Evaluation of a screening method by liquid chromatography-tandem mass spectrometry for estimating effect of drugs on the activation and β-oxidation of fatty acids in mitochondria

Journal of Pharmacy and Pharmacology

Volumn 62, Issue 12, 2010, Pages 1697-1703

  Kasuya, Fumiyo ^a   Nishizawa, Ryota ^a   Masuyama, Teiichi ^a   Kazumi, Maya ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

oxidation; Acyl coenzyme A esters; Fatty acid metabolism; Inhibition; Mitochondria

Indexed keywords

ACYL COENZYME A; DICLOFENAC; FATTY ACID; LONG CHAIN FATTY ACID COENZYME A LIGASE; OCTANOIC ACID; PALMITIC ACID; PARACETAMOL; SALICYLIC ACID; VALPROIC ACID;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYMATIC ASSAY; ENZYME ACTIVITY; EVALUATION; FATTY ACID METABOLISM; FATTY ACID OXIDATION; LIQUID CHROMATOGRAPHY; LIVER MITOCHONDRION; MALE; MOUSE; NONHUMAN; PREDICTION; SCREENING TEST; TANDEM MASS SPECTROMETRY;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-INFECTIVE AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHROMATOGRAPHY, LIQUID; COENZYME A LIGASES; DICLOFENAC; ENZYME INHIBITORS; FATTY ACIDS; LIPID METABOLISM; MALE; MICE; MICE, MUTANT STRAINS; MITOCHONDRIA, LIVER; OXIDATION-REDUCTION; SALICYLIC ACID; TANDEM MASS SPECTROMETRY; VALPROIC ACID;

EID: 78149404318     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2010.01136.x     Document Type: Article

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