Human Melanoblasts in Culture: Expression of BRN2 and Synergistic Regulation by Fibroblast Growth Factor-2, Stem Cell Factor, and Endothelin-3

Journal of Investigative Dermatology

Volumn 121, Issue 5, 2003, Pages 1150-1159

  Cook, Anthony L ^a,b   Donatien, Philippe D ^d,e,f   Smith, Aaron G ^a   Murphy, Mark ^g   Jones, Malcolm K ^c   Herlyn, Meenhard ^f   Bennett, Dorothy C ^d   Leonard, J Helen ^b   Sturm, Richard A ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b Queensland Radium Institute   (Australia)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^f WISTAR INSTITUTE   (United States)

^g UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Melanocyte; Melanoma; POU; Tyrosinase

Indexed keywords

BIOLOGICAL MARKER; CHOLERA TOXIN; ENDOTHELIN 3; FIBROBLAST GROWTH FACTOR 2; LEVODOPA; STEM CELL FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BRN 2; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL ULTRASTRUCTURE; CONTROLLED STUDY; CULTURE MEDIUM; HUMAN; HUMAN TISSUE; MELANOCYTE; NEWBORN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SKIN CULTURE; STEM CELL;

EID: 0242490087     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2003.12562.x     Document Type: Article

References (77)

1. Adema GJ, de Boer AJ, Vogel AM, Loenen WA, Figdor CG: Molecular characterization of the melanocyte lineage-specific antigen gp100. J Biol Chem 269: 20126-20133, 1994
2. Arita Y, Santiago-Schwarz F, Coppock DL.: Survival mechanisms induced by: 12-O-tetradecanoylphorbol-13-acetate in normal human melanocytes include inhibition of apoptosis and increased Bcl-2 expression. Melanoma Res 10:412-420, 2000
3. Atanasoski S, Schreiber E, Fontana A, Herr W: N-Oct 5 is generated by in vitro proteolysis of the neural POU-domain protein N-Oct 3. Oncogene 14: 1287-1294, 1997
4. Baumruker T, Sturm R, Herr W: OBP100 binds remarkably degenerate octamer motifs through specific interactions with flanking sequences. Genes Dev 2: 1400-1413, 1988
5. Bendall AJ, Sturm RA, Danoy PA, Molloy PL: Broad binding-site specificity and affinity properties of octamer 1 and brain octamer-binding proteins. Eur J Biochem 217:799-811, 1993
6. Berking C, Takemoto R, Satyamoorthy K, Elenitsas R, Herlyn M: Basic fibroblast growth factor and ultraviolet B transform melanocytes in human skin. Am J Pathol 158:943-953, 2001
7. Berson JF, Harper DC, Tenza D, Raposo G, Marks MS: Pmel17 initiates preniclanosome morphogenesis within multivesicular bodies. Mol Biol Cell 12:3451-3464, 2001
8. Bohm M, Moellmann G, Cheng E, Alvarez-Franco M, Wagner S, Sassone-Corsi P, Halaban R: Identification of p90RSK as the probable CREB-Scr133 kinase in human melanocytcs. Cell Growth Differ 6:291-302, 1995
9. Chakraborty AK, Platt JT, Kim KK, Kwon BS, Bennett DC, Pawelek JM: Polymerization of 5,6-dihydroxyindole-2-carboxylic acid to melanin by the pmel 17/ silver locus protein. Eur J Biochem 236:180-188, 1996
10. Collarini EJ, Kuhn R, Marshall CJ, Monuki ES, Lemke G, Richardson WD: Down-regulation of the POU transcription factor SCIP is an early event in oligodendrocyte differentiation in vitro. Development 116:193-200, 1992
11. Cook AL, Pollock PM, Welch J, et al: CDKN2A is not the principal target of deletions on the short arm of chromosome 9 in neuroendocrine (Merkel cell) carcinoma of the skin. Int J Cancer 93:361-367, 2001
12. Cox PM, Temperley SM, Kumar H, Goding CR: A distinct octamer-binding protein present in malignant melanoma cells. Nucleic Acids Res 16:11047-11056, 1988
13. Dailey L, Basilico C: Coevolution ot HMG domains and homeodomains and the generation of transcriptional regulation by Sox/POU complexes. J Cell Physiol 186:315-328, 2001
14. De Maziere AM, Muehlethaler K, Van Donselaar E, et al: The melanocytic protein melan-A/MART-1 has a subcellular localization distinct from typical melanosomal proteins. Traffic 3:678-693, 2002
15. Dupin E, Glavieux C, Vaigot P, Le Douarin NM: Endothelin 3 induces the reversion of melanocytes to glia through a neural crest-derived glial-melanocytic progenitor. Prof Natl Acad Sci USA 97:7882-7887, 2000
16. Dupin E, Real C, Glavieux-Pardanaud C, Vaigot P. Le Douarin NM: Reversal of developmental restrictions in neural crest lineages: Transition from Schwann cells to glial-melanocytic precursors in vitro. Proc Natl Acad Sci USA 100:5229-5233, 2003
17. Eisen T, Easty DJ, Bennett DC, Goding CR: The POU domain transcription factor Brn-2. elevated expression in malignant melanoma and regulation of melanocyte-specific gene expression. Oncogene 11:2157-2164, 1995
18. Fujii H, Hamada H: A CNS-specific POU transcription factor, Brn-2, is required for establishing mammalian neural cell lineages. Neuron 11:1197-1206,1993
19. Goding CR: Mitf from neural crest to melanoma. Signal transduction and transcription in the melanocyte lineage. Genes Dev 14:1712-1728, 2000
20. Halaban R: The regulation of normal melanocyte proliferation. Pigment Cell Res 13: 4-14, 2000
21. Halaban R, Langdon R, Birchall N, et al: Basic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes. J Cell Biol 107:1611-1619, 1988a
22. Halaban R, Langdon R, Birchall N, et al: Paracrine stimulation of melanocytes by keratinocytes through basic fibroblast growth factor. Ann N Y Acad Sci 548:180-190, 1988b
23. Hartschuh W, Weihe E, Egner U: Chromogranin A in the mammalian Merkel cell. Cellular and subcellular distribution. J Invest Dermatol 93:641-648, 1989
24. Hemesath TJ, Price ER, Takemoto C, Badalian T, Fisher DE: MAP kinase links the transcription factor microphthalmia to c-Kit signalling in melanocytes. Nature 391:298-301, 1998
25. Herlyn M, Berking C, Li G, Satyamoorthy K: Lessons from melanocyte development for understanding the biological events in naevus and melanoma formation. Melanoma Res 10:303-312, 2000
26. Hirobe T: Basic fibroblast growth factor stimulates the sustained proliferation of mouse epidermal melanoblasts in a serum-free medium in the presence of dibutyryl cyclic AMP and keratinocytes. Development 114:435-445, 1992
27. Holbrook KA, Underwood RA, Vogel AM, Gown AM, Kimball H: The appearance, density and distribution of melanocytes in human embryonic and fetal skin revealed by the anti-melanoma monoclonal antibody. HMB-45. Anat Embryol 180:443-455, 1989
28. Imokawa G, Kobayasi T, Miyagishi M: Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes: Cross-talk via trans-activation of the tyrosine kinase c-kit receptor. J Biol Chem 275:33321-33328, 2000
29. Jaegle M, Mandemakers W, Broos L, et al: The POU factor Oct-6 and Schwann cell differentiation. Science 273:507-510, 1996
30. Jessen KR, Mirsky R: Origin and early development of Schwann cells. Microsc Res Tech 41:393-402, 1998
31. Jimbow K, Quevedo WC Jr, Prota G, Fitzpatrick TB: Biology of melanocytes. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, Fitzpatrick TB (eds). Fitzpatricks Dermatology in General Medicine. New York: McGraw-Hill Health Professions Division, 1999
32. Jordan SA, Jackson IJ: MGF (KIT ligand) is a chemokinetic factor for melanoblast migration into hair follicles. Dev Biol 225:424-436, 2000
33. Kawa Y, Ito M, Ono H, et al: Stem cell factor and/or endothelin-3 dependent immortal melanoblast and melanocyte populations derived from mouse neural crest cells. Pigment Cell Res 13:73-80, 2000
34. Kawakami Y, Eliyahu S, Delgado CH, et al: Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection. Proc Natl Acad Sci USA 91:6458-6462, 1994
35. Kwon BS, Chintamaneni C, Kozak CA, et al: A melanocyte-specific gene, Pmel 17, maps near the silver coat color locus on mouse chromosome 10 and is in a syntenic region on human chromosome 12. Proc Natl Acad Sci USA 88: 9228-9232, 1991
36. Kwon BS, Halaban R, Ponnazhagan S, Kim K, Chintamaneni C, Bennett D, Pickard RT: Mouse silver mutation is caused by a single base insertion in the putative cytoplasmic domain of Pmel 17. Nucleic Acids Res 23:154-158, 1995
37. Lahav R, Dupin E, Lecoin L, Glavieux C, Champeval D, Ziller C, Le Douarin NM: Endothelin 3 selectively promotes survival and proliferation of neural crest-derived glial and melanocytic precursors in vitro. Proc Natl Acad Sci USA 95:14214-14219, 1998
38. Lahav R, Ziller C, Dupin E, Le Douarin NM: Endothelin 3 promotes neural crest cell proliferation and mediates a vast increase in melanocyte number in culture. Proc Natl Acad Sci USA 93:3892-3897, 1996
39. Le Douarin N, Kalcheim C: The Neural Crest, (2nd ed). Cambridge/New York: Cambridge University Press, 1999
40. Lee ZH, Hou L, Moellmann G, et al: Characterization and subcellular localization of human Pmel 17/silver, a 110-kDa (pre) melanosomal membrane protein associated with 5,6,-dihydroxyindole-2-carboxylic acid (DHICA) converting activity J Invest Dermatol 106:605-610, 1996
41. Leonard JH, Cook AL, Van Gele M, Boyle GM, Inglis KJ, Speleman F, Sturm RA: Proneural and proneuroendocrinc transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma. Int J Cancer 101: 103-110, 2002
42. Marks MS, Scabra MC: The melanosome: Membrane dynamics in black and white. Nat Rev Mol Cell Biol 2:738-748, 2001
43. McEwan M, Parsons PG, Moss DJ: Monoclonal antibody against human tyrosinase and reactive with melanotic and amelanotic melanoma cells. J Invest Dermatol 90:515-519, 1988
44. Moellmann G, Halaban R: Growth-factors and signal transduction regulating the proliferation and differentiation of melanocytes. In: Norlund J, Boissy R, Hearing V, King R, Ortonne JP (eds). The Pigmentary System Physiology and Pathophysiology. New York: Oxford University Press, 1998; p 135-149
45. Monk M, Holding C: Human embryonic genes re-expressed in cancer cells. Oncogene 20:8085-8091, 2001
46. Murphy M, Bernard O, Reid K, Bartlett PF: Cell lines derived from mouse neural crest are representative of cells at various stages of differentiation. J Neurobiol 22:522-535, 1991
47. Nesbit M, Nesbit HK, Bennett J, et al: Basic fibroblast growth factor induces a transformed phenotype in normal human melanocytes. Oncogene 18:6469-6476, 1999
48. Nishimura EK, Jordan SA, Oshima H, et al: Dominant role of the niche in melanocyte stem-cell fate determination. Nature 416:854-860, 2002
49. Niwa H, Miyazaki J, Smith AG: Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 24:372-376, 2000
50. Pavan WJ, Tilghman SM: Piebald lethal (sl) acts early to disrupt the development of neural crest-derived melanocytes. Proc Natl Acad Sci USA 91:7159-7163, 1994
51. Price ER, Ding HF, Badalian T, et al: Lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmia. J Biol Chem 273: 17983-17986, 1998
52. Pruss RM, Mirsky R, Raff MC, Thorpe R, Dowding AJ, Anderton BH: All classes of intermediate filaments share a common antigenic determinant defined by a monoclonal antibody. Cell 27:419-428, 1981
53. Reedy MV, Parichy DM, Erickson CA, Mason KA, Frost-Mason SK: Regulation of melanoblast migration and differentiation. In: Norlund J, Boissy R, Hearing V, King R, Ortonne JP (eds). The Pigmentary System Physiology and Pathophysiology. New York: Oxford University Press, 1998; p 75-95
54. Reid K, Nishikawa S, Bartlett PF, Murphy M: Steel factor directs melanocyte development in vitro through selective regulation of the number of c-kit + progenitors. Dev Biol 169:568-579, 1995
55. Reid K, Turnley AM, Maxwell GD, KuriharaY, Kurihara H, Bartlett PF, Murphy M: Multiple roles for endothelin in melanocyte development. Regulation of progenitor number and stimulation of differentiation. Development 122:3911-3919, 1996
56. Reubinoff BE, Pera MF, Fong CY, Trounson A, Bongso A: Embryonic stem cell lines from human blastocysts: Somatic differentiation in vitro. Nat Biotechnol 18:399-404, 2000
57. Rhee JM, Gruber CA, Brodie TB, Trieu M, Turner EE: Highly cooperative homodimerization is a conserved property of neural POU proteins. J Biol Chem 273:34196-34205, 1998
58. Ryan AK, Rosenfeld MG: POU domain family values: Flexibility, partnerships, and developmental codes. Genes Dev 11:1207-1225, 1997
59. Schreiber E, Himmelmann A, Malipiero U, Tobler A, Stahel R, Fontana A: Human small cell lung cancer expresses the octamer DNA-binding and nervous system-specific transcription factor N-Oct 3 (brain-2). Cancer Res 52:6121-6124, 1992
60. Schreiber E, Merchant RE, Wiestler OD, Fontana A: Primary brain tumors differ in their expression of octamer deoxyribonucleic acid-binding transcription factors from long-term cultured glioma cell lines. Neurosurgery 34:129-135, 1994
61. Scott G, Ewing J, Ryan D, Abboud C: Stem cell factor regulates human melanocyte-matrix interactions. Pigment Cell Res 7:44-51, 1994
62. Seiberg M: Keratinocyte-melanocyte interactions during melanosome transfer. Pigment Cell Res 14:236-242, 2001
63. Sim F, Zhao C, Li W, Lakatos A, Franklin R: Expression of the POU-domain transcription factors SCIP/Oct-6 and Brn-2 is associated with Schwann Cell but not oligodendrocyte remyelination of the CNS. Mol Cell Neurosci 20:669-682, 2002
64. Smit DJ, Smith AG, Parsons PG, Muscat GE, Sturm RA: Domains of Brn-2 that mediate homodimerization and interaction with general and melanocytic transcription factors. Eur J Biochem 267:6413-6422, 2000
65. Smith AG, Box NF, Marks LH, et al: The human melanocortin-1 receptor locus: Analysis of transcription unit, locus polymorphism and haplotype evolution. Gene 281:81-94, 2001
66. Smith AG, Brightwell G, Smit SE, Parsons PG, Sturm RA: Redox regulation of Brn-2/N-Oct-3 POU domain DNA binding activity and proteolytic formation of N-Oct-5 during melanoma cell nuclear extraction. Melanoma Res 8: 2-10, 1998
67. Steel KP, Davidson DR, Jackson IJ: TRP-2/DT, a new early melanoblast marker, shows that steel growth factor (c-kit ligand) is a survival factor. Development 115:1111-1119, 1992
68. Sturm RA, Bisshop F, Takahashi H, Parsons PG: A melanoma octamer binding protein is responsive to differentiating agents. Cell Growth Differ 2:519-524, 1991
69. Sturm RA, Das G, Herr W: The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain. Genes Dev 2:1582-1599, 1988
70. Sviderskaya EV Easty DJ, Bennett DC: Impaired growth and differentiation of diploid but not immortal melanoblasts from endothelin receptor B mutant (piebald) mice. Dev Dyn 213:452-463, 1998
71. Sviderskaya EV, Hill SP, Balachandar D, Barsh GS, Bennett DC: Agouti signaling protein and other factors modulating differentiation and proliferation of immortal melanoblasts. Dev Dyn 221:373-379, 2001
72. Sviderskaya EV, Wakeling WF, Bennett DC: A cloned, immortal line of marine melanoblasts inducible to differentiate to melanocytes, Development. 121:1547-1557, 1995
73. Takahashi H, Parsons PG: In vitro phenotypic alteration of human melanoma cells induced by differentiating agents: Heterogeneous effects on cellular growth and morphology, enzymatic activity, and antigenic expression. Pigment Cell Res 3:223-232, 1990
74. Thomson JA, Leonard JH, McGregor K, Sturm RA, Parsons PG: A nonconsensus octamer-recognition sequence (TAATGARAT-motif) identifies a novel DNA binding protein in human Merkel cell carcinoma cell lines. Int J Cancer 58:285-290, 1994
75. Thomson JA, Murphy K, Baker E, Sutherland GR, Parsons PG, Sturm RA: The brn-2 gene regulates the melanocytic phenotype and tumorigenic potential of human melanoma cells. Oncogene 11:691-700, 1995
76. Thomson JA, Parsons PG, Sturm RA: In vivo and in vitro expression of octamer binding proteins in human melanoma metastases, brain tissue, and fibroblasts. Pigment Cell Res 6:13-22, 1993
77. Wehrle-Haller B, Weston JA: Soluble and cell-bound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathway. Development 121:731-742, 1995