Venous irritation, pharmacokinetics, and tissue distribution of tirilazad in rats following intravenous administration of a novel supersaturated submicron lipid emulsion

Pharmaceutical Research

Volumn 16, Issue 6, 1999, Pages 930-938

  Wang, Youmin ^a   Mesfin, Gebre Mariam ^b   Rodríguez, Carlos A ^c   Slatter, John G ^d   Schuette, Margaret R ^d   Cory, Andrea L ^a   Higgins, Michael J ^b  

^a Pharmaceutical Development   (United States)

^b Worldwide Toxicology   (United States)

^c Clinical Pharmacokinetics Unit   (United States)

^d Drug Metab and Disposition Research   (United States)

Author keywords

Pharmacokinetics; Submicron lipid emulsion; Supersaturation; Tirilazad; Tissue distribution; Venous irritation

Indexed keywords

LIPID EMULSION; TIRILAZAD;

ANIMAL EXPERIMENT; ANIMAL MODEL; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; BLOOD VESSEL INJURY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG FORMULATION; DRUG STRUCTURE; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION; WHOLE BODY AUTORADIOGRAPHY;

ANIMALS; AREA UNDER CURVE; CHEMISTRY, PHARMACEUTICAL; EMULSIONS; FEMALE; FREE RADICAL SCAVENGERS; INJECTIONS, INTRAVENOUS; LIPIDS; MALE; PREGNATRIENES; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION; VEINS;

EID: 0032982451     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018846607804     Document Type: Article

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