Effect of pyrazinamidase activity on pyrazinamide resistance in Mycobacterium tuberculosis

Tuberculosis

Volumn 89, Issue 2, 2009, Pages 109-113

  Sheen, Patricia ^a   Ferrer, Patricia ^a   Gilman, Robert H ^a,b   López Llano, Jon ^a   Fuentes, Patricia ^a   Valencia, Eddy ^c   Zimic, Mirko J ^a  

^a Laboratorio de Bioinformática   (Peru)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c INSTITUTO NACIONAL DE SALUD   (Peru)

Author keywords

Enzymatic activity; pncA; Pyrazinamidase; Resistance; Tuberculosis

Indexed keywords

PYRAZINAMIDASE; PYRAZINAMIDE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; AMIDASE; PNCA PROTEIN, MYCOBACTERIUM TUBERCULOSIS; PYRAZINAMIDE DEAMIDASE; RECOMBINANT PROTEIN; TUBERCULOSTATIC AGENT;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME LOCALIZATION; ENZYME PURIFICATION; GENE MUTATION; MOLECULAR CLONING; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; DRUG EFFECTS; ENZYMOLOGY; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MUTATION; PROCEDURES; SPUTUM;

AMIDOHYDROLASES; ANTITUBERCULAR AGENTS; CLONING, MOLECULAR; DRUG RESISTANCE, BACTERIAL; HUMANS; MICROBIAL SENSITIVITY TESTS; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PYRAZINAMIDE; RECOMBINANT PROTEINS; SPUTUM;

EID: 61649111323     PISSN: 14729792     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tube.2009.01.004     Document Type: Article

References (36)

1. Mitchison D.A. The action of antituberculosis drugs in short-course chemotherapy. Tubercle 66 (1985) 219-225
2. Steele M.A., and Des Prez R.M. The role of pyrazinamide in tuberculosis chemotherapy. Chest 94 (1988) 845-850
3. Hu Y., Coates A.R., and Mitchison D.A. Sterilising action of pyrazinamide in models of dormant and rifampicin-tolerant Mycobacterium tuberculosis. Int J Tuberc Lung Dis 10 (2006) 317-322
4. Ministerio de Salud. Magnitud del problema de TB MDR y cobertura de los tratamientos para TB MDR. In: Bonilla C, Jave H, Cortez Y, Millán JC, Bayona J, Mukherjee J, editors. Construyendo alianzas estratégicas para detener la Tuberculosis: La experiencia peruana. Lima, Perú: Ministerio de Salud; 2006. p. 67-73.
5. Zignol M., Hosseini M.S., Wright A., Weezenbeek C.L., Nunn P., Watt C.J., et al. Global incidence of multidrug-resistant tuberculosis. J Infect Dis 194 (2006) 479-485
6. Vasquez-Campos L., Asencios-Solis L., Leo-Hurtado E., Quispe-Torres N., Salazar-Lindo E., Bayona J., et al. Drug resistance trends among previously treated tuberculosis patients in a national registry in Peru, 1994-2001. Int J Tuberc Lung Dis 8 (2004) 465-472
7. Zhang Y., and Mitchison D. The curious characteristics of pyrazinamide: a review. Int J Tuberc Lung Dis 7 (2003) 6-21
8. Cheng S.J., Thibert L., Sanchez T., Heifets L., and Zhang Y. pncA mutations as a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis: spread of a monoresistant strain in Quebec, Canada. Antimicrob Agents Chemother 44 (2000) 528-532
9. Konno K., Feldmann F.M., and McDermott W. Pyrazinamide susceptibility and amidase activity of tubercle bacilli. Am Rev Respir Dis 95 (1967) 461-469
10. Zhang Y., Wade M.M., Scorpio A., Zhang H., and Sun Z. Mode of action of pyrazinamide: disruption of Mycobacterium tuberculosis membrane transport and energetics by pyrazinoic acid. J Antimicrob Chemother 52 (2003) 790-795
11. Wade M.M., and Zhang Y. Mechanisms of drug resistance in Mycobacterium tuberculosis. Front Biosci 9 (2004) 975-994
12. Du X., Wang W., Kim R., Yakota H., Nguyen H., and Kim S.H. Crystal structure and mechanism of catalysis of a pyrazinamidase from Pyrococcus horikoshii. Biochemistry 40 (2001) 14166-14172
13. Scorpio A., Lindholm-Levy P., Heifets L., Gilman R., Siddiqi S., Cynamon M., et al. Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis. Antimicrob Agents Chemother 41 (1997) 540-543
14. Lemaitre N., Sougakoff W., Truffot-Pernot C., and Jarlier V. Characterization of new mutations in pyrazinamide-resistant strains of Mycobacterium tuberculosis and identification of conserved regions important for the catalytic activity of the pyrazinamidase PncA. Antimicrob Agents Chemother 43 (1999) 1761-1763
15. Zhang H., Deng J.Y., Bi L.J., Zhou Y.F., Zhang Z.P., Zhang C.G., et al. Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase. Febs J 275 (2008) 753-762
16. Lemaitre N., Callebaut I., Frenois F., Jarlier V., and Sougakoff W. Study of the structure-activity relationships for the pyrazinamidase (PncA) from Mycobacterium tuberculosis. Biochem J 353 (2001) 453-458
17. Suzuki Y., Suzuki A., Tamaru A., Katsukawa C., and Oda H. Rapid detection of pyrazinamide-resistant Mycobacterium tuberculosis by a PCR-based in vitro system. J Clin Microbiol 40 (2002) 501-507
18. Sheen P. Molecular diagnosis of pyrazinamide resistance and molecular understanding of the pyrazinamidase functionality in Mycobacterium tuberculosis (2008), School of Public Health, Johns Hopkins University, Baltimore
19. van Soolingen D., Hermans P.W., de Haas P.E., Soll D.R., and van Embden J.D. Occurrence and stability of insertion sequences in Mycobacterium tuberculosis complex strains: evaluation of an insertion sequence-dependent DNA polymorphism as a tool in the epidemiology of tuberculosis. J Clin Microbiol 29 (1991) 2578-2586
20. Simonian M., and Smith J. Short protocols in molecular biology (1999), John Wiley & Sons, New York
21. Scorpio A., and Zhang Y. Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus. Nat Med 2 (1996) 662-667
22. Wayne L.G. Simple pyrazinamidase and urease tests for routine identification of mycobacteria. Am Rev Respir Dis 109 (1974) 147-151
23. Kent PT KB. Public health mycobacteriology. a guide for the level III laboratory (1985), USDHHS: Centers for Disease Control, Atlanta
24. McClatchy J.K., Tsang A.Y., and Cernich M.S. Use of pyrazinamidase activity on Mycobacterium tuberculosis as a rapid method for determination of pyrazinamide susceptibility. Antimicrob Agents Chemother 20 (1981) 556-557
25. Trivedi S.S., and Desai S.G. Pyrazinamidase activity of Mycobacterium tuberculosis-a test of sensitivity to pyrazinamide. Tubercle 68 (1987) 221-224
26. Voet D, Voet J. Biochemistry. Jonh Wiley & Sons, Inc; 1995.
27. Fersht A. Structure and mechanism in protein science (1999), W.H. Freeman and Company, United States of America
28. Fersht A. The basic equations of enzyme kinetics. Structure and mechanism in protein science: a guide to enzyme catalysis and protein folding (1999), W.H. Freeman and Company, New York p. 103-31
29. Boshoff H.I., and Mizrahi V. Purification, gene cloning, targeted knockout, overexpression, and biochemical characterization of the major pyrazinamidase from Mycobacterium smegmatis. J Bacteriol 180 (1998) 5809-5814
30. Mestdagh M., Fonteyne P.A., Realini L., Rossau R., Jannes G., Mijs W., et al. Relationship between pyrazinamide resistance, loss of pyrazinamidase activity, and mutations in the pncA locus in multidrug-resistant clinical isolates of Mycobacterium tuberculosis. Antimicrob Agents Chemother 43 (1999) 2317-2319
31. Butler W.R., and Kilburn J.O. Susceptibility of Mycobacterium tuberculosis to pyrazinamide and its relationship to pyrazinamidase activity. Antimicrob Agents Chemother 24 (1983) 600-601
32. Brown T.J., Tansel O., and French G.L. Simultaneous identification and typing of multi-drug-resistant Mycobacterium tuberculosis isolates by analysis of pncA and rpoB. J Med Microbiol 49 (2000) 651-656
33. Endoh T., Yagihashi A., Uehara N., Kobayashi D., Tsuji N., Nakamura M., et al. Pyrazinamide resistance associated with pncA gene mutation in Mycobacterium tuberculosis in Japan. Epidemiol Infect 128 (2002) 337-342
34. Marttila H.J., Marjamaki M., Vyshnevskaya E., Vyshnevskiy B.I., Otten T.F., Vasilyef A.V., et al. pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates from northwestern Russia. Antimicrob Agents Chemother 43 (1999) 1764-1766
35. Lee K.W., Lee J.M., and Jung K.S. Characterization of pncA mutations of pyrazinamide-resistant Mycobacterium tuberculosis in Korea. J Korean Med Sci 16 (2001) 537-543
36. Portugal I., Barreiro L., Moniz-Pereira J., and Brum L. pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates in Portugal. Antimicrob Agents Chemother 48 (2004) 2736-2738