Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 299, Issue 5, 2010, Pages

  Ae, Takako ^a,b   Ohno, Takashi ^a   Hattori, Youichiro ^a   Suzuki, Tatsunori ^a,b   Hosono, Kanako ^a,b   Minamino, Tsutomu ^a,b   Sato, Takehito ^a,b   Uematsu, Satoshi ^c   Akira, Shizuo ^c   Koizumi, Wasaburo ^a   Majima, Masataka ^a,b  

^a KITASATO UNIVERSITY   (Japan)

^b Graduate School of Medicine   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Acetic acid; Growth factor; Mouse; Prostaglandin E2

Indexed keywords

ACETIC ACID; BASIC FIBROBLAST GROWTH FACTOR; CD31 ANTIGEN; CONNECTIVE TISSUE GROWTH FACTOR; CYCLOOXYGENASE 2; MESSENGER RNA; PROSTAGLANDIN E SYNTHASE 1; TRANSFORMING GROWTH FACTOR BETA; ISOMERASE; PROSTAGLANDIN E SYNTHASE; SIGNAL PEPTIDE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVITY; ENZYME LOCALIZATION; GRANULATION TISSUE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; STOMACH ULCER; ANALYSIS OF VARIANCE; ANIMAL; CHEMICALLY INDUCED DISORDER; ENZYME IMMUNOASSAY; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE MUTANT; PATHOPHYSIOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH; TIME; WOUND HEALING;

ACETIC ACID; ANALYSIS OF VARIANCE; ANIMALS; CYCLOOXYGENASE 2; IMMUNOENZYME TECHNIQUES; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTRAMOLECULAR OXIDOREDUCTASES; MALE; MICE; MICE, KNOCKOUT; NEOVASCULARIZATION, PHYSIOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STOMACH; STOMACH ULCER; TIME FACTORS; WOUND HEALING;

EID: 78149481801     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00013.2010     Document Type: Article

References (36)

1. Amagase K, Hayashi S, Nishikawa K, Aihara E, Takeuchi K. Impairment of gastric ulcer healing by alendronate, a nitrogen-containing bisphosphonate, in rats. Dig Dis Sci 52: 1879-1889, 2007.
2. 2-EP3 signaling regulates tumor-associated angiogenesis and tumor growth. J Exp Med 197: 221-232, 2003.
3. Border WA, Noble NA. Transforming growth factor beta in tissue fibrosis. N Engl J Med 331: 1286-1292, 1994.
4. 2 production and alters the gastric prostanoid profile. J Biol Chem 279: 23229-23237, 2004.
5. 2 production in the rat adjuvantinduced arthritis model. J Immunol 170: 4738-4744, 2003.
6. Elander N, Zhou J, Ungerback J, Dimberg J, Soderkvist P. Association between adenomatosis polyposis coli functional status and microsomal prostaglandin E synthase-1 expression in colorectal cancer. Mol Carcinog 48: 401-407, 2009.
7. Engblom D, Saha S, Engstrom L, Westman M, Audoly LP, Jakobsson PJ, Blomqvist A. Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis. Nat Neurosci 6: 1137-1138, 2003.
8. Ernst H, Konturek PC, Hahn EG, Stosiek HP, Brzozowski T, Konturek SJ. Effect of local injection with basic fibroblast growth factor (BFGF) and neutralizing antibody to BFGF on gastric ulcer healing, gastric secretion, angiogenesis and gastric blood flow. J Physiol Pharmacol 52: 377-390, 2001.
9. Gudis K, Tatsuguchi A, Wada K, Futagami S, Nagata K, Hiratsuka T, Shinji Y, Miyake K, Tsukui T, Fukuda Y, Sakamoto C. Microsomal prostaglandin E synthase (mPGES)-1, mPGES-2 and cytosolic PGES expression in human gastritis and gastric ulcer tissue. Lab Invest 85: 225-236, 2005.
10. Halter F, Tarnawski AS, Schmassmann A, Peskar BM. Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives. Gut 49: 443-453, 2001.
11. 2 synthase expression. J Biol Chem 277: 16355-16364, 2002.
12. 2 production. J Neurochem 94: 1546-1558, 2005.
13. Kamoshita E, Ikeda Y, Fujita M, Amano H, Oikawa A, Suzuki T, Ogawa Y, Yamashina S, Azuma S, Narumiya S, Unno N, Majima M. Recruitment of a prostaglandin E receptor subtype, EP3-expressing bone marrow cells is crucial in wound-induced angiogenesis. Am J Pathol 169: 1458-1472, 2006.
14. Lempinen M, Inkinen K, Wolff H, Ahonen J. Connective tissue growth factor in indomethacin-induced rat gastric ulcer. Eur Surg Res 34: 232-238, 2002.
15. Levi S, Goodlad RA, Lee CY, Stamp G, Walport MJ, Wright NA, Hodgson HJ. Inhibitory effect of non-steroidal anti-inflammatory drugs on mucosal cell proliferation associated with gastric ulcer healing. Lancet 336: 840-843, 1990.
16. Majima M, Amano H, Hayashi I. Prostanoid receptor signaling relevant to tumor growth and angiogenesis. Trends Pharmacol Sci 24: 524-529, 2003.
17. Majima M, Hayashi I, Muramatsu M, Katada J, Yamashina S, Katori M. Cyclo-oxygenase-2 enhances basic fibroblast growth factor-induced angiogenesis through induction of vascular endothelial growth factor in rat sponge implants. Br J Pharmacol 130: 641-649, 2000.
18. Massague J. The transforming growth factor-beta family. Annu Rev Cell Biol 6: 597-641, 1990.
19. Mizuno H, Sakamoto C, Matsuda K, Wada K, Uchida T, Noguchi H, Akamatsu T, Kasuga M. Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology 112: 387-397, 1997.
20. 2-biosynthetic pathway. Prog Lipid Res 43: 3-35, 2004.
21. 2 synthase gene. Essential role of the transcription factor Egr-1. J Biol Chem 277: 28601-28608, 2002.
22. Ohno T, Hattori Y, Komine R, Ae T, Mizuguchi S, Arai K, Saeki T, Suzuki T, Hosono K, Hayashi I, Oh-Hashi Y, Kurihara Y, Kurihara H, Amagase K, Okabe S, Saigenji K, Majima M. Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ulcer healing and angiogenesis. Gastroenterology 134: 215-225, 2008.
23. Polonikov AV, Ivanov VP, Belugin DA, Khoroshaya IV, Kolchanova IO, Solodilova MA, Tutochkina MP, Stepchenko AA. Analysis of common transforming growth factor beta-1 gene polymorphisms in gastric and duodenal ulcer disease: pilot study. J Gastroenterol Hepatol 22: 555-564, 2007.
24. Roberts AB, Sporn MB. Transforming growth factor beta. Adv Cancer Res 51: 107-145, 1988.
25. Samuelsson B, Morgenstern R, Jakobsson PJ. Membrane prostaglandin E synthase-1: a novel therapeutic target. Pharmacol Rev 59: 207-224, 2007.
26. Sugimoto Y, Narumiya S, Ichikawa A. Distribution and function of prostanoid receptors: studies from knockout mice. Prog Lipid Res 39: 289-314, 2000.
27. Suthanthiran M, Li B, Song JO, Ding R, Sharma VK, Schwartz JE, August P. Transforming growth factor-beta 1 hyperexpression in African- American hypertensives: a novel mediator of hypertension and/or target organ damage. Proc Natl Acad Sci USA 97: 3479-3484, 2000.
28. 2 generation after administration of mild hyperosmotic saline solution into the gastric lumen. Eicosanoids 3: 23-27, 1990.
29. Tarnawski AS. Cellular and molecular mechanisms of gastrointestinal ulcer healing. Dig Dis Sci 50, Suppl 1: S24-S33, 2005.
30. Toda M, Suzuki T, Hosono K, Hayashi I, Hashiba S, Onuma Y, Amano H, Kurihara Y, Kurihara H, Okamoto H, Hoka S, Majima M. Neuronal system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide. Proc Natl Acad Sci USA 105: 13550-13555, 2008.
31. Trebino CE, Stock JL, Gibbons CP, Naiman BM, Wachtmann TS, Umland JP, Pandher K, Lapointe JM, Saha S, Roach ML, Carter D, Thomas NA, Durtschi BA, McNeish JD, Hambor JE, Jakobsson PJ, Carty TJ, Perez JR, Audoly LP. Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc Natl Acad Sci USA 100: 9044-9049, 2003.
32. 2 synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway. J Immunol 168: 5811-5816, 2002.
33. Wallace JL, Dicay M, McKnight W, Dudar GK. Platelets accelerate gastric ulcer healing through presentation of vascular endothelial growth factor. Br J Pharmacol 148: 274-278, 2006.
34. Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis - correlation in invasive breast carcinoma. N Engl J Med 324: 1-8, 1991.
35. Yamagata K, Matsumura K, Inoue W, Shiraki T, Suzuki K, Yasuda S, Sugiura H, Cao C, Watanabe Y, Kobayashi S. Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever. J Neurosci 21: 2669-2677, 2001.
36. Yoshimatsu K, Golijanin D, Paty PB, Soslow RA, Jakobsson PJ, DeLellis RA, Subbaramaiah K, Dannenberg AJ. Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer. Clin Cancer Res 7: 3971-3976, 2001. (Pubitemid 34044615)