Antimicrobial peptides expression by ocular surface cells in response to Acanthamoeba castellanii: An in vitro study

British Journal of Ophthalmology

Volumn 94, Issue 11, 2010, Pages 1523-1527

  Otri, A M ^a   Mohammed, I ^a   Abedin, A ^a   Cao, Z ^b   Hopkinson, A ^a   Panjwani, N ^b   Dua, Harminder S ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b NEW ENGLAND EYE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN 1; BETA DEFENSIN 3; RIBONUCLEASE; ANTIMICROBIAL CATIONIC PEPTIDE; BETA DEFENSIN; CATHELICIDIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE; COMPLEMENTARY DNA; DEFB 109 PEPTIDE, HUMAN; DEFB-109 PEPTIDE, HUMAN; HEPCIDIN; LIVER EXPRESSED ANTIMICROBIAL PEPTIDE 2, HUMAN; LIVER-EXPRESSED ANTIMICROBIAL PEPTIDE 2, HUMAN; PLASMA PROTEIN; RIBONUCLEASE 7;

ACANTHAMOEBA CASTELLANII; ARTICLE; CORNEA EPITHELIUM; CORNEA LIMBUS; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; KERATITIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; CELL CULTURE; DOWN REGULATION; IMMUNOLOGY; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ACANTHAMOEBA CASTELLANII; ANTIMICROBIAL CATIONIC PEPTIDES; BETA-DEFENSINS; BLOOD PROTEINS; CATHELICIDINS; CELLS, CULTURED; DNA, COMPLEMENTARY; DOWN-REGULATION; EPITHELIUM, CORNEAL; GENE EXPRESSION; HUMANS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBONUCLEASES; UP-REGULATION;

EID: 78149484268     PISSN: 00071161     EISSN: 14682079     Source Type: Journal    
DOI: 10.1136/bjo.2009.178236     Document Type: Article

References (38)

1. Knop E, Knop N. Anatomy and immunology of the ocular surface. Chem Immunol Allergy 2007;92:36-49.
2. Gordon YJ, Romanowski EG, McDermott AM. A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs. Curr Eye Res 2005;30:505-15.
3. Sang Y, Blecha F. Antimicrobial peptides and bacteriocins: alternatives to traditional antibiotics. Anim Health Res Rev 2008;9:227-35.
4. McIntosh RS, Cade JE, Al-Abed M, et al. The spectrum of antimicrobial peptide expression at the ocular surface. Invest Ophthalmol Vis Sci 2005;46:1379-85.
5. Cordingley JS, Wills RA, Villemez CL. Osmolarity is an independent trigger of Acanthamoeba castellanii differentiation. J Cell Biochem 1996;61:167-71.
6. Jaison PL, Cao Z, Panjwani N. Binding of Acanthamoeba to [corrected] mannose-glycoproteins of corneal epithelium: effect of injury. Curr Eye Res 1998;17:770-6.
7. Por YM, Mehta JS, Chua JL, et al. Acanthamoeba keratitis associated with contact lens wear in Singapore. Am J Ophthalmol 2009;148:7-12-2.
8. Joslin CE, Tu EY, McMahon TT, et al. Epidemiological characteristics of a Chicago-area Acanthamoeba keratitis outbreak. Am J Ophthalmol 2006;142:212-17.
9. Yang Z, Cao Z, Panjwani N. Pathogenesis of Acanthamoeba keratitis: carbohydrate-mediated host-parasite interactions. Infect Immun 1997;65:439-45. (Pubitemid 27053206)
10. Hurt M, Niederkorn J, Alizadeh H. Effects of mannose on Acanthamoeba castellanii proliferation and cytolytic ability to corneal epithelial cells. Invest Ophthalmol Vis Sci 2003;44:3424-31.
11. Cao Z, Jefferson DM, Panjwani N. Role of carbohydrate-mediated adherence in cytopathogenic mechanisms of Acanthamoeba. J Biol Chem 1998;273:15838-45. (Pubitemid 28298206)
12. Clarke DW, Alizadeh H, Niederkorn JY. Intracorneal instillation of latex beads induces macrophage-dependent protection against Acanthamoeba keratitis. Invest Ophthalmol Vis Sci 2006;47:4917-25.
13. Mitra MM, Alizadeh H, Gerard RD, et al. Characterization of a plasminogen activator produced by Acanthamoeba castellanii. Mol Biochem Parasitol 1995;73:157-64.
14. Mitro K, Bhagavathiammai A, Zhou OM, et al. Partial characterization of the proteolytic secretions of Acanthamoeba polyphaga. Exp Parasitol 1994;78:377-85. (Pubitemid 24231292)
15. Gipson IK, Spurr-Michaud S, Argueso P, et al. Mucin gene expression in immortalized human corneal-limbal and conjunctival epithelial cell lines. Invest Ophthalmol Vis Sci 2003;44:2496-506.
16. Robertson DM, Li L, Fisher S, et al. Characterization of growth and differentiation in a telomerase-immortalized human corneal epithelial cell line. Invest Ophthalmol Vis Sci 2005;46:470-8. (Pubitemid 40270324)
17. Castro-Munozledo F. Corneal epithelial cell cultures as a tool for research, drug screening and testing. Exp Eye Res 2008;86:459-69.
18. Jensen T, Barnes WG, Meyers D. Axenic cultivation of large populations of Acanthamoeba castellanii (JBM). J Parasitol 1970;56:904-6.
19. Ueta M, Kinoshita S. Innate immunity of the ocular surface. Brain Res Bull 2009;81:219-28.
20. Hazlett LD. Corneal response to Pseudomonas aeruginosa infection. Prog Retin Eye Res 2004;23:1-30.
21. Huang LC, Jean D, Proske RJ, et al. Ocular surface expression and in vitro activity of antimicrobial peptides. Curr Eye Res 2007;32:595-609. (Pubitemid 47400679)
22. McDermott AM. The role of antimicrobial peptides at the ocular surface. Ophthalmic Res 2009;41:60-75.
23. Schuster FL, Jacob LS. Effects of magainins on ameba and cyst stages of Acanthamoeba polyphaga. Antimicrob Agents Chemother 1992;36:1263-71.
24. Feldman ST, Speaker M, Cleveland P. Effect of magainins on Acanthamoeba castellanii. Rev Infect Dis 1991;13(Suppl 5):S439.
25. Sacramento RS, Martins RM, Miranda A, et al. Differential effects of alpha-helical and beta-hairpin antimicrobial peptides against Acanthamoeba castellanii. Parasitology 2009;136:813-21.
26. Harder J, Bartels J, Christophers E, et al. Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic. J Biol Chem 2001;276:5707-13.
27. Pigeon C, Ilyin G, Courselaud B, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001;276:7811-19. (Pubitemid 37385574)
28. Ganz T. Hepcidin - a peptide hormone at the interface of innate immunity and iron metabolism. Curr Top Microbiol Immunol 2006;306:183-98.
29. Flanagan JL, Willcox MD. Role of lactoferrin in the tear film. Biochimie 2009;91:35-43.
30. Krause A, Neitz S, Magert HJ, et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett 2000;480:147-50.
31. Wang X, Zhang Z, Louboutin JP, et al. Airway epithelia regulate expression of human beta-defensin 2 through Toll-like receptor 2. FASEB J 2003;17:1727-9.
32. Abedin A, Mohammed I, Hopkinson A, et al. A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection. Invest Ophthalmol Vis Sci 2008;49:28-33.
33. Gordon YJ, Huang LC, Romanowski EG, et al. Human cathelicidin (LL-37), a multifunctional peptide, is expressed by ocular surface epithelia and has potent antibacterial and antiviral activity. Curr Eye Res 2005;30:385-94.
34. Maltseva IA, Fleiszig SM, Evans DJ, et al. Exposure of human corneal epithelial cells to contact lenses in vitro suppresses the upregulation of human beta-defensin-2 in response to antigens of Pseudomonas aeruginosa. Exp Eye Res 2007;85:142-53.
35. Townes CL, Michailidis G, Hall J. The interaction of the antimicrobial peptide cLEAP-2 and the bacterial membrane. Biochem Biophys Res Commun 2009;387:500-3.
36. Hocquellet A, Odaert B, Cabanne C, et al. Structure-activity relationship of human liver-expressed antimicrobial peptide 2. Peptides 2009;31:58-66.
37. Harder J, Schroder JM. RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin. J Biol Chem 2002;277:46779-84. (Pubitemid 35417681)
38. Dart JK, Saw VP, Kilvington S. Acanthamoeba keratitis: diagnosis and treatment update 2009. Am J Ophthalmol 2009;148:487-99-2.