Potent antiplatelet activity of sesamol in an in vitro and in vivo model: Pivotal roles of cyclic AMP and p38 mitogen-activated protein kinase

Journal of Nutritional Biochemistry

Volumn 21, Issue 12, 2010, Pages 1214-1221

  Chang, Chao C ^a,b   Lu, Wan J ^a   Chiang, Cheng W ^b   Jayakumar, Thanasekaran ^a   Ong, Eng T ^b   Hsiao, George ^a   Fong, Tsorng H ^a   Chou, Duen S ^a   Sheu, Joen R ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b CATHAY GENERAL HOSPITAL   (Taiwan)

Author keywords

Cyclic AMP; Nitric oxide; P38 MAPK; Platelet activation; PLC 2; Sesamol

Indexed keywords

9 (TETRAHYDRO 2 FURYL)ADENINE; ANTIOXIDANT; CALCIUM; CYCLIC AMP; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROXYL RADICAL; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PHOSPHOLIPASE C GAMMA2; PROTEIN KINASE C; SESAMOL; THROMBOXANE A2; UNCLASSIFIED DRUG; VASODILATOR STIMULATED PHOSPHOPROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CALCIUM MOBILIZATION; DRUG ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION;

ANIMALS; ANTIOXIDANTS; BENZODIOXOLES; BLOOD PLATELETS; CELL ADHESION MOLECULES; COLLAGEN; CYCLIC AMP; CYCLIC GMP; HUMANS; MICE; MICROFILAMENT PROTEINS; NITRIC OXIDE SYNTHASE TYPE III; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENOLS; PHOSPHOPROTEINS; PHOSPHORYLATION; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS;

MUS;

EID: 78249234191     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2009.10.009     Document Type: Article

References (26)

1. Jan K.C., Ho C.T., Hwang L.S. Bioavailability and tissue distribution of sesamol in rat. J Agric Food Chem 2008, 56:7032-7037.
2. Fukuda Y., Nagata M., Osawa T., Namiki M. Contribution of lignan analogues to antioxidative activity of refined unroasted sesame seed oil. J Am Oil Chem Soc 1986, 63:1027-1031.
3. Kaur I.P., Saini A. Sesamol exhibits antimutagenic activity against oxygen species mediated mutagenicity. Mutat Res 2000, 470:71-76.
4. Kapadia G.J., Azuine M.A., Tokuda H., Takasaki M., Mukainaka T., Konoshima T., et al. Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis. Pharmacol Res 2002, 45:499-505.
5. Sharma S., Kaur I.P. Development and evaluation of sesamol as an antiaging agent. Int J Dermatol 2006, 45:200-208.
6. Jacklin A., Ratledge C., Welham K., Bilko D., Newton C.J. The sesame seed oil constituent, sesamol, induces growth arrest and apoptosis of cancer and cardiovascular cells. Ann NY Acad Sci 2003, 1010:374-380.
7. Chen P.R., Lee C.C., Chang H., Tsai C.E. Sesamol regulates plasminogen activator gene expression in cultured endothelial cells: a potential effect on the fibrinolytic system. J Nutr Biochem 2005, 16:59-64.
8. Chen P.R., Tsai C.E., Chang H., Liu T.L., Lee C.C. Sesamol induces nitric oxide release from human umbilical vein endothelial cells. Lipids 2005, 40:955-961.
9. Sheu J.R., Lee C.R., Lin C.H., Hsiao G., Ko W.C., Chen Y.C., et al. Mechanisms involved in the antiplatelet activity of Staphylococcus aureus lipoteichoic acid in human platelets. Thromb Haemost 2000, 72:617-621.
10. Schleinitz M.D., Weiss J.P., Owens D.K. Clopidogrel versus aspirin for secondary prophylaxis of vascular events: a cost-effectiveness analysis. Am J Med 2004, 116:797-806.
11. Sheu J.R., Hung W.C., Wu C.H., Ma M.C., Kan Y.C., Lin C.H., et al. Reduction in lipopolysaccharide-induced thrombocytopenia by triflavin in a rat model of septicemia. Circulation 1999, 99:3056-3062.
12. Chou D.S., Hsiao G., Shen M.Y., Tsai Y.J., Chen T.F., Sheu J.R. ESR spin-trapping of a carbon-centered free radical from agonist-stimulated human platelets. Free Radic Biol Med 2005, 39:237-248.
13. Hsiao G., Lin K.H., Chang Y., Chen T.L., Tzu N.H., Chou D.S., et al. Protective mechanisms of inosine in platelet activation and cerebral ischemic damage. Arterioscler Thromb Vasc Biol 2005, 25:1998-2004.
14. Singer W.D., Brown H.A., Sternweis P.C. Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D. Annu Rev Biochem 1997, 66:475-509.
15. Aszodi A., Pfeifer A., Ahmad M., Glauner M., Zhou X.H., Ny L., et al. The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function. EMBO J 1999, 18:37-48.
16. Mangin P., Yuan Y., Goncalves I., Eckly A., Freund M., Cazenave J.P., et al. Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA. J Biol Chem 2003, 278:32880-32891.
17. Pascale A., Amadio M., Govoni S., Battaini F. The aging brain, a key target for the future: the protein kinase C involvement. Pharmacol Res 2007, 55:560-569.
18. Bunney T.D., Katan M. Phospholipase C epsilon: linking second messengers and small GTPases. Trends Cell Biol 2006, 16:640-648.
19. Ragab A., Severin S., Gratacap M.P., Aguado E., Malissen M., Jandrot-Perrus M., et al. Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC gamma 2 activation. Blood 2007, 110:2466-2474.
20. Bugaud F., Nadal-Wollbold F., Levy-Toledano S., Rosa J.P., Bryckaert M. Regulation of c-jun-NH2 terminal kinase and extracellular-signal regulated kinase in human platelets. Blood 1999, 94:3800-3805.
21. Hughes P.E., Renshaw M.W., Pfaff M., Forsyth J., Keivens V.M., Schwartz M.A., et al. Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway. Cell 1997, 88:521-530.
22. Ravi D., Muniyappa H., Das K.C. Caffeine inhibits UV-mediated NF-kappaB activation in A2058 melanoma cells: an ATM-PKCdelta-p38 MAPK-dependent mechanism. Mol Cell Biochem 2008, 308:193-200.
23. 2 cascade in hydroperoxide-stressed platelets. Free Radic Biol Med 2003, 35:616-625.
24. Walter U., Eigenthaler M., Geiger J., Reinhard M. Role of cyclic nucleotide-dependent protein kinases and their common substrate VASP in the regulation of human platelets. Adv Exp Med Biol 1993, 344:237-249.
25. Gkaliagkousi E., Ritter J., Ferro A. Platelet-derived nitric oxide signaling and regulation. Circ Res 2007, 101:654-662.
26. Queen L.R., Xu B., Horinouchi K., Fisher I., Ferro A. β2-Adrenoceptors activate nitric oxide synthase in human platelets. Circ Res 2000, 87:39-44.