Comparison of changes in mRNA expression of spinal glutamate transporters following induction of two neuropathic pain models

Spinal Cord

Volumn 48, Issue 11, 2010, Pages 791-797

  Mirzaei, V ^a   Manaheji, H ^a   Maghsoudi, N ^a   Zaringhalam, J ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

allodynia; chronic pain; glutamate transporters; hyperalgesia; peripheral neuropathy

Indexed keywords

EXCITATORY AMINO ACID TRANSPORTER; GLUTAMATE TRANSPORTER; MESSENGER RNA; VESICULAR GLUTAMATE TRANSPORTER 1;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HYPERALGESIA; MALE; NEUROPATHIC PAIN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; CHRONIC DISEASE; CONSTRICTION; DISEASE MODELS, ANIMAL; GLUTAMIC ACID; MALE; PAIN MEASUREMENT; PERIPHERAL NERVOUS SYSTEM DISEASES; RATS; RATS, WISTAR; RNA, MESSENGER; SCIATIC NEUROPATHY; UP-REGULATION;

EID: 78149282924     PISSN: 13624393     EISSN: 14765624     Source Type: Journal    
DOI: 10.1038/sc.2010.21     Document Type: Article

References (20)

1. Polgar E, Hughes DI, Arham AZ, Todd AJ. Loss of neurons from Laminas I-III of the spinal dorsal horn is not required for development of tactile allodynia in the spared nerve injury model of neuropathic pain. J Neurosci 2005; 25: 6658-6666.
2. Coderre TJ, Katz J, Vaccarino AL, Melzack R. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 1993; 52: 259-285.
3. Kim KJ, Yoon YW, Chung JM. Comparison of three rodent neuropathic pain models. Exp Brain Res 1997; 113: 200-206.
4. Schmitt AB, Breuer S, Liman J, Buss A, Schlangen C, Pech K et al. Identification of regeneration - associated genes after central and peripheral nerve injury in the adult rat. BMC Neurosci 2003; 19: 4-8.
5. Decosterd I, Woolf CJ. Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain 2000; 87: 149-158.
6. Chen W, Aoki C, Mahadomrongkul V, Gruber CE, Wang GJ, Blitzblau R et al. Expression of a variant form of the glutamate transporter GLT-1 in neuronal cultures and in neurons and astrocytes in the rat brain. J Neurosci 2002; 22: 2142-2152.
7. +- dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) of the blood - brain barrier. J Biol Chem 1999; 274: 31891-31895.
8. Sung B, Lim G, Mao J. Altered expression and uptake activity of spinal glutamate transporters after nerve injury contribute to the pathogenesis of neuropathic pain in rats. J Neurosci 2003; 23: 2899-2910.
9. Tao YX, Gu J, Stephens Jr RL. Role of spinal cord glutamate transporter during normal sensory transmission and pathological Pain. Mol Pain 2005; 1: 30.
10. Vera-Portocarrero LP, Mills CD, Ye Z, Fullwood SD, McAdoo DJ, Hulsebosch CE et al. Rapid changes in expression of glutamate transporters after spinal cord injury. Brain Res 2002; 927: 104-110.
11. Bennett GJ. Experimental Neuropathic Pain in Animals: Models and Mechanisms. Pain: an Updated Review. Seattle: IASP Press, 2005. pp 97-105.
12. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983; 16: 109-110.
13. Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988; 33: 87-107.
14. Decosterd I, Allchorne A, Woolf CJ. Differential analgesic sensitivity of two distinct neuropathic pain models. Anesth Analg 2004; 99: 457-463.
15. Lim J, Lam YC, Kistler J, Donaldson PJ. Molecular characterization of the cysteine/glutamate exchanger and the excitatory amino acid transporters in the rat lens. Invest Ophthalmol Vis Sci 2005; 46: 2869-2877.
16. Yamamoto T, Yaksh LT. Spinal pharmacology of thermal hyper-esthesia induced by constriction injury of sciatic nerve excitatory amino acid antagonists. Pain 1992; 49: 121-128.
17. Mosconi T, Kruyer L. Fixed - diameter polyethylene cuffs applied to the rat sciatic nerve induces a painful neuropathy: ultrastructural morphometric analysis of axonal alterations. Pain 1998; 60: 37-57.
18. Saade NE, Amin HA, Chalouhi S, Baki SA, Jabbar SJ, Atweh SF. Spinal pathways involved in supraspinal modulation of neuropathic manifestations in rats. Pain 2006; 126: 280-295.
19. Parada CA, Vivancos GG, Tambeli CH, Cunha F de Q, Ferreira SH. Activation of presynaptic NMDA receptors coupled to Na V 1.8- resistant sodium channel C-fibers causes retrograde mechanical nociceptor sensitization. Proc Natl Acad Sci USA 2003; 100: 2923-2928.
20. Miralles VJ, Martinez-Lopez I, Zaragoza R, Boorras E, Garcia C, Pallardo FV et al. Na+ dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) in primary astrocyte cultures: effect of oxidative stress. Brain Res 2005; 922: 21-29.