EHMAPK, the mitogen-activated protein kinase from Entamoeba histolytica is associated with cell survival

PLoS ONE

Volumn 5, Issue 10, 2010, Pages

  Ghosh, Anupama Sardar ^a   Ray, Doel ^a   Dutta, Suman ^a   Raha, Sanghamitra ^a  

^a SAHA INSTITUTE OF NUCLEAR PHYSICS   (India)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; HEAT SHOCK PROTEIN; HYDROGEN PEROXIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; RECOMBINANT PROTEIN; THREONINE; TYROSINE; PRIMER DNA;

ARTICLE; AUTOPHOSPHORYLATION; CELL SURVIVAL; CELLULAR STRESS RESPONSE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENTAMOEBA HISTOLYTICA; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME PURIFICATION; ENZYME SPECIFICITY; ESCHERICHIA COLI; GENE EXPRESSION PROFILING; IN VIVO STUDY; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE SURVIVAL; PARASITE VIABILITY; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; ENZYMOLOGY; IMMUNOPRECIPITATION; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING;

ENTAMOEBA HISTOLYTICA; MAMMALIA;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CELL SURVIVAL; DNA PRIMERS; ENTAMOEBA HISTOLYTICA; HYDROGEN PEROXIDE; IMMUNOPRECIPITATION; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 78149453391     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0013291     Document Type: Article

References (27)

1. Bardwell L (2006) Mechanisms of MAPK signalling specificity. Biochem Soc Trans 34: 837-841.
2. Junttila MR, Li SP, Westermarck J (2008) Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. Faseb J 22: 954-965.
3. Pimienta G, Pascual J (2007) Canonical and alternative MAPK signaling. Cell Cycle 6: 2628-2632.
4. Ellis JG, Davila M, Chakrabarti R (2003) Potential involvement of extracellular signal-regulated kinase 1 and 2 in encystation of a primitive eukaryote, Giardia lamblia. Stage-specific activation and intracellular localization. J Biol Chem 278: 1936-1945.
5. Rangarajan R, Bei AK, Jethwaney D, Maldonado P, Dorin D, et al. (2005) A mitogen-activated protein kinase regulates male gametogenesis and transmission of the malaria parasite Plasmodium berghei. EMBO Rep 6: 464-469.
6. Dorin-Semblat D, Quashie N, Halbert J, Sicard A, Doerig C, et al. (2007) Functional characterization of both MAP kinases of the human malaria parasite Plasmodium falciparum by reverse genetics. Mol Microbiol 65: 1170-1180.
7. Morales MA, Renaud O, Faigle W, Shorte SL, Spath GF (2007) Overexpression of Leishmania major MAP kinases reveals stage-specific induction of phosphotransferase activity. Int J Parasitol 37: 1187-1199.
8. Vicente JB, Ehrenkaufer GM, Saraiva LM, Teixeira M, Singh U (2009) Entamoeba histolytica modulates a complex repertoire of novel genes in response to oxidative and nitrosative stresses: implications for amebic pathogenesis. Cell Microbiol 11: 51-69.
9. Ray D, Dutta S, Banerjee S, Banerjee R, Raha S (2005) Identification, structure, and phylogenetic relationships of a mitogen-activated protein kinase homologue from the parasitic protist Entamoeba histolytica. Gene 346: 41-50.
10. Anamika K, Bhattacharya A, Srinivasan N (2008) Analysis of the protein kinome of Entamoeba histolytica. Proteins 71: 995-1006.
11. Diamond LS, Harlow DR, Cunnick CC (1978) A new medium for the axenic cultivation of Entamoeba histolytica and other Entamoeba. Trans R Soc Trop Med Hyg 72: 431-432.
12. Wilson K, Collart FR, Huberman E, Stringer JR, Ullman B (1991) Amplification and molecular cloning of the IMP dehydrogenase gene of Leishmania donovani. J Biol Chem 266: 1665-1671.
13. Erickson AK, Payne DM, Martino PA, Rossomando AJ, Shabanowitz J, et al. (1990) Identification by mass spectrometry of threonine 97 in bovine myelin basic protein as a specific phosphorylation site for mitogen-activated protein kinase. J Biol Chem 265: 19728-19735.
14. Ghosh AS, Dutta S, Raha S (2010) Hydrogen peroxide-induced apoptosis-like cell death in Entamoeba histolytica. Parasitol Int 59: 166-172.
15. Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, et al. (2005) Control of MAPK signalling: from complexity to what really matters. Oncogene 24: 5533-5542.
16. Markevich NI, Hoek JB, Kholodenko BN (2004) Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades. J Cell Biol 164: 353-359.
17. Lee JT, Jr., McCubrey JA (2002) The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia. Leukemia 16: 486-507.
18. Mishima K, Inoue K, Hayashi Y (2002) Overexpression of extracellular-signal regulated kinases on oral squamous cell carcinoma. Oral Oncol 38: 468-474.
19. Aikawa R, Komuro I, Yamazaki T, Zou Y, Kudoh S, et al. (1997) Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats. J Clin Invest 100: 1813-1821.
20. Chen W, Martindale JL, Holbrook NJ, Liu Y (1998) Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc. Mol Cell Biol 18: 5178-5188.
21. Ng DC, Bogoyevitch MA (2000) The mechanism of heat shock activation of ERK mitogen-activated protein kinases in the interleukin 3-dependent ProB cell line BaF3. J Biol Chem 275: 40856-40866.
22. Ward P, Equinet L, Packer J, Doerig C (2004) Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote. BMC Genomics 5: 79.
23. Lacey MR, Brumlik MJ, Yenni RE, Burow ME, Curiel TJ (2007) Toxoplasma gondii expresses two mitogen-activated protein kinase genes that represent distinct protozoan subfamilies. J Mol Evol 64: 4-14.
24. Coulombe P, Meloche S (2007) Atypical mitogen-activated protein kinases: structure, regulation and functions. Biochim Biophys Acta 1773: 1376-1387.
25. Klevernic IV, Stafford MJ, Morrice N, Peggie M, Morton S, et al. (2006) Characterization of the reversible phosphorylation and activation of ERK8. Biochem J 394: 365-373.
26. Klevernic IV, Martin NM, Cohen P (2009) Regulation of the activity and expression of ERK8 by DNA damage. FEBS Lett 583: 680-684.
27. Andreeva AV, Kutuzov MA (2008) Protozoan protein tyrosine phosphatases. Int J Parasitol 38: 1279-1295.