Dynamic changes of α-hexachlorocyclohexane and its enantiomers in various tissues of Japanese Rabbits (Oyctolagus cuniculus) after oral or dermal exposure

Chemosphere

Volumn 81, Issue 11, 2010, Pages 1486-1491

  Xue, Miao ^a   Shen, Guofeng ^a   Yu, Jialing ^a   Zhang, Diyu ^a   Lu, Zhijiang ^a   Wang, Bin ^a   Lu, Yan ^a   Cao, Jun ^a   Tao, Shu ^a  

^a PEKING UNIVERSITY   (China)

Author keywords

Dermal exposure; Oral exposure; Rabbits; Toxicokinetics; HCH enantiomers

Indexed keywords

ENANTIOMERS; HISTOLOGY; TISSUE;

DERMAL EXPOSURE; ENANTIOMERIC FRACTIONS; HEXACHLOROCYCLOHEXANES; ORAL EXPOSURE; RABBITS; TOXICOKINETIC MODEL; TOXICOKINETICS; TWO-COMPARTMENT MODELS;

BLOOD;

ALPHA HEXACHLOROCYCLOHEXANE; PESTICIDE;

ABSORPTION; BIOACCUMULATION; BLOOD; CONCENTRATION (COMPOSITION); FUNCTIONAL MORPHOLOGY; HCH; LAGOMORPH; MAGNITUDE; NUMERICAL MODEL; TOXICITY;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; BLOOD; BLOOD BRAIN BARRIER; BLOOD FLOW VELOCITY; BRAIN TISSUE; CHIRALITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENANTIOMER; ENANTIOSELECTIVITY; EXPOSURE; FAT CONTENT; INTESTINE; KIDNEY PARENCHYMA; LIVER; MALE; MUSCLE TISSUE; NONHUMAN; RABBIT; TOXICOKINETICS;

ORYCTOLAGUS CUNICULUS;

EID: 78249244155     PISSN: 00456535     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2010.08.046     Document Type: Article

References (37)

1. Blüthgen A., Nijhuis H., Heeschen W. Behaviour of HCH isomers in ruminants and the environment. In Hexachlorcyclohexanals Schadstoff in Lebensmitteln, Deutache Forschungsgemeinschafft 1983, Verlag Chemie, Weinheim, pp. 128-142.
2. Botella B., Crespo J., Rivas A., Cerrillo I., Olea-Serrano M., Olea N. Exposure of women to organochlorine pesticides in southern Spain. Environ. Res. 2004, 96:34-40.
3. Buser H.R., Müller M.D., Rappe C. Enantioselective determination of chlordane components using chiral high-resolution gas chromatography-mass spectrometry with application to environmental samples. Environ. Sci. Technol. 1992, 26:1533-1540.
4. Butte W., Fox K., Zauke G. Kinetics of bioaccumulation and clearance of isomeric hexachlorocyclohexanes. Sci. Total Environ. 1991, 109:377-382.
5. Clark T.P., Norstrom R.J., Fox G.A., Won H.T. Dynamics of organochlorine compounds in herring-gulls (Larus-Argentatus). 2. A 2-compartent model and data for 10 compounds. Environ. Toxicol. Chem. 1987, 6:547-559.
6. Covaci A., Gheorghe A., Schepen P. Distribution of organochlorine pesticides, polychlorinated biphenyls and alpha-HCH enantiomers in pork tissues. Chemosphere 2004, 56:757-776.
7. Creton S., Billington R., Davies W., Dent M.P., Hawksworth G.M., Parry S., Travis K.Z. Application of toxicokinetics to improve chemical risk assessment: implications for the use of animals. Regul. Toxicol. Pharm. 2009, 55:291-299.
8. Ernst W. Determination of bioconcentration potential of marine organisms - steady state approach. 1. Bioconcentration data for 7 chlorinated pesticides in mussels (Mytilus edulis) and their relation to solubility data. Chemosphere 1977, 6:731-740.
9. Fisk A.T., Hoekstra P.F., Gagnon J.M., Duffe J., Norstrom R.J., Hobson K.A., Kwan M., Muir D.C.G. Influence of habitat, trophic ecology and lipids on, and spatial trends of, organochlorine contaminants in Arctic marine invertebrates. Mar. Ecol-Prog. Ser. 2003, 262:201-214.
10. Garrison A.W. Probing the enantioselectivity of chiral pesticides. Environ. Sci. Technol. 2006, 40:16-23.
11. Gibaldi, M., Perrier, D., 1982. Pharmacokinetics, 2nd, ed., Marcel Dekker, New York.
12. Gibaldi, M., Prescott, L., 1983. Handbook of clinical pharmacokinetics, ADIS Health Science Press, New York.
13. Hoekstra P.F., O'Hara T.M., Backus S.M., Hanns C., Muir D.C.G. Concentrations of persistent organochlorine contaminants in bowhead whale tissues and other biota from northern Alaska: implications for human exposure from a subsistence diet. Environ. Res. 2005, 98:329-340.
14. Hummert K., Vetter W., Luckas B. Levels of alpha-HCH, lindane, and enantiomeric ratios of alpha-HCH in marine mammals from the northern hemisphere. Chemosphere. 1995, 31:3489-3500.
15. Jones K.C. Determination of polychlorinated biphenyls in human foodstuffs and tissues: suggestions for a selective congener analytical approach. Sci. Total Environ. 1988, 68:141-159.
16. Kallenborn R., Hühnerfuss H., König W.A. Enantioselective Metabolism of (±)-l, 2, 3, 4, 5, 6- hexachlorocyclohexane in organs of the eider duck. Angew. Chem. 1991, 30:320-321.
17. Kania-Korwel I., Garrison A.W., Avants J.K., Hornbuckle K.C., Robertson L.W., Sulkowski W.W., Lehmler H.J. Distribution of chiral PCBs in selected tissues in the laboratory rat. Environ. Sci. Technol. 2006, 55:291-299.
18. Li Y.F. Global technical hexachlorocyclohexane usage and its contamination consequences in the environment: from 1948 to 1997. Sci. Total Environ. 1999, 232:121-158.
19. Luurtsema G., de Lange E.C.M., Lammertsma A.A., Franssen E.J.F. Transport across the blood-brain barrier: Stereoselectivity and PET-tracers. Mol. Imaging. Biol. 2004, 6:306-318.
20. Möller K., Hühnerfuss H. On the diversity of enzymatic degradation pathways of α-hexachlorocyclohexane as determined by chiral gas chromatography. J. High Resolut. Chromatogr. 1993, 16:672-673.
21. Möller K., Hühnerfuss H., Wolfle D. Differential effects of the enantiomers of α-hexachlorocyclohexane (α-HCH) on cytotoxicity and growth stimulation in primary rat hepatocytes. Organohal. Compd. 1996, 29:357-360.
22. Mossner S., Spraker T.R., Becker P.R., Ballschmiter K. Ratios of enantiomers of alpha-HCH and determination of alpha-HCH, beta-HCH, and gamma-HCH isomers in brain and other tissues of neonatal northern fur seals (Callorhinus-Ursinus). Chemosphere 1992, 24:1171-1180.
23. Müller T.A., Kohler H.P.E. Chirality of pollutants-effects on metabolism and fate. Appl. Microbiol. Biotechnol. 2004, 64:300-316.
24. Ngo M.A., OMalley M., Howard I. Maibachc percutaneous absorption and exposure assessment of pesticides. J. Appl. Toxicol. 2010, 30:91-114.
25. Norstrom R.J., Clark T.P., Enright M., Leung B., Drouillard K.G., MacDonald C.R. ABAM, a model for bioaccumulation of POPs in birds: validation for adult herring gulls and their eggs in Lake Ontario. Environ. Sci. Technol. 2007, 41:4339-4347.
26. Portig J., Stein K., Vohland H.W. Preferential distribution of a-HCH into cerebral white matter. Xenobiotica 1989, 19:123-130.
27. Ruus A., Skaare J.U., Ingebrigtsen K. Disposition and depuration of lindane (γ-HCH) and polychlorinated biphenyl-110 (2, 3, 39, 49, 6-pentachlorobiphenyl) in cod (Gadus morhua) and bullrout (Myoxocephalus scorpius) after single oral exposure. Environ. Toxicol. Chem. 2001, 20:2377-2382.
28. Sanders L.M. Drug delivery system and routes of administration of peptide and protein drugs. Eur. J. Drug Metab. Pharmacokinet. 1990, 15:95-102.
29. Shen H., Virtanen H.E., Main K., Kaleva M., Anderson A.M., Skakkebak N.E., Toppari J., Schramm K.-W. Enantiomeric ratios as indicator of exposure processes for persistent pollutants in human placentas. Chemosphere 2006, 62:390-395.
30. Ulrich E.M., Willett K., Caperell-Grant A., Bigsby R.M., Hites R.A. Understanding enantioselective processes, a laboratory rat model for α-hexachlorocyclohexane accumulation. Environ. Sci. Technol. 2001, 35:1604-1609.
31. Verner M.A., Ayotte P., Muckle G., Charbonneau M., Haddad S.A. Physiologically based pharmacokinetic model for the assessment of infant exposure to persistent organic pollutants in epidemiologic studies. Environ. Health Perspect. 2009, 117:481-487.
32. Vetter W., Schurig V. Enantioselective determination of chiral organochlorine compounds in biota by gas chromatography on modified cyclodextrins. J. Chromatogr. A 1997, 774:143-175.
33. Vigano L., Galassi S., Gatto M. Factors affecting the bioconcentration of hexachlorocyclohexanes in early life stages of Oncorhynchus-Mykiss. Environ. Toxicol. Chem. 1992, 11:535-540.
34. Wiberg K., Letcher R.J., Sandau C.D., Norstrom R.J., Tysklind M., Bidleman T.F. The enantioselective bioaccumulation of chiral chlordane and α-HCH contaminants in the polar bear food chain. Environ. Sci. Technol. 2000, 34:2668-2674.
35. Willett K.L., Ulrich E.M., Hites R.A. Differential toxicity and environmental fates of hexachlorocyclohexane isomers. Environ. Sci. Technol. 1998, 32:2197-2207.
36. Yang D.B., Li X.Q., Tao S., Wang Y.Q., Cheng Y., Zhang D.Y., Yu L.C. Enantioselective behavior of alpha-HCH in mouse and quail tissues. Environ. Sci. Technol. 2010, 44:1854-1859.
37. Yu Y.X., Tao S., Liu W.X., Lu X.X., Wang X.J., Wong M.H. Dietary intake and human milk residues of hexachlorocyclohexane isomers in two Chinese cities. Environ. Sci. Technol. 2009, 43:4830-4835.