-
2
-
-
52749089488
-
Long-term operation of depth filter perfusion systems (DFPS) for monoclonal antibody production using recombinant CHO cells: effect of temperature, pH, and dissolved oxygen
-
Lee J.C., Kim D.Y., Oh D.J., Chang H.N. Long-term operation of depth filter perfusion systems (DFPS) for monoclonal antibody production using recombinant CHO cells: effect of temperature, pH, and dissolved oxygen. Biotechnol Bioprocess Eng 2008, 13:401-409.
-
(2008)
Biotechnol Bioprocess Eng
, vol.13
, pp. 401-409
-
-
Lee, J.C.1
Kim, D.Y.2
Oh, D.J.3
Chang, H.N.4
-
3
-
-
0037929694
-
Metabolic engineering of apoptosis in cultured animal cells: implications for the biotechnology industries
-
Vives J., Juanola S., Cairo J.J., Godia F. Metabolic engineering of apoptosis in cultured animal cells: implications for the biotechnology industries. Metab Eng 2003, 5:124-132.
-
(2003)
Metab Eng
, vol.5
, pp. 124-132
-
-
Vives, J.1
Juanola, S.2
Cairo, J.J.3
Godia, F.4
-
4
-
-
0034129598
-
The growth factor inhibitor suramin reduces apoptosis and cell aggregation in protein-free CHO cell batch cultures
-
Zanghi J.A., Renner W.A., Bailey J.E., Fussenegger M. The growth factor inhibitor suramin reduces apoptosis and cell aggregation in protein-free CHO cell batch cultures. Biotechnol Prog 2000, 16:319-325.
-
(2000)
Biotechnol Prog
, vol.16
, pp. 319-325
-
-
Zanghi, J.A.1
Renner, W.A.2
Bailey, J.E.3
Fussenegger, M.4
-
5
-
-
0037161615
-
The protection of hybridoma cells from apoptosis by caspase inhibition allows culture recovery when exposed to noninducing conditions
-
Tinto A., Gabernet C., Vives J., Prats E., Cairo J.J., Cornudella L., et al. The protection of hybridoma cells from apoptosis by caspase inhibition allows culture recovery when exposed to noninducing conditions. J Biotechnol 2002, 95:205-214.
-
(2002)
J Biotechnol
, vol.95
, pp. 205-214
-
-
Tinto, A.1
Gabernet, C.2
Vives, J.3
Prats, E.4
Cairo, J.J.5
Cornudella, L.6
-
6
-
-
23244447615
-
Effect of N-acetylcystein on butyrate-treated Chinese hamster ovary cells to improve the production of recombinant human interferon-beta-1a
-
Oh H.K., So M.K., Yang J., Yoon H.C., Ahn J.S., Lee J.M., et al. Effect of N-acetylcystein on butyrate-treated Chinese hamster ovary cells to improve the production of recombinant human interferon-beta-1a. Biotechnol Prog 2005, 21:1154-1164.
-
(2005)
Biotechnol Prog
, vol.21
, pp. 1154-1164
-
-
Oh, H.K.1
So, M.K.2
Yang, J.3
Yoon, H.C.4
Ahn, J.S.5
Lee, J.M.6
-
7
-
-
70449679155
-
Expression of Bombyx mori 30Kc19 protein in Escherichia coli and its anti-apoptotic effect in Sf9 cell
-
Rhee W.J., Lee E.H., Park T.H. Expression of Bombyx mori 30Kc19 protein in Escherichia coli and its anti-apoptotic effect in Sf9 cell. Biotechnol Bioprocess Eng 2009, 14:645-650.
-
(2009)
Biotechnol Bioprocess Eng
, vol.14
, pp. 645-650
-
-
Rhee, W.J.1
Lee, E.H.2
Park, T.H.3
-
8
-
-
0037199148
-
Selected amino acids protect hybridoma and CHO cells from elevated carbon dioxide and osmolality
-
deZengotita V.M., Abston L.R., Schmelzer A.E., Shaw S., Miller W.M. Selected amino acids protect hybridoma and CHO cells from elevated carbon dioxide and osmolality. Biotechnol Bioeng 2002, 78:741-752.
-
(2002)
Biotechnol Bioeng
, vol.78
, pp. 741-752
-
-
deZengotita, V.M.1
Abston, L.R.2
Schmelzer, A.E.3
Shaw, S.4
Miller, W.M.5
-
9
-
-
0031899540
-
Effect of Bcl-2 expression on hybridoma cell growth in serum-supplemented, protein free and diluted media
-
Fassnacht D., Rossing S., Franek K., AI-Rubeai M., Portner R. Effect of Bcl-2 expression on hybridoma cell growth in serum-supplemented, protein free and diluted media. Cytotechnology 1998, 26:219-225.
-
(1998)
Cytotechnology
, vol.26
, pp. 219-225
-
-
Fassnacht, D.1
Rossing, S.2
Franek, K.3
Ai-Rubeai, M.4
Portner, R.5
-
10
-
-
0032486578
-
In hybridoma cultures, deprivation of any single amino acid leads to apoptotic death, which is suppressed by the expression of the bcl-2 gene
-
Simpson N.H., Singh R.P., Perani A., Goldenzon C., AI-Rubeai M. In hybridoma cultures, deprivation of any single amino acid leads to apoptotic death, which is suppressed by the expression of the bcl-2 gene. Biotechnol Bioeng 1998, 59:90-98.
-
(1998)
Biotechnol Bioeng
, vol.59
, pp. 90-98
-
-
Simpson, N.H.1
Singh, R.P.2
Perani, A.3
Goldenzon, C.4
AI-Rubeai, M.5
-
11
-
-
0029048389
-
Over-expression of Bcl-2, apoptosis suppressing gene: prolonged viable culture period of hybridoma and enhanced antibody production
-
Itoh Y.H., Suzuki E. Over-expression of Bcl-2, apoptosis suppressing gene: prolonged viable culture period of hybridoma and enhanced antibody production. Biotechnol Bioeng 1995, 48:118-122.
-
(1995)
Biotechnol Bioeng
, vol.48
, pp. 118-122
-
-
Itoh, Y.H.1
Suzuki, E.2
-
12
-
-
0034724930
-
Bcl-2 mediated suppression of apoptosis in myeloma NSO cultures
-
Tey B.T., Singh R.P., Piredda L., Piacentini M., AI-Rubeai M. Bcl-2 mediated suppression of apoptosis in myeloma NSO cultures. J Biotechnol 2000, 79:147-159.
-
(2000)
J Biotechnol
, vol.79
, pp. 147-159
-
-
Tey, B.T.1
Singh, R.P.2
Piredda, L.3
Piacentini, M.4
Ai-Rubeai, M.5
-
13
-
-
0034607154
-
Overexpression of Bcl-2 family members enhances survival of mammalian cells in response to various culture insults
-
Mastrangelo A.J., Hardwick J.M., Zou S., Betenbaugh M.J. Overexpression of Bcl-2 family members enhances survival of mammalian cells in response to various culture insults. Biotechnol Bioeng 2000, 67:555-564.
-
(2000)
Biotechnol Bioeng
, vol.67
, pp. 555-564
-
-
Mastrangelo, A.J.1
Hardwick, J.M.2
Zou, S.3
Betenbaugh, M.J.4
-
14
-
-
0034607272
-
Influence of bcl-2 on cell death during the cultivation of a Chinese hamster ovary cell line expressing a chimeric antibody
-
Tey B.T., Singh R.P., Piredda L., Piacentini M., AI-Rubeai M. Influence of bcl-2 on cell death during the cultivation of a Chinese hamster ovary cell line expressing a chimeric antibody. Biotechnol Bioeng 2000, 68:31-43.
-
(2000)
Biotechnol Bioeng
, vol.68
, pp. 31-43
-
-
Tey, B.T.1
Singh, R.P.2
Piredda, L.3
Piacentini, M.4
AI-Rubeai, M.5
-
15
-
-
0035810689
-
Comparison of Bcl-2 to a Bcl-2 deletion mutant for mammalian cells exposed to culture insults
-
Figueroa B., Sauerwald T.M., Mastrangelo A.J., Hardwick J.M., Betenbaugh M.J. Comparison of Bcl-2 to a Bcl-2 deletion mutant for mammalian cells exposed to culture insults. Biotechnol Bioeng 2001, 73(3):211-222.
-
(2001)
Biotechnol Bioeng
, vol.73
, Issue.3
, pp. 211-222
-
-
Figueroa, B.1
Sauerwald, T.M.2
Mastrangelo, A.J.3
Hardwick, J.M.4
Betenbaugh, M.J.5
-
16
-
-
0037279943
-
Protective effect of viral homologues of bcl-2 on hybridoma cells under apoptosis-inducing conditions
-
Vives J., Juanola S., Cairo J.J., Prats E., Cornudella L., Godia F. Protective effect of viral homologues of bcl-2 on hybridoma cells under apoptosis-inducing conditions. Biotechnol Prog 2003, 19:84-89.
-
(2003)
Biotechnol Prog
, vol.19
, pp. 84-89
-
-
Vives, J.1
Juanola, S.2
Cairo, J.J.3
Prats, E.4
Cornudella, L.5
Godia, F.6
-
17
-
-
1442277071
-
Aven and Bcl-xL enhance protection against apoptosis for mammalian cells exposed to various culture conditions
-
Figueroa B., Chen S., Oyler G.A., Hardwick J.M., Betenbaugh M.J., Sauerwald T.M. Aven and Bcl-xL enhance protection against apoptosis for mammalian cells exposed to various culture conditions. Biotechnol Bioeng 2004, 85(6):589-600.
-
(2004)
Biotechnol Bioeng
, vol.85
, Issue.6
, pp. 589-600
-
-
Figueroa, B.1
Chen, S.2
Oyler, G.A.3
Hardwick, J.M.4
Betenbaugh, M.J.5
Sauerwald, T.M.6
-
18
-
-
1442344781
-
A comparison of the properties of a Bcl-xL variant to the wild-type anti-apoptosis inhibitor in mammalian cell cultures
-
Figueroa B., Sauerwald T.M., Oyler G.A., Hardwick J.M., Betenbaugh M.J. A comparison of the properties of a Bcl-xL variant to the wild-type anti-apoptosis inhibitor in mammalian cell cultures. Metab Eng 2003, 5(4):230-245.
-
(2003)
Metab Eng
, vol.5
, Issue.4
, pp. 230-245
-
-
Figueroa, B.1
Sauerwald, T.M.2
Oyler, G.A.3
Hardwick, J.M.4
Betenbaugh, M.J.5
-
19
-
-
25144476279
-
L mediates increased production of humanized monoclonal antibodies in Chinese hamster ovary cells
-
L mediates increased production of humanized monoclonal antibodies in Chinese hamster ovary cells. Biotechnol Bioeng 2005, 91(7):779-792.
-
(2005)
Biotechnol Bioeng
, vol.91
, Issue.7
, pp. 779-792
-
-
Gisela, G.C.1
William, P.S.2
-
20
-
-
0037419710
-
Study of caspase inhibitors for limiting death in mammalian cell cultures
-
Sauerwald T.M., Oyler G.A., Betenbaugh M.J. Study of caspase inhibitors for limiting death in mammalian cell cultures. Biotechnol Bioeng 2003, 81:329-340.
-
(2003)
Biotechnol Bioeng
, vol.81
, pp. 329-340
-
-
Sauerwald, T.M.1
Oyler, G.A.2
Betenbaugh, M.J.3
-
21
-
-
0028168514
-
Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition
-
Komiyama T., Ray C.A., Pickup D.J., Howard A.D., Thornberry N.A., Peterson E.P., et al. Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition. J Biol Chem 1994, 269:19331-19337.
-
(1994)
J Biol Chem
, vol.269
, pp. 19331-19337
-
-
Komiyama, T.1
Ray, C.A.2
Pickup, D.J.3
Howard, A.D.4
Thornberry, N.A.5
Peterson, E.P.6
-
22
-
-
0034728791
-
Silkworm hemolymph inhibits baculovirus-induced insect cell apoptosis
-
Rhee W.J., Park T.H. Silkworm hemolymph inhibits baculovirus-induced insect cell apoptosis. Biochem Biophys Res Commun 2000, 271:186-190.
-
(2000)
Biochem Biophys Res Commun
, vol.271
, pp. 186-190
-
-
Rhee, W.J.1
Park, T.H.2
-
23
-
-
0036321895
-
Inhibition of human cell apoptosis by silkworm hemolymph
-
Choi S.S., Rhee W.J., Park T.H. Inhibition of human cell apoptosis by silkworm hemolymph. Biotechnol Prog 2002, 18:874-878.
-
(2002)
Biotechnol Prog
, vol.18
, pp. 874-878
-
-
Choi, S.S.1
Rhee, W.J.2
Park, T.H.3
-
24
-
-
0034806263
-
Isolation and characterization of an apoptosis-inhibiting component from the hemolymph of Bombyx mori
-
Kim E.J., Rhee W.J., Park T.H. Isolation and characterization of an apoptosis-inhibiting component from the hemolymph of Bombyx mori. Biochem Biophys Res Commun 2001, 285:224-228.
-
(2001)
Biochem Biophys Res Commun
, vol.285
, pp. 224-228
-
-
Kim, E.J.1
Rhee, W.J.2
Park, T.H.3
-
26
-
-
0023928375
-
Structure and expression of mRNA coding for major plasma proteins of Bombyx mori
-
Sakai N., Mori S., Izumi S., Haino-Fukushima K., Ogura T., Maekawa H., et al. Structure and expression of mRNA coding for major plasma proteins of Bombyx mori. Biochim Biophys Acta 1988, 949:224-232.
-
(1988)
Biochim Biophys Acta
, vol.949
, pp. 224-232
-
-
Sakai, N.1
Mori, S.2
Izumi, S.3
Haino-Fukushima, K.4
Ogura, T.5
Maekawa, H.6
-
27
-
-
1142293805
-
Inhibition of apoptosis by a Bombyx mori gene
-
Kim E.J., Rhee W.J., Park T.H. Inhibition of apoptosis by a Bombyx mori gene. Biotechnol Prog 2004, 20:324-329.
-
(2004)
Biotechnol Prog
, vol.20
, pp. 324-329
-
-
Kim, E.J.1
Rhee, W.J.2
Park, T.H.3
-
28
-
-
33750961223
-
Enhancement of cell growth and viability of CHO cells in serum-free media by 30Kc6 gene expression
-
Park J.G., Choi S.S., Park T.H. Enhancement of cell growth and viability of CHO cells in serum-free media by 30Kc6 gene expression. Process Biochem 2007, 42:8-15.
-
(2007)
Process Biochem
, vol.42
, pp. 8-15
-
-
Park, J.G.1
Choi, S.S.2
Park, T.H.3
-
29
-
-
33749340617
-
Enhancement of recombinant protein production in Chinese hamster ovary cells through anti-apoptosis engineering using 30Kc6 gene
-
Choi S.S., Rhee W.J., Kim E.J., Park T.H. Enhancement of recombinant protein production in Chinese hamster ovary cells through anti-apoptosis engineering using 30Kc6 gene. Biotechnol Bioeng 2006, 95(3):459-467.
-
(2006)
Biotechnol Bioeng
, vol.95
, Issue.3
, pp. 459-467
-
-
Choi, S.S.1
Rhee, W.J.2
Kim, E.J.3
Park, T.H.4
-
30
-
-
58149250505
-
Beneficial effect of 30Kc6 gene expression on production of recombinant interferon-β in serum-free suspension culture of CHO cells
-
Koo T.Y., Park J.H., Park H.H., Park T.H. Beneficial effect of 30Kc6 gene expression on production of recombinant interferon-β in serum-free suspension culture of CHO cells. Process Biochem 2008, 44(2):287-296.
-
(2008)
Process Biochem
, vol.44
, Issue.2
, pp. 287-296
-
-
Koo, T.Y.1
Park, J.H.2
Park, H.H.3
Park, T.H.4
-
31
-
-
27144457667
-
Monoclonal antibody successes in the clinic
-
Reichert J.M., Rosensweig C.J., Faden L.B., Dewitz M.C. Monoclonal antibody successes in the clinic. Nat Biotechnol 2005, 23:1073-1078.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 1073-1078
-
-
Reichert, J.M.1
Rosensweig, C.J.2
Faden, L.B.3
Dewitz, M.C.4
-
32
-
-
4644309963
-
Production technologies for monoclonal antibodies and their fragments
-
Andersen D.C., Reilly D.E. Production technologies for monoclonal antibodies and their fragments. Curr Opin Biotechnol 2004, 15:456-462.
-
(2004)
Curr Opin Biotechnol
, vol.15
, pp. 456-462
-
-
Andersen, D.C.1
Reilly, D.E.2
-
33
-
-
29144489512
-
Selection strategies for the establishment of recombinant Chinese hamster ovary cell line with dihydrofolate reductase-mediated gene amplification
-
Jun S.C., Kim M.S., Baik J.Y., Hwang S.O., Lee G.M. Selection strategies for the establishment of recombinant Chinese hamster ovary cell line with dihydrofolate reductase-mediated gene amplification. Appl Microbiol Biotechnol 2005, 69(2):162-169.
-
(2005)
Appl Microbiol Biotechnol
, vol.69
, Issue.2
, pp. 162-169
-
-
Jun, S.C.1
Kim, M.S.2
Baik, J.Y.3
Hwang, S.O.4
Lee, G.M.5
-
34
-
-
0025806764
-
Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1
-
Smiley S.T., Reers M., Mottola-Hartshorn C., Lin M., Chen A., Smith T.W., et al. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proc Natl Acad Sci 1991, 88:3671-3675.
-
(1991)
Proc Natl Acad Sci
, vol.88
, pp. 3671-3675
-
-
Smiley, S.T.1
Reers, M.2
Mottola-Hartshorn, C.3
Lin, M.4
Chen, A.5
Smith, T.W.6
|