Kinetics and inhibition of nicotinamidase from mycobacterium tuberculosis

Biochemistry

Volumn 49, Issue 44, 2010, Pages 9613-9619

  Seiner, Derrick R ^a   Hegde, Subray S ^a   Blanchard, John S ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; DEUTERIUM KINETIC ISOTOPE EFFECT; ENZYMATIC ACTIVITIES; ESSENTIAL COMPONENT; MYCOBACTERIUM TUBERCULOSIS; NICOTINIC ACID; NITRILASE; NUCLEOPHILIC ATTACK; PH DEPENDENCE; PK VALUES; PRODRUGS; PYRAZINAMIDE; SALVAGE PATHWAY; SUBSEQUENT HYDROLYSIS; TETRAHEDRAL INTERMEDIATES; THIOESTERS; THIOL GROUPS;

ACIDS; AMIDES; AMINO ACIDS; DEUTERIUM; ENZYMES; HYDROLYSIS;

ENZYME ACTIVITY;

AMMONIA; CYSTEINE; DEUTERIUM; IODOACETAMIDE; NICOTINAMIDASE; NICOTINAMIDE DERIVATIVE; NITRILASE; PYRAZINAMIDE; WATER;

ARTICLE; CATALYSIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; HYDROLYSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PH; PRIORITY JOURNAL; STEADY STATE;

AMIDOHYDROLASES; ANTITUBERCULAR AGENTS; CLONING, MOLECULAR; HUMANS; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; PYRAZINAMIDE; TUBERCULOSIS;

MYCOBACTERIUM TUBERCULOSIS;

EID: 78149340118     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1011157     Document Type: Article

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