Liver X receptor agonist methyl-3β-hydroxy-5α,6α- epoxycholanate attenuates atherosclerosis in apolipoprotein e knockout mice without increasing plasma triglyceride

Pharmacology

Volumn 86, Issue 5-6, 2010, Pages 306-312

  Yan, Wei ^a   Zhang, Tongxin ^a   Cheng, Jun ^a   Zhou, Xiangdong ^a   Qu, Xiaolong ^a   Hu, Houyuan ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Atherosclerosis; ATP binding cassette transporter A1; Liver X receptor; Macrophages

Indexed keywords

ABC TRANSPORTER A1; APOLIPOPROTEIN E; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIVER X RECEPTOR AGONIST; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; MESSENGER RNA; METHYL 3BETA HYDROXY 5ALPHA,6ALPHA EPOXYCHOLANATE; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; ARTERY WALL; ARTICLE; ATHEROGENESIS; CELL CULTURE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIPID BLOOD LEVEL; LIPID METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAINING;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; ATP-BINDING CASSETTE TRANSPORTERS; CELLS, CULTURED; CHENODEOXYCHOLIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HUMANS; HYDROCARBONS, FLUORINATED; MACROPHAGES; MALE; MICE; MICE, KNOCKOUT; ORPHAN NUCLEAR RECEPTORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SULFONAMIDES; TRIGLYCERIDES;

EID: 78149299478     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000321320     Document Type: Article

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