Analysis of the inflammatory response in HY-TCR transgenic mice highlights the pathogenic potential of CD4-CD8- T cells

Autoimmunity

Volumn 43, Issue 8, 2010, Pages 672-681

  Maione, Francesco ^a,b   Paschalidis, Nikolaos ^a   Iqbal, Asif Jilani ^a   Crompton, Tessa ^c   Perretti, Mauro ^a   D'Acquisto, Fulvio ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

double negative T cells; DTH; HY TCR; inflammation; positive and negative selection

Indexed keywords

CARRAGEENAN; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; HY ANTIGEN; T LYMPHOCYTE RECEPTOR; ZYMOSAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL EXPANSION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DELAYED HYPERSENSITIVITY; FEMALE; IN VIVO STUDY; INFLAMMATION; LYMPHOCYTE FUNCTION; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PAW EDEMA; PERITONITIS; SEX RATIO; T LYMPHOCYTE; TRANSGENE;

ANIMALS; AUTOIMMUNITY; CARRAGEENAN; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; H-Y ANTIGEN; HISTOCYTOCHEMISTRY; HYPERSENSITIVITY, DELAYED; IMMUNOPHENOTYPING; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SEX FACTORS; T-LYMPHOCYTES; ZYMOSAN;

EID: 78149429743     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.3109/08916931003678296     Document Type: Article

References (41)

1. Starr TK, Jameson SC, Hogquist KA. Positive and negative selection of T cells. Annu Rev Immunol 2003;21:139-176.
2. von Boehmer H, Aifantis I, Gounari F, Azogui O, Haughn L, Apostolou I, Jaeckel E, Grassi F, Klein L. Thymic selection revisited: How essential is it? Immunol Rev 2003;191:62-78.
3. von Boehmer H, Kisielow P. Negative selection of the T-cell repertoire: Where and when does it occur? Immunol Rev 2006; 209:284-289.
4. Egawa T, Kreslavsky T, Littman DR, von Boehmer H. Lineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping. PLoS One 2008;3(1):e1512.
5. von Boehmer H, Kirberg J, Rocha B. An unusual lineage of alpha/beta T cells that contains autoreactive cells. J Exp Med 1991;174(5):1001-1008.
6. Kisielow P, Bluthmann H, Staerz UD, Steinmetz M, von Boehmer H. Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature 1988;333(6175):742-746.
7. Rocha B, von Boehmer H, Guy-Grand D. Selection of intraepithelial lymphocytes with CD8 alpha/alpha co-receptors by self-antigen in the murine gut. Proc Natl Acad Sci USA 1992;89(12):5336-5340.
8. Teh HS, Kisielow P, Scott B, Kishi H, Uematsu Y, Bluthmann H, von Boehmer H. Thymic major histocompat-ibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells. Nature 1988; 335(6187):229-233.
9. Bruno L, Fehling HJ, von Boehmer H. The alpha beta T cell receptor can replace the gamma delta receptor in the development of gamma delta lineage cells. Immunity 1996; 5(4):343-352.
10. Buch T, Rieux-Laucat F, Forster I, Rajewsky K. Failure of HY-specific thymocytes to escape negative selection by receptor editing. Immunity 2002;16(5):707-718.
11. Yamagata T, Benoist C, Mathis D. A shared gene-expression signature in innate-like lymphocytes. Immunol Rev 2006;210: 52-66.
12. Yamagata T, Mathis D, Benoist C. Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells. Nat Immunol 2004;5(6):597-605.
13. Teh HS, Kishi H, Scott B, Von Boehmer H. Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules. J Exp Med 1989;169(3):795-806.
14. Ianaro A, O'Donnell CA, Di Rosa M, Liew FY. A nitric oxide synthase inhibitor reduces inflammation, down-regulates inflammatory cytokines and enhances interleukin-10 pro-duction in carrageenin-induced oedema in mice. Immunology 1994;82(3):370-375.
15. Ianaro A, Xu D, O'Donnell CA, Di Rosa M, Liew FY. Expression of TGF-beta in attenuated Salmonella typhimurium: Oral administration leads to the reduction of inflammation, IL-2 and IFN-gamma, but enhancement of IL-10, in carrageenin-induced oedema in mice. Immunology 1995; 84(1):8-15.
16. Maione F, Paschalidis N, Mascolo N, Dufton N, Perretti M, D'Acquisto F. Interleukin 17 sustains rather than induces inflammation. Biochem Pharmacol 2009;77(5):878-887.
17. Chatterjee BE, Yona S, Rosignoli G, Young RE, Nourshargh S, Flower RJ, Perretti M. Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro. J Leukoc Biol 2005;78(3):639-646.
18. Damazo AS, Yona S, Flower RJ, Perretti M, Oliani SM. Spatial and temporal profiles for anti-inflammatory gene expression in leukocytes during a resolving model of peritonitis. J Immunol 2006;176(7):4410-4418.
19. D'Acquisto F, Paschalidis N, Sampaio AL, Merghani A, Flower RJ, Perretti M. Impaired T cell activation and increased Th2 lineage commitment in Annexin-1-deficient T cells. Eur J Immunol 2007;37(11):3131-3142.
20. Posadas I, Bucci M, Roviezzo F, Rossi A, Parente L, Sautebin L, Cirino G. Carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression. Br J Pharmacol 2004;142(2):331-338.
21. Medzhitov R. Origin and physiological roles ofinflammation. Nature 2008;454(7203):428-435.
22. Takada H, Hiromatsu K, Matsuzaki G, Muramori K, Nomoto K. Peritoneal gamma delta T cells induced by Escherichia coli infection in mice. Correlation between Thy-1 phenotype and host minor lymphocyte-stimulating phenotype. JImmunol 1993;151(4):2062-2069.
23. Rajakariar R, Lawrence T, Bystrom J, Hilliard M, Colville-Nash P, Bellingan G, Fitzgerald D, Yaqoob MM, Gilroy DW. Novel biphasic role for lymphocytes revealed during resolving inflammation. Blood 2008;111(8):4184-4192.
24. Gilroy DW, Colville-Nash PR, McMaster S, Sawatzky DA, Willoughby DA, Lawrence T Inducible cyclooxygenase-derived 15-deoxy(Delta)12-14PGJ2 brings about acute inflammatory resolution in rat pleurisy by inducing neutrophil and macrophage apoptosis. FASEB J 2003;17(15): 2269-2271.
25. Kim KD, Zhao J, Auh S, Yang X, Du P, Tang H, Fu YX. Adaptive immune cells temper initial innate responses. Nat Med 2007;13(10):1248-1252.
26. Matuszyk J. Use of anti-H-Y/Db transgenic mice in studies on T-lymphocyte development and mechanisms of leukemogen-esis. Postepy Hig Med Dosw 1995;49(1):61-65.
27. Simpson E, Scott D, Chandler P. The male-specific histocompatibility antigen, H-Y: A history of transplantation, immune response genes, sex determination and expression cloning. Annu Rev Immunol 1997;15:39-61.
28. Eberl G, Littman DR. Thymic origin ofintestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells. Science 2004;305(5681):248-251.
29. He D, Wu L, Kim HK, Li H, Elmets CA, Xu H. IL-17 and IFN-gamma mediate the elicitation ofcontact hypersensitivity responses by different mechanisms and both are required for optimal responses. J Immunol 2009;183(2):1463-1470.
30. Crispin JC, Oukka M, Bayliss G, Cohen RA, Van Beek CA, Stillman IE, Kyttaris VC, Juang YT, Tsokos GC. Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J Immunol 2008;181(12):8761-8766.
31. Crispin JC, Tsokos GC. Human TCR-alphabeta+ CD4\CD8\T cells can derive from CD8 + T cells and display an inflammatory effector phenotype. J Immunol 2009;183(7): 4675-4681.
32. Di Rosa M, Willoughby DA. Screens for anti-inflammatory drugs. J Pharm Pharmacol 1971;23(4):297-298.
33. Di Rosa M, Giroud JP, Willoughby DA. Studies on the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. J Pathol 1971; 104(1):15-29.
34. Black CA. Delayed type hypersensitivity: Current theories with an historic perspective. Dermatol Online J 1999;5(1):7.
35. Bannenberg G, Moussignac RL, Gronert K, Devchand PR, Schmidt BA, Guilford WJ, Bauman JG, Subramanyam B, Perez HD, Parkinson JF, Serhan CN. Lipoxins and novel 15-epi-lipoxin analogs display potent anti-inflammatory actions after oral administration. Br J Pharmacol 2004; 143(1):43-52.
36. Rajakariar R, Hilliard M, Lawrence T, Trivedi S, Colville-Nash P, Bellingan G, Fitzgerald D, Yaqoob MM, Gilroy DW. Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyDelta12 14 PGJ2. Proc Natl Acad Sci USA 2007; 104(52):20979-20984.
37. Sneller MC, Straus SE, Jaffe ES, Jaffe JS, Fleisher TA, Stetler-Stevenson M, Strober W A novel lymphoproliferative/autoimmune syndrome resembling murine lpr/gld disease. J Clin Invest 1992;90(2):334-341.
38. Masuda T, Ohteki T, Abo T, Seki S, Nose S, Nagura H, Kumagai K. Expansion of the population of double negative CD4\8\Talpha beta-cells in the liver is a common feature of autoimmune mice. J Immunol 1991;147(9):2907-2912.
39. Sainis K, Datta SK. CD4+ T cell lines with selective patterns of autoreactivity as well as CD4\CD8\T helper cell lines augment the production of idiotypes shared by pathogenic anti-DNAautoantibodies in theNZB × SWRmodelof lupus nephritis. J Immunol 1988;140(7):2215-2224.
40. Riol-Blanco L, Lazarevic V, Awasthi A, Mitsdoerffer M, Wilson BS, Croxford A, Waisman A, Kuchroo VK, Glimcher LH, Oukka M. IL-23 receptor regulates unconven-tional IL-17-producing T cells that control bacterial infec-tions. J Immunol 2010;184(4):1710-1720.
41. Oreshkova T, Wang H, Seier AM, Sindrilaru A, Varga G, Grabbe S, Scharffetter-Kochanek K, Peters T. Beta(2) integrin deficiency yields unconventional double-negative T cells distinct from mature classical natural killer T cells in mice. Immunology 2009;128(2):271-286.