Influence of dietary nucleotides on liver structural recovery and hepatocyte binuclearity in cirrhosis induced by thioacetamide

Gut

Volumn 38, Issue 2, 1996, Pages 260-264

  Torres Lopez M I ^a   Fernandez, I ^a   Fontana, L ^b   Gil, A ^b   Rios, A ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

Author keywords

Binuclearity; Cirrhosis; Dietary nucleotides; Liver recovery; Thioacetamide

Indexed keywords

NUCLEOTIDE; THIOACETAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET; FEMALE; HISTOLOGY; LIVER CELL; LIVER CIRRHOSIS; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

EID: 0030024047     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.38.2.260     Document Type: Article

References (25)

1. Gupta DN. Production of cancer of the bile duct with thioacetamide. Nature 1955; 175: 257.
2. Anghileri LJ, Heidbreder M, Weiler G, Dermietzel R. Hepatocarcinogenesis by thioacetamide: correlations of histological and biochemical changes, and possible role of cell injury. Exp Cell Biol 1977; 45: 34-47.
3. Popper H. Pathological aspects of cirrhosis. Am J Pathol 1977; 87: 228-58.
4. Dasgupta A, Chatterjee R, Chowdhury JR. Thioacetamide-induced hepatocarcinoma in rats. Oncology 1981; 38: 249-53.
5. Becker FF. Thioacetamide hepatocarcinogenesis. J Natl Cancer Inst 1983; 71: 553-8.
6. Müller D, Sommer M, Kretzschmar M, Zimmermann T, Buko VU, Lukivskaya OJ, et al. Lipids peroxidation in thioacetamide-induced macronodular rat liver cirrhosis. Arch Toxicol 1991; 65: 199-203.
7. 4 an adequate model of human cirrhosis? Hepatology 1983; 3: 112-20.
8. Zimmermann T, Müller A, Machnik G, Franke H, Schubert H, Dargel R. Biochemical and morphological studies on production and regression of experimental liver cirrhosis induced by thioacetamide in Uje: WIST rats. Z Versuchstierkd 1987; 30: 165-80.
9. Mullen KD, McCullough AJ. Problems with animal models of chronic liver disease: suggestion for improvement in standardization. Hepatology 1989; 9: 500-3.
10. Kretzschmar M, Machnik G, Müller A, Splinter F-K, Zimmermann T, Klinger W. Experimental treatment of thioacetamide-induced liver cirrhosis by metenolone acetate. A morphological and biochemical study. Exp Pathol 1991; 42: 37-46.
11. Latifi R, Killam RW, Dudrick SJ. Nutritional support in liver failure. Surg Clin North Am 1991; 71: 567-78.
12. Müller MJ, Reiger A, Willmann O, Lautz HU, Balks HJ, Von Zur Mühlen A, et al. Metabolic responses to lipid infusions in patients with liver cirrhosis. Clin Nutr 1992; 11: 193-206.
13. Gil A. Role of dietary nucleotides in artificial nutrition. J Clin Nutr Gastroenterol 1989; 2: 67-70.
14. Ogoshi S, Iwasa M, Yonezawa T, Tamiya T. Effect of nucleotide and nucleoside mixture on rats given total parenteral nutrition after 70% hepatectomy. JPEN 1985; 9: 339-42.
15. Ogoshi S, Iwasa M, Kitagawa S, Ohmori Y, Mizobuchi S, Iwasa Y, et al. Effects of parenteral nutrition with nucleoside and nucleotide mixture on D-galactosamine-induced liver injury in rats. JPEN 1988; 12: 53-7.
16. Ohyagani H, Nishimatsu S, Kanbara Y, Usami M, Saitoh Y. Effects of nucleosides and a nucleotide on DNA and RNA syntheses by the salvage and the novo pathway in primary monolayers cultures of hepatocytes and hepatoma cells. JPEN 1989; 13: 51-8.
17. Kachi K, French SW. The connection between the nuclei of binucleated hepatocytes: an ultrastructural study. J Submicrosc Cytol Pathol 1994; 26: 163-72.
18. Jack EM, Bentley P, Bieri F, Muakkassah-Kelly SF, Stäubli W, Suter J, et al. Increase in hepatocyte and nuclear volume and decrease in the population of binucleated cells in preneoplastic foci of rat liver: a stereological study using the nucleator method. Hepatology 1990; 11: 286-97.
19. ILAR. Control of diets in laboratory animal experimentation. Nutr Abstract Rev: Livestock Feeds and Feeding 1979; 49: 413-9.
20. Council of Europe (1982). European convention for the protection of vertebrate animals used for experimental and other scientific purposes. Addendum III. Strasbourg: 9 July 1982.
21. Zar JH. Biostatistical analysis. 2nd ed. Englewood Cliffs: Prentice-Hall, 1984.
22. Dixon WJ, Brown MB, Engelman L, Jennrich RI. BMDP statistical software manual. Berkeley: University of California Press, 1990.
23. Diez-Fernández C, Boscá L, Fernández-Simón L, Alvarez A, Cascales M. Relationship between genomic DNA ploidy and parameters of liver damage during necrosis and regeneration induced by thioacetamide. Hepatology 1993; 18: 912-8.
24. Michalopoulos GK. Liver regeneration: molecular mechanisms of growth control. FASEB J 1990; 4: 176.
25. Palombo JD, Bowers JL, Clouse ME, McCullough A, Forse RA, Ristrian BR. Hepatic utilization of exogenous nucleotide precussors for restoration of ATP after cold ischemia in rats. Am J Clin Nutr 1993; 57: 420-7.