Partial least squares analysis and mixture design for the study of the influence of composition variables on lipidic nanoparticle characteristics

Journal of Pharmaceutical Sciences

Volumn 99, Issue 11, 2010, Pages 4603-4615

  Malzert Freon A ^a   Hennequin, D ^b   Rault, S ^a  

^a CENTRE D ETUDES ET DE RECHERCHE SUR LE MÉDICAMENT DE NORMANDIE   (France)

^b UNIVERSITÉ DE CAEN   (France)

Author keywords

Labrasol ; Mixture design; Nanoparticles; Partial least squares; Size

Indexed keywords

LABRAFAC; LABRASOL; LIPID; LIPOID; NANOPARTICLE; SALUTOL; UNCLASSIFIED DRUG;

ARTICLE; DISPERSION; LIPID COMPOSITION; NANOENCAPSULATION; PARTIAL LEAST SQUARES REGRESSION; PARTICLE SIZE; POLYDISPERSITY INDEX; STATISTICAL MODEL;

EID: 78149325375     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22177     Document Type: Article

References (26)

1. Eriksson L, Johansson E, Wikström C. 1998. Mixture design-design generation, PLS analysis, and model usage. Chemometr Intell Lab Syst 43: 1-24.
2. Mathieu D, Phan-Tan-Luu R. 2001. Planification d'expériences en formulation: Optimisation. Techniques de l'Ingénieur, traité Génie des procédés J2: 1-15.
3. Aubert-Pouëssel A, Venier-Julienne MC, Saulnier P, Sergent M, Benoît JP. 2004. Preparation of PLGA microparticles by an emulsion-extraction process using glycofurol as polymer solvent. Pharm Res 21: 2384-2391.
4. Heurtault B, Saulnier P, Pech B, Venier-Julienne MC, Proust JE, Phan-Tan-Luu R, Benoit JP. 2003. The influence of lipid nanocapsule composition on their size distribution. Eur J Pharm Sci 18: 55-61.
5. Shafiq S, Shakeel F, Talegaonkar S, Ahmad FJ, Khar RK, Ali M. 2007. Development and bioavailability assessment of ramipril nanoemulsion formulation. Eur J Pharm Biopharm 66: 227-243.
6. Bjerknes K, Braenden JU, Smistad G, Agerkvist I. 2003. Evaluation of different formulation studies on air-filled polymeric microcapsules by multivariate analysis. Int J Pharm 257: 1-14.
7. Malzert-Fréon A, Saint-Lorant G, Hennequin D, Gauduchon P, Poulain L, Rault S. 2010. Influence of the introduction of a solubility enhancer on the formulation of lipidic nanoparticles with improved drug loading rates. Eur J Pharm Biopharm.
8. Gaumet M, Vargas A, Gurny R, Delie F. 2008. Nanoparticles for drug delivery: The need for precision in reporting particle size parameters. Eur J Pharm Biopharm 69: 1-9.
9. Anton N, Gayet P, Benoit JP, Saulnier P. 2007. Nano-emulsions and nanocapsules by the PIT method: An investigation on the role of the temperature cycling on the emulsion phase inversion. Int J Pharm 344: 44-52.
10. Cun D, Foged C, Yang M, Frøkjær S, Nielsen HM. 2009. Preparation and characterization of poly(dl-lactide-co-glycolide) nanoparticles for siRNA delivery. Int J Pharm.
11. Dubochet J, Adrian M, Chang JJ, Homo JC, Lepault J, McDowall AW, Schultz P. 1988. Cryo-electron microscopy of vitrified specimens. Q Rev Biophys 21: 129-228.
12. Ericksson L, Johansson E, Kettaney-Wold N, Wold S. 2001. Multi- and megavariate data analysis, principles and applications. Umeå: Umetrics Academy.
13. de Aguiar PF, Bourguignon B, Khots MS, Massart DL, Phan-Tan-Luu R. 1995. D-optimal designs. Chemometr Intell Lab Syst 30: 199-210.
14. Mathieu D, Phan-Tan-Luu R. 2001. Planification d'expériences en formulation. Techniques de l'Ingénieur, traité Génie des procédés J2: 1-3.
15. Heurtault B, Saulnier P, Pech B, Proust JE, Benoit JP. 2002. A novel phase inversion-based process for the preparation of lipid nanocarriers. Pharm Res 19: 875-880.
16. Sado G, Sad MC. 2000. Les plans d'expériences, de l'expérimentation à l'assurance qualité, Nouvelle édition. Paris: AFNOR Technique.
17. Zhang Q, Jiang X, Jiang W, Lu W, Su L, Shi Z. 2004. Preparation of nimodipine-loaded microemulsion for intranasal delivery and evaluation on the targeting efficiency to the brain. Int J Pharm 275: 85-96.
18. Ito Y, Arai H, Uchino K, Iwasaki K, Shibata N, Takada K. 2005. Effect of adsorbents on the absorption of lansoprazole with surfactant. Int J Pharm 289: 69-77.
19. Zhao X, Liu JP, Zhang X, Li Y. 2006. Enhancement of transdermal delivery of theophylline using microemulsion vehicle. Int J Pharm 327: 58-64.
20. Pattarino F, Marengo E, Gasco MR, Carpignano R. 1993. Experimental design and partial least squares in the study of complex mixtures: Microemulsions as drug carriers. Int J Pharm 91: 157-165.
21. Dudásová D, Rune Flåten G, Sjöblom J, Øye G. 2009. Stability of binary and ternary model oil-field particle suspensions: A multivariate analysis approach. J Colloid Interface Sci 337: 464-471.
22. Eriksson L, Johansson E, Wold S. 1997. Proceedings of QSAR in Environmental Sciences-VII. Pensacola, FL: Setac-Press.
23. Solans C, Izquierdo P, Nolla J, Azemar N, Garcia-Celma MJ. 2005. Nano-emulsions. Curr Opin Coll Interface Sci 10: 102-110.
24. Ito Y, Kusawake T, Ishida M, Tawa R, Shibata N, Takada K. 2005. Oral solid gentamicin preparation using emulsifier and adsorbent. J Control Rel 105: 23-31.
25. Ito Y, Kusawake T, Prasad YV, Sugioka N, Shibata N, Takada K. 2006. Preparation and evaluation of oral solid heparin using emulsifier and adsorbent for in vitro and in vivo studies. Int J Pharm 317: 114-119.
26. Hu Z, Tawa R, Konishi T, Shibata N, Takada K. 2001. A novel emulsifier, labrasol, enhances gastrointestinal absorption of gentamicin. Life Sci 69: 2899-2910.