메뉴 건너뛰기




Volumn 42, Issue 6, 2010, Pages 384-387

Effect of l-ornithine l-aspartate against thioacetamide-induced hepatic damage in rats

Author keywords

Hepatopathy; ornithine aspartate; oxidative stress; thioacetamide

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; GLUTATHIONE; ORNITHINE ASPARTATE; THIOACETAMIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

EID: 78149387568     PISSN: 02537613     EISSN: 19983751     Source Type: Journal    
DOI: 10.4103/0253-7613.71926     Document Type: Article
Times cited : (30)

References (30)
  • 1
    • 0031454592 scopus 로고    scopus 로고
    • Effect of ornithine aspartate infusion on elevated serum ammonia concentration in cirrhotic patients- results of randomized placebo-controlled double blind multicentre trial
    • Feher J, Lang I, Gogl A, Varga L, Tampos G, Pronia L. Effect of ornithine aspartate infusion on elevated serum ammonia concentration in cirrhotic patients- results of randomized placebo-controlled double blind multicentre trial. Med Sci Monit 1997;3:669-73.
    • (1997) Med Sci Monit , vol.3 , pp. 669-673
    • Feher, J.1    Lang, I.2    Gogl, A.3    Varga, L.4    Tampos, G.5    Pronia, L.6
  • 2
    • 0031852152 scopus 로고    scopus 로고
    • L-ornithine- L-aspartate in experimental portal systemic encephalopathy: Therapeutic efficacy and mechanism of action
    • Rose C, Michalak A, Pannunzio P, Therein G, Quack G, Kircheis G. L-ornithine- L-aspartate in experimental portal systemic encephalopathy: Therapeutic efficacy and mechanism of action. Metab Brain Dis 1998;13:147-57.
    • (1998) Metab Brain Dis , vol.13 , pp. 147-157
    • Rose, C.1    Michalak, A.2    Pannunzio, P.3    Therein, G.4    Quack, G.5    Kircheis, G.6
  • 3
    • 0007505162 scopus 로고
    • Hepatic encephalopathy
    • Butterworth RF. Hepatic encephalopathy. Neurologist 1995;1:95-104.
    • (1995) Neurologist , vol.1 , pp. 95-104
    • Butterworth, R.F.1
  • 4
    • 0038702293 scopus 로고    scopus 로고
    • The molecular pathogenesis of hepatic encephalopathy
    • Jalan R, Shawcross D, Daveis N. The molecular pathogenesis of hepatic encephalopathy, Int J Biochem Cell Biol 2003;35:1175-81.
    • (2003) Int J Biochem Cell Biol , vol.35 , pp. 1175-1181
    • Jalan, R.1    Shawcross, D.2    Daveis, N.3
  • 5
    • 0025361955 scopus 로고
    • Nitrogen metabolism and ornithine cycle function
    • Meijer AJ, Lamers WH, Chamuleau RA. Nitrogen metabolism and ornithine cycle function, Physiol Rev 1990;70:701-48.
    • (1990) Physiol Rev , vol.70 , pp. 701-748
    • Meijer, A.J.1    Lamers, W.H.2    Chamuleau, R.A.3
  • 8
    • 0030803169 scopus 로고    scopus 로고
    • Treatment of cirrhotic rats with L-ornithine-L-aspartate enhances urea synthesis and lowers serum ammonia levels
    • Gebhardt R, Beckers G, Guanitz F, Haupt W, Jonitza D, Klein S. Treatment of cirrhotic rats with L-ornithine-L-aspartate enhances urea synthesis and lowers serum ammonia levels. J Pharmacol Exp Ther 1997;283:1-6.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 1-6
    • Gebhardt, R.1    Beckers, G.2    Guanitz, F.3    Haupt, W.4    Jonitza, D.5    Klein, S.6
  • 9
    • 0036988608 scopus 로고    scopus 로고
    • Clinical efficacy of l-ornithinel- aspartate in the management of hepatic encephalopathy
    • Kircheis G, Wettstein M, Dahl S, Haussinger D. Clinical efficacy of l-ornithinel- aspartate in the management of hepatic encephalopathy. Metab Brain Dis 2002;17:453-62.
    • (2002) Metab Brain Dis , vol.17 , pp. 453-462
    • Kircheis, G.1    Wettstein, M.2    Dahl, S.3    Haussinger, D.4
  • 10
    • 58549112777 scopus 로고    scopus 로고
    • L-ornitine-l-aspartate in the management of hepatic encephalopathy: A meta analysis
    • Jiang Q, Jiang XH, Zheng MH, Chen YP. l-ornitine-l-aspartate in the management of hepatic encephalopathy: A meta analysis. J Gastroenterol Hepatol 2009;24:9-14.
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. 9-14
    • Jiang, Q.1    Jiang, X.H.2    Zheng, M.H.3    Chen, Y.P.4
  • 11
    • 33845413403 scopus 로고    scopus 로고
    • Co-administration of C-Phycocyamin ameliorates thioacetamide induced hepatic encephalopathy in wistar rats
    • Sathyasaikumar KV, Swapna I, Reddy PV, Murthy CR, Roy KR, Gupta A, et al. Co-administration of C-Phycocyamin ameliorates thioacetamide induced hepatic encephalopathy in wistar rats. J Neurol Sci 2007;252:67-75.
    • (2007) J Neurol Sci , vol.252 , pp. 67-75
    • Sathyasaikumar, K.V.1    Swapna, I.2    Reddy, P.V.3    Murthy, C.R.4    Roy, K.R.5    Gupta, A.6
  • 12
    • 50049108335 scopus 로고    scopus 로고
    • Effects of fulminant hepatic encephalopathy on the adult rat brain antioxidant status and the activities of acetylcholinestrase Na(+), K(+)- and Mg(2+) -ATPase: Comparison of the enzymes response to in vitro treatment with ammonia
    • Zarros A, Theocharis S, Skandali N, Tsakiris S. Effects of fulminant hepatic encephalopathy on the adult rat brain antioxidant status and the activities of acetylcholinestrase, Na(+), K(+)- and Mg(2+) -ATPase: Comparison of the enzymes response to in vitro treatment with ammonia. Metab Brain Dis 2008;23:255-64.
    • (2008) Metab Brain Dis , vol.23 , pp. 255-264
    • Zarros, A.1    Theocharis, S.2    Skandali, N.3    Tsakiris, S.4
  • 13
    • 66349129125 scopus 로고
    • A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases
    • Reitman S, Frankel AS. A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Am J Clin Pathol 1957;28:53-6.
    • (1957) Am J Clin Pathol , vol.28 , pp. 53-56
    • Reitman, S.1    Frankel, A.S.2
  • 14
    • 77049203740 scopus 로고
    • Estimation of plasma phosphatase by determination of hydrolyzed phenol with amino antipyrine
    • King PR, King EJ. Estimation of plasma phosphatase by determination of hydrolyzed phenol with amino antipyrine. J Clin Pathol 1954;7:322-6.
    • (1954) J Clin Pathol , vol.7 , pp. 322-326
    • King, P.R.1    King, E.J.2
  • 16
    • 3042934967 scopus 로고
    • Tissue sulphydryl groups
    • Ellman GL. Tissue sulphydryl groups. Arch Biochem Biophys 1959;82:70-7.
    • (1959) Arch Biochem Biophys , vol.82 , pp. 70-77
    • Ellman, G.L.1
  • 17
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animals tissues by thioabarbituric acid reaction
    • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animals tissues by thioabarbituric acid reaction. Anal Biochem 1979;95:351-8.
    • (1979) Anal Biochem , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 20
    • 0036135185 scopus 로고    scopus 로고
    • Evaluation of hepatoprotective potential of jigrine post treatment against thioacetamide induced hepatic damage
    • Aftab A, Pillai KK, Najmi AK, Ahmad SJ, Pal SN, Balani DK. Evaluation of hepatoprotective potential of jigrine post treatment against thioacetamide induced hepatic damage. J Ethnopharmacol 2002;79:35-41.
    • (2002) J Ethnopharmacol , vol.79 , pp. 35-41
    • Aftab, A.1    Pillai, K.K.2    Najmi, A.K.3    Ahmad, S.J.4    Pal, S.N.5    Balani, D.K.6
  • 21
    • 0001255753 scopus 로고
    • Liver tumours in rats fed thiourea or thioacetamide
    • Fitzhugh OG, Nelson AA. Liver tumours in rats fed thiourea or thioacetamide. Science 1948;108:626-8.
    • (1948) Science , vol.108 , pp. 626-628
    • Fitzhugh, O.G.1    Nelson, A.A.2
  • 22
    • 0015951937 scopus 로고
    • Non-hepatic thioacetamide injury, the morphological features of proximal tubular injury
    • Barker EA, Smucklear EA. Non-hepatic thioacetamide injury, the morphological features of proximal tubular injury. Am J Pathol 1994;74:575-90.
    • (1994) Am J Pathol , vol.74 , pp. 575-590
    • Barker, E.A.1    Smucklear, E.A.2
  • 24
    • 1942424081 scopus 로고    scopus 로고
    • Hepatoprotective activity of Trianthema portulacastum L. against paracetamol and thioacetamide intoxication in albino rats
    • Kumar G, Banu GS, Pappa PV, Sundararajan M, Pandian MR. Hepatoprotective activity of Trianthema portulacastum L. against paracetamol and thioacetamide intoxication in albino rats. J Ethnopharmacol 2004;92:37-40.
    • (2004) J Ethnopharmacol , vol.92 , pp. 37-40
    • Kumar, G.1    Banu, G.S.2    Pappa, P.V.3    Sundararajan, M.4    Pandian, M.R.5
  • 25
    • 4744350979 scopus 로고    scopus 로고
    • Dietary nucleotides enhance the liver redox state and protein synthesis in cirrhotic rats
    • Perez MJ, Sanchez-Medina F, Torres M, Gil A, Saurez A. Dietary nucleotides enhance the liver redox state and protein synthesis in cirrhotic rats. J Nutr 2004;134:2504-8.
    • (2004) J Nutr , vol.134 , pp. 2504-2508
    • Perez, M.J.1    Sanchez-Medina, F.2    Torres, M.3    Gil, A.4    Saurez, A.5
  • 26
    • 0030024047 scopus 로고    scopus 로고
    • Influence of dietary nucleotide on liver structural recovery and hepatocyte binuclearity in cirrhosis induced by thioacetamide
    • Torres-Lopez MI, Fernandez I, Gil A, Rios A. Influence of dietary nucleotide on liver structural recovery and hepatocyte binuclearity in cirrhosis induced by thioacetamide. Gut 1996;38:260-4.
    • (1996) Gut , vol.38 , pp. 260-264
    • Torres-Lopez, M.I.1    Fernandez, I.2    Gil, A.3    Rios, A.4
  • 27
    • 0018195033 scopus 로고
    • Serum enzymes are indicators of chemical induced liver damage
    • Drotman RB, Lawhorn GT. Serum enzymes are indicators of chemical induced liver damage. Drug Chem Tox 1978;1:163-71.
    • (1978) Drug Chem Tox , vol.1 , pp. 163-171
    • Drotman, R.B.1    Lawhorn, G.T.2
  • 28
    • 0000509676 scopus 로고
    • Free radical and auto-oxidant systems in health and disease
    • Sinclair AJ, Barnett AH, Lunie J. Free radical and auto-oxidant systems in health and disease. J Appl Med 1991;17:409.
    • (1991) J Appl Med , vol.17 , pp. 409
    • Sinclair, A.J.1    Barnett, A.H.2    Lunie, J.3
  • 29
    • 0027715183 scopus 로고
    • Effects of ornithine aspartate on plasma ammonia and amino acids in patients with cirrhosis. A double blind, randomized study using a four fold cross over design
    • Staedt U, Leweling H, Gladisch R, Kortsik C, Hagmuller E, Holm E. Effects of ornithine aspartate on plasma ammonia and amino acids in patients with cirrhosis. A double blind, randomized study using a four fold cross over design. J Hepatol 1993;19:424-30.
    • (1993) J Hepatol , vol.19 , pp. 424-430
    • Staedt, U.1    Leweling, H.2    Gladisch, R.3    Kortsik, C.4    Hagmuller, E.5    Holm, E.6
  • 30
    • 0035113807 scopus 로고    scopus 로고
    • Hepatic encephalopathy: Metabolic consequence of cirrhosis often is reversible
    • Abou-Assi S, Vlahsevic ZR. Hepatic encephalopathy: Metabolic consequence of cirrhosis often is reversible. Postgrad Med 2001;109:52-70.
    • (2001) Postgrad Med , vol.109 , pp. 52-70
    • Abou-Assi, S.1    Vlahsevic, Z.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.