
28. King R, Katuntu D, Lifshay J, et al. Processes and outcomes of HIV sero-status disclosure to sexual partners among people living with HIV in Uganda. AIDS Behav 2008; 12(2): 232-43.
29. Davis KR, Weller SC. The effectiveness of condoms in reducing heterosexual transmission of HIV. Fam Plann Perspect 1999; 31(6): 272-9.
30. Granich RM, Gilks CF, Dye C, De Cock KM, Williams BG. Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet 2009; 373: 48-57.
31. De Cock KM, Crowley SP, Lo YR, Granich RM, Williams BG. Preventing HIV transmission with antiretrovirals. Bull World Health Organ 2009; 87: 488.
32. Hudson CP. The importance of transmission of HIV in discordant couples in the population dynamics of HIV infection in rural Africa. Int J STD AIDS 1996; 7: 302-6.
33. Ayuo PO, Were E, Wools-Kaloustran K, et al. Determinants in HIV counseling and testing in couples in North Rift Kenya. East Afr Med J 2009; 8(2): 83-8.
34. Bunnell RE, Nassozi J, Marum E, et al. Living with discordance: knowledge, challenges, and prevention strategies of HIV-discordant couples in Uganda. AIDS Care 2005; 17(8): 999-1012.
35. Desgrees-du-Lou A, Orne-Gliemann J. Couple-centered testing and counseling for HIV serodiscordant heterosexual couples in sub-Saharan Africa. Reprod Health Matters 2008; 16(32): 151-61.
36. Were WA, Mermin JH, Wamai N, et al. Undiagnosed HIV infection and couple HIV discordance among household members of HIV-infected people receiving antiretroviral therapy in Uganda. J Acquir Immune Defic Syndr 2006; 43: 91-5.
37. Were E, Wools-Kaloustran K, Baliddawa J, et al. Stakeholders perception of HIV sero-discordant couples in Western Kenya. East Afr Med J 2008; 85: 326-33.
38. McKenna SL, Muyinda GK, Roth D, et al. Rapid HIV testing and counseling for voluntaru testing centers in Africa. AIDS 1997; 11(Suppl 1): S103-S110.
39. Bakari JP, McKenna S, Myrick A, et al. Rapid voluntary testing and counseling for HIV: acceptability and feasibility in Zambian antenatal care clinics. Ann NY Acad Sci 2000; 918: 64-76.
40. Allen SA, Karita E, N'gandu N, et al. The evolution of voluntary testing and counseling as an HIV prevention strategy. In: Gibney L, DiClemente RJ, Vermund SH, eds. Preventing HIV in developing countries: Biomedical and behavioral approaches. New York: Plenum Press; 1999: 87-108.
41. Weinhardt LS, Carey MP, Johnson BT, Bickman NL. Effects of HIV counseling and testing on sexual risk behavior: a meta-analytic review of published research, 1985-1997. Am J Public Health 1999; 89(9): 1397-405.
42. Morin SF, Khumalo-Sakutukwa G, Charlebois ED, et al. Removing barriers to knowing HIV status: same-day mobile testing in Zimbabwe. J Acquir Immune Defic Syndr 2006; 24: 218-24.
43. Msuya SE, Mbizvo EM, Hussain A, et al. Low male partner participation in antenatal HIV counseling and testing in northern Tanzania: implications for preventive programs. AIDS Care 2008; 20(6): 700-9.
44. Katz DA, KairieJN, Stewart GC, et al. Male perspectives of incorporating men into antenatal HIV counseling and testing. PLoS One 2009; 4(11): e7602.
45. Reece M, Hollub A, Nangami M, Lane K. Assessing male spousal engagement with prevention of mother-to-child transmission programs in western Kenya. AIDS Care 2010; May 11: 1-8 [Epub ahead of print].
46. Machekano R, McFarland W, Hudes ES, et al. Correlates of HIV test results seeking and utilization of partner counseling services in a cohort of male factory workers in Zimbabwe. AIDS Behav 2000; 4(1): 63-70.
47. Guthrie BL, Bruyn G, Farquhar C. HIV-1-discordant couples in sub-Saharan Africa: Explanations and implications for high rates of discordancy. Curr HIV Res 2007; 5: 416-29.
48. Mishra V, Vaessen M, Assche SB, Hong R. Why do so many HIV-discordant couples in sub-Saharan Africa have female partners infected, not male partners? HIV/AIDS Implementers' meeting: Kigali, Rwanda, June 18, 2007. Accessed at: http://www.hivimplementers.com/2007/agenda/pdf/U3/U3-Mishra%20Abstract%201717.ppt.pdf. June 7, 2010.
49. Akanu CI, Erhabor O, Babatunde S. Pre-marital HIV testing in couples from faith-based organizations: Experience in Port Harcourt, Nigeria. Niger J Med 2005; 14: 39-44.
50. Uneke CJ, Alo M, Ogbu O. Mandatory pre-marital HIV testing in Nigeria: The public health and social implications. AIDS Care 2007; 19(1): 116-21.
51. Bunnell RE, Ekwaru JP, Solberg P, et al. Changes in sexual behavior and risk of HIV transmission after antiretroviral therapy and prevention interventions in rural Uganda. AIDS 2006; 20: 85-92.
52. Bunnell RE, Mermin J, De Cock KM. HIV prevention for a threatened continent: Implementing positive prevention in Africa. JAMA 2006; 296(7): 855-8.
53. Emusu D, Ivankova N, Jolly P, et al. Experience of sexual violence among women in HIV discordant unions after voluntary HIV counseling and testing: a qualitative critical incident study in Uganda. AIDS Care 2009; 21(11): 1363-70.
54. Porter L, Hao L, Bishai D, et al. HIV Status and Union Dissolution in Sub-Saharan Africa: The Case of Rakai, Uganda. Demography 2004; 41(3): 465-82.
55. Temmerman M, Ndinya-Achola J, Ambani J, Piot P. The right not to know HIV test results. Lancet 1995; 345: 969-70.
56. WHO. Gender dimensions of HIV status disclosure to sexual partners: Rates, barriers and outcomes: A review paper; 2004. Available at: http://www.who.int/gender/documents/en/genderdim ensions.pdf. Accessed September 12, 2009.
57. Medley A, Garcia-Moreno C, McGill S, Maman S. Rates, barriers and outcomes of HIV status disclosure among women in developing countries: implications for prevention of mother-to-child transmission programmes. Bull World Health Organ 2004; 82: 299-307.
58. Serovich JM, McDowell TL, Grafsky EL. Women's report of regret of HIV disclosure to family, friends and partners. AIDS Behav 2008; 12(2): 227-31.
59. Hira SK, Feldblum PJ, Kamanga J, et al. Condom use and nonoxynol-9 use and the incidence of HIV infection in serodiscordant couples in Zambia. Int J STD AIDS 1997; 8(4): 243-50.
60. Ahmed S, Lutalo T, Wawer M, et al. HIV incidence and sexually transmitted disease prevalence associated with condom use: a population study in Rakai, Uganda. AIDS 2001; 15: 2171-79.
61. Kamenga M, Ryder R, Jingu M, et al. Evidence of marked sexual behavior change associated with low HIV-1 seroconversion in 149 married couples with sero-discordant HIV-1 status: experience at an HIV counseling center in Zaire. AIDS 1991; 5: 61-7.
62. Beksinska ME, Rees VH, McIntyre JA, Wilkinson D. Acceptability of the female condom in different groups of women in South Africa -a multicentred study to inform the national female condom introductory strategy. S Afr Med J 2001; 91: 672-8.
63. Minnis AM, Padian NS. Effectiveness of female controlled barrier methods in preventing sexually transmitted infections and HIV: current evidence and future research directions. Sex Transm Infect 2005; 81(3): 193-200.
64. Welsh MJ, Feldblum PJ, Kuyoh MA, Mwarogo P, Kungu D. Condom use during a community intervention trial in Kenya. Int J STD AIDS 2001; 12:469-74.
65. Choi KH, Gregorich SE, Anderson K, Grinstead O, Gomez CA. Patterns and predictors of female condom use among ethnically diverse women attending family planning clinics. Sex Transm Dis 2003; 30: 91-8.
66. Schwartlander B, Stover J, Walker N, et al. AIDS resource needs for HIV/AIDS. Science 2001; 292: 2434-6.
67. Coldiron ME, Stephenson R, Chomba E, et al. The relationship between alcohol consumption and unprotected sex among known HIV-discordant couples in Rwanda and Zambia. AIDS Behav 2008; 12: 594-603.
68. Zablotska IB, Gray RH, Serwadda D, Sewankambo NK, Lutalo T. Alcohol use before sex and HIV acquisition: A longitudinal study in Rakai, Uganda. AIDS 2006; 20:1191-1196.
69. Simbayi, LC, Kalichman SC, Jooste S, et al. Alcohol use and sexual risks for HIV infection among men and women receiving sexually transmitted infection clinic services in Cape Town, South Africa. J Stud Alcohol 2004; 65: 434-42.
70. Kongnyuy EJ, Wiysonge CS. Alcohol use and extramarital sex among men in Cameroon. BMC Int Health Hum Rights 2007; 7: 6.
71. Kalichman SC, Simbayi LC, Vermaak R, et al. Randomized trial of a community-based alcohol-related HIV risk-reduction intervention for men and women in Cape Town, South Africa. Ann Behav Med 2008; 36(3): 270-9.
72. Kalichman SC, Simbayi LC, Vermaak R, et al. HIV/AIDS risk-reduction counseling for alcohol using sexually transmitted infections clinic patients in Cape Town, South Africa. J Acquir Immune Defic Syndr 2007; 44(5): 594-600.
73. Vernazza P, Hirschel B, Bernasconi E, Flepp M. Les personnes seropositives ne souffrant d'aucune autre MST et suivant un traitment antiretroviral efficace ne transmettent pas le VIH par voie sexuelle. Bulletin des Medecins Suisses 2008; 89: 165-69.
74. Donnell D, Baeten JM, Kiarie J, et al. Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis. Lancet 2010; 375: 2092-8.
75. Attia S, Egger M, Muller M, et al. Sexual transmission of HIV according to viral load and antiretroviral therapy: systematic review & meta-analysis. AIDS 2009; 23: 1397-404.
76. Sadiq ST, Taylor S, Kaye S, et al. The effects of antiretroviral therapy on HIV-1 RNA loads in seminal plasma in HIV-positive patients with and without ureteritis. AIDS 2002; 16: 219-25.
77. Kalichman SC, Cage M, Barnett T, et al. Human immunodeficiency virus in semen and plasma: investigation of sexual transmission risk behavioral correlates. AIDS Res Hum Retroviruses 2001; 17: 1695-703.
78. Vernazza PL, Gilliam BL, Dyer J, et al. Quantification of HIV in semen: correlation with antiretroviral treatment and immune status. AIDS 1997; 11: 987-93.
79. Wilson DP, Law MG, Grulich AE, Cooper DA, Kaldor JM. Relation between HIV viral load and infectiousness: a model-based analysis. Lancet 2008; 372: 314-20.
80. Crepaz N, Hart TA, Marks G. Highly active antiretroviral therapy and sexual risk behavior: a meta-analytic review. JAMA 2004; 292(2): 224-36.
81. Kennedy C, O'reilly O, Medley A, Sweat M. The impact of HIV treatment on risk behavior in developing countries: A systematic review. AIDS Care 2007; 19(6): 707-20.
82. Auvert B, Taljaard D, Lagarde E, et al. Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 Trial. PLoS Med 2005; 2(11): e298.
83. Bailey RC, Moses S, Parker CB, et al. Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomized controlled trial. Lancet 2007; 369: 643-56.
84. Gray RH, Kigozi G, Serwadda D, et al. Male circumcision for HIV prevention in men in Rakai, Uganda: a randomized trial. Lancet 2007; 369: 657-66.
85. Gray RH, Kiwanuka N, Quinn TC, et al. Male circumcision and HIV acquisition: cohort studies in Rakai, Uganda. AIDS 2000; 14(15): 2371-81.
86. Mugwanya KK, Baeten JM, Nakku-Joloba E, et al. Knowledge and attitudes about male circumcision for HIV-1 prevention among heterosexual HIV-1 serodiscordant partnerships in Kampala, Uganda. AIDS and Behavior 2010; Doi: 10.1007/s10461-010-9696-x.
87. Turner AN, Morrison CS, Padian NS, et al. Men's circumcision status and women's risk of HIV acquisition in Zimbabwe and Uganda. AIDS 2007; 21: 1779-89.
88. Freeman EE, Weiss HA, Glynn JR, et al. Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies. AIDS 2006; 20: 73-83.
89. Wald A, Link K. Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis. J Infect Dis 2002; 185: 45-52.
90. Lingappa JR, Baeten JM, Wald A, et al. Daily acyclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomized placebo-controlled trial. Lancet 2010; 375: 824-33.
91. Celum C, Wald A, Lingappa JR, et al. Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2. N Engl J Med 2010; 362(5): 427-39.
92. Celum C, Wald A, Hughes J, et al. Effect of acyclovir on HIV-1 acquisition in herpes simplex virus 2 sero-positive women and men who have sex with men: a randomized, double-blind, placebo-controlled trial. Lancet 2008; 371: 2109-19.
93. Watson-Jones D, Weiss HA, Rusizoka M, et al. Effect of Herpes Simplex Suppression on Incidence of HIV among Women in Tanzania. N Engl J Med 2008; 358: 1560-71.
94. Youle M, Wainberg MA. Pre-exposure chemoprophylaxis (PREP) as an HIV prevention strategy. J Int Assoc Physicians 2003; 2: 102-5.