Functional inactivation of triosephosphate isomerase through phosphorylation during etoposide-induced apoptosis in HeLa cells: Potential role of Cdk2

Toxicology

Volumn 278, Issue 2, 2010, Pages 224-228

  Lee, Won Hee ^a   Choi, Joon Seok ^a   Byun, Mi Ran ^a   Koo, Kyo tan ^a   Shin, Soona ^a   Lee, Seung Ki ^a   Surh Young Joon, Y J ^a  

^a Seoul National University   (South Korea)

Author keywords

Apoptosis; Cdk2; Phosphorylation; Triosephosphate isomerase

Indexed keywords

CYCLIN A; CYCLIN DEPENDENT KINASE 2; DIHYDROXYACETONE PHOSPHATE; ETOPOSIDE; GLUCOSE ALDEHYDE 3 PHOSPHATE; IRON; MUTANT PROTEIN; OLOMOUCINE; PHOSPHOPROTEIN; SUGAR PHOSPHATE; TRIOSEPHOSPHATE ISOMERASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; CATALYSIS; CELL LYSATE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; ENERGY YIELD; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; ENZYME PURIFICATION; ENZYME SUBSTRATE; FEMALE; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN TARGETING; PROTEOMICS; TWO DIMENSIONAL GEL ELECTROPHORESIS;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CYCLIN A; CYCLIN-DEPENDENT KINASE 2; DIHYDROXYACETONE PHOSPHATE; ETOPOSIDE; HELA CELLS; HUMANS; KINETIN; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEOMICS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRIOSE-PHOSPHATE ISOMERASE; UP-REGULATION;

EID: 78149471547     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2010.02.005     Document Type: Article

References (29)

1. Adachi S., Ito H., Tamamori-Adachi M., Ono Y., Nozato T., Abe S., Ikeda M., Marumo F., Hiroe M. Cyclin A/cdk2 activation is involved in hypoxia-induced apoptosis in cardiomyocytes. Circ. Res. 2001, 88:408-414.
2. Beranova-Giorgianni S., Zhao Y., Desiderio D.M., Giorgianni F. Phosphoproteomic analysis of the human pituitary. Pituitary 2006, 9:109-120.
3. Choi J.S., Shin S., Jin Y.H., Yim H., Koo K.T., Chun K.H., Oh Y.T., Lee W.H., Lee S.K. Cyclin-dependent protein kinase 2 activity is required for mitochondrial translocation of Bax and disruption of mitochondrial transmembrane potential during etoposide-induced apoptosis. Apoptosis 2007, 12:1229-1241.
4. Clem B., Telang S., Clem A., Yalcin A., Meier J., Simmons A., Rasku M.A., Arumugam S., Dean W.L., Eaton J., Lane A., Trent J.O., Chesney J. Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol. Cancer Ther. 2008, 7:110-120.
5. Deb-Basu D., Aleem E., Kaldis P., Felsher D.W. CDK2 is required by MYC to induce apoptosis. Cell Cycle 2006, 5:1342-1347.
6. Dephoure N., Zhou C., Villén J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:10762-10767.
7. Funasaka T., Hu H., Hogan V., Raz A. Down-regulation of phosphoglucose isomerase/autocrine motility factor expression sensitizes human fibrosarcoma cells to oxidative stress leading to cellular senescence. J. Biol. Chem. 2007, 282:36362-36369.
8. Gharahdaghi F., Weinberg C.R., Meagher D.A., Imai B.S., Mische S.M. Mass spectrometric identification of proteins from silver-stained polyacrylamide gel: a method for the removal of silver ions to enhance sensitivity. Electrophoresis 1999, 2:601-605.
9. Guix F.X., Ill-Raga G., Bravo R., Nakaya T., de Fabritiis G., Coma M., Miscione G.P., Villà-Freixa J., Suzuki T., Fernàndez-Busquets X., Valverde M.A., de Strooper B., Muñoz F.J. Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation. Brain 2009, 132:1335-1345.
10. Hakem A., Sasaki T., Kozieradzki I., Penninger J.M. The Cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis. J. Exp. Med. 1999, 189:957-968.
11. Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined Titania/C18 biphasic column. Anal. Sci. 2008, 24:161-166.
12. Jin Y.H., Yim H., Park J.H., Lee S.K. Cdk2 activity is associated with depolarization of mitochondrial membrane potential during apoptosis. Biochem. Biophys. Res. Commun. 2003, 305:974-980.
13. Jin Y.H., Yoo K.J., Lee Y.H., Lee S.K. Caspase 3-mediated cleavage of p21WAF1/CIP1-associated with the cyclin A-cyclin-dependent kinase 2 complex is a prerequisite for apoptosis in SK-HEP-1 cells. J. Biol. Chem. 2000, 275:30256-30263.
14. Kerr J.F., Wyllie A.H., Currie A.R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J Cancer 1972, 26:239-257.
15. Kim S.G., Kim S.N., Jong H.S., Kim N.K., Hong S.H., Kim S.J., Bang Y.J. Caspase-mediated Cdk2 activation is a critical step to execute transforming growth factor-beta1-induced apoptosis in human gastric cancer cells. Oncogene 2001, 20:1254-1265.
16. Kondoh H. Cellular life span and the Warburg effect. Exp. Cell. Res. 2008, 314:1923-1928.
17. Kueck A., Opipari A.W., Griffith K.A., Tan L., Choi M., Huang J., Wahl H., Liu J.R. Resveratrol inhibits glucose metabolism in human ovarian cancer cells. Gynecol. Oncol. 2007, 107:450-457.
18. Le Naour F., Hohenkirk L., Grolleau A., Misek D.E., Lescure P., Geiger J.D., Hanash S., Beretta L. Profiling changes in gene expression during differentiation and maturation of monocyte-derived dendritic cells using both oligonucleotide microarrays and proteomics. J. Biol. Chem. 2001, 276:17920-17931.
19. Lewis T.S., Hunt J.B., Aveline L.D., Jonscher K.R., Louie D.F., Yeh J.M., Nahreini T.S., Resing K.A., Ahn N.G. Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry. Mol. Cell 2000, 6:1343-1354.
20. Liem D.A., Zhao P., Angelis E., Chan S.S., Zhang J., Wang G., Berthet C., Kaldis P., Ping P., Maclellan W.R. Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury. J. Mol. Cell Cardiol. 2008, 45:610-616.
21. Oh Y.T., Chun K.H., Park B.D., Choi J.S., Lee S.K. Regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 by protein kinase C delta-mediated phosphorylation. Apoptosis 2007, 12:1339-1347.
22. Park J.A., Kim K.W., Kim S.I., Lee S.K. Caspase-3 specifically cleaves p21WAF1/CIP1 in the earlier stage of apoptosis in SK-HEP-1 human hepatoma cells. Eur. J. Biochem. 1998, 257:242-248.
23. Pedersen P.L. Tumor mitochondria and the bioenergetics of cancer cells. Prog. Exp. Tumor Res. 1978, 22:190-274.
24. Pelicano H., Martin D.S., Xu R.H., Huang P. Glycolysis inhibition for anticancer treatment. Oncogene 2006, 25:4633-4646.
25. Reed T.T., Pierce W.M., Turner D.M., Markesbery W.R., Butterfield D.A. Proteomic identification of nitrated brain proteins in early Alzheimer's disease inferior parietal lobule. J. Cell. Mol. Med. 2009, 13:2019-2029.
26. Shevchenko A., Wilm M., Vorm O., Mann M. Mass spectrometric sequencing of proteins from silver-stained polyacrylamide gels. Anal. Chem. 1996, 68:850-858.
27. Van den Heuvel S., Harlow E. Distinct roles for cyclin-dependent kinases in cell cycle control. Science 1993, 262:2050-2054.
28. Warburg O. On respiratory impairment in cancer cells. Science 1956, 124:269-270.
29. Yu F., Megyesi J., Safirstein R.L., Price P.M. Involvement of the CDK2-E2F1 pathway in cisplatin cytotoxicity in vitro and in vivo. Am. J. Physiol. Renal. Physiol. 2007, 293:F52-F59.