Brn2 is a transcription factor regulating keratinocyte differentiation with a possible role in the pathogenesis of lichen planus

PLoS ONE

Volumn 5, Issue 10, 2010, Pages

  Shi, Ge ^a,c   Sohn, Kyung Cheol ^a   Choi, Dae Kyoung ^a   Kim, Yu Jin ^a   Kim, Seong Jin ^b   Ou, Bai Sheng ^c   Piao, Yong Jun ^d   Lee, Young Ho ^a   Yoon, Tae Jin ^e   Lee, Young ^a   Seo, Young Joon ^a   Kim, Chang Deok ^a   Lee, Jeung Hoon ^a  

^a Chungnam National University   (South Korea)

^b Chonnam National University Medical School   (South Korea)

^c GUANGXI UNIVERSITY OF CHINESE MEDICINE   (China)

^d DALIAN MEDICAL UNIVERSITY   (China)

^e Gyeongsang National University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

FILAGGRIN; INVOLUCRIN; LORICRIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BRN2; UNCLASSIFIED DRUG; HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR BRN 2; TRANSCRIPTION FACTOR BRN-2; TRANSCRIPTION FACTOR POU;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; FEMALE; GROWTH INHIBITION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; LICHEN PLANUS; NONHUMAN; PATHOGENESIS; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; ANIMAL; CYTOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ADENOVIRIDAE; RATTUS;

ANIMALS; CELL DIFFERENTIATION; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; KERATINOCYTES; POU DOMAIN FACTORS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 78149441712     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0013216     Document Type: Article

References (44)

1. Kalinin AE, Kajava AV, Steinert PM (2002) Epithelial barrier function: assembly and structural features of the cornified cell envelope. Bioessays 24: 789-800.
2. Steinert PM, Marekov LN (1995) The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope. J Biol Chem 270: 17702-17711.
3. Eckert RL, Crish JF, Efimova T, Dashti SR, Deucher A, et al. (2004) Regulation of involucrin gene expression. J Invest Dermatol 123: 13-22.
4. Verrijzer CP, Van der Vliet PC (1993) POU domain transcription factors. Biochim Biophys Acta 1173: 1-21.
5. Wegner M, Drolet DW, Rosenfeld MG (1993) POU-domain proteins: structure and function of developmental regulators. Curr Opin Cell Biol 5: 488-498.
6. Ryan AK, Rosenfeld MG (1997) POU domain family values, flexibility, partnerships and developmental codes. Genes Dev 11: 1207-1225.
7. Fujii H, Hamada H (1993) A CNS-specific POU transcription factor, Brn-2, is required for establishing mammalian neural cell lineages. Neuron 11: 1197-1206.
8. Li P, He X, Gerrero MR, Mok M, Aggarwal A, et al. (1993) Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors. Genes Dev 7: 2483-2496.
9. Schonemann MD, Ryan AK, McEvilly RJ, O'Connell SM, Arias CA, et al. (1995) Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2. Genes Dev 9: 3122-3155.
10. Nakai S, Kawano H, Yudate T, Nishi M, Kuno J, et al. (1995) The POU domain trnscription factor Brn-2 is required for the determination of specific neuronal lineages in the hypothalamus of the mouse. Genes Dev 9: 3109-3121.
11. Eisen T, Easty DJ, Bennett DC, Goding CR (1995) The POU domain transcription factor Brn-2: elevated expression in malignant melanomaand regulation of melanocyte-specific gene expression. Oncogene 11: 2157-2164.
12. Sturm RA, O'Sullivan BJ, Thomson JA, Jamshidi N, Pedley J, et al. (1994) Expression studies of pigmentation and POU-domain genes in human melanoma cells. Pigment Cell Res 7: 235-240.
13. Cook AL, Donatien PD, Smith AG, Murphy M, Jones MK, et al. (2003) Human melanoblasts in culture: expression of BRN2 and synergistic regulation by fibroblast growth factor-2, stem cell factor, and endothelin-3. J Invest Dermatol 121: 1150-1159.
14. Cook AL, Sturm RA (2009) POU domain transcription factors: BRN2 as a regulator of melanocytic growth and tumourigenesis. Pigment Cell Melanoma Res 21: 611-626.
15. Goodall J, Martinozzi S, Dexter TJ, Champeval D, Carreira S, et al. (2004) Brn-2 expression controls melanoma proliferation and is directly regulated by bcatenin. Mol Cell Biol 24: 2915-2922.
16. Goodall J, Wellbrock C, Dexter TJ, Roberts K, Marais R, et al. (2004) The Brn-2 transcription factor links activated BRAF to melanoma proliferation. Mol Cell Biol 24: 2923-2931.
17. Seo EY, Namkung JH, Lee KM, Lee WH, Im M, et al. Analysis of calciuminducible genes in keratinocytes using suppression subtractive hybridization and cDNA microarray. Genomics 86: 528-538.
18. Matthews JB, Scully CM, Potts AJ (1984) Oral lichen planus: an immunoperoxidase study using monoclonal antibodies to lymphocyte subsets. Br J Dermatol 111: 587-595.
19. Kilpi AM (1987) Activation marker analysis of mononuclear cell infiltrates of oral lichen planus in situ. Scand J Dent Res 95: 174-180.
20. Kilpi AM (1988) Characterization of mononuclear cells of inflammatory infiltrates in oral tissues. A histochemical and immunohistochemical study of labial salivary glands in Sjögren's syndrome and of oral lesions in systemic lupus erythematosus and in lichen planus. Proc Finn Dent Soc 84: 5-93.
21. Jungell P, Konttinen YT, Nortamo P, Malmström M (1989) Immunoelectron microscopic study of distribution of T cell subsets in oral lichen planus. Scand J Dent Res 97: 361-367.
22. Welter JF, Gali H, Crish J, Eckert RL (1996) Regulation of human involucrin promoter activity by POU domain protein. J Biol Chem 271: 14727-14733.
23. Delhase M, Castrillo JL, de la Hoya M, Rajas F, Hooghe-Peters EL (1996) AP-1 and Oct-1 transcription factors down-regulate the expression of the human PIT1/GHF1 gene. J Biol Chem 271: 32349-32358.
24. Jang SI, Karaman-Jurukovska N, Morasso MI, Steinert PM, Markova NG (2000) Complex interactions between epidermal POU domain and activator protein 1 transcription factors regulate the expression of the profilaggrin gene in normal human epidermal keratinocytes. J Biol Chem 275: 15295-15304.
25. Wakabayashi N, Itoh K, Wakabayashi J, Motohashi H, Noda S, et al. (2003) Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet 35: 238-245.
26. Hohl D (1993) Expression patterns of loricrin in dermatological disorders. Am J Dermatopathol 15: 20-27.
27. Eisenberg E, Murphy GF, Krutchkoff DJ (1987) Involucrin as a diagnostic marker in oral lichenoid lesions. Oral surg oral Med Pathol 64: 313-319.
28. Ichikawa E, Watanabe S, Takahashi H (1997) Keratin and involucrin expression in discoid lupus erythematosus and lichen planus. Arch Dermatol Res 289: 519-526.
29. Lee JJ, Kuo MY, Cheng SJ, Chiang CP, Jeng JH, et al. (2005) Higher expressions of p53 and proliferating cell nuclear antigen (PCNA) in atrophic oral lichen planus and patients with areca quid chewing. Oral surg Oral pathol Oral Radiol Endod 99: 471-478.
30. Kikuchi A, Amagai M, Nishikawa T (1992) Association of ras p21 with differentiation of epidermal keratinocytes in proliferating skin diseases. J Deramatol Sci 4: 83-86.
31. Medenica M, Lorincz A (1977) Lichen planus: an ultrastructural study. Acta Derm Venereol 57: 55-62.
32. Hashimoto K (1976) Apoptosis in lichen planus and several other dermatoses. Acta Dermatol Venereol 56: 187-210.
33. Weedon D (1980) Apoptosis in lichen planus. Clin Exp Dermatol 5: 425-430.
34. Dekker NP, Lozada-Nur F, Lagenaur LA, MacPhail LA, Bloom CY, et al. (1997) Apoptosis-associated markers in oral lichen planus. J Oral Pathol Med 26: 170-175.
35. Shimizu M, Higaki M, Kawashima M (1997) The role of granzyme B-expressing CD8-positive T cells in apoptosis of keratinocytes in lichen planus. Arch Dermatol Res 289: 527-532.
36. Bloor BK, Malik FK, Odell EW, Morgan PR (1999) Quantitative assessment of apoptosis in oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 88: 187-195.
37. Neppelberg E, Johannessen AC, Jonsson R (2001) Apoptosis in oral lichen planus. Eur J Oral Sci 109: 361-364.
38. De Boer OJ, van der Loos CM, Teeling P, van der Wal AC, Teunissen MB (2007) Immunohistochemical analysis of regulatory T cell markers FOXP3 and GITR on CD4 + CD25 + T cells in normal skin and inflammatory dermatoses. J Histochem Cytochem 55: 891-898.
39. Ishii T (1987) Immunohistochemical demonstration of T cell subsets and accessory cells in oral lichen planus. J Oral Pathol 16: 356-361.
40. Yoon HK, Sohn KC, Lee JS, Kim YJ, Bhak J, et al. (2008) Prediction and evaluation of protein-protein interaction in keratinocyte differentiation. Biochem Biophys Res Commun 377: 662-667.
41. Sohn KC, Shi G, Jang S, Choi DK, Lee Y, et al. (2009) Pitx2, a beta-cateninregulated transcription factor, regulates the differentiation of outer root sheath cells cultured in vitro. J Dermatol Sci 54: 6-11.
42. Tollefson AE, Kuppuswamy M, Shashkova EV, Doronin K, Wold WS (2007) Preparation and titration of CsCl-banded adenovirus stocks. Methods Mol Med 130: 223-235.
43. Fajas L, Landsberg RL, Huss-Garcia Y, Sardet C, Lees JA, et al. (2002) E2Fs regulate adipocyte differentiation. Dev Cell 3: 39-49.
44. Piao YJ, Lee CH, Zhu MJ, Kye KC, Kim JM, et al. (2005) Involvement of urokinase-type plasminogen activator in sphingosylphosphorylcholine-induced angiogenesis. Exp Dermatol 14: 356-362.