Xerostomia, hyposalivation and sialadenitis in patients with chronic hepatitis C are not associated with the detection of HCV RNA in saliva or salivary glands

Journal of Clinical Pathology

Volumn 63, Issue 11, 2010, Pages 1002-1007

  Grossmann, Soraya De Mattos Camargo ^a   Teixeira, Rosângela ^a   De Oliveira, Guilherme Corrêa ^b   Gleber Netto, Frederico Omar ^a   Araújo, Flávio Marcos Gomes ^b   Araújo, Filipe Maia ^a   Do Carmo, Maria Auxiliadora Vieira ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS RNA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPOSALIVATION; MALE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SALIVA; SALIVARY GLAND; SIALOADENITIS; XEROSTOMIA;

ADOLESCENT; ADULT; AGED; CROSS-SECTIONAL STUDIES; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; MALE; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; SALIVA; SALIVARY GLANDS, MINOR; SIALADENITIS; XEROSTOMIA; YOUNG ADULT;

EID: 78149357715     PISSN: 00219746     EISSN: 14724146     Source Type: Journal    
DOI: 10.1136/jcp.2010.080036     Document Type: Article

References (39)

1. Ghany MG, Strader DB, Thomas DL, et al. American Association for the Study of Liver Diseases. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology 2009;49:1335-74.
2. Zignego AL, Craxì A. Extrahepatic manifestations of hepatitis C virus infection. Clin Liver Dis 2008;12:611-36. (Pubitemid 351958487)
3. Cacoub P, Renou C, Rosenthal E, et al. Extrahepatic manifestations associated with hepatitis C virus infection: a prospective multicenter study of 321 patients. Medicine 2000;79:47-56.
4. Haddad J, Deny P, Munz-Gotheil C, et al. Lymphocytic sialadnitis of Sjögren's syndrome associated with chronic hepatitis C virus liver disease. Lancet 1992;339:321-32.
5. Nagao Y, Hanada S, Shishido S, et al. Incidence of Sjögren's syndrome in Japanese patients with hepatitis C virus infection. J Gastroenterol Hepatol 2003;18:258-66.
6. Ramos-Casals M, Font J. Extrahepatic manifestations in patients with chronic hepatitis C virus infection. Curr Opin Rheumatol 2005;17:447-55.
7. Fried MW, Shindo M, Fong TL, et al. Absence of hepatitis C viral RNA from saliva and semen of patients with chronic hepatitis C. Gastroenterol 1992;102:1306-8.
8. Ferreiro MC, Prieto MH, Rodríguez SB, et al. Whole stimulated salivate flow in patients with chronic hepatitis C virus infection. J Oral Pathol Med 2002;31:117-20.
9. Henderson L, Muir M, Mills PR, et al. Oral health of patients with HCV infection: a pilot study. Oral Dis 2001;7:271-5.
10. Boscagli A, Hatron PY, Canva-Delcambre V, et al. Sicca syndrome and hepatitis C virus infection: a Gougerot-Sjögren pseudo-syndrome? Rev Med Interne 1996;17:375-80.
11. Hay EM, Thomas E, Pal B, et al. Weak association between symptoms and objective testing for dry eyes and dry mouth: results from a population based study. Ann Rheum Dis 1998;57:20-4.
12. Verbaan H, Carlson J, Eriksson S, et al. Extrahepatic manifestations of chronic hepatitis C infection and the interrelationship between primary Sjögren's syndrome and hepatitis C in Swedish patients. J Intern Med 1999;245:127-32.
13. Loustaud-Ratti V, Riche A, Liozon E, et al. Prevalence and characteristics of Sjögren's syndrome or Sicca syndrome in chronic hepatitis C virus infection: a prospective study. J Rheumatol 2001;28:2245-51.
14. Ramos-Casals M, Garcia-Carrasco M, Cervera R, et al. Is hepatitis C virus a sialotropic virus? Am J Pathol 2001;159:1593-4.
15. Ramos-Casals M, Muñoz S, Zerón PB. Hepatitis C virus and Sjögren's syndrome: trigger or mimic? Rheum Dis Clin North Am 2008;34:869-84.
16. Ohoka S, Tanaka Y, Amako Y, et al. Sialadenitis in patients with chronic hepatitis C is not directly related to hepatitis C virus. Hepatol Res 2003;27:23-9.
17. Jensen SB, Pedersen AM, Reibel J, et al. Xerostomia and hypofunction of the salivate glands in cancer therapy. Support Care Cancer 2003;11:207-25. (Pubitemid 36723567)
18. Chan SW, McOmish F, Holmes EC, et al. Analysis of a new hepatitis C virus type and its phylogenetic relationship to existing variants. J Gen Virol 1992;73:1131-41.
19. Oliveira GC, Carmo RA, Rocha MO, et al. Hepatitis C virus genotypes in hemophiliacs in the state of Minas Gerais, Brazil. Transfusion 1999;39:1194-9.
20. McOmish F, Yap PL, Dow BC, et al. Geographical distribution of hepatitis C virus genotypes in blood donors: an international collaborative survey. J Clin Microbiol 1994;32:884-92.
21. Waterhouse JP, Doniach I. Post-mortem prevalence of focal lymphocytic adenitis of the submandibular salivary gland. J Pathol Bacteriol 1966;91:53-64.
22. Chisholm DM, Mason DK. Labial salivary gland biopsy in Sjögren's disease. J Clin Path 1968;21:656-60.
23. Modi AA, Liang TJ. Hepatitis C: a clinical review. Oral Dis 2008;14:10-14.
24. Vieira M, Freire R, Mangualde J, et al. Hepatite C - casuística da consulta de hepatologia de um hospital distrital. J Port Gastrenterol 2007;14:134-40.
25. Grossmann SMC, Teixeira R, Aguiar MC, et al. Oral mucosal conditions in chronic hepatitis C Brazilian patients: a cross-sectional study. J Public Health Dent 2009;69:168-75.
26. Moorthy M, Daniel HD, Kurian G, et al. An evaluation of saliva as an alternative to plasma for the detection of hepatitis C virus antibodies. Indian J Med Microbiol 2008;26:327-32.
27. Blackard JT, Kemmer N, Sherman KE. Extrahepatic replication of HCV: insights into clinical manifestations and biological consequences. Hepatology 2006;44:15-22.
28. Carrozzo M. Oral diseases associated with hepatitis C virus infection. Part 1. Sialadenitis and salivate glands lymphoma. Oral Dis 2008;14:123-30.
29. Scott CA, Avellini C, Desinan L, et al. Chronic lymphocytic sialoadenitis in HCV-related chronic liver disease: comparison of Sjögren's Syndrome. Histopathol 1997;30:41-8.
30. Laskus T, Radkowski M, Wang LF, et al. Uneven distribution of hepatitis C virus quasispecies in tissues from subjects with end-stage liver disease: confounding effect of viral adsorption and mounting evidence for the presence of low-level extrahepatic replication. J. Virol 2000;74:1014-17.
31. Liou TC, Chang TT, Young KC, et al. Detection of HCV RNA in saliva, urine, seminal fluid, and ascites. J Med Virol 1992;37:197-202.
32. Komiyama K, Kawamura F, Arakawa Y, et al. Detection of hepatitis C virus (HCV)-RNA in saliva and gastric juice. Adv Exp Med Biol 1995;371b:995-7.
33. Maticic M, Poljak M, Kramar B, et al. Detection of hepatitis C virus RNA from gingival crevicular fluid and its relation to virus presence in saliva. J Periodontol 2001;72:11-16.
34. Lins L, Almeida H, Vitvisk L, et al. Detection of hepatitis C virus RNA in saliva is not related to oral health status or viral load. J Med Virol 2005;77:216-20.
35. Sagnelli E, Coppola N, Scolastico C, et al. Virologic and clinical expressions of reciprocal inhibitory effect of hepatitis B, C and delta viruses in patients with chronic hepatitis. Hepatol 2000;32:1106-10.
36. Wang CC, Morishima C, Chung M, et al. High serum hepatitis c virus (HCV) RNA load predicts the presence of HCV RNA in saliva from individuals with chronic and acute HCV infection. J Infect Dis 2006;193:672-6.
37. Pawlotsky JM, Ben Yahia M, Andre C, et al. Immunological disorders in C virus chronic active hepatitis: a prospective case-control study. Hepatology 1994;19:841-8.
38. Jorgensen C, Legouffe MC, Perney P, et al. Sicca syndrome associated with hepatitis C virus infection. Arthritis Rheum 1996;39:1166-71.
39. Grossmann SMC, Aguiar MCF, Teixeira R, et al. Oral lichen planus and chronic hepatitis C: a controversial association. Am J Clin Pathol 2007;127:800-4.