Three-dimensional microwave imaging of realistic numerical breast phantoms via a multiple-frequency inverse scattering technique

Medical Physics

Volumn 37, Issue 8, 2010, Pages 4210-4226

  Shea, Jacob D ^a   Kosmas, Panagiotis ^a,b   Hagness, Susan C ^a   Van Veen, Barry D ^a  

^a University of Wisconsin Madison   (United States)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

breast; microwaves; parametric imaging; phantoms; tomography

Indexed keywords

DIELECTRIC PROPERTIES; FINITE DIFFERENCE TIME DOMAIN METHOD; HISTOLOGY; IMAGE RECONSTRUCTION; INTEGRAL EQUATIONS; INVERSE PROBLEMS; ITERATIVE METHODS; MAXWELL EQUATIONS; MICROWAVES; NUMERICAL METHODS; PHANTOMS; RISK ASSESSMENT; TIME DOMAIN ANALYSIS; TISSUE; TOMOGRAPHY;

BREAST; BREAST CANCER RISK ASSESSMENTS; DISPERSIVE DIELECTRICS; FREQUENCY DEPENDENT CHARACTERISTICS; HELMHOLTZ WAVE EQUATION; MAMMOGRAPHIC BREAST DENSITIES; PARAMETRIC IMAGING; THREEDIMENSIONAL (3-D);

MEDICAL IMAGING;

DIAGNOSTIC AGENT;

ALGORITHM; ARTICLE; BREAST TUMOR; COMPUTER ASSISTED DIAGNOSIS; IMAGE ENHANCEMENT; IMAGE QUALITY; INSTRUMENTATION; METHODOLOGY; MICROWAVE RADIATION; RADIATION SCATTERING; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; THREE DIMENSIONAL IMAGING;

ALGORITHMS; BREAST NEOPLASMS; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; MICROWAVES; PHANTOMS, IMAGING; REPRODUCIBILITY OF RESULTS; SCATTERING, RADIATION; SENSITIVITY AND SPECIFICITY;

EID: 78149488406     PISSN: 00942405     EISSN: None     Source Type: Journal    
DOI: 10.1118/1.3443569     Document Type: Article

References (65)

1. J. A. Harvey and V. E. Bovbjerg, "Quantitative assessment of mammographic breast density: Relationship with breast cancer risk," Radiology 230, 29-41 (2004).
2. M. Lazebnik, L. McCartney, D. Popovic, C. B. Watkins, M. J. Lindstrom, J. Harter, S. Sewall, A. Magliocco, J. H. Booske, M. Okoniewski, and S. C. Hagness, "A large-scale study of the ultrawideband microwave dielectric properties of normal breast tissue obtained from reduction surgeries," Phys. Med. Biol. 52, 2637-2656 (2007).
3. K. Kerlikowske, L. Ichikawa, D. L. Miglioretti, D. S. M. Buist, P. M. Vacek, R. Smith-Bindman, B. Yankaskas, P. A. Carney, and R. Ballard-Barbash, "Longitudinal measurement of clinical mammographic breast density to improve estimation of breast cancer risk," J. Natl. Cancer Inst. 99, 386-395 (2007).
4. P. C. Stomper, D. J. D'Souza, P. A. DiNitto, and M. A. Arredondo, "Analysis of parenchymal density on mammograms in 1353 women 25-79 years old," AJR, Am. J. Roentgenol. 167, 1261-1265 (1996).
5. N. F. Boyd, H. Guo, L. J. Martin, L. Sun, J. Stone, E. Fishell, R. A. Jong, G. Hislop, A. Chiarelli, S. Minkin, and M. J. Yaffe, "Mammographic density and the risk and detection of breast cancer," N. Engl. J. Med. 356, 227-236 (2007).
6. G. A. Colditz, W. A. Willett, D. J. Hunter, M. J. Stampfer, J. E. Manson, C. H. Hennekens, B. A. Rosner, and F. E. Speizer, "Family history, age, and risk of breast-cancer - Prospective data from the nurses health study," JAMA, J. Am. Med. Assoc. 270, 338-343 (1993).
7. C. J. D'Orsi, L. W. Bassett, and W. A. Berg, Breast Imaging Reporting and Data System: ACR BI-RADS-Mammography, 4th ed. (American College of Radiology, Reston, 2003).
8. K. E. Martin, M. A. Helvie, C. Zhou, M. A. Roubidoux, J. E. Bailey, C. Paramagul, C. E. Blane, K. A. Klein, S. S. Sonnad, and H. Chan, "Mammographic density measured with quantitative computer-aided method: Comparison with radiologists' estimates and BI-RADS categories," Radiology 240, 656-665 (2006).
9. S. van Engeland, P. R. Snoeren, H. Huisman, C. Boetes, and N. Karssemeijer, "Volumetric breast density estimation from full-field digital mammograms," IEEE Trans. Med. Imaging 25, 273-282 (2006).
10. C. K. Glide-Hurst, N. Duric, and P. Littrup, "A new method for quantitative analysis of mammographic density," Med. Phys. 34, 4491-4498 (2007).
11. K. Nie, J. Chen, S. Chan, M. I. Chau, H. J. Yu, S. Bahri, T. Tseng, O. Nalcioglu, and M. Su, "Development of a quantitative method for analysis of breast density based on three-dimensional breast MRI," Med. Phys. 35, 5253-5262 (2008).
12. W. A. Berg, J. D. Blume, A. M. Adams, R. A. Jong, R. G. Barr, D. E. Lehrer, E. D. Pisano, W. P. Evans, M. C. Mahoney, L. Hovanessian Larsen, G. J. Gabrielli, and E. B. Mendelson, "Reasons women at elevated risk of breast cancer refuse breast MR imaging screening: ACRIN 66661," Radiology 254, 79-87 (2010).
13. E. Zastrow, S. K. Davis, M. Lazebnik, F. Kelcz, B. D. Van Veen, and S. C. Hagness, "Development of anatomically realistic numerical breast phantoms with accurate dielectric properties for modeling microwave interactions with the human breast," IEEE Trans. Biomed. Eng. 55, 2792-2800 (2008).
14. M. Lazebnik, D. Popovic, L. McCartney, C. B. Watkins, M. J. Lindstrom, J. Harter, S. Sewall, T. Ogilvie, A. Magliocco, T. M. Breslin, W. Temple, D. Mew, J. H. Booske, M. Okoniewski, and S. C. Hagness, "A large-scale study of the ultrawideband microwave dielectric properties of normal, benign, and malignant breast tissues obtained from cancer surgeries," Phys. Med. Biol. 52, 6093-6115 (2007).
15. E. C. Fear, X. Li, S. C. Hagness, and M. A. Stuchly, "Confocal microwave imaging for breast cancer detection: Localization of tumors in three dimensions," IEEE Trans. Biomed. Eng. 49, 812-822 (2002).
16. E. J. Bond, S. C. Hagness, and B. D. Van Veen, "Microwave imaging via space-time beam forming for early detection of breast cancer," IEEE Trans. Antennas Propag. 51, 1690-1705 (2003).
17. X. Li, S. K. Davis, S. C. Hagness, D. van der Weide, and B. D. Van Veen, "Microwave imaging via space-time beam forming: Experimental investigation of tumor detection in multi-layer breast phantoms," IEEE Trans. Microwave Theory Tech. 52, 1856-1865 (2004).
18. J. M. Sill and E. C. Fear, "Tissue sensing adaptive radar for breast cancer detection - Experimental investigation of simple tumor models," IEEE Trans. Microwave Theory Tech. 53, 3312-3319 (2005).
19. M. Klemm, I. Craddock, J. Leendertz, A. Preece, and R. Benjamin, "Experimental and clinical results of breast cancer detection using UWB microwave radar," in Proceedings of the IEEE International Symposium on Antennas and Propagation, 2008.
20. P. Kosmas and C. Rappaport, "A matched filter FDTD-based time reversal algorithm for microwave breast cancer detection," IEEE Trans. Antennas Propag. 54, 1257-1264 (2006).
21. P. M. Meaney, M. W. Fanning, D. Li, S. P. Poplack, and K. D. Paulsen, "A clinical prototype for active microwave imaging of the breast," IEEE Trans. Microwave Theory Tech. 48, 1841-1853 (2000).
22. A. E. Bulyshev, S. Y. Semenov, A. E. Souvorov, R. H. Svenson, A. G. Nazarov, Y. E. Sizov, and G. P. Tatsis, "Computational modeling of three-dimensional microwave tomography of breast cancer," IEEE Trans. Biomed. Eng. 48, 1053-1056 (2001).
23. Z. Q. Zhang and Q. H. Liu, "Three-dimensional nonlinear image reconstruction for microwave biomedical imaging," IEEE Trans. Biomed. Eng. 51, 544-548 (2004).
24. Q. Fang, P. M. Meaney, and K. D. Paulsen, "Microwave image reconstruction of tissue property dispersion characteristics utilizing multiplefrequency information," IEEE Trans. Microwave Theory Tech. 52, 1866-1875 (2004).
25. Q. Fang, P. M. Meaney, S. D. Geimer, A. V. Streltsov, and K. D. Paulsen, "Microwave image reconstruction from 3-D field coupled to 2-D parameter estimation," IEEE Trans. Med. Imaging 23, 475-484 (2004).
26. T. Rubæk, P. M. Meaney, P. Meincke, and K. D. Paulsen, "Nonlinear microwave imaging for breast-cancer screening using Gauss-Newton's method and the CGLS inversion algorithm," IEEE Trans. Antennas Propag. 55, 2320-2331 (2007).
27. J. E. Johnson, T. Takenaka, and T. Tanaka, "Two-dimensional time-domain inverse scattering for quantitative analysis of breast composition," IEEE Trans. Biomed. Eng. 55, 1941-1945 (2008).
28. T. Rubæk, O. S. Kim, and P. Meincke, "Computational validation of a 3-D microwave imaging system for breast-cancer screening," IEEE Trans. Antennas Propag. 57, 2105-2115 (2009).
29. D. W. Winters, J. D. Shea, P. Kosmas, B. D. Van Veen, and S. C. Hagness, "Three-dimensional microwave breast imaging: Dispersive dielectric properties estimation using patient-specific basis functions," IEEE Trans. Med. Imaging 28, 969-981 (2009).
30. P. M. Meaney, M. W. Fanning, T. Raynolds, C. J. Fox, Q. Q. Fang, C. A. Kogel, S. P. Poplack, and K. D. Paulsen, "Initial clinical experience with microwave breast imaging in women with normal mammography," Acad. Radiol. 14, 207-218 (2007).
31. S. P. Poplack, T. D. Tosteson, W. A. Wells, B. W. Pogue, P. M. Meaney, A. Hartov, C. A. Kogel, S. K. Soho, J. J. Gibson, and K. D. Paulsen, "Electromagnetic breast imaging: Results of a pilot study in women with abnormal mammograms," Radiology 243, 350-359 (2007).
32. M. Lazebnik, E. L. Madsen, G. R. Frank, and S. C. Hagness, "Tissue-mimicking phantom materials for narrowband and ultrawideband microwave applications," Phys. Med. Biol. 50, 4245-4258 (2005).
33. A. Abubakar, P. M. van den Berg, and J. J. Mallorqui, "Imaging of biomedical data using a multiplicative regularized contrast source inversion method," IEEE Trans. Microwave Theory Tech. 50, 1761-1771 (2002).
34. S. Y. Semenov, R. H. Svenson, A. E. Bulyshev, A. E. Souvorov, A. G. Nazarov, Y. E. Sizov, A. V. Pavlovsky, V. Y. Borisov, B. A. Voinov, G. I. Simonova, A. N. Starostin, V. G. Posukh, G. P. Tatsis, and V. Y. Baranov, "Three-dimensional microwave tomography: Experimental prototype of the system and vector Born reconstruction method," IEEE Trans. Biomed. Eng. 46, 937-946 (1999).
35. D. Li, P. M. Meaney, and K. D. Paulsen, "Conformal microwave imaging for breast cancer detection," IEEE Trans. Microwave Theory Tech. 51, 1179-1186 (2003).
36. C. Gilmore, A. Abubakar, W. Hu, T. M. Habashy, and P. M. van den Berg, "Microwave biomedical data inversion using the finite-difference contrast source inversion method," IEEE Trans. Antennas Propag. 57, 1528-1538 (2009).
37. P. Mojabi and J. LoVetri, "Microwave biomedical imaging using the multiplicative regularized Gauss-Newton inversion," IEEE Antennas Wireless Propag. Lett. 8, 645-648 (2009).
38. UWCEM numerical breast phantom repository, http://uwcem.ece.wisc.edu.
39. S. Gabriel, R. W. Lau, and C. Gabriel, "The dielectric properties of biological tissues: III. Parametric models for the dielectric spectrum of tissues," Phys. Med. Biol. 41, 2271-2293 (1996).
40. A. Taflove and S. C. Hagness, Computational Electrodynamics: The Finite-Difference Time-Domain Method, 3rd ed. (Artech House, Norwood, 2005).
41. W. C. Chew, Waves and Fields in Inhomogeneous Media (IEEE, Piscataway, 1995).
42. R. F. Remis and P. M. van den Berg, "On the equivalence of the Newton-Kantorovich and distorted Born methods," Inverse Probl. 16, L1-L4 (2000).
43. J. Nocedal and S. J. Wright, Nonlinear Optimization, 2nd ed. (Springer, New York, 2006).
44. P. M. Meaney, K. D. Paulsen, and T. P. Ryan, "Two-dimensional hybrid element image reconstruction for TM illumination," IEEE Trans. Antennas Propag. 43, 239-247 (1995).
45. Z. Q. Zhang, Q. H. Liu, C. Xiao, E. Ward, G. Ybarra, and W. T. Joines, "Microwave breast imaging: 3-D forward scattering simulation," IEEE Trans. Biomed. Eng. 50, 1180-1189 (2003).
46. A. E. Bulyshev, A. E. Souvorov, S. Y. Semenov, V. G. Posukh, and Y. E. Sizov, "Three-dimensional vector microwave tomography: Theory and computational experiments," Inverse Probl. 20, 1239-1259 (2004).
47. T. J. Cui, W. C. Chew, A. A. Aydiner, and S. Chen, "Inverse scattering of two-dimensional dielectric objects buried in a lossy earth using the distorted Born iterative method," IEEE Trans. Geosci. Remote Sens. 39, 339-346 (2001).
48. T. J. Cui, Y. Qin, G. Wang, and W. C. Chew, "Low-frequency detection of two-dimensional buried objects using high-order extended born approximations," Inverse Probl. 20, S41-S62 (2004).
49. A. E. Bulyshev, A. E. Souvorov, S. Y. Semenov, R. H. Svenson, A. G. Nazarov, Y. E. Sizov, and G. P. Tatsis, "Three-dimensional microwave tomography. theory and computer experiments in scalar approximation," Inverse Probl. 16, 863-875 (2000).
50. M. Lazebnik, M. C. Converse, J. H. Booske, and S. C. Hagness, "Ultrawide-band temperature-dependent dielectric properties of animal liver tissue in the microwave frequency range," Phys. Med. Biol. 51, 1941-1955 (2006).
51. M. Lazebnik, M. Okoniewski, J. H. Booske, and S. C. Hagness, "Highly accurate Debye models for normal and malignant breast tissue dielectric properties at microwave frequencies," IEEE Microw. Wirel. Compon. Lett. 17, 822-824 (2007).
52. Y. Saad, Iterative Methods for Sparse Linear Systems, 2nd ed. (SIAM, Philadelphia, 2003).
53. P. C. Hansen, Rank-Deficient and Discrete Ill-Posed Problems: Numerical Aspects of Linear Inversion (SIAM, Philadelphia, 1998).
54. A. Abubakar, T. M. Habashy, V. L. Druskin, L. Knizhnerman, and D. Alumbaugh, "2.5D forward and inverse modeling for interpreting low-frequency electromagnetic measurements," Geophysics 73, F165-F177 (2008).
55. D. Calvetti, G. Landi, L. Reichel, and F. Sgallari, "Non-negativity and iterative methods for ill-posed problems," Inverse Probl. 20, 1747-1758 (2004).
56. P. M. Meaney, E. Demidenko, N. K. Yagnamurthy, D. Li, M. W. Fanning, and K. D. Paulsen, "A two-stage microwave image reconstruction procedure for improved internal feature extraction," Med. Phys. 28, 2358-2369 (2001).
57. A. Abubakar, W. Hu, P. M. van den Berg, and T. M. Habashy, "A finite-difference contrast source inversion method," Inverse Probl. 24, 065004 (2008).
58. D. W. Winters, E. J. Bond, B. D. Van Veen, and S. C. Hagness, "Estimation of the frequency-dependent average dielectric properties of breast tissue using a time-domain inverse scattering technique," IEEE Trans. Antennas Propag. 54, 3517-3528 (2006).
59. T. Rubæk and V. Zhurbenko, "Prototype of microwave imaging system for breast-cancer screening," in Proceedings of the 13th International Symposium on Antenna Technology and Applied Electromagnetics and the Canadian Radio Sciences Meeting, Banff, Alberta, Canada, 2009.
60. D. W. Winters, J. D. Shea, E. L. Madsen, G. R. Frank, B. D. Van Veen, and S. C. Hagness, "Estimating the breast surface using UWB microwave monostatic backscatter measurements," IEEE Trans. Biomed. Eng. 55, 247-256 (2008).
61. T. C. Williams, J. M. Sill, and E. C. Fear, "Breast surface estimation for radar-based breast imaging systems," IEEE Trans. Biomed. Eng. 55, 1678-1686 (2008).
62. D. Popovic, L. McCartney, C. Beasley, M. Lazebnik, M. Okoniewski, S. C. Hagness, and J. H. Booske, "Precision open-ended coaxial probes for in vivo and ex vivo dielectric spectroscopy of biological tissues at microwave frequencies," IEEE Trans. Microwave Theory Tech. 53, 1713-1722 (2005).
63. J. D. Shea, S. C. Hagness, and B. D. Van Veen, "Hardware acceleration of FDTD computations for 3-D microwave breast tomography," in Proceedings of the IEEE International Symposium on Antennas and Propagation, Charleston, SC, 2009.
64. J. D. Shea, P. Kosmas, S. C. Hagness, and B. D. Van Veen, "Contrast-enhanced microwave breast imaging," in Proceedings of the 13th International Symposium on Antenna Technology and Applied Electromagnetics and the Canadian Radio Sciences Meeting, Banff, Alberta, Canada, 2009.
65. J. D. Shea, P. Kosmas, B. D. Van Veen, and S. C. Hagness, "Contrast-enhanced microwave imaging of breast tumors: A computational study using 3D realistic numerical phantoms," Inverse Probl. (in press).