N-methyl-N′-nitro-N-nitrosoguanidine induces and cooperates with 12-O-tetradecanoylphorbol-1,3-acetate/sodium butyrate to enhance Epstein-Barr virus reactivation and genome instability in nasopharyngeal carcinoma cells

Chemico-Biological Interactions

Volumn 188, Issue 3, 2010, Pages 623-634

  Huang, Sheng Yen ^a   Fang, Chih Yeu ^b   Tsai, Ching Hwa ^c   Chang, Yao ^b   Takada, Kenzo ^d   Hsu, Tsuey Ying ^c   Chen, Jen Yang ^a,b,c  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Epstein Barr virus; Genome instability; MNNG; Viral reactivation

Indexed keywords

BUTYRIC ACID; HISTONE H2AX; METHYLNITRONITROSOGUANIDINE; PHORBOL 13 ACETATE 12 MYRISTATE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA;

ARTICLE; CANCER RISK; CARCINOMA CELL; CHEMICAL CARCINOGENESIS; COCARCINOGENESIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DOUBLE STRANDED DNA BREAK; EPSTEIN BARR VIRUS; GENE INDUCTION; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; LONG TERM EXPOSURE; NASOPHARYNX CARCINOMA; PROMOTER REGION; TRANSCRIPTION INITIATION; VIRUS REACTIVATION;

BUTYRIC ACID; CELL LINE, TUMOR; DNA BREAKS, DOUBLE-STRANDED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; GENOMIC INSTABILITY; HERPESVIRUS 4, HUMAN; HUMANS; IMMEDIATE-EARLY PROTEINS; METHYLNITRONITROSOGUANIDINE; MICRONUCLEUS TESTS; NASOPHARYNGEAL NEOPLASMS; PHORBOL ESTERS; PROMOTER REGIONS, GENETIC; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; TETRADECANOYLPHORBOL ACETATE; TRANS-ACTIVATORS; TRANSCRIPTIONAL ACTIVATION; VIRUS ACTIVATION;

HUMAN HERPESVIRUS 4;

EID: 78149470136     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.09.020     Document Type: Article

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