Effect of drug-polymer interaction on the release characteristics of methacrylic acid copolymer microcapsules containing theophylline

Artificial Organs

Volumn 22, Issue 8, 1998, Pages 651-656

  Hsiue, Ging Ho ^a   Liao, Chao Ming ^a   Lin, Shan Yang ^b  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Drug polymer interaction; Eudragit L; Microcapsules; Theophylline

Indexed keywords

CONTROLLED DRUG DELIVERY; CURVE FITTING; DRUG INTERACTIONS; FOURIER TRANSFORM INFRARED SPECTROSCOPY; HYDROGEN; MICROSTRUCTURE; TARGETED DRUG DELIVERY;

ANHYDRATES; DRUG-POLYMER INTERACTION; EUDRAGIT; EUDRAGIT L; METHACRYLIC ACIDS; MICROCAPSULES; QUANTITATIVE INVESTIGATION; RELEASE CHARACTERISTICS; SOLVENT EVAPORATION METHOD; THEOPHYLLINE;

HYDROGEN BONDS;

COPOLYMER; EUDRAGIT; METHACRYLIC ACID; THEOPHYLLINE;

ARTICLE; DRUG BINDING; DRUG RELEASE; FOURIER TRANSFORMATION; HYDROGEN BOND; INFRARED SPECTROSCOPY; MICROCAPSULE; PRIORITY JOURNAL;

EID: 0031848078     PISSN: 0160564X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1594.1998.04804.x     Document Type: Article

References (20)

1. Okhamafe AO, York P. Thermal characterization of drug/ polymer and excipient/polymer interactions in some film coating formulation. J Pharm Pharmacol 1989;41:1-6.
2. Lin SY, Cheng CL, Perng RI. Solid state interaction studies of drug-polymers II. Warfarin-Eudragit E, RL or S resins. Eur J Pharm Sci 1994;1:313-22.
3. Jenquih MR, Liebowifz SM, Sarabia RE, McGinity JW. Physical and chemical factors influencing the release of drugs from acrylic resin films. J Pharm Sci 1990;79:811-6.
4. Mortada LM, Bostanian LA, Salib NN. Interaction of oxyphenbutazone with polyvinylpyrrolidone. Pharmazie 1990;45: 350-3.
5. See NA, Russell JR, Connors KA, Bass P. Adsorption of inorganic and organic ions to polycarbophil as a means of sustained-release dosage formulation. Pharm Res 1987;4: 244-7.
6. Yuasa H, Suzuki T. Application of the solid dispersion method to the controlled release of medicine. VI. Release mechanism of a slightly water soluble medicine and interaction between flurbiprofen and hydroxylpropyl cellulose in solid dispersion. Chem Pharm Bull 1994;42:354.
7. Reynolds JEF, ed. The extra pharmacopoeia, 29th ed., London: Martindale, 1988:1526-30.
8. Hermellin VM. Method of making a prolonged action medicinal tablet, U.S. Patent 3109775, 1963.
9. David S, Brooke D, Gallian C. Sustained release tablet containing at least 95% theophylline, U.S. Patent 4465660, 1984.
10. Vashi VI, Meyer MC. Effect of pH on the in vitro dissolution and in vivo adsorption of controlled-release theophylline in dogs. J Pharm Sci 1988;77:760-4.
11. Takeuchi H, Handa T, Kawashima Y. Controlled release theophylline tablet with acrylic polymers prepared by spray-drying technique in aqueous system. Drug Dev Ind Pharm 1989;15:1999-2106.
12. Cameron CG, McGinity JW. Controlled-release theophylline tablet formulations containing acrylic resins II. Combination resin formulations. Drug Dev Ind Pharm 1987;13:1409-27.
13. Lin SY, Kao YH. Effect of Eudragit resins and dibasic calcium phosphate on the compaction and dissolution behavior of directly compressible controlled-release theophylline tablet. Drug Dev Ind Pharm 1990;16:855-74.
14. Pimentel GC, McClellan AL. The hydrogen bond. New York: W.H. Freeman and Co. 1960:11-66.
15. Higuchi T. Mechanism of sustained-action medication. J Pharm Sci 1963;52:1145-9.
16. Price JC. Diffusion controlled systems: Polymeric microcapsulesin, In: Tarcha PJ, ed. Polymers for controlled drug delivery. New York: CRC Press, 1991:1-15.
17. Cangelosi F, Shaw MT. Hydrogen bonding in polymer systems. Polym Eng Sci 1983;23:669-75.
18. Painter PC, Tang WL, Graf JF, Thomson B, Cloeman MM. Formation of molecular composites through hydrogen-bonding interactions. Macromolecules 1991;24:3929-36.
19. Wu JC, Chen HY, Chen H. Studies on the properties of ethylcellulose microcapsules prepared by emulsion non-solvent addition method in the presence of non-solvent in polymer solution. J Microencap 1994;11:519-29.
20. Agyilirah GA, Banker GS. Polymers for enteric coating applications. In: Tarcha PJ, ed. Polymers for controlled drug delivery. New York: CRC Press, 1991:39-66.