COL1A1 oligodeoxynucleotides decoy: Biochemical and morphologic effects in an acute wound repair model

Experimental and Molecular Pathology

Volumn 89, Issue 3, 2010, Pages 307-313

  Rosensteel, Shawn M ^a   Wilson, Ronald P ^a   White, Sheryl L ^b   Ehrlich, H Paul ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

DsODN; Fibroblast; Oligodeoxynucleotides; Type I collagen

Indexed keywords

COLLAGEN FIBER; COLLAGEN TYPE 1; COLLAGEN TYPE 1 A1; COLLAGEN TYPE 3; EDOXUDINE; FIBRONECTIN; OLIGODEOXYRIBONUCLEOTIDE; POLYVINYL ALCOHOL; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BIREFRINGENCE; CELL DENSITY; CELL STRUCTURE; CONNECTIVE TISSUE; CONTROLLED STUDY; DRUG ACTIVITY; FIBROBLAST; FLUORESCENCE; GRANULATION TISSUE; HISTOPATHOLOGY; IMPLANTATION; MALE; NONHUMAN; POLARIZATION; PROTEIN SYNTHESIS; QUALITY CONTROL; QUANTITATIVE ANALYSIS; RAT; STAINING; WOUND HEALING;

ANIMALS; CICATRIX; COLLAGEN TYPE I; CONNECTIVE TISSUE; FIBROSIS; GRANULATION TISSUE; IMMUNOBLOTTING; MICROSCOPY, FLUORESCENCE; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; RATS; RATS, SPRAGUE-DAWLEY; REGULATORY ELEMENTS, TRANSCRIPTIONAL; TRANSFORMING GROWTH FACTOR BETA1; WOUND HEALING;

RATTUS;

EID: 78249252029     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2010.07.003     Document Type: Article

References (26)

1. Ahn J.D., Kim C.H., Magae J., Kim Y.H., Kim H.J., Park K.K., et al. E2F decoy oligodeoxynucleotides effectively inhibit growth of human tumor cells. Biochem. Biophys. Res. Commun. 2003, 310:1048-1053.
2. Akagi Y., Isaka Y., Arai M., Kaneko T., Takenaka M., Moriyama T., et al. Inhibition of TGF-beta 1 expression by antisense oligonucleotides suppressed extracellular matrix accumulation in experimental glomerulonephritis. Kidney Int. 1996, 50:148-155.
3. Akhtar S., Lewis K. Antisense oligonucleotide delivery to cultured macrophages is improved by incorporation into sustained-release biodegradable polymer microspheres. Int. J. Pharm. 1997, 151:57-67.
4. Ariyan S., Enriquez R., Krizek T.J. Wound contraction and fibrocontractive disorders. Arch. Surg. 1978, 113:1034-1046.
5. Balza E., Borsi L., Allemanni G., Zardi L. Transforming growth factor beta regulates the levels of different fibronectin isoforms in normal human cultured fibroblasts. FEBS Lett. 1988, 228:42-44.
6. Bombaro K.M., Engrav L.H., Carrougher G.J., Wiechman S.A., Faucher L., Costa B.A., et al. What is the prevalence of hypertrophic scarring following burns?. Burns 2003, 29:299-302.
7. Boros D.L., Singh K.P., Gerard H.C., Hudson A.P., White S.L., Cutroneo K.R. A novel nonsteroidal antifibrotic oligo decoy containing the TGF-beta element found in the COL1A1 gene, which regulates murine schistosomiasis liver fibrosis. J. Cell. Physiol. 2005, 204:370-374.
8. Cutroneo K.R. How is Type I procollagen synthesis regulated at the gene level during tissue fibrosis. J Cell Biochem vol. 2003, 90(1):1-5.
9. Cutroneo K.R. Evidence for TGF-beta1 and bleomycin intracellular signaling through autocrine regulation of Smad 3 binding to the proximal promoter of the Smad 7 gene. J. Cell. Biochem. 2006, 97:933-939.
10. Cutroneo K.R., Sterling K.M. How do glucocorticoids compare to oligo decoys as inhibitors of collagen synthesis and potential toxicity of these therapeutics?. J. Cell. Biochem. 2004, 92:6-15.
11. Cutroneo K.R., Meisler N., Counts D.F. Anti-inflammatory prednisolone derivatives inhibit collagen synthesis and pro-alpha(1) (I) collagen promoter activity in rat skin fibroblasts. Wound Repair Regen. 1994, 2:292-296.
12. Fisher A.A., Ye D., Sergueev D.S., Fisher M.H., Shaw B.R., Juliano R.L. Evaluating the specificity of antisense oligonucleotide conjugates. A DNA array analysis. J Biol Chem 2002, 277:22980-22984.
13. Hudson D.A., Renshaw A. An algorithm for the release of burn contractures of the extremities. Burns 2006, 32:663-668.
14. Koyama H., Raines E.W., Bornfeldt K.E., Roberts J.M., Ross R. Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors. Cell 1996, 87:1069-1078.
15. Leventhal D., Furr M., Reiter D. Treatment of keloids and hypertrophic scars: a meta-analysis and review of the literature. Arch. Facial Plast. Surg. 2006, 8:362-368.
16. Ling E., Robinson D.S. Transforming growth factor-beta1: its anti-inflammatory and pro-fibrotic effects. Clin. Exp. Allergy 2002, 32:175-178.
17. Liu X., Li P., Chen X.Y., Zhou Y.G. C-ski promotes skin fibroblast proliferation but decreases type I collagen: implications for wound healing and scar formation". Clin. Exp. Dermatol. 2009, 35(4):417-424.
18. Massague J. How cells read TGF-beta signals. Nat. Rev. Mol. Cell Biol. 2000, 1:169-178.
19. Meisler N., Shull S., Xie R., Long G.L., Absher M., Connolly J.P., et al. Glucocorticoids coordinately regulate type I collagen pro alpha 1 promoter activity through both the glucocorticoid and transforming growth factor beta response elements: a novel mechanism of glucocorticoid regulation of eukaryotic genes. J. Cell. Biochem. 1995, 59:376-388.
20. Mizuide M., Hara T., Furuya T., Takeda M., Kusanagi K., Inada Y., Mori M., Imamura T., Miyazawa K., Miyazono K. Two short segments of Smad3 are important for specific interaction of Smad3 with C-ski and Snon. J. Biol. Chem. 2003, 278:531-536.
21. Morishita R., Aoki M., Kaneda Y. Decoy oligodeoxynucleotides as novel cardiovascular drugs for cardiovascular disease. Ann. NY Acad. Sci. 2001, 947:294-301. discussion - 2.
22. Oishi Y., Fu Z.W., Ohnuki Y., Kato H., Noguchi T. Molecular basis of the alteration in skin collagen metabolism in response to in vivo dexamethasone treatment: effects on the synthesis of collagen type I and III, collagenase, and tissue inhibitors of metalloproteinases. Br. J. Dermatol. 2002, 147:859-868.
23. Saray Y., Gulec A.T. Treatment of keloids and hypertrophic scars with dermojet injections of bleomycin: a preliminary study. Int. J. Dermatol. 2005, 44:777-784.
24. Slemp A.E., Kirschner R.E. Keloids and scars: a review of keloids and scars, their pathogenesis, risk factors, and management. Curr. Opin. Pediatr. 2006, 18:396-402.
25. Whang S.W., Lee K.Y., Cho S.B., Lee S.J., Kang J.M., Kim Y.K., et al. Burn scars treated by pinhole method using a carbon dioxide laser. J. Dermatol. 2006, 33:869-872.
26. Xia H., Nho R., Kleidon J., Kahm J., Henke C.A. Polymerized collagen inhibits fibroblast proliferation via a mechanism involving the formation of a beta1 integrin-protein phosphatase 2a-tuberous sclerosis complex 2 complex that suppresses S6K1 activity. J. Biol. Chem. 2008, 283:20350-20360.