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Volumn 13, Issue 12, 2010, Pages 1829-1844

Reactive oxygen species-dependent c-fos/activator protein 1 induction upregulates heme oxygenase-1 expression by bradykinin in brain astrocytes

Author keywords

[No Author keywords available]

Indexed keywords

BRADYKININ; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN C FOS; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

EID: 78149294702     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2009.2957     Document Type: Article
Times cited : (58)

References (53)
  • 2
    • 33846924300 scopus 로고    scopus 로고
    • How many transcription factors does it take to turn on the heme oxygenase-1 gene?
    • Alam J and Cook JL. How many transcription factors does it take to turn on the heme oxygenase-1 gene? Am J Respir Cell Mol Biol 36: 166-174, 2007.
    • (2007) Am J Respir Cell Mol Biol , vol.36 , pp. 166-174
    • Alam, J.1    Cook, J.L.2
  • 3
    • 4544360319 scopus 로고    scopus 로고
    • Regulation of heme oxygenase-1 gene transcription: Recent advances and highlights from the International Conference (Uppsala 2003) on Heme Oxygenase
    • Alam J, Igarashi K, Immenschuh S, Shibahara S, and Tyrrell RM. Regulation of heme oxygenase-1 gene transcription: recent advances and highlights from the International Conference (Uppsala, 2003) on Heme Oxygenase. Antioxid Redox Signal 6: 924-933, 2004.
    • (2004) Antioxid Redox Signal , vol.6 , pp. 924-933
    • Alam, J.1    Igarashi, K.2    Immenschuh, S.3    Shibahara, S.4    Tyrrell, R.M.5
  • 4
    • 33744989974 scopus 로고    scopus 로고
    • Inhibition of the ERK/MAP kinase pathway attenuates heme oxygenase-1 expression and heme-mediated neuronal injury
    • Benvenisti-Zarom L, Chen-Roetling J, and Regan RF. Inhibition of the ERK/MAP kinase pathway attenuates heme oxygenase-1 expression and heme-mediated neuronal injury. Neurosci Lett 398: 230-234, 2006.
    • (2006) Neurosci Lett , vol.398 , pp. 230-234
    • Benvenisti-Zarom, L.1    Chen-Roetling, J.2    Regan, R.F.3
  • 5
    • 0035026563 scopus 로고    scopus 로고
    • COX-2-dependent delayed dilatation of cerebral arterioles in response to bra-dykinin
    • Brian JE Jr., Faraci FM, and Moore SA. COX-2-dependent delayed dilatation of cerebral arterioles in response to bra-dykinin. Am J Physiol Heart Circ Physiol 280: H2023-H2029, 2001.
    • (2001) Am J Physiol Heart Circ Physiol , vol.280
    • Brian Jr., J.E.1    Faraci, F.M.2    Moore, S.A.3
  • 6
    • 0035149749 scopus 로고    scopus 로고
    • Reactive oxygen radicals in signaling and damage in the ischemic brain
    • Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 21: 2-14, 2001.
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 2-14
    • Chan, P.H.1
  • 7
    • 0029073263 scopus 로고
    • Role of protein kinase C subtypes a and d in the regulation of bradykinin-stimulated phosphoinositide breakdown in astrocytes
    • Chen CC, Chang J, and Chen WC. Role of protein kinase C subtypes a and d in the regulation of bradykinin-stimulated phosphoinositide breakdown in astrocytes. Mol Pharmacol 48: 39-47, 1995.
    • (1995) Mol Pharmacol , vol.48 , pp. 39-47
    • Chen, C.C.1    Chang, J.2    Chen, W.C.3
  • 8
    • 33646050056 scopus 로고    scopus 로고
    • Heme oxygenase-1 contributes to the cytoprotection of alpha-lipoic acid via activation of p44/42 mitogen-activated protein ki-nase in vascular smooth muscle cells
    • Cheng PY, Lee YM, Shih NL, Chen YC, and Yen MH. Heme oxygenase-1 contributes to the cytoprotection of alpha-lipoic acid via activation of p44/42 mitogen-activated protein ki-nase in vascular smooth muscle cells. Free Radic Biol Med 40: 1313-1322, 2006.
    • (2006) Free Radic Biol Med , vol.40 , pp. 1313-1322
    • Cheng, P.Y.1    Lee, Y.M.2    Shih, N.L.3    Chen, Y.C.4    Yen, M.H.5
  • 9
    • 33749051394 scopus 로고    scopus 로고
    • Early activation of bradykinin B2 receptor aggravates reactive oxygen species generation and renal damage in ischemia/reperfusion injury
    • Chiang WC, Chien CT, Lin WW, Lin SL, Chen YM, Lai CF, Wu KD, Chao J, and Tsai TJ. Early activation of bradykinin B2 receptor aggravates reactive oxygen species generation and renal damage in ischemia/reperfusion injury. Free Radic Biol Med 41: 1304-1314, 2006.
    • (2006) Free Radic Biol Med , vol.41 , pp. 1304-1314
    • Chiang, W.C.1    Chien, C.T.2    Lin, W.W.3    Lin, S.L.4    Chen, Y.M.5    Lai, C.F.6    Wu, K.D.7    Chao, J.8    Tsai, T.J.9
  • 10
    • 54449093276 scopus 로고    scopus 로고
    • The role of oxidative stress and NADPH oxidase in cerebrovascular disease
    • Chrissobolis S and Faraci FM. The role of oxidative stress and NADPH oxidase in cerebrovascular disease. Trends Mol Med 14: 495-502, 2008.
    • (2008) Trends Mol Med , vol.14 , pp. 495-502
    • Chrissobolis, S.1    Faraci, F.M.2
  • 11
    • 0029043582 scopus 로고
    • How MAP kinases are regulated
    • Cobb MH and Goldsmith EJ. How MAP kinases are regulated. J Biol Chem 270: 14843-14846, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 14843-14846
    • Cobb, M.H.1    Goldsmith, E.J.2
  • 12
    • 42049090394 scopus 로고    scopus 로고
    • Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections
    • Cuadrado A and Rojo AI. Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections. Curr Pharm Des 14: 429-442, 2008.
    • (2008) Curr Pharm des , vol.14 , pp. 429-442
    • Cuadrado, A.1    Rojo, A.I.2
  • 13
    • 3142710108 scopus 로고    scopus 로고
    • Redox regulation of angiotensin II signaling in the heart
    • Das DK, Maulik N, and Engelman RM. Redox regulation of angiotensin II signaling in the heart. J Cell Mol Med 8: 144-152, 2004.
    • (2004) J Cell Mol Med , vol.8 , pp. 144-152
    • Das, D.K.1    Maulik, N.2    Engelman, R.M.3
  • 14
  • 15
    • 0027523219 scopus 로고
    • Glutathione depletion induces heme oxygenase-1 (HSP32) mRNA and protein in rat brain
    • Ewing JF and Maines MD. Glutathione depletion induces heme oxygenase-1 (HSP32) mRNA and protein in rat brain. J Neurochem 60: 1512-1519, 1993.
    • (1993) J Neurochem , vol.60 , pp. 1512-1519
    • Ewing, J.F.1    Maines, M.D.2
  • 16
    • 42049112071 scopus 로고    scopus 로고
    • Inducers of heme oxygenase-1
    • Ferrándiz ML and Devesa I. Inducers of heme oxygenase-1. Curr Pharm Des 14: 473-486, 2008.
    • (2008) Curr Pharm des , vol.14 , pp. 473-486
    • Ferrándiz, M.L.1    Devesa, I.2
  • 17
    • 0033021002 scopus 로고    scopus 로고
    • Neuroinflammatory processes are important in neurodegenerative diseases: An hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development
    • Floyd RA. Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development. Free Radic Biol Med 26: 1346-1355, 1999.
    • (1999) Free Radic Biol Med , vol.26 , pp. 1346-1355
    • Floyd, R.A.1
  • 19
    • 33745013111 scopus 로고    scopus 로고
    • Oxidative stress and neurodegeneration: Where are we now?
    • Halliwell B. Oxidative stress and neurodegeneration: where are we now? J Neurochem 97: 1634-1658, 2006.
    • (2006) J Neurochem , vol.97 , pp. 1634-1658
    • Halliwell, B.1
  • 21
    • 33845696273 scopus 로고    scopus 로고
    • BK-induced COX-2 expression via PKC-d-dependent activation of p42/p44 MAPK and NF-kB in astrocytes
    • Hsieh HL, Wang HH, Wu CY, Jou MJ, Yen MH, Parker P, and Yang CM. BK-induced COX-2 expression via PKC-d-dependent activation of p42/p44 MAPK and NF-kB in astrocytes. Cell Signal 19: 330-340, 2007.
    • (2007) Cell Signal , vol.19 , pp. 330-340
    • Hsieh, H.L.1    Wang, H.H.2    Wu, C.Y.3    Jou, M.J.4    Yen, M.H.5    Parker, P.6    Yang, C.M.7
  • 22
    • 28444434774 scopus 로고    scopus 로고
    • BK-induced cytosolic phospholipase A2 expression via sequential PKC-d, p42/p44 MAPK, and NF-kB activation in rat brain astrocytes
    • Hsieh HL, Wu CY, Hwang TL, Yen MH, Parker P, and Yang CM. BK-induced cytosolic phospholipase A2 expression via sequential PKC-d, p42/p44 MAPK, and NF-kB activation in rat brain astrocytes. J Cell Physiol 206: 246-254, 2006.
    • (2006) J Cell Physiol , vol.206 , pp. 246-254
    • Hsieh, H.L.1    Wu, C.Y.2    Hwang, T.L.3    Yen, M.H.4    Parker, P.5    Yang, C.M.6
  • 23
    • 45549092958 scopus 로고    scopus 로고
    • Bradykinin induces matrix metalloproteinase-9 expression and cell migration through a PKC-d-dependent ERK/Elk-1 pathway in astro-cytes
    • Hsieh HL, Wu CY, and Yang CM. Bradykinin induces matrix metalloproteinase-9 expression and cell migration through a PKC-d-dependent ERK/Elk-1 pathway in astro-cytes. Glia 56: 619-632, 2008.
    • (2008) Glia , vol.56 , pp. 619-632
    • Hsieh, H.L.1    Wu, C.Y.2    Yang, C.M.3
  • 24
    • 3142654125 scopus 로고    scopus 로고
    • Intracellular signalings underlying bradykinin-induced matrix metallo-proteinase-9 expression in rat brain astrocyte-1
    • Hsieh HL, Yen MH, Jou MJ, and Yang CM. Intracellular signalings underlying bradykinin-induced matrix metallo-proteinase-9 expression in rat brain astrocyte-1. Cell Signal 16: 1163-1176, 2004.
    • (2004) Cell Signal , vol.16 , pp. 1163-1176
    • Hsieh, H.L.1    Yen, M.H.2    Jou, M.J.3    Yang, C.M.4
  • 25
    • 33744960694 scopus 로고    scopus 로고
    • NADPH oxi-dases of the brain: Distribution, regulation, and function
    • Infanger DW, Sharma RV, and Davisson RL. NADPH oxi-dases of the brain: distribution, regulation, and function. Antioxid Redox Signal 8: 1583-1596, 2006.
    • (2006) Antioxid Redox Signal , vol.8 , pp. 1583-1596
    • Infanger, D.W.1    Sharma, R.V.2    Davisson, R.L.3
  • 26
    • 0036263403 scopus 로고    scopus 로고
    • Role of mitogen-and stress-activated kinases in ischemic injury
    • Irving EA and Bamford M. Role of mitogen-and stress-activated kinases in ischemic injury. J Cereb Blood Flow Metab 22: 631-647, 2002.
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 631-647
    • Irving, E.A.1    Bamford, M.2
  • 27
    • 0022109068 scopus 로고
    • Properties of rat brain astrocytes in long-term culture
    • Jou TC, Jou MJ, Chen JY, and Lee SY. [Properties of rat brain astrocytes in long-term culture]. J Formos Med Assoc 84: 865-881, 1985.
    • (1985) J Formos Med Assoc , vol.84 , pp. 865-881
    • Jou, T.C.1    Jou, M.J.2    Chen, J.Y.3    Lee, S.Y.4
  • 28
    • 0032889677 scopus 로고    scopus 로고
    • Redox regulation of cellular signalling
    • Kamata H and Hirata H. Redox regulation of cellular signalling. Cell Signal 11: 1-14, 1999.
    • (1999) Cell Signal , vol.11 , pp. 1-14
    • Kamata, H.1    Hirata, H.2
  • 29
    • 0027458015 scopus 로고
    • The role of bradykinin in mediating ischemic brain edema in rats
    • Kamiya T, Katayama Y, Kashiwagi F, and Terashi A. The role of bradykinin in mediating ischemic brain edema in rats. Stroke 24: 571-575, 1993.
    • (1993) Stroke , vol.24 , pp. 571-575
    • Kamiya, T.1    Katayama, Y.2    Kashiwagi, F.3    Terashi, A.4
  • 30
    • 0035947265 scopus 로고    scopus 로고
    • Reactive oxygen species mediate Ab (25-35)-induced activation of BV-2 mi-croglia
    • Kang J, Park EJ, Jou I, Kim JH, and Joe EH. Reactive oxygen species mediate Ab (25-35)-induced activation of BV-2 mi-croglia. Neuroreport 12: 1449-1452, 2001.
    • (2001) Neuroreport , vol.12 , pp. 1449-1452
    • Kang, J.1    Park, E.J.2    Jou, I.3    Kim, J.H.4    Joe, E.H.5
  • 31
    • 0026554428 scopus 로고
    • 0-dichlorofluorescein as an indicator of reactive oxygen species formation and oxidative stress
    • 0-dichlorofluorescein as an indicator of reactive oxygen species formation and oxidative stress. Chem Res Toxicol 5: 227-231, 1992.
    • (1992) Chem Res Toxicol , vol.5 , pp. 227-231
    • Lebel, C.P.1    Ischiropoulos, H.2    Bondy, S.C.3
  • 32
    • 0033789565 scopus 로고    scopus 로고
    • Free radical pathways in CNS injury
    • Lewén A, Matz P, and Chan PH. Free radical pathways in CNS injury. J Neurotrauma 17: 871-890, 2000.
    • (2000) J Neurotrauma , vol.17 , pp. 871-890
    • Lewén, A.1    Matz, P.2    Chan, P.H.3
  • 33
    • 14944361889 scopus 로고    scopus 로고
    • NADPH oxidase produces reactive oxygen species and maintains survival of rat as-trocytes
    • Liu Q, Kang JH, and Zheng RL. NADPH oxidase produces reactive oxygen species and maintains survival of rat as-trocytes. Cell Biochem Funct 23: 93-100, 2005.
    • (2005) Cell Biochem Funct , vol.23 , pp. 93-100
    • Liu, Q.1    Kang, J.H.2    Zheng, R.L.3
  • 34
    • 0030923630 scopus 로고    scopus 로고
    • The heme oxygenase system: A regulator of second messenger gases
    • Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 37: 517-554, 1997.
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 517-554
    • Maines, M.D.1
  • 35
    • 0022632224 scopus 로고
    • Characterization of two constitutive forms of rat liver microsomal heme oxygenase. only one molecular species of the enzyme is inducible
    • Maines MD, Trakshel GM, and Kutty RK. Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible. J Biol Chem 261: 411-419, 1986.
    • (1986) J Biol Chem , vol.261 , pp. 411-419
    • Maines, M.D.1    Trakshel, G.M.2    Kutty, R.K.3
  • 36
    • 0023654799 scopus 로고
    • Nucleotide sequence and organization of the rat heme oxygenase gene
    • Müller RM, Taguchi H, and Shibahara S. Nucleotide sequence and organization of the rat heme oxygenase gene. J Biol Chem 262: 6795-6802, 1987.
    • (1987) J Biol Chem , vol.262 , pp. 6795-6802
    • Müller, R.M.1    Taguchi, H.2    Shibahara, S.3
  • 37
    • 3442888512 scopus 로고    scopus 로고
    • Redox regulation of glial inflammatory response to lipopolysaccharide and in-terferong
    • Pawate S, Shen Q, Fan F, and Bhat NR. Redox regulation of glial inflammatory response to lipopolysaccharide and in-terferong. J Neurosci Res 77: 540-551, 2004.
    • (2004) J Neurosci Res , vol.77 , pp. 540-551
    • Pawate, S.1    Shen, Q.2    Fan, F.3    Bhat, N.R.4
  • 38
    • 0030772376 scopus 로고    scopus 로고
    • Novel inhibitors of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo
    • Pierce JW, Schoenleber R, Jesmok G, Best J, Moore SA, Collins T, and Gerritsen ME. Novel inhibitors of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem 272: 21096-21103, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 21096-21103
    • Pierce, J.W.1    Schoenleber, R.2    Jesmok, G.3    Best, J.4    Moore, S.A.5    Collins, T.6    Gerritsen, M.E.7
  • 39
    • 0346463000 scopus 로고    scopus 로고
    • NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia
    • Qin L, Liu Y, Wang T, Wei SJ, Block ML, Wilson B, Liu B, and Hong JS. NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia. J Biol Chem 279: 1415-1421, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 1415-1421
    • Qin, L.1    Liu, Y.2    Wang, T.3    Wei, S.J.4    Block, M.L.5    Wilson, B.6    Liu, B.7    Hong, J.S.8
  • 41
    • 33645945014 scopus 로고    scopus 로고
    • Heme oxygenase-1/carbon monoxide: From basic science to therapeutic applications
    • Ryter SW, Alam J, and Choi AM. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev 86: 583-650, 2006.
    • (2006) Physiol Rev , vol.86 , pp. 583-650
    • Ryter, S.W.1    Alam, J.2    Choi, A.M.3
  • 42
    • 13244256816 scopus 로고    scopus 로고
    • Heme oxygenase-1: Redox regulation of a stress protein in lung and cell culture models
    • Ryter SW and Choi AM. Heme oxygenase-1: redox regulation of a stress protein in lung and cell culture models. An-tioxid Redox Signal 7: 80-91, 2005.
    • (2005) An-tioxid Redox Signal , vol.7 , pp. 80-91
    • Ryter, S.W.1    Choi, A.M.2
  • 44
    • 0029032632 scopus 로고
    • Expression of heme oxygenase-1 in the senescent and Alzheimer-diseased brain
    • Schipper HM, Cissé S, and Stopa EG. Expression of heme oxygenase-1 in the senescent and Alzheimer-diseased brain. Ann Neurol 37: 758-768, 1995.
    • (1995) Ann Neurol , vol.37 , pp. 758-768
    • Schipper, H.M.1    Cissé, S.2    Stopa, E.G.3
  • 45
    • 0029984062 scopus 로고    scopus 로고
    • Antioxidant and redox regulation of gene transcription
    • Sen CK and Packer L. Antioxidant and redox regulation of gene transcription. FASEB J 10: 709-720, 1996.
    • (1996) FASEB J , vol.10 , pp. 709-720
    • Sen, C.K.1    Packer, L.2
  • 46
    • 34547439281 scopus 로고    scopus 로고
    • Astroglia over-expressing heme oxygenase-1 predispose co-cultured PC12 cells to oxidative injury
    • Song L, Song W, and Schipper HM. Astroglia over-expressing heme oxygenase-1 predispose co-cultured PC12 cells to oxidative injury. J Neurosci Res 85: 2186-2195, 2007.
    • (2007) J Neurosci Res , vol.85 , pp. 2186-2195
    • Song, L.1    Song, W.2    Schipper, H.M.3
  • 47
    • 54949143147 scopus 로고    scopus 로고
    • Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders
    • Syapin PJ. Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders. Br J Pharmacol 155: 623-640, 2008.
    • (2008) Br J Pharmacol , vol.155 , pp. 623-640
    • Syapin, P.J.1
  • 48
    • 0014348401 scopus 로고
    • The enzymatic conversion of heme to bilirubin by microsomal heme oxy-genase
    • Tenhunen R, Marver HS, and Schmid R. The enzymatic conversion of heme to bilirubin by microsomal heme oxy-genase. Proc Natl Acad Sci \USA 61: 748-755, 1968.
    • (1968) Proc Natl Acad Sci \USA , vol.61 , pp. 748-755
    • Tenhunen, R.1    Marver, H.S.2    Schmid, R.3
  • 50
    • 11844269840 scopus 로고    scopus 로고
    • Phos-phorylation of NF-kB and IkB proteins: Implications in cancer and inflammation
    • Viatour P, Merville MP, Bours V, and Chariot A. Phos-phorylation of NF-kB and IkB proteins: implications in cancer and inflammation. Trends Biochem Sci 30: 43-52, 2005.
    • (2005) Trends Biochem Sci , vol.30 , pp. 43-52
    • Viatour, P.1    Merville, M.P.2    Bours, V.3    Chariot, A.4
  • 52
    • 33750430654 scopus 로고    scopus 로고
    • Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells
    • Yuan X, Xu C, Pan Z, Keum YS, Kim JH, Shen G, Yu S, Oo KT, Ma J, and Kong AN. Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells. Mol Carcinog 45: 841-850, 2006.
    • (2006) Mol Carcinog , vol.45 , pp. 841-850
    • Yuan, X.1    Xu, C.2    Pan, Z.3    Keum, Y.S.4    Kim, J.H.5    Shen, G.6    Yu, S.7    Oo, K.T.8    Ma, J.9    Kong, A.N.10
  • 53
    • 0041705974 scopus 로고    scopus 로고
    • Transcrip-tional regulation of interleukin (IL)-8 by bradykinin in human airway smooth muscle cells involves prostanoid-dependent activation of AP-1 and nuclear factor (NF)-IL-6 and prostanoid-independent activation of NF-kB
    • Zhu YM, Bradbury DA, Pang L, and Knox AJ. Transcrip-tional regulation of interleukin (IL)-8 by bradykinin in human airway smooth muscle cells involves prostanoid-dependent activation of AP-1 and nuclear factor (NF)-IL-6 and prostanoid-independent activation of NF-kB. J Biol Chem 278: 29366-29375, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 29366-29375
    • Zhu, Y.M.1    Bradbury, D.A.2    Pang, L.3    Knox, A.J.4


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