Suppressed protein expression of the death-associated protein kinase enhances 5-fluorouracil-sensitivity but not etoposide-sensitivity in human endometrial adenocarcinoma cells

Oncology Reports

Volumn 24, Issue 5, 2010, Pages 1401-1405

  Tanaka, Tetsuji ^a   Bai, Tao ^a   Yukawa, Kazunori ^b  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^b MEIJO UNIVERSITY   (Japan)

Author keywords

5 fluorouracil; Cisplatin; Death associated protein kinase; Drug sensitivity; Etoposide

Indexed keywords

CISPLATIN; DEATH ASSOCIATED PROTEIN KINASE; DEATH RECEPTOR 4; ETOPOSIDE; FLUOROURACIL; SMALL INTERFERING RNA;

ARTICLE; CANCER CELL; CANCER COMBINATION CHEMOTHERAPY; CELL DEATH; CONTROLLED STUDY; DRUG EFFECT; DRUG SENSITIVITY; DRUG TARGETING; ENDOMETRIUM CARCINOMA; FEMALE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOCARCINOMA; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS REGULATORY PROTEINS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; ENDOMETRIAL NEOPLASMS; ETOPOSIDE; FEMALE; FLUOROURACIL; GENE KNOCKDOWN TECHNIQUES; HUMANS; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 78149325278     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000999     Document Type: Article

References (21)

1. Deiss LP, Feinstein E, Berissi H, Cohen O and Kimchi A: Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. Genes Dev 9: 15-30, 1995.
2. 2+/ calmodulin-dependent, cytoskeleton-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity. EMBO J 16: 998-1008, 1997.
3. Kissil JL, Feinstein E, Cohen O, Jones PA, Tsai YC, Knowles MA, Eydmann ME and Kimchi A: DAP kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene. Oncogene 15: 403-407, 1997.
4. Inbal B, Cohen O, Polak-Charcon S, Kopolovic J, Vadai E, Eisenbach L and Kimchi A: DAP kinase links the control of apoptosis to metastasis. Nature 390: 180-184, 1997.
5. Cohen O, Inbal B, Kissil JL, Raveh T, Berissi H, Spivak-Kroizaman T, Feinstein E and Kimchi A: DAP kinase participates in TNF-alpha- and Fas-induced apoptosis and its function requires the death domain. J Cell Biol 146: 141-148, 1999.
6. Jang CW, Chen CH, Chen CC, Chen JY, Su YH and Chen RH: TGFβ induces apoptosis through Smad-mediated expression of DAP kinase. Nat Cell Biol 4: 51-58, 2002.
7. Raveh T, Droguett G, Horwitz MS, De Pinho RA and Kimchi A: DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation. Nat Cell Biol 3: 1-7, 2001.
8. Pelled D, Raveh T, Riebeling C, Fridkin M, Berissi H, Futerman AH and Kimchi A: Death-associated protein (DAP) kinase plays a central role in ceramide induced apoptosis in cultured hippocampal neurons. J Biol Chem 277: 1957-1961, 2002.
9. Yamamoto M, Hioki T, Nakajima-Iijima S and Uchino S: DAP kinase activity is critical for C (2)-ceramide-induced apoptosis in PC12 cells. Eur J Biochem 269: 139-147, 2002.
10. Wang WJ, Kuo JC, Yao CC and Chen RH: DAP kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals. J Cell Biol 159: 169-179, 2002.
11. Jin Y, Blue EK, Dixon S, Hou L, Wysolmerski RB and Gallagher PJ: Identification of a new form of death-associated protein kinase that promotes cell survival. J Biol Chem 276: 39667-39678, 2001.
12. Jin Y and Gallagher PJ: Antisense depletion of death-associated protein kinase promotes apoptosis. J Biol Chem 278: 51587-51593, 2003.
13. Bai T, Tanaka T, Yukawa K and Umesaki N: Reduced expression of death-associated protein kinase in human uterine and ovarian carcinoma cells. Oncol Rep 11: 661-665, 2003.
14. Li L, Tanaka T, Yukawa K, Akira S and Umesaki N: Irinotecan-indiced ovarian follicular apoptosis is atteuated by deleting the kinase domain of death-associated protein kinase. Int J Oncol 34: 905-914, 2009.
15. Bai T, Tanaka T, Yukawa K and Umesaki N: A novel mechanism for acquired cisplatin-resistance: suppressed translation of death-associated protein kinase mRNA is insensitive to 5-aza-2′-deoxycitidine and trichostatin in cisplatin-resistant cervical squamous cancer cells. Int J Oncol 28: 497-508, 2006.
16. Ishiwata I, Ishiwata C, Soma M, Arai J and Oshikawa H: Establishment of human endometrial adenocarcinoma cell line containing estradiol-17 beta and progesteron receptors. Gynecol Oncol 17: 281-290, 1984.
17. Bai T, Tanaka T and Yukawa K: Targeted knockdown of death-associated protein kinase expression induces TRAIL-mediated apoptosis in human endometrial adenocarcinoma cells. Int J Oncol 37: 203-210, 2010.
18. Tanaka T, Bai T and Yukawa K: Death-associated protein kinase is essential for the survival of various types of uterine cancer cells. Int J Oncol 37: 1017-1022, 2010.
19. Pei XH, Bai F, Tsutsui T, Kiyokawa H and Xiong Y: Genetic evidence for functional dependency of p18Ink4c on Cdk4. Mol Cell Biol 24: 6653-6664, 2004.
20. Morishita A, Masaki T, Yoshiji H, Nakai S, Ogi T, Miyauchi Y, Yoshida S, Funaki T, Uchida N, Kita Y, Funakoshi F, Usuki H, Okada S, Izushi K, Watanabe S, Kurokohchi K and Kuriyama S: Reduced expression of cell cycle regulator p18(INK4C) in human hepatocellular carcinoma. Hepatology 40: 677-686, 2004.
21. Van Veelen W, Klompmaker R, Gloerich M, van Gasteren CJ, Kalkhoven E, Berger R, Lips CJ, Medema RH, Hoeppener JW and Acton DS: P18 is a tumor suppressor gene involved in human medullary thyroid carcinoma and pheochromocytoma development. Int J Cancer 124: 339-345, 2009.